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Effect of improved anterior capsule polishing on visual quality after cataract surgery
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作者 Dang Guanxing Zhou Xin +3 位作者 Wang Congyi li yan Wu li'an Ma Bo 《国际眼科杂志》 2026年第2期187-196,共10页
AIM:To assess the visual acuity and visual quality of cataract patients who received femtosecond laser-assisted cataract surgery(FLACS)and multifocal intraocular lens(MIOL)implantation with an improved polishing techn... AIM:To assess the visual acuity and visual quality of cataract patients who received femtosecond laser-assisted cataract surgery(FLACS)and multifocal intraocular lens(MIOL)implantation with an improved polishing technique during a 1-year follow-up period.METHODS:This study included 74 eyes from 37 patients,comprising 17 males and 20 females,with a mean age of 51.74±7.80 years.Using a coin toss method,one eye per patient was randomly selected for improved anterior capsular polishing,while the other eye received standard irrigation/aspiration(I/A)polishing.The polishing group consisted of 37 eyes,including 21 right and 16 left eyes,while the control group comprised the contralateral fellow eyes of the same individuals in the polishing group.Visual acuity and quality of the patients were evaluated before surgery and at 1 wk,1,6,and 12 mo after surgery.The OPD-Scan III was utilized to assess high-order aberrations,while the optical quality analysis system(OQAS)was employed to evaluate modulation transfer function(MTF cutoff),Strehl ratio(SR),and objective scatter index(OSI)for the purpose of visual quality assessment.Paired t-tests and repeated measures analysis of variance(ANOVA)were utilized to compare the results,and the SNK-q post hoc test was applied to identify significant differences.RESULTS:The polishing group’s uncorrected distant visual acuity(UDVA)and uncorrected near visual acuity(UNVA)significantly improved 1-week post-surgery(all P<0.05).At 12-months,UDVA,UNVA,and corrected distant visual acuity(CDVA)were better than the control group(P<0.05).The MTF cutoff,SR,OSI,and high-order aberrations in the polishing group also showed significant improvements compared to the control group at 12 mo(P<0.05).CONCLUSION:The improved capsular polishing method has been demonstrated to effectively maintain visual acuity and visual quality in patients with MIOL after FLACS within 1 a. 展开更多
关键词 anterior capsule polishing visual quality cataract surgery femtosecond laser
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川芎嗪通过miR-143-3p靶向调节LIMK1/cofilin通路减轻脂多糖诱导的小鼠急性肺损伤 被引量:3
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作者 薛蕾 刘小碣 +4 位作者 陶伟婷 闵思敏 高可飞 李言 张永 《临床肺科杂志》 2025年第1期13-23,共11页
目的 探究川芎嗪(TMP)通过miR-143-3p靶向调节LIM激酶1/丝切蛋白(LIMK1/cofilin)信号通路对脂多糖(LPS)诱导的小鼠急性肺损伤(ALI)的影响。方法 将C57BL/6小鼠随机分为对照组(CON组)、模型组(LPS组)、TMP组、空载病毒组(GFP组)、过表达m... 目的 探究川芎嗪(TMP)通过miR-143-3p靶向调节LIM激酶1/丝切蛋白(LIMK1/cofilin)信号通路对脂多糖(LPS)诱导的小鼠急性肺损伤(ALI)的影响。方法 将C57BL/6小鼠随机分为对照组(CON组)、模型组(LPS组)、TMP组、空载病毒组(GFP组)、过表达miR-143-3p组、敲低miR-143-3p组,每组10只。HE染色观察肺组织病理变化情况;ELISA检测肺泡灌洗液(BALF)中白细胞介素1β(IL-1β)、白细胞介素6(IL-6)、肿瘤坏死因子α(TNF-α)含量;肺湿/干比(肺W/D)、BALF中白细胞数量、蛋白浓度以及埃文斯蓝(Evans Blue)染料检测肺血管通透性;Western Blot检测p-LIMK1、p-cofilin的表达情况。结果 与CON组相比,LPS组肺组织病理损伤加重,肺损伤评分、肺W/D、BALF白细胞数量、蛋白浓度和炎症因子、Evans Blue渗漏、p-LIMK1、p-cofilin表达水平增加(P均<0.01);与LPS组相比,过表达miR-143-3p组肺组织病理损伤减轻,肺损伤评分、BALF白细胞数量、蛋白浓度和炎症因子、Evans Blue渗漏降低(P均<0.01),肺W/D降低(P<0.05),p-LIMK1、p-cofilin表达水平降低(P<0.01,P<0.05);与LPS组相比,TMP组肺组织病理损伤减轻,肺损伤评分、肺W/D、BALF白细胞数量、蛋白浓度和炎症因子、Evans Blue渗漏降低(P均<0.01),p-LIMK1、p-cofilin表达水平降低(P<0.01,P<0.05);与TMP组相比,敲低miR-143-3p组逆转了TMP对LPS诱导的小鼠ALI的改善作用(P均<0.01)。双荧光素酶实验证实miR-143-3p可靶向调控LIMK1表达(P<0.001)。结论 TMP通过上调miR-143-3p来抑制LIMK1/cofilin信号通路,从而减轻LPS诱导的小鼠ALI。 展开更多
