目的探讨脑立清胶囊联合曲美他嗪治疗冠心病合并高血压的疗效以及对血清Salusin-β和孤独G蛋白偶联受体配体(Apelin)水平的影响。方法选取2016年7月至2018年7月收治的冠心病合并高血压患者90例。按随机数字表法将患者分为对照组和观察组...目的探讨脑立清胶囊联合曲美他嗪治疗冠心病合并高血压的疗效以及对血清Salusin-β和孤独G蛋白偶联受体配体(Apelin)水平的影响。方法选取2016年7月至2018年7月收治的冠心病合并高血压患者90例。按随机数字表法将患者分为对照组和观察组,每组45例。在接受常规治疗的基础上,对照组给予曲美他嗪20 mg,po,tid;观察组给予曲美他嗪20 mg,po,tid+脑立清胶囊3粒,po,bid。连续治疗12周后,比较2组血压、心功能、血清Salusin-β和Apelin水平。结果与对照组比较,观察组患者治疗后左心室舒张末期内径(LVEDD)和左心室收缩末期内径(LVESD)降低更明显,左心室射血分数(LVEF)、舒张早期/舒张晚期最大血流速度(E/A)和六分钟步行试验(6 MWT)中步行总距离升高更显著(P<0.01)。治疗后,2组患者的24 h平均收缩压(24 h SBP)、舒张压(24 h DBP)均较治疗前明显降低(P<0.01),但组间差异无统计学意义(P>0.05)。与对照组比较,观察组患者治疗后血清Salusin-β水平降低更明显,Apelin水平升高更显著(P<0.01)。结论脑立清胶囊联合曲美他嗪治疗冠心病合并高血压的疗效明显,调节血清Salusin-β和Apelin水平可能是其疗效途径之一。展开更多
目的探究非诺贝特联用辛伐他汀治疗2型糖尿病(T2DM)合并血脂异常患者的疗效和安全性。方法纳入如皋市人民医院2022年1月至2024年1月收治的100例T2DM合并血脂异常患者,按照信封法将患者随机分为辛伐他汀组(n=50,二甲双胍每次0.5 g、每日2...目的探究非诺贝特联用辛伐他汀治疗2型糖尿病(T2DM)合并血脂异常患者的疗效和安全性。方法纳入如皋市人民医院2022年1月至2024年1月收治的100例T2DM合并血脂异常患者,按照信封法将患者随机分为辛伐他汀组(n=50,二甲双胍每次0.5 g、每日2次,辛伐他汀每次10 mg、每日1次,持续服用3个月)与联合非诺贝特组(n=50,在辛伐他汀组基础上加用非诺贝特,每次0.1 g,每日1次,持续服用3个月)。对比两组临床疗效、血糖指标[空腹血糖(FPG)、餐后2 h血糖(2 h PG)、糖化血红蛋白(HbA1c)]、血脂指标[甘油三酯(TG)、总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)、载脂蛋白B(ApoB)]、体质量[体脂百分比(BF%)、BMI]、内皮功能指标[一氧化氮(NO)、内皮素1(ET-1)]以及药品不良反应。结果联合非诺贝特组的临床疗效高于辛伐他汀组(χ^(2)=4.000,P=0.046);治疗后,两组FPG、2 h PG、HbA1c均下降,联合非诺贝特组各指标低于辛伐他汀组(t=3.093、2.204、2.825,P=0.003、0.030、0.006);治疗后,两组TG、TC、LDL-C、ApoB均下降,HDL-C上升,联合非诺贝特组TG、TC、LDL-C、ApoB低于辛伐他汀组(t=2.580、4.060、5.112、5.369,P=0.011、<0.001、<0.001、<0.001),HDL-C高于辛伐他汀组(t=4.849,P<0.001);联合非诺贝特组血脂达标率高于辛伐他汀组(χ^(2)=4.332,P=0.037);治疗后,两组BF%、BMI均下降,联合非诺贝特组各指标低于辛伐他汀组(t=5.323、6.539,均P<0.001);治疗后,两组NO均上升,ET-1下降,联合非诺贝特组NO高于辛伐他汀组(t=4.976,P<0.001),联合非诺贝特组ET-1低于辛伐他汀组(t=4.688,P<0.001),差异均有统计学意义。联合非诺贝特组不良反应发生率(8.00%)与辛伐他汀组(4.00%)比较,差异无统计学意义(χ^(2)=0.709,P=0.400)。结论非诺贝特联用辛伐他汀可有效治疗T2DM合并血脂异常,控制患者血糖血脂,降低体质量,改善血管内皮指标,药物安全有效。展开更多
To optimize the CO_(2) adsorption performance of carbon materials,this study proposed a preparation method for biomass-based porous carbon through hydrothermal carbonization coupled with nitrogen source optimization a...To optimize the CO_(2) adsorption performance of carbon materials,this study proposed a preparation method for biomass-based porous carbon through hydrothermal carbonization coupled with nitrogen source optimization and K_(2)CO_(3) activation.The effects of different nitrogen sources(urea,piperazine,melamine,and