Purpose–The bridge expansion joint(BEJ)is a key device for accommodating spatial displacement at the beam end,and for providing vertical support for running trains passing over the gap between the main bridge and the...Purpose–The bridge expansion joint(BEJ)is a key device for accommodating spatial displacement at the beam end,and for providing vertical support for running trains passing over the gap between the main bridge and the approach bridge.For long-span railway bridges,it must also be coordinated with rail expansion joint(REJ),which is necessary to accommodate the expansion and contraction of,and reducing longitudinal stress in,the rails.The main aim of this study is to present analysis of recent developments in the research and application of BEJs in high-speed railway(HSR)long-span bridges in China,and to propose a performance-based integral design method for BEJs used with REJs,from both theoretical and engineering perspectives.Design/methodology/approach–The study first presents a summary on the application and maintenance of BEJs in HSR long-span bridges in China representing an overview of their state of development.Results of a survey of typical BEJ faults were analyzed,and field testing was conducted on a railway cable-stayed bridge in order to obtain information on the major mechanical characteristics of its BEJ under train load.Based on the above,a performance-based integral design method for BEJs with maximum expansion range 1600 mm(±800 mm),was proposed,covering all stages from overall conceptual design to consideration of detailed structural design issues.The performance of the novel BEJ design thus derived was then verified via theoretical analysis under different scenarios,full-scale model testing,and field testing and commissioning.Findings–Two major types of BEJs,deck-type and through-type,are used in HSR long-span bridges in China.Typical BEJ faults were found to mainly include skewness of steel sleepers at the bridge gap,abnormally large longitudinal frictional resistance,and flexural deformation of the scissor mechanisms.These faults influence BEJ functioning,and thus adversely affect track quality and train running performance at the beam end.Due to their simple and integral structure,deck-type BEJs with expansion range 1200 mm(±600 mm)or less have been favored as a solution offering improved operational conditions,and have emerged as a standard design.However,when the expansion range exceeds the above-mentioned value,special design work becomes necessary.Therefore,based on engineering practice,a performance-based integral design method for BEJs used with REJs was proposed,taking into account four major categories of performance requirements,i.e.,mechanical characteristics,train running quality,durability and insulation performance.Overall BEJ design must mainly consider component strength and the overall stiffness of BEJ;the latter factor in particular has a decisive influence on train running performance at the beam end.Detailed BEJ structural design must stress minimization of the frictional resistance of its sliding surface.The static and dynamic performance of the newlydesigned BEJ with expansion range 1600 mm have been confirmed to be satisfactory,via numerical simulation,full-scale model testing,and field testing and commissioning.Originality/value–This research provides a broad overview of the status of BEJs with large expansion range in HSR long-span bridges in China,along with novel insights into their design.展开更多
This work reveals the significant effects of cobalt(Co)on the microstructure and impact toughness of as-quenched highstrength steels by experimental characterizations and thermo-kinetic analyses.The results show that ...This work reveals the significant effects of cobalt(Co)on the microstructure and impact toughness of as-quenched highstrength steels by experimental characterizations and thermo-kinetic analyses.The results show that the Co-bearing steel exhibits finer blocks and a lower ductile-brittle transition temperature than the steel without Co.Moreover,the Co-bearing steel reveals higher transformation rates at the intermediate stage with bainite volume fraction ranging from around 0.1 to 0.6.The improved impact toughness of the Co-bearing steel results from the higher dense block boundaries dominated by the V1/V2 variant pair.Furthermore,the addition of Co induces a larger transformation driving force and a lower bainite start temperature(BS),thereby contributing to the refinement of blocks and the increase of the V1/V2 variant pair.These findings would be instructive for the composition,microstructure design,and property optimization of high-strength steels.展开更多