关键词 川芎嗪 急性肺损伤 LIMK1/cofilin通路 miR-143-3p
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盘州大厂茶(Camellia tachangensis)的生物碱类、儿茶素类及氨基酸类组成特性分析
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作者 杨春 郭燕 +6 位作者 乔大河 梁思慧 李燕 李彦福 密孝增 杨世雄 陈正武 《西南农业学报》 北大核心 2025年第3期507-518,共12页
【目的】探明盘州大厂茶生化组成特性,为贵州野生茶树的系统鉴定,特色盘州大厂茶新品种选育、种质资源保护及开发利用提供依据。【方法】采用高效液相色谱法对25份盘州大厂茶及3份对照的29种生化组分进行检测,结合OPLS-DA分析、相关性... 【目的】探明盘州大厂茶生化组成特性,为贵州野生茶树的系统鉴定,特色盘州大厂茶新品种选育、种质资源保护及开发利用提供依据。【方法】采用高效液相色谱法对25份盘州大厂茶及3份对照的29种生化组分进行检测,结合OPLS-DA分析、相关性分析、主成分分析和聚类分析对盘州大厂茶生化组成特性及生化品质进行综合评价。【结果】盘州大厂茶种质存在丰富的遗传多样性,28种生化组分变异系数为0.79%(GCG)~241.4%(丙氨酸),平均为46.08%;遗传多样性指数为0.861(丙氨酸)~2.001(EC),平均为1.798。苦茶碱、ECG和茶氨酸分别构成盘州大厂茶中的优势生物碱类、儿茶素类和氨基酸类。通过OPLS-DA分析,筛选出11种VIP大于1.0的生化组分:咖啡碱、EGCG、苦茶碱、半胱氨酸、脯氨酸、GCG、甲硫氨酸、ECG、EGC、茶氨酸和EC,可用于区分盘州大厂茶和栽培种茶树。28种生化组分间的相关关系存在一定规律,生物碱类与氨基酸类的相关关系强于其与儿茶素类间的相关关系;儿茶素类间存在一定的协同性与拮抗性,EC与EGCG、GCG呈显著负相关,EGCG与EGC、ECG呈极显著正相关;氨基酸类间相关性较强,且多为正相关,脯氨酸、酪氨酸、赖氨酸、异亮氨酸、亮氨酸和苯丙氨酸相互间呈极显著正相关。主成分分析提取到8种主成分,累计贡献率为82.834%,第1主成分的决定生化因子异亮氨酸、亮氨酸、丝氨酸、赖氨酸、苯丙氨酸和脯氨酸是评价盘州大厂茶生化品质的关键。聚类分析将25份盘州大厂茶分为2类,A类包括PZ-01、PZ-02、PZ-03等8份盘州大厂茶种质,其余种质为B类,其中,A类的苦茶碱和精氨酸含量显著高于B类,丝氨酸、苏氨酸、脯氨酸、酪氨酸、赖氨酸、异亮氨酸、亮氨酸和苯丙氨酸含量极显著高于B类。【结论】盘州大厂茶具有生化特异性,苦茶碱、EC、ECG和甲硫氨酸是盘州大厂茶的特异高积累生化组分。氨基酸类既是评价盘州大厂茶种质生化品质的关键也是造成盘州大厂茶种质内部分化的关键。PZ-01、PZ-02、PZ-06、PZ-09和PZ-16具备培育特异茶树新品种的应用价值。 展开更多
关键词 盘州 大厂茶 苦茶碱 主成分分析 聚类分析
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FliC蛋白佐剂对伪狂犬病病毒Bartha-K61株弱毒疫苗的黏膜免疫作用
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作者 梁力荣 柯海意 +8 位作者 臧莹安 翟少伦 康桦华 蒋智勇 李艳 张昆丽 周霞 勾红潮 李春玲 《中国畜牧兽医》 北大核心 2025年第10期4864-4873,共10页
【目的】探讨FliC蛋白作为黏膜佐剂对伪狂犬病病毒(Pseudorabies virus,PRV)Bartha-K61弱毒疫苗株的免疫增强作用,为PRV黏膜疫苗的研发奠定基础。【方法】将鼠伤寒沙门菌FliC基因克隆连接至原核表达载体pET-28a(+),连接产物转化大肠杆菌... 【目的】探讨FliC蛋白作为黏膜佐剂对伪狂犬病病毒(Pseudorabies virus,PRV)Bartha-K61弱毒疫苗株的免疫增强作用,为PRV黏膜疫苗的研发奠定基础。【方法】将鼠伤寒沙门菌FliC基因克隆连接至原核表达载体pET-28a(+),连接产物转化大肠杆菌Trans10感受态细胞,提取质粒后进行双酶切鉴定并测序;将FliC-pET-28a转化大肠杆菌BL21(DE3)感受态细胞,诱导表达FliC蛋白,通过考马斯亮蓝染色和Western blotting对纯化后的FliC蛋白进行鉴定。设置Bartha-K61病毒液组和商品化Bartha-K61疫苗组作为对照,将FliC蛋白作为黏膜佐剂与Bartha-K61病毒液混合,滴鼻2次免疫BALB/c小鼠,测定免疫前(0 d)、免疫后7、14、21、28和35 d小鼠血清IgG和IgA水平,免疫后第35天对各组小鼠分别滴鼻PRV GD-WH病毒液10^(4.5) TCID_(50),攻毒后每日观察并记录小鼠生存状况。【结果】成功获得重组质粒FliC-pET-28a,实现了FliC蛋白的可溶性表达,纯化后的FliC蛋白大小约为58 ku。小鼠免疫试验结果显示,二免后Bartha-K61病毒液+FliC蛋白组血清IgG和IgA抗体均显著高于Bartha-K61病毒液组和商品化Bartha-K61疫苗组(P<0.05)。攻毒保护试验结果显示,Bartha-K61病毒液+FliC蛋白免疫能给小鼠提供100%的保护力,抵抗PRV GD-WH的致死性攻击,具有高于Bartha-K61病毒液单独免疫的保护力。【结论】FliC蛋白佐剂对PRV Bartha-K61弱毒疫苗株具有黏膜免疫增强作用,并使小鼠获得一定的免疫保护效力。 展开更多
关键词 FliC蛋白 伪狂犬病病毒弱毒疫苗 黏膜免疫
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南瓜新品种龙贝1号的选育
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作者 赵丹 温玲 +6 位作者 王远纤 王喜庆 李柱刚 王珣 许春梅 李岩 杨帆 《中国瓜菜》 北大核心 2026年第1期229-232,共4页
龙贝1号是以H2017-41-1为母本、H2017-40-3为父本配置而成的杂交1代贝贝型南瓜新品种。该品种早熟,在黑龙江省春季棚室栽培果实发育期29 d左右,全生育期87 d。植株长势健壮,分枝性强,叶片浓绿,坐果性突出。果实扁圆形,外观靓丽,商品性佳... 龙贝1号是以H2017-41-1为母本、H2017-40-3为父本配置而成的杂交1代贝贝型南瓜新品种。该品种早熟,在黑龙江省春季棚室栽培果实发育期29 d左右,全生育期87 d。植株长势健壮,分枝性强,叶片浓绿,坐果性突出。果实扁圆形,外观靓丽,商品性佳;果皮黑绿色,果线细长、浅绿色,果肉黄色,平均果肉厚度1.8 cm,品质佳,软糯香甜,平均干物质含量(w)21%,总糖含量8.34%,可溶性固形物含量10.7%。单果质量0.6 kg左右,连续坐果能力强,中抗病毒病。棚室栽培667 m^(2)产量1887 kg左右,耐贮运性好。该品种适应性强,适于全国各地保护地栽培。 展开更多
关键词 南瓜 新品种 龙贝1号 杂交1代
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人才型住房政策与数字创新创业活跃度
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作者 李言 毛丰付 《经济与管理》 北大核心 2026年第1期19-28,共10页
伴随数字经济快速发展,如何提高数字创新创业活跃度成为相关研究关注的重点,但现有研究尚未从人才供给角度思考该问题。从数字人才集聚水平渠道切入,构建人才型住房政策影响数字创新创业活跃度的作用机制,基于中国2011—2019年城市层面... 伴随数字经济快速发展,如何提高数字创新创业活跃度成为相关研究关注的重点,但现有研究尚未从人才供给角度思考该问题。从数字人才集聚水平渠道切入,构建人才型住房政策影响数字创新创业活跃度的作用机制,基于中国2011—2019年城市层面数据,利用网络爬虫法构建人才型住房政策数据库,并根据政策文本内容构建人才型住房政策强度指标,采用面板双向固定效应模型识别人才型住房政策对数字创新创业活跃度的影响效应和作用机制。研究发现:人才型住房政策强度增加能够显著提高数字创新创业活跃度,上述结论通过了稳健性检验。异质性分析结果表明,在沿海地区、南方地区、数字创新创业活跃度较低的城市,人才型住房政策对数字创新创业活跃度的推动作用更好。机制分析结果表明,人才型住房政策主要通过提升数字人才集聚水平提高数字创新创业活跃度。进一步分析发现,周边城市人才型住房政策强度增加会对本地数字创新创业活跃度产生不利影响。 展开更多
