Background:Once a global financial crisis breaks out,the interdependence between different financial markets suddenly increases and leads to a significant contagion.Methods:With 39 countries used as samples,this paper...Background:Once a global financial crisis breaks out,the interdependence between different financial markets suddenly increases and leads to a significant contagion.Methods:With 39 countries used as samples,this paper analyzes the interdependence between the stock market and the government bond market during the crisis periods.Results:It proves that the investor focuses more on the safety of their portfolio so there is neither a flight from quality nor a positive spillover during a crisis period.When one market is safer than the other market in the same country,a flight to quality occurs between the two markets;however,when the two markets in one country are both risky,negative spillover appears between these two markets.Conclusions:This means a flight to quality from the stock market to the short-term government bond will occur more frequently than will occur from the stock market to the long-term government bond markets.In addition,a flight to quality always emerges in developed markets,while negative spillovers take place in emerging markets and in the PIIGS countries(Portugal,Italy,Ireland,Greece,and Spain,referred to hereon as“PIIGS”)in the European Debt Crisis.展开更多
Hydrogen peroxide(H2O2)plays a significant role in regulating a variety of biological processes.Dysregulation of H2O2 can lead to various diseases.Although numerous fluorescent imaging probes for H2O2 have been report...Hydrogen peroxide(H2O2)plays a significant role in regulating a variety of biological processes.Dysregulation of H2O2 can lead to various diseases.Although numerous fluorescent imaging probes for H2O2 have been reported,the development of H2O2 ratiometric fluorescent probe with large Stokes shift remains rather limited.Such probes have shown distinct advantages,such as minimized interference from environment and improved signal-to noise ratio.In this work,we reported a new pyrene-based compound Py-VPB as H2O2 fluorescent probe in vitro.The probe demonstrated ratiometric detection behavior,large Stokes shift and large emission shift.In addition,the probe showed high sensitivity and selectivity towards H2O2 in vitro.Based on these excellent properties,we successfully applied Py-VPB to the visualization of exogenous and endogenous H2O2 in living cells.Cell imaging study also showed that our probe was localized in the mitochondria.We envision that the probe can provide a useful tool for unmasking the biological roles of mitochondrial H2O2 in living systems.展开更多
The application of generative artificial intelligence(AI)is bringing about notable changes in anime creation.This paper surveys recent advancements and applications of diffusion and language models in anime generation...The application of generative artificial intelligence(AI)is bringing about notable changes in anime creation.This paper surveys recent advancements and applications of diffusion and language models in anime generation,focusing on their demonstrated potential to enhance production efficiency through automation and personalization.Despite these benefits,it is crucial to acknowledge the substantial initial computational investments required for training and deploying these models.We conduct an in-depth survey of cutting-edge generative AI technologies,encompassing models such as Stable Diffusion and GPT,and appraise pivotal large-scale datasets alongside quantifiable evaluation metrics.Review of the surveyed literature indicates the achievement of considerable maturity in the capacity of AI models to synthesize high-quality,aesthetically compelling anime visual images from textual prompts,alongside discernible progress in the generation of coherent narratives.However,achieving perfect long-form consistency,mitigating artifacts like flickering in video sequences,and enabling fine-grained artistic control remain critical ongoing challenges.Building upon these advancements,research efforts have increasingly pivoted towards the synthesis of higher-dimensional content,such as video and three-dimensional assets,with recent studies demonstrating significant progress in this burgeoning field.Nevertheless,formidable challenges endure amidst these advancements.Foremost among these are the substantial computational exigencies requisite for training and deploying these sophisticated models,particularly pronounced in the realm of high-dimensional generation such as video synthesis.Additional persistent hurdles include maintaining spatial-temporal consistency across complex scenes and mitigating ethical considerations surrounding bias and the preservation of human creative autonomy.This research underscores the transformative potential and inherent complexities of AI-driven synergy within the creative industries.We posit that future research should be dedicated to the synergistic fusion of diffusion and autoregressive models,the integration of multimodal inputs,and the balanced consideration of ethical implications,particularly regarding bias and the preservation of human creative autonomy,thereby establishing a robust foundation for the advancement of anime creation and the broader landscape of AI-driven content generation.展开更多