Autism spectrum disorder (ASD) is a neurodevelopmental disorder with considerable clinical and genetic heterogeneity.In this study,we identified all classes of genomic variants from whole-genome sequencing (WGS) datas...Autism spectrum disorder (ASD) is a neurodevelopmental disorder with considerable clinical and genetic heterogeneity.In this study,we identified all classes of genomic variants from whole-genome sequencing (WGS) dataset of 32 Chinese trios with ASD,including de novo mutations,inherited variants,copy number variants (CNVs) and genomic structural variants.A higher mutation rate (Poisson test,P<2.2×10^(-16)) in exonic (1.37×10^(-8)) and 3'-UTR regions (1.42×10^(-8)) was revealed in comparison with that of whole genome (1.05×10^(-8)).Using an integrated model,we identified 87 potentially risk genes (P<0.01) from 4832 genes harboring various rare deleterious variants,including CHD8 and NRXN2,implying that the disorders may be in favor to multiple-hit.In particular,frequent rare inherited mutations of several microcephaly-associated genes (ASPM,WDR62,and ZNF335)were found in ASD.In chromosomal structure analyses,we found four de novo CNVs and one de novo chromosomal rearrangement event,including a de novo duplication of UBE3A-containing region at 15q11.2-q13.1,which causes Angelman syndrome and microcephaly,and a disrupted TNR due to de novo chromosomal translocation t (1;5) (q25.1;q33.2).Taken together,our results suggest that abnormalities of centrosomal function and chromatin remodeling of the microcephaly-associated genes may be implicated in pathogenesis of ASD.Adoption of WGS as a new yet efficient technique to illustrate the full genetic spectrum in complex disorders,such as ASD,could provide novel insights into pathogenesis,diagnosis and treatment.展开更多
The objective of this work is to explore how to realize the homogenization of emergency clinical decision, and it means that patients receive the same effect of clinical decisions and the treatment in a different hosp...The objective of this work is to explore how to realize the homogenization of emergency clinical decision, and it means that patients receive the same effect of clinical decisions and the treatment in a different hospital. In order to achieve that, emergency doctors should first have the same clinical thinking and thinking mode which is the biggest challenge for homogenization of emergency clinical decision. The task of emergency medicine is to give priority to the treatment of critically ill patients, so step-down thinking of “excluding life-threatening symptoms first” is the basis, the preemptive thinking is the means, and Process thinking is the key of homogenization;The initial diagnosis and treatment mode of symptom-oriented is the starting point for emergency decision;establishing a unified “checklist” can not only broaden the lateral thinking of emergency doctors, but also unify the thinking of differential diagnosis of emergency;dynamic observation should run through the whole diagnosis and treatment process, which is necessary for the homogenization of emergency decision.展开更多
<strong>Objective</strong><span style="font-family:;" "=""><span style="font-family:Verdana;"><strong>: </strong>To evaluate the clinical value of...<strong>Objective</strong><span style="font-family:;" "=""><span style="font-family:Verdana;"><strong>: </strong>To evaluate the clinical value of transcranial color Doppler ultrasound (TCCD) in assessing cerebral function after cardiopulmonary resuscitation (CPR). </span><b><span style="font-family:Verdana;">Methods</span></b><span style="font-family:Verdana;">: A prospective study was conducted in 52 patients with cardiac arrest treated by CPR from January 2018 to January 2020, and its clinical data were analyzed</span></span><span style="font-family:Verdana;">. </span><span style="font-family:;" "=""><span style="font-family:Verdana;">According to classification of cerebral performance category (CPC), 31 cases (CPC grade 1 - 2) were selected in the good prognosis group and 21 cases (CPC grade 3 - 5) in the poor prognosis group. The cerebral blood flow was measured by transcranial Doppler ultrasound (TCCD) 24 h after CPR, and the differences were compared between the two groups in stroke index, diastolic blood flow velocity (Vd), systolic peak blood flow velocity (Vs) and mean peak blood flow velocity (Vm). The ROC curve of cerebral blood flow after CPR was drawn to predict the prognosis of brain function. </span><b><span style="font-family:Verdana;">Results</span></b><span style="font-family:Verdana;">: The data showed that the pulsatility index of middle cerebral artery of the poor prognosis group decreased within 24 h</span></span><span style="font-family:Verdana;">;</span><span style="font-family:Verdana;">the difference between the two groups was statistically significant (p < 0.05);the Vd, Vs, Vm increased in the good prognosis group</span><span style="font-family:Verdana;">;</span><span style="font-family:;" "=""><span style="font-family:Verdana;">the difference between the two groups was statistically significant (p < 0.05). The ROC curve of cerebral blood flow after CPR was drawn to predict the prognosis of brain function, and the results showed that the area under the curve and the optimal critical value of cerebral blood flow were 0.731 and 5.69. The sensitivity and specificity were 67.3% and 79.1% respectively. </span><b><span style="font-family:Verdana;">Conclusion</span></b><span style="font-family:Verdana;">: The cerebral blood flow increase in the early stage of successful CPR is positively correlated with the prognosis of cerebral functional resuscitation. Monitoring intracranial blood flow after CPR by TCCD has clinical value to evaluate prognosis of brain function.</span></span>展开更多
