AIM: To determine the validity of the non-invasive method of CT perfusion (CTP) in rat model of hepatic diffuse disease. METHODS: Twenty-eight Wistar rats were divided into two groups. Liver diffuse lesions were induc...AIM: To determine the validity of the non-invasive method of CT perfusion (CTP) in rat model of hepatic diffuse disease. METHODS: Twenty-eight Wistar rats were divided into two groups. Liver diffuse lesions were induced by diethyln-itrosamine in 14 rats of test group. Rats in control group were bred with pure water. From the 1st to 12th wk after the test group was intervened, both groups were studied every week with CTP. CTP parameters of liver parenchyma in different periods and pathologic changes in two groups were compared and analyzed. RESULTS: The process of hepatic diffuse lesions in test groups was classified into three stages or periods according to the pathologic alterations, namely hepatitis, hepatic fibrosis, and cirrhosis. During this period, hepatic artery flow (HAF) of control group declined slightly, mean transit time (MTT), blood flow (BF) and volume (BV) increased, but there were no significant differences between different periods. In test group, HAF tended to increase gradually, MTT prolonged obviously, BV and BF decreased at the same time. The results of statistical analysis revealed that the difference in the HAF ratio of test group to control group was significant. The ratio of BV and BF in test group to control group in stage of hepatitis and hepatic cirrhosis, hepatic fibrosis and early stage of hepatic cirrhosis was significantly different, but there was no significant difference between hepatitis and hepatic fibrosis. The main pathological changes in stage of hepatitis were swelling of hepatic cells, while sinusoid capillarization and deposition of collagen aggravated gradually in the extravascular Disse's spaces in stage of fibrosis and early stage of cirrhosis. CONCLUSION: The technique could reflect some early changes of hepatic blood perfusion in rat with liver diffuse disease and is valuable for their early diagnosis.展开更多
AIM: To evaluate the role of multiphasic scanning by multirow-detector helical CT (MDCT) in detecing small hypervascular hepatocellular carcinoma (SHCC).METHODS: Multiphasic scanning was carried out in 75patients with...AIM: To evaluate the role of multiphasic scanning by multirow-detector helical CT (MDCT) in detecing small hypervascular hepatocellular carcinoma (SHCC).METHODS: Multiphasic scanning was carried out in 75patients with SHCC with Marconi MX8000 CT scanner. The early arterial phase (EAP), late arterial phase (LAP) and the portal venous phase (PVP) scans were started at 21 s, 34 s and 85 s respectively. The mean difference of CT values between tumor and liver parenchyma for each scanning phase was measured, and the sensitivity of detection of SHCC in each of these phases and in the combined phase was calculated and statistically analyzed.RESULTS: The mean difference of CT values between tumor and liver parenchyma was significant in 71 lesions≥1 cm in three phases (P＜0.05). In 91 tumor foci, the detectability of SHCC was 45.1%, 83.5% and 92.3% in EAP, LAP and double arterial phases (DAP), respectively. The early arterial phase plus the portal venous phase and the double arterial phase plus the portal venous phase were 94.5%, 97.8%,respectively. Whereas the detectability in LAP plus PVP and in DAP plus PVP had no statistical difference.CONCLUSION: The utility of faster speed and thinner slice MDCT and multiphase scanning protocol can improve the detectability of hypervascular small hepatocellular carcinoma.Among which LAP is superior to EAP in depicting the lesions.展开更多
AIM: To evaluate the value of superparamagnetic iron oxide(SPIO) enhanced MRI in characterizing focal hepaticlesions.METHODS: Fourty-three patients (32 men, 11 women, meanage 51 years, age range 25-74 years ) with pre...AIM: To evaluate the value of superparamagnetic iron oxide(SPIO) enhanced MRI in characterizing focal hepaticlesions.METHODS: Fourty-three patients (32 men, 11 women, meanage 51 years, age range 25-74 years ) with previouslyidentified focal hepatic lesions were enrolled into this study.All the patients underwent plain, Gd-DTPA enhanced MRIand the SPIO enhanced MRI 1-7d later. The surgico-pathologic diagnosis was established in 31 cases and thediagnosis in other 12 cases was made on the basis of clinicalfindings and biochemical teets. The signal changes oflesions were analyzed and the CNRs of lesion-to-liver weremeasured before and after SPIO enhancement. The datawere analyzed by paired t test.RESULTS: Focal hepatic lesions included primaryhepatocellular carcinoma (HCC, n= 22), hemangioma (n=5), cyst ( n = 4), metastases ( n = 5), cirrhotic nodule ( n =4), focal nodular hyperplasia (FNH, n = 5 ) and othermiscellaneous lesions ( n = 6). After SPIO enhancement,HCC demonstrated iso- or slight hyperintensity on T1Wl andmoderate hyperintersity on T2Wl, hemangioma showedmoderate hyperintensity on T1Wl and obvious hyperintensityon T2Wl, the SI of cyst had no change either on T1 WI or onT2Wl, cirrhotic nodules revealed iso-intensity on T2Wl, andthe SI of FNH decreased significantly on T2Wl. No specificmanifestations were found in the other 6 miscellaneouslesions after SPIO enhancement.CONCLUSION: SPIO enhanced-MRI can improve thecharacterization confidence for diagnosis of focal hepaticlesions.展开更多