BACKGROUND Patients with acute-on-chronic liver failure(ACLF)experience severe immune dysfunction.Liver transplantation(LT)significantly improves survival outcomes.However,the characteristics of peripheral blood lymph...BACKGROUND Patients with acute-on-chronic liver failure(ACLF)experience severe immune dysfunction.Liver transplantation(LT)significantly improves survival outcomes.However,the characteristics of peripheral blood lymphocyte subsets(PBLSs)in this patient population are not well defined,and the dynamics of immune reconstitution post-LT are insufficiently understood.AIM To characterize PBLSs in patients with ACLF prior to LT and to evaluate PBLS reconstitution after LT.METHODS Clinical data from patients undergoing LT in the Transplantation Center,The Third Xiangya Hospital from January 2022 to December 2023 were analyzed retrospectively.Our cohort comprised 44 patients with ACLF,16 patients with acute decompensation of cirrhosis,and 23 patients with compensated cirrhosis.Twenty healthy volunteers were included as controls.PBLSs were evaluated across all groups.The relationship between PBLSs and post-LT prognosis was assessed,and dynamic changes in PBLSs among patients with ACLF were analyzed at different time points.RESULTS Patients with ACLF exhibited a marked reduction in PBLSs compared with healthy volunteers.Natural killer(NK)cell counts were further reduced in patients with ACLF when compared with patients with compensated cirrhosis.PBLSs did not correlate with the etiology or severity of ACLF or with established liver failure scores.Following LT,a rapid restoration of NK cells and B cells was observed in patients with ACLF.However,the cluster of differentiation(CD)3+T cell and CD4+T cell counts decreased 14 days post-LT and subsequently returned to preoperative levels by day 21.CONCLUSION Patients with ACLF exhibited markedly reduced PBLSs,with decreased NK cells potentially linked to progression from compensated cirrhosis to liver failure.NK and B cell were rapidly restored after LT.展开更多
Electronic auctions(e-auctions)remove the physical limitations of traditional auctions and bring this mechanism to the general public.However,most e-auction schemes involve a trusted auctioneer,which is not always cre...Electronic auctions(e-auctions)remove the physical limitations of traditional auctions and bring this mechanism to the general public.However,most e-auction schemes involve a trusted auctioneer,which is not always credible in practice.Some studies have applied cryptography tools to solve this problem by distributing trust,but they ignore the existence of collusion.In this paper,a blockchain-based Privacy-Preserving and Collusion-Resistant scheme(PPCR)for double auctions is proposed by employing both cryptography and blockchain technology,which is the first decentralized and collusion-resistant double auction scheme that guarantees bidder anonymity and bid privacy.A two-server-based auction framework is designed to support off-chain allocation with privacy preservation and on-chain dispute resolution for collusion resistance.A Dispute Resolution agreement(DR)is provided to the auctioneer to prove that they have conducted the auction correctly and the result is fair and correct.In addition,a Concise Dispute Resolution protocol(CDR)is designed to handle situations where the number of accused winners is small,significantly reducing the computation cost of dispute resolution.Extensive experimental results confirm that PPCR can indeed achieve efficient collusion resistance and verifiability of auction results with low on-chain and off-chain computational overhead.展开更多