关键词 人才型住房政策 数字创新创业活跃度 数字人才集聚水平 网络爬虫法
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Lignin-derived carbon fibers:A green path from biomass to advanced materials 被引量:1
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作者 li yan Hai liu +2 位作者 yanfan yang lin Dai Chuanling Si 《Carbon Energy》 2025年第3期11-33,共23页
Carbon fibers(CFs)with notable comprehensive properties,such as light weight,high specific strength,and stiffness,have garnered considerable interest in both academic and industrial fields due to their diverse and adv... Carbon fibers(CFs)with notable comprehensive properties,such as light weight,high specific strength,and stiffness,have garnered considerable interest in both academic and industrial fields due to their diverse and advanced applications.However,the commonly utilized precursors,such as polyacrylonitrile and pitch,exhibit a lack of environmental sustainability,and their costs are heavily reliant on fluctuating petroleum prices.To meet the substantial market demand for CFs,significant efforts have been made to develop cost-effective and sustainable CFs derived from biomass.Lignin,the most abundant polyphenolic compound in nature,is emerging as a promising precursor which is well-suited for the production of CFs due to its renewable nature,low cost,high carbon content,and aromatic structures.Nevertheless,the majority of lignin raw materials are currently derived from pulping and biorefining industrial by-products,which are diverse and heterogeneous in nature,restricting the industrialization of lignin-derived CFs.This review classifies fossil-derived and biomass-derived CFs,starting from the sources and chemical structures of raw lignin,and outlines the preparation methods linked to the performance of lignin-derived CFs.A comprehensive discussion is presented on the relationship between the structural characteristics of lignin,spinning preparation,and structure-morphology-property of ligninderived CFs.Additionally,the potential applications of these materials in various domains,including energy,catalysis,composites,and other advanced products,are also described with the objective of spotlighting the unique merits of lignin.Finally,the current challenges faced and future prospects for the advancement of lignin-derived CFs are proposed. 展开更多
关键词 advanced materials carbon fibers chemical structure LIGNIN VALORIZATION
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阿特拉津降解真菌Candida tropicalis的分离鉴定与降解特性
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作者 于海玲 李妍 +3 位作者 王明元 彭汇涵 陈其煌 林永华 《亚热带农业研究》 2025年第3期145-153,共9页
[目的]筛选可以在南方湿热土壤环境中降解阿特拉津的真菌菌株,并了解其降解特性,以期为微生物修复阿特拉津污染土壤提供候选菌株。[方法]采用富集培养的方法,分离厦门市农田土壤中能够降解阿特拉津的菌株,并结合基因序列测定对其进行鉴... [目的]筛选可以在南方湿热土壤环境中降解阿特拉津的真菌菌株,并了解其降解特性,以期为微生物修复阿特拉津污染土壤提供候选菌株。[方法]采用富集培养的方法,分离厦门市农田土壤中能够降解阿特拉津的菌株,并结合基因序列测定对其进行鉴定;同时采用单因素试验法,研究不同环境条件(温度、pH、菌液接种量、阿特拉津初始浓度及碳源)对菌株降解特性的影响。[结果]经分离筛选得到1株降解菌AX1。该菌株呈圆形,边缘整齐、光滑,白色、不透明,无鞭毛。结合形态学特征和基因序列测定结果,菌株AX1被鉴定为热带假丝酵母菌(Candida tropicalis)。该菌株降解阿特拉津的最适温度为30℃,最适pH值范围为6~8,最适外加碳源为葡萄糖。在以上最适宜条件下培养72 h,对初始质量浓度为20 mg·L^(-1)阿特拉津的降解率为49.67%,对50 mg·L^(-1)阿特拉津的降解率为42.26%。[结论]从南方湿热土壤中分离的真菌菌株AX1能够降解阿特拉津,丰富了降解阿特拉津的微生物菌种资源。 展开更多
关键词 阿特拉津 热带假丝酵母菌 微生物降解 富集培养
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脂联素、胎盘生乳素与妊娠期糖尿病及新生儿出生体质量关系的研究
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作者 杨敏 李岩 +3 位作者 乔炳龙 李超 马春玲 李灿 《精准医学杂志》 2026年第1期32-35,39,共5页