polyaniline)and activation temperatures on the physicochemical features and CO_(2) adsorption characteristics of the porous carbons were systematically investigated.The results indicated that different nitrogen sources showed varying impacts on the CO_(2) uptake of porous carbons,and not all nitrogen sources enhanced the adsorption performance.The urea and piperazine doped porous carbons exhibited relatively low nitrogen contents and specific surface areas.Whereas the melamine doped carbons showed higher nitrogen contents and specific surface areas,but lacked narrow micropores,limiting their CO_(2) adsorption performance.In contrast,PAC-700,prepared using polyaniline as nitrogen source,featured a well-developed pore structure,abundant narrow micropores and pyrrolic-N groups,endowing it with enhanced CO_(2) adsorption capability.At 0℃/1 bar and 25℃/1 bar,the CO_(2) uptake of PAC-700 reached 6.85 and 4.64 mmol/g,respectively.Additionally,PAC-700 maintained a CO_(2) uptake retention ratio of 99%after 5 adsorption-desorption cycles and exhibited good CO_(2)/N_(2) selectivity of 22.4−51.6.These findings highlighted the advantageous CO_(2) adsorption performance of PAC-700,indicating its substantial application potential in the domain of carbon capture.展开更多
文摘目的探讨脑立清胶囊联合曲美他嗪治疗冠心病合并高血压的疗效以及对血清Salusin-β和孤独G蛋白偶联受体配体(Apelin)水平的影响。方法选取2016年7月至2018年7月收治的冠心病合并高血压患者90例。按随机数字表法将患者分为对照组和观察组,每组45例。在接受常规治疗的基础上,对照组给予曲美他嗪20 mg,po,tid;观察组给予曲美他嗪20 mg,po,tid+脑立清胶囊3粒,po,bid。连续治疗12周后,比较2组血压、心功能、血清Salusin-β和Apelin水平。结果与对照组比较,观察组患者治疗后左心室舒张末期内径(LVEDD)和左心室收缩末期内径(LVESD)降低更明显,左心室射血分数(LVEF)、舒张早期/舒张晚期最大血流速度(E/A)和六分钟步行试验(6 MWT)中步行总距离升高更显著(P<0.01)。治疗后,2组患者的24 h平均收缩压(24 h SBP)、舒张压(24 h DBP)均较治疗前明显降低(P<0.01),但组间差异无统计学意义(P>0.05)。与对照组比较,观察组患者治疗后血清Salusin-β水平降低更明显,Apelin水平升高更显著(P<0.01)。结论脑立清胶囊联合曲美他嗪治疗冠心病合并高血压的疗效明显,调节血清Salusin-β和Apelin水平可能是其疗效途径之一。
文摘目的探究非诺贝特联用辛伐他汀治疗2型糖尿病(T2DM)合并血脂异常患者的疗效和安全性。方法纳入如皋市人民医院2022年1月至2024年1月收治的100例T2DM合并血脂异常患者,按照信封法将患者随机分为辛伐他汀组(n=50,二甲双胍每次0.5 g、每日2次,辛伐他汀每次10 mg、每日1次,持续服用3个月)与联合非诺贝特组(n=50,在辛伐他汀组基础上加用非诺贝特,每次0.1 g,每日1次,持续服用3个月)。对比两组临床疗效、血糖指标[空腹血糖(FPG)、餐后2 h血糖(2 h PG)、糖化血红蛋白(HbA1c)]、血脂指标[甘油三酯(TG)、总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)、载脂蛋白B(ApoB)]、体质量[体脂百分比(BF%)、BMI]、内皮功能指标[一氧化氮(NO)、内皮素1(ET-1)]以及药品不良反应。