Berberine,an isoquinoline quaternary alkaloid,is a molecule with significant therapeutic adaptability.It has been identified,isolated,and measured in a wide range of plant families and species.Of these,Berberis stands...Berberine,an isoquinoline quaternary alkaloid,is a molecule with significant therapeutic adaptability.It has been identified,isolated,and measured in a wide range of plant families and species.Of these,Berberis stands out as a significant natural source of berberine,with Berberis vulgaris(B.vulgaris)bark being one of the most notable.The numerous health benefits associated with berberine include its potential use in the treatment of diseases,such as cancer,cardiovascular diseases,diabetes,and neurological disorders.The principal use of berberine has been for its antidiarrheal properties,which may have several modes of action.Its potent antioxidant and anti-inflammatory effects are responsible for its preventive action against stomach ulcers,and it has been found to kill dangerous gut bacteria while boosting the species and numbers of health-promoting bacteria.It protects the colon by influencing the production of several immune factors in addition to upregulating the Wnt-βcreatinine signaling cascade.Berberine has shown its potential in regulating cholesterol metabolism by elevating the levels of low-density lipoprotein receptor in the liver.This review comprehensively examines the pharmacokinetics,multifaceted bioactivities,and gutprotective roles of berberine,providing a detailed analysis of its diverse physiological functions and potential clinical applications to advance the understanding and management of gastrointestinal diseases.展开更多
Both the inplane and out-of-plane transverse vibrations of aviscoelastic cable subjected to an initial stress distributinguniform on the cross section are studied. The constitution of thecable material is as- sumed to...Both the inplane and out-of-plane transverse vibrations of aviscoelastic cable subjected to an initial stress distributinguniform on the cross section are studied. The constitution of thecable material is as- sumed to be of the hereditary integral type.The partial differential -integral equations of motion are derivedfirst. Then by applying Galerkin's method, the governing equationsare reduced to a set of second-order non- linear differential-integral equations which are solved by finite difference numericalintegration procedures. Finally, the effects of the viscosityparameter and the elastic parameter on the transient amplitudes ofthe first Mode are investigated by numerical simulation.展开更多
The almost sure stability of homogeneous viscoelastic platessubjected to a random wide-band stationary in-plane load isinvestigated. The viscoelastic behavior of the plate is described interms of the Bo- ltzmann super...The almost sure stability of homogeneous viscoelastic platessubjected to a random wide-band stationary in-plane load isinvestigated. The viscoelastic behavior of the plate is described interms of the Bo- ltzmann superposition principle, the relaxationkernels of which are represented by the sums of exponents. On theassumption that the in-plane load is random wide-band stationaryprocess, sufficient conditions for al- Most sure stability ofviscoelastic plates are obtained by the applications of Lyapunov'sdirect method.展开更多
文摘Berberine,an isoquinoline quaternary alkaloid,is a molecule with significant therapeutic adaptability.It has been identified,isolated,and measured in a wide range of plant families and species.Of these,Berberis stands out as a significant natural source of berberine,with Berberis vulgaris(B.vulgaris)bark being one of the most notable.The numerous health benefits associated with berberine include its potential use in the treatment of diseases,such as cancer,cardiovascular diseases,diabetes,and neurological disorders.The principal use of berberine has been for its antidiarrheal properties,which may have several modes of action.Its potent antioxidant and anti-inflammatory effects are responsible for its preventive action against stomach ulcers,and it has been found to kill dangerous gut bacteria while boosting the species and numbers of health-promoting bacteria.It protects the colon by influencing the production of several immune factors in addition to upregulating the Wnt-βcreatinine signaling cascade.Berberine has shown its potential in regulating cholesterol metabolism by elevating the levels of low-density lipoprotein receptor in the liver.This review comprehensively examines the pharmacokinetics,multifaceted bioactivities,and gutprotective roles of berberine,providing a detailed analysis of its diverse physiological functions and potential clinical applications to advance the understanding and management of gastrointestinal diseases.
基金the National Natural Science Foundation of China (No.59635140)the National Postdoctoral Foundation of China.
文摘Both the inplane and out-of-plane transverse vibrations of aviscoelastic cable subjected to an initial stress distributinguniform on the cross section are studied. The constitution of thecable material is as- sumed to be of the hereditary integral type.The partial differential -integral equations of motion are derivedfirst. Then by applying Galerkin's method, the governing equationsare reduced to a set of second-order non- linear differential-integral equations which are solved by finite difference numericalintegration procedures. Finally, the effects of the viscosityparameter and the elastic parameter on the transient amplitudes ofthe first Mode are investigated by numerical simulation.
基金the National Natural Science Foundation of China (No.59635140)the National Postdoctoral Foundation.
文摘The almost sure stability of homogeneous viscoelastic platessubjected to a random wide-band stationary in-plane load isinvestigated. The viscoelastic behavior of the plate is described interms of the Bo- ltzmann superposition principle, the relaxationkernels of which are represented by the sums of exponents. On theassumption that the in-plane load is random wide-band stationaryprocess, sufficient conditions for al- Most sure stability ofviscoelastic plates are obtained by the applications of Lyapunov'sdirect method.