目的探讨产妇外周血、脐血和羊水中的脂联素(APN)和胎盘生乳素(hPL)水平与妊娠期糖尿病及新生儿出生体质量之间的关系,并分析APN和hPL之间的相关性。方法以2023年1—5月在青岛大学附属医院西海岸院区分娩的妊娠期糖尿病产妇41例为糖尿病... 目的探讨产妇外周血、脐血和羊水中的脂联素(APN)和胎盘生乳素(hPL)水平与妊娠期糖尿病及新生儿出生体质量之间的关系,并分析APN和hPL之间的相关性。方法以2023年1—5月在青岛大学附属医院西海岸院区分娩的妊娠期糖尿病产妇41例为糖尿病组,以同期在本院分娩的正常产妇41例为对照组。检测两组产妇外周血、脐血及羊水中APN和hPL水平并进行比较,APN和hPL的相关性及APN、hPL与新生儿出生体质量的相关性分析采用Spearman线性分析。结果糖尿病组产妇外周血、羊水、脐血中APN水平和脐血中hPL水平均明显低于对照组(t=-2.956~-2.436,P<0.05);对照组产妇脐血当中APN、hPL水平与新生儿出生体质量呈正相关(r=0.389、0.346,P<0.05),糖尿病组产妇脐血当中APN、hPL水平与新生儿出生体质量呈负相关(r=-0.324、-0.447,P<0.05);糖尿病组产妇脐血中hPL水平与脐血中APN水平呈正相关(r=0.341,P<0.05)。结论产妇外周血、脐血、羊水中的APN水平和脐血中的hPL水平降低可能与产妇妊娠期糖尿病的发生有关,脐血中APN、hPL水平与新生儿出生体质量的相关性可能受产妇血糖代谢的影响;脐血中APN水平升高可能会对脐血中hPL表达具有一定的促进作用。 展开更多
关键词 糖尿病 妊娠 脂联素 胎盘催乳激素 出生体质量 相关性分析 婴儿 新生
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Resilio:一种大模型弹性训练容错系统
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作者 李焱 杨偲乐 +9 位作者 刘成春 王林梅 田瑶琳 张信航 朱昱 李莼蒲 孙磊 颜深根 肖利民 张伟丰 《计算机研究与发展》 北大核心 2025年第6期1380-1395,共16页
具备千亿级参数的大型语言模型正在引领当今人工智能与异构计算的技术革新及商业模式的深刻转变.然而,大模型训练任务需要长时间占用大量的硬件资源,软硬件故障发生的频率高且类型较多,并且故障原因难定位导致训练中断时间较长.针对大... 具备千亿级参数的大型语言模型正在引领当今人工智能与异构计算的技术革新及商业模式的深刻转变.然而,大模型训练任务需要长时间占用大量的硬件资源,软硬件故障发生的频率高且类型较多,并且故障原因难定位导致训练中断时间较长.针对大模型训练过程中面临的网络中断、节点宕机、进程崩溃等多种典型故障,提出一种大模型弹性容错系统Resilio来提供高效自动的恢复机制.基于模型训练的并行策略与硬件的存储层次特点,Resilio通过多层次优化检查点读写操作和即时检查点保存机制,对于千亿规模参数模型,可以将端到端故障恢复时间缩短至10min以内,模型中断后的重新训练时间缩短至单次训练迭代时间.当集群资源弹性变化时,Resilio能够快速准确地获取大模型训练最优并行策略配置,与容错调度组件共同确保系统的自适应能力,弹性调度训练资源用以提升作业的训练效率和集群GPU资源利用率. 展开更多
关键词 大模型训练 深度学习 容错 故障检测 弹性训练 自动并行
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Structure variation of cadmium naphthalene⁃diphosphonates with the changing rigidity of N⁃donor auxiliary ligands
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作者 XU yan li Suzhi +3 位作者 li yan FENG Lushun SUN Wentao li Xinxing 《无机化学学报》 北大核心 2025年第2期395-406,共12页
Five cadmium naphthalene-diphosphonates,formulated as[Cd_(1.5)(1,4-ndpaH_(2))2(4,4'-bpyH)(4,4'-bpy)0.5(H_(2)O)_(2)]2(1),[Cd(1,4-ndpaH_(2))(1,4-bib)0.5(H_(2)O)](2),[Cd(1,4-ndpaH3)2(1,2-dpe)(H_(2)O)]·(1,2-d... Five cadmium naphthalene-diphosphonates,formulated as[Cd_(1.5)(1,4-ndpaH_(2))2(4,4'-bpyH)(4,4'-bpy)0.5(H_(2)O)_(2)]2(1),[Cd(1,4-ndpaH_(2))(1,4-bib)0.5(H_(2)O)](2),[Cd(1,4-ndpaH3)2(1,2-dpe)(H_(2)O)]·(1,2-dpe)·7H_(2)O(3),(1,2-bixH)[Cd3(1,4-ndpaH)(1,4-ndpaH_(2))2(H_(2)O)_(2)](4),and[Cd(1,4-ndpaH_(2))(H_(2)O)]·H_(2)O(5),have been synthesized from the selfassembly reactions of 1,4-naphthalenediphosphonic acid(1,4-ndpaH4)with Cd(NO3)2·4H_(2)O by introducing auxiliary ligands with variation of rigidity,such as 4,4'-bipyridine(4,4'-bpy),1,4-bis(1-imidazolyl)benzene(1,4-bib),1,2-di(4-pyridyl)ethylene(1,2-dpe),1,3-di(4-pyridyl)propane(1,3-dpp),and bis(imidazol-1-ylmethyl)benzene(1,2-bix),respectively.Structure resolution by single-crystal X-ray diffraction reveals that compound 1 possesses a layered framework,in which the{Cd3(PO2)2}trimers made up of corner-sharing two{CdO4N2}and one{CdO6}octahedra are connected by phosphonate groups,forming a ribbon,which are cross-linked by 4,4'-bipy ligands,forming a 2D layer.Compound 2 shows a 3D open-framework structure,where chains of corner-sharing{CdO4N}trigonal bipyramids and{PO3C}tetrahedra are cross-linked by 1,4-bib and/or phosphonate groups.A 1D ladder-like chain structure is found in compound 3,where the ladder-like chains made up of corner-sharing{CdO5N}octahedra and{PO3C}tetra hedra are connected by 1,4-ndpaH_(2)^(2-).Both compounds 4 and 5 obtained by the introduction of flexible ligands during the synthesis show a 2D layered structure,which is formed by ligand crosslinking double metal chains.Interestingly,In 4,flexible 1,2-bix was singly protonated,as vip molecules,filled between layer and layer,while flexible ligand 1,3-dpp is absent in 5.Photophysical measurements indicate that compounds 1-5 show ligand-centered emissions. 展开更多
