OBJECTIVE:To observe whether electroacupuncture stimulation of auricular concha region(EA-ACR)on behavior changes of depression by loss of control over stress model(LOC),and whether its effect is improved by regulatin...OBJECTIVE:To observe whether electroacupuncture stimulation of auricular concha region(EA-ACR)on behavior changes of depression by loss of control over stress model(LOC),and whether its effect is improved by regulating the expression levels of hydroxytryptamine(serotonin,5-HT)1A receptor(5-HT_(1A)R)/hydroxytryptamine(serotonin,5-HT)2A receptor(5-HT_(2A)R)in hippocampus.METHODS:LOC was prepared using a Skinner box,and EA-ACR to observe behavioral changes,and Western Blot was used to detect the changes of 5-HT_(1A)R/5-HT_(2A)R in the hippocampus,and then observe the changes of EA-ACR behavior after microinjection of 5-HT_(1A)R/5-HT_(2A)R antagonist into the hippocampus.RESULTS:EA-ACR improve depressive-like behavior,up-regulated 5-HT_(1A)R expression and down-regulated 5-HT_(2A)R expression in hippocampal brain area.EA-ACR did not improve depression-like behavior after hippocampal microinjection of 5-HT_(1A)R antagonist,while injection of 5-HT_(2A)R antagonists can improve depressionlike behaviors.CONCLUSION:EA-ACR can improve depressive-like behaviors.Loss of control over stress leads to upregulation of 5-HT_(1A)R and down-regulation of 5-HT_(2A)R in the hippocampus,while EA-ACR mainly improves depressive behavior by regulating 5-HT_(1A)R in Hip.展开更多
Located in the eastern part of the East Qinling molybdenum belt, the Donggou deposit is a superlarge porphyry molybdenum deposit discovered in recent years. The authors performed highly precise dating of the mineraliz...Located in the eastern part of the East Qinling molybdenum belt, the Donggou deposit is a superlarge porphyry molybdenum deposit discovered in recent years. The authors performed highly precise dating of the mineralized porphyry and ores in the Donggou molybdenum deposit. A SHRIMP U-Pb zircon dating of the Donggou aluminous A-type granite-porphyry gave a rock-forming age of 112±1 Ma, and the ICP-MS Re-Os analyses of molybdenite from the molybdenum deposit yielded ReOs model ages ranging from 116.5±1.7 to 115.5±1.7 Ma for the deposit. The ages obtained by the two methods are quite close, suggesting that the rocks and ores formed approximately at the same time. The Donggou molybdenum deposit formed at least 20 Ma later than the Jinduicheng, Nannihu, Shangfanggou and Leimengou porphyry molybdenum deposits in the same molybdenum belt, implying that these deposits were formed in different tectonic settings.展开更多
The SHRIMP U-Pb zircon dating result of the Tongshi magmatic complex in western Shandong is presented in this paper. The Tongshi magmatic complex comprises fine-grained porphyritic diorite and syenitic porphyry. Eight...The SHRIMP U-Pb zircon dating result of the Tongshi magmatic complex in western Shandong is presented in this paper. The Tongshi magmatic complex comprises fine-grained porphyritic diorite and syenitic porphyry. Eighteen analyses for fine-grained porphyritic diorite gave two concordia ages, in which ten analyses constitute the young age group, giving ^206Pb/^238U ages ranging from 167.9 Ma to 183 Ma with a weighted mean age of 175.7±3.8 Ma, and the other eight yielded ^207Pb/^206Pb ages of 2502 Ma to 2554 Ma with a weighted mean 2518±11 Ma. Two analyses for syenitic porphyry gave ages of 2485 Ma and 2512 Ma, respectively. The age of 175.7±3.8 Ma indicates that the crystallization of the Tongshi magmatic complex occurred in the Middle Jurassic, whereas that of 2518±11 Ma is interpreted as the age of inherited magmatic zircons in the Neoarchean Wutai period.展开更多