AIM: To evaluate the value of postprocessing techniques of CT colonography, including multiplanar reformation (MPR), virtual colonoscopy (VC), shaded surface display (SSD) and Raysum, in detection of colorectal carcin...AIM: To evaluate the value of postprocessing techniques of CT colonography, including multiplanar reformation (MPR), virtual colonoscopy (VC), shaded surface display (SSD) and Raysum, in detection of colorectal carcinomas. METHODS: Sixty-four patients with colorectal carcinoma underwent volume scanning with spiral CT. MPR, VC, SSD and Raysum images were obtained by using four kinds of postprocessing techniques in workstation. The results were comparatively analyzed according to circumferential extent, lesion length and pathology pattern of colorectal carcinomas. All diagnoses were proved pathologically and surgically. RESULTS: The accuracy of circumferential extent of colorectal carcinoma determined by MPR, VC, SSD and Raysum was 100.0%, 82.8%, 79.7% and 79.7%, respectively. There was a significant statistical difference between MPR and VC. The consistent rate of lesion length was 89.1%, 76.6%, 95.3% and 100.0%, respectively. There was a statistical difference between VC and SSD. The accuracy of discriminating pathology pattern was 81.3%, 92.2%, 71.9% and 71.9%, respectively. There was a statistical difference between VC and SSD. MPR could determine accurately the circumference of colorectal carcinoma, Raysum could determine the length of lesion more precisely than SSD, VC was helpful in discriminating pathology patterns. CONCLUSION: MPR, VC, SSD and Raysum have advantage and disadvantage in detection of colorectal carcinoma, use of these methods in combination can disclose the lesion more accurately.展开更多
AIM: To assess the accuracy of three-dimensional contrastenhanced magnetic resonance angiography (3D CE MRA) in evaluation of the portal vein involvement in patients with hepatic tumors.METHODS: 3D CE MlRA was perform...AIM: To assess the accuracy of three-dimensional contrastenhanced magnetic resonance angiography (3D CE MRA) in evaluation of the portal vein involvement in patients with hepatic tumors.METHODS: 3D CE MlRA was performed in 62 patients with hepatic tumors to assess the patency of the main, right and left portal veins before hepatic surgery. A total of 186 veins were examined for encasement, occlusion and tumor thrombosis. The results of 3D CE NRA diagnosis were then correlated with the surgical-pathological and intra-operative sonographic findings.RESULTS: 3D CE MRA correctly detected 48 of 49 involved and 135 of 137 noninvolved portal veins with the sensitivity of 98 %, specificity of 99 %, positive predictive value of 96 % and negative predictive value of 99 %.CONCLUSION: 3D CE NRA is accurate in evaluation of the portal vein involvement in patients with hepatic tumors.展开更多
基金Supported by a Grant from the Ministry of Public Health of China, No. 20011420
文摘AIM: To determine the validity of the non-invasive method of CT perfusion (CTP) in rat model of hepatic diffuse disease. METHODS: Twenty-eight Wistar rats were divided into two groups. Liver diffuse lesions were induced by diethyln-itrosamine in 14 rats of test group. Rats in control group were bred with pure water. From the 1st to 12th wk after the test group was intervened, both groups were studied every week with CTP. CTP parameters of liver parenchyma in different periods and pathologic changes in two groups were compared and analyzed. RESULTS: The process of hepatic diffuse lesions in test groups was classified into three stages or periods according to the pathologic alterations, namely hepatitis, hepatic fibrosis, and cirrhosis. During this period, hepatic artery flow (HAF) of control group declined slightly, mean transit time (MTT), blood flow (BF) and volume (BV) increased, but there were no significant differences between different periods. In test group, HAF tended to increase gradually, MTT prolonged obviously, BV and BF decreased at the same time. The results of statistical analysis revealed that the difference in the HAF ratio of test group to control group was significant. The ratio of BV and BF in test group to control group in stage of hepatitis and hepatic cirrhosis, hepatic fibrosis and early stage of hepatic cirrhosis was significantly different, but there was no significant difference between hepatitis and hepatic fibrosis. The main pathological changes in stage of hepatitis were swelling of hepatic cells, while sinusoid capillarization and deposition of collagen aggravated gradually in the extravascular Disse's spaces in stage of fibrosis and early stage of cirrhosis. CONCLUSION: The technique could reflect some early changes of hepatic blood perfusion in rat with liver diffuse disease and is valuable for their early diagnosis.