关键词 naphthalene diphosphate N-donor auxiliary ligands crystal structure RIGIDITY flexibility
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Study on Affecting Factors of the Consistency of Printed Electrodes Based on an Online Pressure Monitoring System
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作者 CAI Zi-mu GU Jin-tao +2 位作者 CHENG Guang-kai XU Guang-yi li yan 《印刷与数字媒体技术研究》 北大核心 2025年第2期91-97,共7页
In order to address the current inability of screen printing to monitor printing pressure online,an online printing pressure monitoring system applied to screen printing machines was designed in this study.In this stu... In order to address the current inability of screen printing to monitor printing pressure online,an online printing pressure monitoring system applied to screen printing machines was designed in this study.In this study,the consistency of printed electrodes was measured by using a confocal microscope and the pressure distribution detected by online pressure monitoring system was compared to investigate the relationship.The results demonstrated the relationship between printing pressure and the consistency of printed electrodes.As printing pressure increases,the ink layer at the corresponding position becomes thicker and that higher printing pressure enhances the consistency of the printed electrodes.The experiment confirms the feasibility of the online pressure monitoring system,which aids in predicting and controlling the consistency of printed electrodes,thereby improving their performance. 展开更多
关键词 Printing pressure Consistency of printed electrodes Screen printing Online monitoring
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李岩运用三步手诊法辨治腹泻型肠易激综合征肝郁脾虚证验案举隅
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作者 焦召华 徐家淳 +1 位作者 李景行 李岩 《江西中医药》 2026年第1期31-34,共4页
基于天津市名中医李岩临床经验,系统阐述其应用“三步手诊法”辨治腹泻型肠易激综合征肝郁脾虚证的理论内涵。首先,通过观察手掌肝区、胃区等特定区域的形态与色泽以定病位。进而,通过分析掌纹、血络等内容以定病性,明确其病机为肝郁脾... 基于天津市名中医李岩临床经验,系统阐述其应用“三步手诊法”辨治腹泻型肠易激综合征肝郁脾虚证的理论内涵。首先,通过观察手掌肝区、胃区等特定区域的形态与色泽以定病位。进而,通过分析掌纹、血络等内容以定病性,明确其病机为肝郁脾虚、本虚标实。在此基础上,针对病机采用疏肝健脾法,选取特色疗法毫火针进行干预。“三步手诊法”在腹泻型肠易激综合征肝郁脾虚证的诊疗中具有重要的辅助诊断价值,可有效指导实践。 展开更多
关键词 三步手诊法 腹泻型肠易激综合征 肝郁脾虚
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The Solidification and Corrosion Behavior Determination of the Ti/B Added Zn-Al-Mg Alloys 被引量:2
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作者 XU Chengliang TENG Huaxiang +3 位作者 JIANG Guangrui li yan li Min liU Guanghui 《Journal of Wuhan University of Technology(Materials Science)》 SCIE EI CAS 2022年第4期707-715,共9页
The solidification and corrosion behavior of the Ti/B added Zn-Al-Mg alloys were experimentally investigated by means of microstructure characterization and electrochemical test.The basic calculations were carried out... The solidification and corrosion behavior of the Ti/B added Zn-Al-Mg alloys were experimentally investigated by means of microstructure characterization and electrochemical test.The basic calculations were carried out to predict the characteristics of the Ti-added Zn-Al-Mg alloys.The Zn-Al-Mg ingots with minor doping of Ti/B were prepared and solidified under different cooling rate,including air cooling,water quenching and furnace cooling.The scanning electron microscopy(SEM)and the X-ray diffraction method(XRD)were used to determine the microstructures and phase types of the alloy samples.It could be discovered that trace TiAl3 particles were dispersed in the Ti/B added alloy samples which provide the heterogeneous nucleation sites to refine the size of the dendrites and the eutectic microstructures.More fined microstructures