Given the swift proliferation of structural health monitoring(SHM)technology within tunnel engineering,there is a demand on proficiently and precisely imputing the missing monitoring data to uphold the precision of di...Given the swift proliferation of structural health monitoring(SHM)technology within tunnel engineering,there is a demand on proficiently and precisely imputing the missing monitoring data to uphold the precision of disaster prediction.In contrast to other SHM datasets,the monitoring data specific to tunnel engineering exhibits pronounced spatiotemporal correlations.Nevertheless,most methodologies fail to adequately combine these types of correlations.Hence,the objective of this study is to develop spatiotemporal recurrent neural network(ST-RNN)model,which exploits spatiotemporal information to effectively impute missing data within tunnel monitoring systems.ST-RNN consists of two moduli:a temporal module employing recurrent neural network(RNN)to capture temporal dependencies,and a spatial module employing multilayer perceptron(MLP)to capture spatial correlations.To confirm the efficacy of the model,several commonly utilized methods are chosen as baselines for conducting comparative analyses.Furthermore,parametric validity experiments are conducted to illustrate the efficacy of the parameter selection process.The experimentation is conducted using original raw datasets wherein various degrees of continuous missing data are deliberately introduced.The experimental findings indicate that the ST-RNN model,incorporating both spatiotemporal modules,exhibits superior interpolation performance compared to other baseline methods across varying degrees of missing data.This affirms the reliability of the proposed model.展开更多
Interparticle frictional interactions are ubiquitous in colloidal systems,exerting a profound influence on their structural and physical attributes.In this study,we employed Brownian dynamics simulations to explore th...Interparticle frictional interactions are ubiquitous in colloidal systems,exerting a profound influence on their structural and physical attributes.In this study,we employed Brownian dynamics simulations to explore the non-equilibrium dynamics in colloidal systems,focusing particularly on the role of tangential friction and its influence on the macroscopic physical properties of colloids.We found that the disruption of instantaneous time-reversal symmetry by tangential frictional interactions can trigger the self-assembly of colloidal systems into intricate network configurations,and these novel structures exhibit unique depletion force and rheological properties that set them apart from traditional colloidal gel systems.These findings not only help deepen our comprehension of the self-assembly phenomena in non-equilibrium colloidal systems but also offer fresh insights for the development of colloidal materials with tailored characteristics.展开更多
To the Editor：Despite of the rapid increase of donation after cardiac death （DCD） in China, the shortage of organs continues to be a major problem. Every organ procured is so valuable that it should never be discar...To the Editor：Despite of the rapid increase of donation after cardiac death （DCD） in China, the shortage of organs continues to be a major problem. Every organ procured is so valuable that it should never be discarded easily, especially a liver that could save a patient＇s life in an emergency. This leads to the use of grafts from donors with unrecognized Here and unusual diseases, including schistosomiasis. we reported a case of orthotopic liver transplantation （OLT） from a donor with Schistosorna japonicurn to a patient with end-stage cirrhosis due to HBV infection.展开更多
To explore the effect of non-uniform polarization on orbital angular momentum(OAM) in anisotropic medium, in this work investigated are the evolution of the spiral spectra and OAM densities of non-uniformly polarized ...To explore the effect of non-uniform polarization on orbital angular momentum(OAM) in anisotropic medium, in this work investigated are the evolution of the spiral spectra and OAM densities of non-uniformly polarized vortex(NUPV)beams in uniaxial crystals propagating orthogonal to the optical axis, and also the case of uniformly polarized vortex(UPV)beams with left-handed elliptical polarization. In the input plane, the NUPV beams present their spiral spectra of m-mode concentrated at m = l ± 1 modes rather than m = l mode, and reveal the relation among topological charge l, mode of spiral spectra m and the power weight value Rmexpressed by l=∑^(∞)_(m)=-∞Rm. is still satisfied for UPV beams in uniaxially anisotropic crystals, whereas for NUPV beams their relations are no longer valid owing to non-uniform polarization. Furthermore, the analysis indicates that the asymmetrical distribution of power weight of spiral spectra and the non-zero value in the sum of longitudinal OAM densities originate from the initial non-uniform polarization and anisotropy in uniaxial crystals rather than topological charges. In addition, the relation between spiral spectrum and longitudinal OAM density is numerically discussed. This work may provide an avenue for OAM-based communications,optical metrology, and imaging by varying the initial non-uniform polarization.展开更多
基金This paper is funded by China Postdoctoral Science Foundation(2014M550985)National Science Foundation of China(71532013,71528001).
