OBJECTIVE:To assess the efficacy of point application therapy(PAT)in alleviating the exacerbation of chronic respiratory diseases represented by bronchial asthma.METHODS:In this multicenter randomized placebocontrolle...OBJECTIVE:To assess the efficacy of point application therapy(PAT)in alleviating the exacerbation of chronic respiratory diseases represented by bronchial asthma.METHODS:In this multicenter randomized placebocontrolled trial,eligible bronchial asthma patients received placebo PAT on the dog days of the first summer to establish a baseline,and then patients who continued to participate in the trial and repassed the eligibility review were randomized to receive regular or placebo PAT in the next two consecutive summers.The primary outcome was the change from baseline in the number of asthma exacerbations at 24 months.Secondary outcomes included severity of asthma exacerbation,asthma control test(ACT)score,percentage of forced expiratory volume in 1 s(FEV1)to the predicated value(FEV1%pred),peak expiratory flow(PEF),ratio of FEV1 to forced vital capacity(FEV1/FVC),and use of palliative drugs during bronchial asthma exacerbations at 12 and 24 months.The adverse events(AEs)were also assessed.RESULTS:A total of 835 patients with bronchial asthma were randomized in this trial.Compared with the placebo control,the PAT significantly decreased the mean number of asthma exacerbations(1.42;95%confidence interval,0.69 to 2.14;P<0.001),and increased the FEV1%pred at 24 months(P=0.039)and FEV1/FVC at 12 months(P=0.01)and 24 months(P=0.01).There were no significant differences between the groups in PEF or ACT score at 12 and 24 months,or in FEV1%pred at 12 months.Treatment-related AEs were mild and more common in the PAT group than in the placebo PAT group.No serious AEs were reported.CONCLUSION:PAT conducted on dog days could reduce asthma exacerbations in patients with bronchial asthma.展开更多
叠前偏移技术在地震数据处理中发挥着非常重要的作用。然而,利用偏移速度分析方法处理复杂地质构造时,往往难以精准重建速度模型,导致共成像点道集的同相轴发生弯曲,影响构造的成像精度。基于动态时间规整算法的地震数据叠加方法通过匹...叠前偏移技术在地震数据处理中发挥着非常重要的作用。然而,利用偏移速度分析方法处理复杂地质构造时,往往难以精准重建速度模型,导致共成像点道集的同相轴发生弯曲,影响构造的成像精度。基于动态时间规整算法的地震数据叠加方法通过匹配参考地震道与其他地震道的相似性来校正同相轴的一致性,但当各地震道之间的幅值差异较大,或者地震数据信噪比较低时,该方法易出现错误匹配的情况,进而导致波形发生畸变,因而影响了其在道集校正中的应用效果。针对上述问题,提出了一种基于迭代光滑动态时间规整算法(iterative smooth dynamic time warping,ISDTW)的共成像点道集叠加方法,该方法引入平滑约束和迭代策略对规整路径进行优化,提高了道集的校正精度和同相轴的一致性。特别是在复杂地质条件下,ISDTW算法取得了较好的成像效果。合成数据和实际数据的测试结果验证了ISDTW算法在减少局部匹配误差、提升地震成像质量方面的显著优势。展开更多
基金Supported by“12th Five-year” National Science and Technology Pillar Program by the Ministry of Science and Technology of the People’s Republic of China:Clinical Evaluation and Technical Operation Specification Research on Preventing Bronchial Asthma Attacks by Acupoint Application in Winter Disease Summer Treatment(No. 2015BAI04B11)。
文摘OBJECTIVE:To assess the efficacy of point application therapy(PAT)in alleviating the exacerbation of chronic respiratory diseases represented by bronchial asthma.METHODS:In this multicenter randomized placebocontrolled trial,eligible bronchial asthma patients received placebo PAT on the dog days of the first summer to establish a baseline,and then patients who continued to participate in the trial and repassed the eligibility review were randomized to receive regular or placebo PAT in the next two consecutive summers.The primary outcome was the change from baseline in the number of asthma exacerbations at 24 months.Secondary outcomes included severity of asthma exacerbation,asthma control test(ACT)score,percentage of forced expiratory volume in 1 s(FEV1)to the predicated value(FEV1%pred),peak expiratory flow(PEF),ratio of FEV1 to forced vital capacity(FEV1/FVC),and use of palliative drugs during bronchial asthma exacerbations at 12 and 24 months.The adverse events(AEs)were also assessed.RESULTS:A total of 835 patients with bronchial asthma were randomized in this trial.Compared with the placebo control,the PAT significantly decreased the mean number of asthma exacerbations(1.42;95%confidence interval,0.69 to 2.14;P<0.001),and increased the FEV1%pred at 24 months(P=0.039)and FEV1/FVC at 12 months(P=0.01)and 24 months(P=0.01).There were no significant differences between the groups in PEF or ACT score at 12 and 24 months,or in FEV1%pred at 12 months.Treatment-related AEs were mild and more common in the PAT group than in the placebo PAT group.No serious AEs were reported.CONCLUSION:PAT conducted on dog days could reduce asthma exacerbations in patients with bronchial asthma.
文摘叠前偏移技术在地震数据处理中发挥着非常重要的作用。然而,利用偏移速度分析方法处理复杂地质构造时,往往难以精准重建速度模型,导致共成像点道集的同相轴发生弯曲,影响构造的成像精度。基于动态时间规整算法的地震数据叠加方法通过匹配参考地震道与其他地震道的相似性来校正同相轴的一致性,但当各地震道之间的幅值差异较大,或者地震数据信噪比较低时,该方法易出现错误匹配的情况,进而导致波形发生畸变,因而影响了其在道集校正中的应用效果。针对上述问题,提出了一种基于迭代光滑动态时间规整算法(iterative smooth dynamic time warping,ISDTW)的共成像点道集叠加方法,该方法引入平滑约束和迭代策略对规整路径进行优化,提高了道集的校正精度和同相轴的一致性。特别是在复杂地质条件下,ISDTW算法取得了较好的成像效果。合成数据和实际数据的测试结果验证了ISDTW算法在减少局部匹配误差、提升地震成像质量方面的显著优势。