with the addition of both Ti and B were obtained compared with those with the merely addition of Ti,and the water cooled alloys presented the finest microstructures due to the fastest cooling rate.It could also be noticed that with the increasing solidification rate,the percentage of the MgZn_(2) phase turned out to be higher because of the Mg_(2)Zn_(11)↔MgZn_(2) transition,which is in consistent with the results in the actual hot-dip galvanizing process.Electrochemical experiments in the previous work included methods the of the Tafel polarization test and the electrochemical impedance spectroscopy test(EIS).Results show that the quenched Zn-Al-Mg alloy with the addition of both Ti and B takes on best corrosion resistance.Consequently,the addition of certain amount of Ti/B elements and the appropriate elevation of the cooling rate will be the practicable approaches to optimize the microstructure and the corrosion resistance of the Zn-Al-Mg coatings in the actual galvanizing process. 展开更多
关键词 Ti/B added Zn-Al-Mg alloy cooling rate SOLIDIFICATION corrosion resistance
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ELISA和UPLC-MS/MS联合检测粮食中玉米赤霉烯酮残留 被引量:4
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作者 李妍 裴世春 +5 位作者 王岩 高建伟 甄玉萍 马明欣 张品 谢铁志 《食品科学》 EI CAS CSCD 北大核心 2016年第16期229-234,共6页
建立酶联免疫吸附分析(enzyme-linked immunosorbent assay,ELISA)和超高效液相色谱-串联质谱(ultra performance liquid chromatograph-tandem mass spectrometry,UPLC-MS/MS)联合测定粮食中玉米赤霉烯酮的快速检测方法。样品经乙腈-水... 建立酶联免疫吸附分析(enzyme-linked immunosorbent assay,ELISA)和超高效液相色谱-串联质谱(ultra performance liquid chromatograph-tandem mass spectrometry,UPLC-MS/MS)联合测定粮食中玉米赤霉烯酮的快速检测方法。样品经乙腈-水-乙酸(70∶29∶1,V/V)溶液提取,采用ELISA筛选出阳性样品后利用UPLC-MS/MS进行验证。实验探讨了ELISA和UPLC-MS/MS联合检测法的有效性和测定中存在的问题及其矫正方法,并且研究了UPLC-MS/MS中样品净化与未净化的回收率。结果表明,本实验建立的ELISA和UPLC-MS/MS联合检测方法快速、高效,适用于大批量粮食样品中玉米赤霉烯酮残留量的快速评估。 展开更多
关键词 玉米赤霉烯酮 酶联免疫分析法 超高效液相色谱-串联质谱联用仪 粮食 检测
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Apelin-13对小鼠血脂代谢的影响及其机制研究 被引量:4
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作者 张敏 李建磊 +5 位作者 朱雨婷 陈羽 林泽 吴琼 李焰 孙艳发 《畜牧兽医学报》 CAS CSCD 北大核心 2020年第9期2207-2215,共9页
本研究旨在探索Apelin-13调控小鼠血脂代谢的生理机制。试验选取体重相近的小鼠96只,随机分为4个处理,每个处理4个重复。对照组和3个试验组小鼠分别每天皮下注射100μL 0.9%的生理盐水、10、20和50μg·kg^-1的Apelin-13,试验期为1... 本研究旨在探索Apelin-13调控小鼠血脂代谢的生理机制。试验选取体重相近的小鼠96只,随机分为4个处理,每个处理4个重复。对照组和3个试验组小鼠分别每天皮下注射100μL 0.9%的生理盐水、10、20和50μg·kg^-1的Apelin-13,试验期为14 d。测定小鼠的生长性能、血清Apelin-13和血脂含量,并采用Illumina Novaseq测序平台进行小鼠肝组织转录组测序(RNA-seq)。结果表明,与对照组相比,皮下注射Apelin-13极显著提高了血清Apelin-13和高密度蛋白胆固醇含量(P<0.01),显著降低了血清甘油三酯含量(P<0.05)。试验组和处理组共检测到340个上调和350个下调的差异表达基因(differentially expressed genes,DEGs)。这些DEGs最显著富集的信号通路为视黄醇代谢,该通路中的细胞色素P450(Cyp)和尿苷二磷酸葡萄糖醛酸转移酶(Ugt)两个超家族基因大部分上调表达。试验结果表明,Apelin-13可能通过调控视黄醇代谢信号通路中的Cyp和Ugt两个超家族基因的表达来调控小鼠的血脂代谢。 展开更多
关键词 小鼠 APELIN-13 视黄醇代谢 DEGs RNA-SEQ
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Research on resonant ring-modified photonic crystal line-defect slow-light waveguide
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作者 liU Qianzhen MA Chengju li yan 《Optoelectronics Letters》 2025年第7期419-426,共8页
This paper presents a photonic crystal(PhC)line-defect slow-light waveguide modified by resonant rings.We introduce resonant rings into the line defect,constructing a slow-light waveguide with high normalized delay ba... This paper presents a photonic crystal(PhC)line-defect slow-light waveguide modified by resonant rings.We introduce resonant rings into the line defect,constructing a slow-light waveguide with high normalized delay bandwidth product(NDBP)and low group velocity dispersion(GVD).We simulate,analyze,and optimize the structural parameters of this slow-light waveguide using the finite difference time domain(FDTD)method,theoretically achieving a maximum group index of 3.7,maximum bandwidth of 15.6 nm,and maximum NDBP of 0.4416 for slow-light effect.The resonant ring-modified PhC slow-light waveguide designed in this paper exhibits GVD lower than the order of 10^(−20)s^(2)/m over a normalized frequency range from 0.3554 to 0.4175.This study is expected to provide theoretical references for the study of slow-light buffering devices based on PhCs with high NDBP values. 展开更多