文摘Background:Once a global financial crisis breaks out,the interdependence between different financial markets suddenly increases and leads to a significant contagion.Methods:With 39 countries used as samples,this paper analyzes the interdependence between the stock market and the government bond market during the crisis periods.Results:It proves that the investor focuses more on the safety of their portfolio so there is neither a flight from quality nor a positive spillover during a crisis period.When one market is safer than the other market in the same country,a flight to quality occurs between the two markets;however,when the two markets in one country are both risky,negative spillover appears between these two markets.Conclusions:This means a flight to quality from the stock market to the short-term government bond will occur more frequently than will occur from the stock market to the long-term government bond markets.In addition,a flight to quality always emerges in developed markets,while negative spillovers take place in emerging markets and in the PIIGS countries(Portugal,Italy,Ireland,Greece,and Spain,referred to hereon as“PIIGS”)in the European Debt Crisis.
基金This work was supported by the Science Technology and Innovation Committee of Shenzhen Municipality(JCYJ20180507181654823)the National Natural Science Foundation of China(21778044)and Sichuan Science and Technology Program(2018JY0360).
文摘Hydrogen peroxide(H2O2)plays a significant role in regulating a variety of biological processes.Dysregulation of H2O2 can lead to various diseases.Although numerous fluorescent imaging probes for H2O2 have been reported,the development of H2O2 ratiometric fluorescent probe with large Stokes shift remains rather limited.Such probes have shown distinct advantages,such as minimized interference from environment and improved signal-to noise ratio.In this work,we reported a new pyrene-based compound Py-VPB as H2O2 fluorescent probe in vitro.The probe demonstrated ratiometric detection behavior,large Stokes shift and large emission shift.In addition,the probe showed high sensitivity and selectivity towards H2O2 in vitro.Based on these excellent properties,we successfully applied Py-VPB to the visualization of exogenous and endogenous H2O2 in living cells.Cell imaging study also showed that our probe was localized in the mitochondria.We envision that the probe can provide a useful tool for unmasking the biological roles of mitochondrial H2O2 in living systems.
基金supported by the National Natural Science Foundation of China(Grant No.62202210).
文摘The application of generative artificial intelligence(AI)is bringing about notable changes in anime creation.This paper surveys recent advancements and applications of diffusion and language models in anime generation,focusing on their demonstrated potential to enhance production efficiency through automation and personalization.Despite these benefits,it is crucial to acknowledge the substantial initial computational investments required for training and deploying these models.We conduct an in-depth survey of cutting-edge generative AI technologies,encompassing models such as Stable Diffusion and GPT,and appraise pivotal large-scale datasets alongside quantifiable evaluation metrics.Review of the surveyed literature indicates the achievement of considerable maturity in the capacity of AI models to synthesize high-quality,aesthetically compelling anime visual images from textual prompts,alongside discernible progress in the generation of coherent narratives.However,achieving perfect long-form consistency,mitigating artifacts like flickering in video sequences,and enabling fine-grained artistic control remain critical ongoing challenges.Building upon these advancements,research efforts have increasingly pivoted towards the synthesis of higher-dimensional content,such as video and three-dimensional assets,with recent studies demonstrating significant progress in this burgeoning field.Nevertheless,formidable challenges endure amidst these advancements.Foremost among these are the substantial computational exigencies requisite for training and deploying these sophisticated models,particularly pronounced in the realm of high-dimensional generation such as video synthesis.Additional persistent hurdles include maintaining spatial-temporal consistency across complex scenes and mitigating ethical considerations surrounding bias and the preservation of human creative autonomy.This research underscores the transformative potential and inherent complexities of AI-driven synergy within the creative industries.We posit that future research should be dedicated to the synergistic fusion of diffusion and autoregressive models,the integration of multimodal inputs,and the balanced consideration of ethical implications,particularly regarding bias and the preservation of human creative autonomy,thereby establishing a robust foundation for the advancement of anime creation and the broader landscape of AI-driven content generation.