结果联合非诺贝特组的临床疗效高于辛伐他汀组(χ^(2)=4.000,P=0.046);治疗后,两组FPG、2 h PG、HbA1c均下降,联合非诺贝特组各指标低于辛伐他汀组(t=3.093、2.204、2.825,P=0.003、0.030、0.006);治疗后,两组TG、TC、LDL-C、ApoB均下降,HDL-C上升,联合非诺贝特组TG、TC、LDL-C、ApoB低于辛伐他汀组(t=2.580、4.060、5.112、5.369,P=0.011、<0.001、<0.001、<0.001),HDL-C高于辛伐他汀组(t=4.849,P<0.001);联合非诺贝特组血脂达标率高于辛伐他汀组(χ^(2)=4.332,P=0.037);治疗后,两组BF%、BMI均下降,联合非诺贝特组各指标低于辛伐他汀组(t=5.323、6.539,均P<0.001);治疗后,两组NO均上升,ET-1下降,联合非诺贝特组NO高于辛伐他汀组(t=4.976,P<0.001),联合非诺贝特组ET-1低于辛伐他汀组(t=4.688,P<0.001),差异均有统计学意义。联合非诺贝特组不良反应发生率(8.00%)与辛伐他汀组(4.00%)比较,差异无统计学意义(χ^(2)=0.709,P=0.400)。结论非诺贝特联用辛伐他汀可有效治疗T2DM合并血脂异常,控制患者血糖血脂,降低体质量,改善血管内皮指标,药物安全有效。
基金supported by the National Key R&D Program(2022YFC3902403)Fundamental Research Funds for the Central Universities(2024JC001,2019JG002)Technology Innovation Special Fund of Jiangsu Province for Carbon Dioxide Emission Peaking and Carbon Neutrality(BE2022307)。
文摘To optimize the CO_(2) adsorption performance of carbon materials,this study proposed a preparation method for biomass-based porous carbon through hydrothermal carbonization coupled with nitrogen source optimization and K_(2)CO_(3) activation.The effects of different nitrogen sources(urea,piperazine,melamine,and polyaniline)and activation temperatures on the physicochemical features and CO_(2) adsorption characteristics of the porous carbons were systematically investigated.The results indicated that different nitrogen sources showed varying impacts on the CO_(2) uptake of porous carbons,and not all nitrogen sources enhanced the adsorption performance.The urea and piperazine doped porous carbons exhibited relatively low nitrogen contents and specific surface areas.Whereas the melamine doped carbons showed higher nitrogen contents and specific surface areas,but lacked narrow micropores,limiting their CO_(2) adsorption performance.In contrast,PAC-700,prepared using polyaniline as nitrogen source,featured a well-developed pore structure,abundant narrow micropores and pyrrolic-N groups,endowing it with enhanced CO_(2) adsorption capability.At 0℃/1 bar and 25℃/1 bar,the CO_(2) uptake of PAC-700 reached 6.85 and 4.64 mmol/g,respectively.Additionally,PAC-700 maintained a CO_(2) uptake retention ratio of 99%after 5 adsorption-desorption cycles and exhibited good CO_(2)/N_(2) selectivity of 22.4−51.6.These findings highlighted the advantageous CO_(2) adsorption performance of PAC-700,indicating its substantial application potential in the domain of carbon capture.