关键词 finite difference time domain fdtd methodtheoretically line defect slow light waveguide normalized delay bandwidth product resonant rings low group velocity dispersion gvd we resonant ringswe maximum ndb photonic crystal
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Clinical study of Yiqi Liangxue Shengji prescription(益气凉血生肌方)for improving cardiac function after myocardial ischemiareperfusion injury in patients with acute myocardial infarction:arandomized,double-blind,placebo-controlled trial
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作者 li Yuxuan li yan +7 位作者 WANG Wujiao CUI Xiaoyun WAN Jie ZHOU Kun LU Jinjin liU Jing liN Qian li Dong 《Journal of Traditional Chinese Medicine》 2025年第4期836-844,共9页
OBJECTIVE:To evaluate the effect of Yiqi Liangxue Shengji prescription(益气凉血生肌方,YQLXSJ)on cardiac function and outcomes in acute myocardial infarction(AMI)patients with myocardial ischemiareperfusion injury(MIRI... OBJECTIVE:To evaluate the effect of Yiqi Liangxue Shengji prescription(益气凉血生肌方,YQLXSJ)on cardiac function and outcomes in acute myocardial infarction(AMI)patients with myocardial ischemiareperfusion injury(MIRI)and to determine its clinical efficacy.METHODS:This prospective,randomized,double-blind,placebo-controlled trial enrolled hospitalized patients with AMI who underwent percutaneous coronary intervention and experienced MIRI either intraoperatively or postoperatively.Participants were randomly allocated to the treatment group,which received YQLXSJ,or the control group,which received a placebo,concurrent with standard Western Medicine therapy.The intervention period lasted 8 weeks.The primary outcome measure was left ventricular ejection fraction(LVEF),determined by echocardiography.Secondary outcomes included Nterminal pro brain natriuretic peptide(NT-pro BNP)and cardiac troponin I(cTnI)levels,left ventricular internal diameter,major adverse cardiovascular events(MACE),angina pectoris scores,and Chinese medicine evidence scores.RESULTS:Following 8 weeks of intervention,the treatment group demonstrated a significant increase in LVEF and a marked reduction in NT-pro BNP when compared to the control group.There was also a significant decrease in peak cTnI levels,Chinese medicine evidence scores,and angina pectoris scores.The control group's left ventricular end-systolic diameter(LVESD)significantly increased compared to baseline after 8 weeks(P<0.05),whereas the treatment group's LVESD showed no significant change from baseline(P>0.05).Although the treatment group showed a downward trend in MACE incidence compared to the control group,this difference was not statistically significant(P>0.05).CONCLUSIONS:This study demonstrated that the addition of YQLXSJ to standard therapy can improve cardiac function and alleviate clinical symptoms in AMI patients with MIRI,and also showed a potential to mitigate the incidence of MACE.Furthermore,YQLXSJ displayed a favorable safety profile in clinical application. 展开更多
关键词 myocardial reperfusion injury stroke volume natriuretic peptide brain troponin I randomized controlled trial BLIND Yiqi Liangxue Shengji prescription