基金Supported by the National Natural Science Foundation of China,No.82300857.
文摘BACKGROUND Patients with acute-on-chronic liver failure(ACLF)experience severe immune dysfunction.Liver transplantation(LT)significantly improves survival outcomes.However,the characteristics of peripheral blood lymphocyte subsets(PBLSs)in this patient population are not well defined,and the dynamics of immune reconstitution post-LT are insufficiently understood.AIM To characterize PBLSs in patients with ACLF prior to LT and to evaluate PBLS reconstitution after LT.METHODS Clinical data from patients undergoing LT in the Transplantation Center,The Third Xiangya Hospital from January 2022 to December 2023 were analyzed retrospectively.Our cohort comprised 44 patients with ACLF,16 patients with acute decompensation of cirrhosis,and 23 patients with compensated cirrhosis.Twenty healthy volunteers were included as controls.PBLSs were evaluated across all groups.The relationship between PBLSs and post-LT prognosis was assessed,and dynamic changes in PBLSs among patients with ACLF were analyzed at different time points.RESULTS Patients with ACLF exhibited a marked reduction in PBLSs compared with healthy volunteers.Natural killer(NK)cell counts were further reduced in patients with ACLF when compared with patients with compensated cirrhosis.PBLSs did not correlate with the etiology or severity of ACLF or with established liver failure scores.Following LT,a rapid restoration of NK cells and B cells was observed in patients with ACLF.However,the cluster of differentiation(CD)3+T cell and CD4+T cell counts decreased 14 days post-LT and subsequently returned to preoperative levels by day 21.CONCLUSION Patients with ACLF exhibited markedly reduced PBLSs,with decreased NK cells potentially linked to progression from compensated cirrhosis to liver failure.NK and B cell were rapidly restored after LT.
基金supported by the National Key R&D Program of China (No.2020YFB1005500)the Leading-edge Technology Program of Jiangsu Natural Science Foundation (No.BK20202001)+1 种基金the Fundamental Research Funds for the Central Universities (No.XJSJ23040)the Postdoctoral Science Foundation of Jiangsu Province (No.2021K596C)。
文摘Electronic auctions(e-auctions)remove the physical limitations of traditional auctions and bring this mechanism to the general public.However,most e-auction schemes involve a trusted auctioneer,which is not always credible in practice.Some studies have applied cryptography tools to solve this problem by distributing trust,but they ignore the existence of collusion.In this paper,a blockchain-based Privacy-Preserving and Collusion-Resistant scheme(PPCR)for double auctions is proposed by employing both cryptography and blockchain technology,which is the first decentralized and collusion-resistant double auction scheme that guarantees bidder anonymity and bid privacy.A two-server-based auction framework is designed to support off-chain allocation with privacy preservation and on-chain dispute resolution for collusion resistance.A Dispute Resolution agreement(DR)is provided to the auctioneer to prove that they have conducted the auction correctly and the result is fair and correct.In addition,a Concise Dispute Resolution protocol(CDR)is designed to handle situations where the number of accused winners is small,significantly reducing the computation cost of dispute resolution.Extensive experimental results confirm that PPCR can indeed achieve efficient collusion resistance and verifiability of auction results with low on-chain and off-chain computational overhead.
基金supported by the National Natural Science Foundation of China(Grant Nos.51991395 and 42293355)geological survey project of China Geological Survey:Support for Geo-hazard monitoring,early warning and prevention(Grant No.DD20230085).
