摘要
AIM: To evaluate the value of superparamagnetic iron oxide(SPIO) enhanced MRI in characterizing focal hepaticlesions.METHODS: Fourty-three patients (32 men, 11 women, meanage 51 years, age range 25-74 years ) with previouslyidentified focal hepatic lesions were enrolled into this study.All the patients underwent plain, Gd-DTPA enhanced MRIand the SPIO enhanced MRI 1-7d later. The surgico-pathologic diagnosis was established in 31 cases and thediagnosis in other 12 cases was made on the basis of clinicalfindings and biochemical teets. The signal changes oflesions were analyzed and the CNRs of lesion-to-liver weremeasured before and after SPIO enhancement. The datawere analyzed by paired t test.RESULTS: Focal hepatic lesions included primaryhepatocellular carcinoma (HCC, n= 22), hemangioma (n=5), cyst ( n = 4), metastases ( n = 5), cirrhotic nodule ( n =4), focal nodular hyperplasia (FNH, n = 5 ) and othermiscellaneous lesions ( n = 6). After SPIO enhancement,HCC demonstrated iso- or slight hyperintensity on T1Wl andmoderate hyperintersity on T2Wl, hemangioma showedmoderate hyperintensity on T1Wl and obvious hyperintensityon T2Wl, the SI of cyst had no change either on T1 WI or onT2Wl, cirrhotic nodules revealed iso-intensity on T2Wl, andthe SI of FNH decreased significantly on T2Wl. No specificmanifestations were found in the other 6 miscellaneouslesions after SPIO enhancement.CONCLUSION: SPIO enhanced-MRI can improve thecharacterization confidence for diagnosis of focal hepaticlesions.
AIM:To evaluate the value of superparamagnetic iron oxide (SPIO)enhanced MRI in characterizing focal hepatic lesions. METHODS:Fourty-three patients(32 men,11 women,mean age 51 years,age range 25-74 years)with previously identified focal hepatic lesions were enrolled into this study. All the patients underwent plain,Gd-DTPA enhanced MRI and the SPIO enhanced MRI 1-7d later.The surgico- pathologic diagnosis was established in 31 cases and the diagnosis in other 12 cases was made on the basis of clinical findings and biochemical tests,The signal changes of lesions were analyzed and the CNRs of lesion-to-liver were measured before and after SPIO enhancement.The data were analyzed by paired t test. RESULTS:Focal hepatic lesions included primary hepatocellular carcinoma(HCC,n=22),hemangioma(n= 5),cyst(n=4),metastases(n=5),cirrhotic nodule(n= 4),focal nodular hyperplasia(FNH,n=5)and other miscellaneous lesions(n=6).After SPIO enhancement, HCC demonstrated iso-or slight hyperintensity on T1 WI and moderate hyperintersity on T2WI,hemangioma showed moderate hyperintensity on TIWI and obvious hyperintensity on T2WI,the SI of cyst had no change either on TIWI or on T2WI,cirrhotic nodules revealed iso-intensity on T2WI,and the SI of FNH decreased significantly on T2WI.No specific manifestations were found in the other 6 miscellaneous lesions after SPIO enhancement. CONCLUSION:SPIO enhanced-MRI can improve the characterization confidence for diagnosis of focal hepatic lesions.
基金
the Health Ministry Programme No.97030220