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锂离子电池LiLa_(0.02)Mn_(1.98)O_4正极材料的合成及电化学性能 被引量:3
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作者 李燕 陶扬 +3 位作者 白红丽 白玮 向明武 郭俊明 《中国有色金属学报》 EI CAS CSCD 北大核心 2021年第8期2198-2209,共12页
采用液相无焰燃烧法制备单晶多面体LiLa_(0.02)Mn_(1.98)O_4材料,通过X射线衍射(XRD)、场发射扫描电子显微镜(FESEM)和透射电子显微镜(TEM)等表征手段对材料的结构和形貌进行分析,并通过恒电流充放电、循环伏安(CV)、交流阻抗(EIS)等测... 采用液相无焰燃烧法制备单晶多面体LiLa_(0.02)Mn_(1.98)O_4材料,通过X射线衍射(XRD)、场发射扫描电子显微镜(FESEM)和透射电子显微镜(TEM)等表征手段对材料的结构和形貌进行分析,并通过恒电流充放电、循环伏安(CV)、交流阻抗(EIS)等测试分析材料的电化学性能。结果表明:掺杂La^(3+)没有改变LiMn_(2)O_(4)的尖晶石结构。在25℃、1C和5C倍率条件下,LiLa_(0.02)Mn_(1.98)O_4初始放电比容量分别为112.7和94.5mA·h/g,循环500次后,LiLa_(0.02)Mn_(1.98)O_4的容量保持率为64.42%和81.45%,而LiMn_(2)O_(4)样品的容量保持率分别为53.69%和56.9%;特别是在10C高倍率下,LiMn_(2)O_(4)样品的初始放电比容量仅有44.7mA·h/g,同样条件下,LiLa_(0.02)Mn_(1.98)O_4首次放电比容量达73.5mA·h/g,循环500次后,容量保持率为81.09%。CV和EIS测试发现,掺杂后的材料有较好的循环可逆性,较大的锂离子扩散系数1.04×10^(-16)cm^(2)/s,对循环2000次后的极片进行分析,材料的晶体结构和颗粒形貌基本没有变化,适量的La掺杂能够稳定材料的晶体结构,有效抑制Jahn-Teller,提高材料的循环性能。 展开更多
关键词 尖晶石型LiMn_(2)O_(4) 镧掺杂 去顶角八面体 锂离子电池 正极材料
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Strain rate of Boso slow slip events related to seismic activity after 2011 using GNSS data
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作者 li yan Xinzheng Xiao +2 位作者 Tieding Lu Ahmed El-Mowafy Meng li 《Geodesy and Geodynamics》 2025年第6期644-655,共12页
The March 11,2011,MW9.0 Tohoku-Oki earthquake,in Japan,caused rapid strain release near the epicenter,while the Boso Peninsula,located farther away,experienced stress redistribution,leading to changes in the recurrenc... The March 11,2011,MW9.0 Tohoku-Oki earthquake,in Japan,caused rapid strain release near the epicenter,while the Boso Peninsula,located farther away,experienced stress redistribution,leading to changes in the recurrence interval of slow slip events(SSEs)and regional strain.This study focuses on three detected post-2011 Boso SSEs,utilizing a segmented model displacement time series measured by Global Navigation Satellite System(GNSS)to calculate velocity and strain rate fields for eight periods before,during,and after the SSEs.Results show that the 2011 earthquake and the three SSEs significantly alter the velocity field in the Boso region,with SSE velocities predominantly oriented southeast,reaching maximum values of 26.9 cm/a,10.6 cm/a,and 38.5 cm/adnearly opposite to non-SSE periods.After the third SSE,the velocity field nearly returns to its pre-earthquake state,with a maximum of 1.8 cm/a.The maximum shear strain rates during the three SSEs are 25.88×10^(-7) a^(-1),11.38×10^(-7) a^(-1),and 29.02×10^(-7) a^(-1)(i.e.,per annum),significantly higher than those during non-slow slip periods,with principal strain rates following a similar pattern.The spatial distribution of strain rates during the SSEs indicates greater deformation compared to the non-slip periods,dominated by northwest-southeast extension and southwest-northeast compression.Spatiotemporal analysis reveals a strong correlation between seismic frequency and strain rate during the SSEs,with time correlation coefficients of 0.85,0.88,and 0.9.Although larger accumulated strain results in stronger strain release during the latter two SSEs,not all strain is fully released,suggesting that earthquake swarms accompanying the SSEs may contribute to the partial release of unreleased strain.This study,through the analysis of GNSS data,evaluates the spatiotemporal distribution of strain fields during periodic SSEs,contributing to further research on strain accumulation and release,and aiding in the analysis of this regional seismic activity. 展开更多
关键词 Strain rates Slow slip events Seismic activity GNSS VELOCITY
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