文摘Given the swift proliferation of structural health monitoring(SHM)technology within tunnel engineering,there is a demand on proficiently and precisely imputing the missing monitoring data to uphold the precision of disaster prediction.In contrast to other SHM datasets,the monitoring data specific to tunnel engineering exhibits pronounced spatiotemporal correlations.Nevertheless,most methodologies fail to adequately combine these types of correlations.Hence,the objective of this study is to develop spatiotemporal recurrent neural network(ST-RNN)model,which exploits spatiotemporal information to effectively impute missing data within tunnel monitoring systems.ST-RNN consists of two moduli:a temporal module employing recurrent neural network(RNN)to capture temporal dependencies,and a spatial module employing multilayer perceptron(MLP)to capture spatial correlations.To confirm the efficacy of the model,several commonly utilized methods are chosen as baselines for conducting comparative analyses.Furthermore,parametric validity experiments are conducted to illustrate the efficacy of the parameter selection process.The experimentation is conducted using original raw datasets wherein various degrees of continuous missing data are deliberately introduced.The experimental findings indicate that the ST-RNN model,incorporating both spatiotemporal modules,exhibits superior interpolation performance compared to other baseline methods across varying degrees of missing data.This affirms the reliability of the proposed model.
基金the support of the National Natural Science Foundation of China(Grant Nos.12274448,12325405,and 12174390)the National Key R&D Program of China(Grant No.2022YFF0503504)。
文摘Interparticle frictional interactions are ubiquitous in colloidal systems,exerting a profound influence on their structural and physical attributes.In this study,we employed Brownian dynamics simulations to explore the non-equilibrium dynamics in colloidal systems,focusing particularly on the role of tangential friction and its influence on the macroscopic physical properties of colloids.We found that the disruption of instantaneous time-reversal symmetry by tangential frictional interactions can trigger the self-assembly of colloidal systems into intricate network configurations,and these novel structures exhibit unique depletion force and rheological properties that set them apart from traditional colloidal gel systems.These findings not only help deepen our comprehension of the self-assembly phenomena in non-equilibrium colloidal systems but also offer fresh insights for the development of colloidal materials with tailored characteristics.
基金supported by a grant from the Wu Jieping Medical Foundation(320.6750.15070)
文摘To the Editor：Despite of the rapid increase of donation after cardiac death （DCD） in China, the shortage of organs continues to be a major problem. Every organ procured is so valuable that it should never be discarded easily, especially a liver that could save a patient＇s life in an emergency. This leads to the use of grafts from donors with unrecognized Here and unusual diseases, including schistosomiasis. we reported a case of orthotopic liver transplantation （OLT） from a donor with Schistosorna japonicurn to a patient with end-stage cirrhosis due to HBV infection.
基金supported by the Science and Technology Program of Sichuan Province, China (Grant No. 23NSFSC1097)。
文摘To explore the effect of non-uniform polarization on orbital angular momentum(OAM) in anisotropic medium, in this work investigated are the evolution of the spiral spectra and OAM densities of non-uniformly polarized vortex(NUPV)beams in uniaxial crystals propagating orthogonal to the optical axis, and also the case of uniformly polarized vortex(UPV)beams with left-handed elliptical polarization. In the input plane, the NUPV beams present their spiral spectra of m-mode concentrated at m = l ± 1 modes rather than m = l mode, and reveal the relation among topological charge l, mode of spiral spectra m and the power weight value Rmexpressed by l=∑^(∞)_(m)=-∞Rm. is still satisfied for UPV beams in uniaxially anisotropic crystals, whereas for NUPV beams their relations are no longer valid owing to non-uniform polarization. Furthermore, the analysis indicates that the asymmetrical distribution of power weight of spiral spectra and the non-zero value in the sum of longitudinal OAM densities originate from the initial non-uniform polarization and anisotropy in uniaxial crystals rather than topological charges. In addition, the relation between spiral spectrum and longitudinal OAM density is numerically discussed. This work may provide an avenue for OAM-based communications,optical metrology, and imaging by varying the initial non-uniform polarization.