基金the Natural Science Foundation of Shaanxi Province:Acupuncture’s Anxiolytic Effects in Uncontrollable Stress:Modulation of the Median Raphe Nucleus to Ventral Hippocampus Serotonergic Pathway(No.2022JQ-949)the National Natural Science Foundation of China:Study on the Mechanisms of Learning and Memory Impairment induced by Chronic Pain and the Intervention Effects of Acupuncture(No.82004489)。
文摘OBJECTIVE:To observe whether electroacupuncture stimulation of auricular concha region(EA-ACR)on behavior changes of depression by loss of control over stress model(LOC),and whether its effect is improved by regulating the expression levels of hydroxytryptamine(serotonin,5-HT)1A receptor(5-HT_(1A)R)/hydroxytryptamine(serotonin,5-HT)2A receptor(5-HT_(2A)R)in hippocampus.METHODS:LOC was prepared using a Skinner box,and EA-ACR to observe behavioral changes,and Western Blot was used to detect the changes of 5-HT_(1A)R/5-HT_(2A)R in the hippocampus,and then observe the changes of EA-ACR behavior after microinjection of 5-HT_(1A)R/5-HT_(2A)R antagonist into the hippocampus.RESULTS:EA-ACR improve depressive-like behavior,up-regulated 5-HT_(1A)R expression and down-regulated 5-HT_(2A)R expression in hippocampal brain area.EA-ACR did not improve depression-like behavior after hippocampal microinjection of 5-HT_(1A)R antagonist,while injection of 5-HT_(2A)R antagonists can improve depressionlike behaviors.CONCLUSION:EA-ACR can improve depressive-like behaviors.Loss of control over stress leads to upregulation of 5-HT_(1A)R and down-regulation of 5-HT_(2A)R in the hippocampus,while EA-ACR mainly improves depressive behavior by regulating 5-HT_(1A)R in Hip.
基金supported by the National Natural Science Foundation of China(Grant 40434011)China Geological Survey Project of the Ministry of Land and Resources(Grant 1212010535804).
文摘Located in the eastern part of the East Qinling molybdenum belt, the Donggou deposit is a superlarge porphyry molybdenum deposit discovered in recent years. The authors performed highly precise dating of the mineralized porphyry and ores in the Donggou molybdenum deposit. A SHRIMP U-Pb zircon dating of the Donggou aluminous A-type granite-porphyry gave a rock-forming age of 112±1 Ma, and the ICP-MS Re-Os analyses of molybdenite from the molybdenum deposit yielded ReOs model ages ranging from 116.5±1.7 to 115.5±1.7 Ma for the deposit. The ages obtained by the two methods are quite close, suggesting that the rocks and ores formed approximately at the same time. The Donggou molybdenum deposit formed at least 20 Ma later than the Jinduicheng, Nannihu, Shangfanggou and Leimengou porphyry molybdenum deposits in the same molybdenum belt, implying that these deposits were formed in different tectonic settings.
基金This study was supported by the Major State Basic Rsearch Program of China(grant G1999043211)National Natural Science Foundation of China(grant 40272088).
文摘The SHRIMP U-Pb zircon dating result of the Tongshi magmatic complex in western Shandong is presented in this paper. The Tongshi magmatic complex comprises fine-grained porphyritic diorite and syenitic porphyry. Eighteen analyses for fine-grained porphyritic diorite gave two concordia ages, in which ten analyses constitute the young age group, giving ^206Pb/^238U ages ranging from 167.9 Ma to 183 Ma with a weighted mean age of 175.7±3.8 Ma, and the other eight yielded ^207Pb/^206Pb ages of 2502 Ma to 2554 Ma with a weighted mean 2518±11 Ma. Two analyses for syenitic porphyry gave ages of 2485 Ma and 2512 Ma, respectively. The age of 175.7±3.8 Ma indicates that the crystallization of the Tongshi magmatic complex occurred in the Middle Jurassic, whereas that of 2518±11 Ma is interpreted as the age of inherited magmatic zircons in the Neoarchean Wutai period.