基金the Ministry Public Health Programme,No.97030220
文摘AIM: To evaluate the role of multiphasic scanning by multirow-detector helical CT (MDCT) in detecing small hypervascular hepatocellular carcinoma (SHCC).METHODS: Multiphasic scanning was carried out in 75patients with SHCC with Marconi MX8000 CT scanner. The early arterial phase (EAP), late arterial phase (LAP) and the portal venous phase (PVP) scans were started at 21 s, 34 s and 85 s respectively. The mean difference of CT values between tumor and liver parenchyma for each scanning phase was measured, and the sensitivity of detection of SHCC in each of these phases and in the combined phase was calculated and statistically analyzed.RESULTS: The mean difference of CT values between tumor and liver parenchyma was significant in 71 lesions≥1 cm in three phases (P＜0.05). In 91 tumor foci, the detectability of SHCC was 45.1%, 83.5% and 92.3% in EAP, LAP and double arterial phases (DAP), respectively. The early arterial phase plus the portal venous phase and the double arterial phase plus the portal venous phase were 94.5%, 97.8%,respectively. Whereas the detectability in LAP plus PVP and in DAP plus PVP had no statistical difference.CONCLUSION: The utility of faster speed and thinner slice MDCT and multiphase scanning protocol can improve the detectability of hypervascular small hepatocellular carcinoma.Among which LAP is superior to EAP in depicting the lesions.
文摘AIM: To evaluate the value of superparamagnetic iron oxide(SPIO) enhanced MRI in characterizing focal hepaticlesions.METHODS: Fourty-three patients (32 men, 11 women, meanage 51 years, age range 25-74 years ) with previouslyidentified focal hepatic lesions were enrolled into this study.All the patients underwent plain, Gd-DTPA enhanced MRIand the SPIO enhanced MRI 1-7d later. The surgico-pathologic diagnosis was established in 31 cases and thediagnosis in other 12 cases was made on the basis of clinicalfindings and biochemical teets. The signal changes oflesions were analyzed and the CNRs of lesion-to-liver weremeasured before and after SPIO enhancement. The datawere analyzed by paired t test.RESULTS: Focal hepatic lesions included primaryhepatocellular carcinoma (HCC, n= 22), hemangioma (n=5), cyst ( n = 4), metastases ( n = 5), cirrhotic nodule ( n =4), focal nodular hyperplasia (FNH, n = 5 ) and othermiscellaneous lesions ( n = 6). After SPIO enhancement,HCC demonstrated iso- or slight hyperintensity on T1Wl andmoderate hyperintersity on T2Wl, hemangioma showedmoderate hyperintensity on T1Wl and obvious hyperintensityon T2Wl, the SI of cyst had no change either on T1 WI or onT2Wl, cirrhotic nodules revealed iso-intensity on T2Wl, andthe SI of FNH decreased significantly on T2Wl. No specificmanifestations were found in the other 6 miscellaneouslesions after SPIO enhancement.CONCLUSION: SPIO enhanced-MRI can improve thecharacterization confidence for diagnosis of focal hepaticlesions.
文摘AIM: To evaluate the value of postprocessing techniques of CT colonography, including multiplanar reformation (MPR), virtual colonoscopy (VC), shaded surface display (SSD) and Raysum, in detection of colorectal carcinomas. METHODS: Sixty-four patients with colorectal carcinoma underwent volume scanning with spiral CT. MPR, VC, SSD and Raysum images were obtained by using four kinds of postprocessing techniques in workstation. The results were comparatively analyzed according to circumferential extent, lesion length and pathology pattern of colorectal carcinomas. All diagnoses were proved pathologically and surgically. RESULTS: The accuracy of circumferential extent of colorectal carcinoma determined by MPR, VC, SSD and Raysum was 100.0%, 82.8%, 79.7% and 79.7%, respectively. There was a significant statistical difference between MPR and VC. The consistent rate of lesion length was 89.1%, 76.6%, 95.3% and 100.0%, respectively. There was a statistical difference between VC and SSD. The accuracy of discriminating pathology pattern was 81.3%, 92.2%, 71.9% and 71.9%, respectively. There was a statistical difference between VC and SSD. MPR could determine accurately the circumference of colorectal carcinoma, Raysum could determine the length of lesion more precisely than SSD, VC was helpful in discriminating pathology patterns. CONCLUSION: MPR, VC, SSD and Raysum have advantage and disadvantage in detection of colorectal carcinoma, use of these methods in combination can disclose the lesion more accurately.
基金National Natural Science Foundation of China,No. 39670230
文摘AIM: To assess the accuracy of three-dimensional contrastenhanced magnetic resonance angiography (3D CE MRA) in evaluation of the portal vein involvement in patients with hepatic tumors.METHODS: 3D CE MlRA was performed in 62 patients with hepatic tumors to assess the patency of the main, right and left portal veins before hepatic surgery. A total of 186 veins were examined for encasement, occlusion and tumor thrombosis. The results of 3D CE NRA diagnosis were then correlated with the surgical-pathological and intra-operative sonographic findings.RESULTS: 3D CE MRA correctly detected 48 of 49 involved and 135 of 137 noninvolved portal veins with the sensitivity of 98 %, specificity of 99 %, positive predictive value of 96 % and negative predictive value of 99 %.CONCLUSION: 3D CE NRA is accurate in evaluation of the portal vein involvement in patients with hepatic tumors.