Since the Industrial Revolution,humanity’s extensive burning of fossil fuels(coal,oil,and natural gas)has led to a continuous rise in the concentration of greenhouse gases,such as carbon dioxide(CO_(2)),in the atmosp...Since the Industrial Revolution,humanity’s extensive burning of fossil fuels(coal,oil,and natural gas)has led to a continuous rise in the concentration of greenhouse gases,such as carbon dioxide(CO_(2)),in the atmosphere.According to data from the World Meteorological Organization(WMO),the global average CO_(2) concentration in 2023 exceeded 420×10^(−6),reaching the highest level in the past 800000 years.This has led to the increasing frequency of extreme climate events-such as glacier melting,sea-level rise,heatwaves,droughts,floods,and hurricanes-posing a severe threat to ecosystems and human society.展开更多
As a typical in-memory computing hardware design, nonvolatile ternary content-addressable memories(TCAMs) enable the logic operation and data storage for high throughout in parallel big data processing. However,TCAM c...As a typical in-memory computing hardware design, nonvolatile ternary content-addressable memories(TCAMs) enable the logic operation and data storage for high throughout in parallel big data processing. However,TCAM cells based on conventional silicon-based devices suffer from structural complexity and large footprintlimitations. Here, we demonstrate an ultrafast nonvolatile TCAM cell based on the MoTe2/hBN/multilayergraphene (MLG) van der Waals heterostructure using a top-gated partial floating-gate field-effect transistor(PFGFET) architecture. Based on its ambipolar transport properties, the carrier type in the source/drain andcentral channel regions of the MoTe2 channel can be efficiently tuned by the control gate and top gate, respectively,enabling the reconfigurable operation of the device in either memory or FET mode. When working inthe memory mode, it achieves an ultrafast 60 ns programming/erase speed with a current on-off ratio of ∼105,excellent retention capability, and robust endurance. When serving as a reconfigurable transistor, unipolar p-typeand n-type FETs are obtained by adopting ultrafast 60 ns control-gate voltage pulses with different polarities.The monolithic integration of memory and logic within a single device enables the content-addressable memory(CAM) functionality. Finally, by integrating two PFGFETs in parallel, a TCAM cell with a high current ratioof ∼10^(5) between the match and mismatch states is achieved without requiring additional peripheral circuitry.These results provide a promising route for the design of high-performance TCAM devices for future in-memorycomputing applications.展开更多
Alterations in the mesenchymal-epithelial transition factor(MET)gene are critical drivers of non-small cell lung cancer(NSCLC).In recent years advances in precision therapies targeting MET alterations have significant...Alterations in the mesenchymal-epithelial transition factor(MET)gene are critical drivers of non-small cell lung cancer(NSCLC).In recent years advances in precision therapies targeting MET alterations have significantly expanded treatment options for NSCLC patients.These alterations include MET exon 14 skipping mutations(MET exon 14 skipping),MET gene amplifications,MET point mutations(primarily kinase domain mutations),and MET protein overexpression.Accurate identification of these alterations and appropriate selection of patient populations and targeted therapies are essential for improving clinical outcomes.The East China Lung Cancer Group,Youth Committee(ECLUNG YOUNG,Yangtze River Delta Lung Cancer Cooperation Group)has synthesized insights from China’s innovative drug development landscape and clinical practice to formulate an expert consensus on the diagnosis and treatment of NSCLC patients with MET alterations.This consensus addresses key areas,such as optimal testing timing,testing methods,testing strategies,quality control measures,and treatment approaches.By offering standardized recommendations,this guidance aims to streamline diagnostic and therapeutic processes and enhance clinical decision-making for NSCLC with MET alterations.展开更多
Hydrogel-based flexible sensors are emerging as ideal candidates for wearable devices and soft robotics.However,most current hydrogels possess limited physicochemical properties,which hinder their practical applicatio...Hydrogel-based flexible sensors are emerging as ideal candidates for wearable devices and soft robotics.However,most current hydrogels possess limited physicochemical properties,which hinder their practical application in long-term and complex scenarios.Herein,inspired by the unique structure of the barnacle,we design multifunctional poly(DMAPA-co-PHEA)hydrogels(CP hydrogels)by employing multiple physical crosslinks in the presence of Ag nanoparticles and NaCl additives.Owing to the synergistic effect of cation-πinteractions,hydrophobic interactions,and ionic bonds,the CP hydrogels exhibit high stretchability(strain up to 1430%),strong adhesion(22.8 kPa),satisfactory antibacterial activity,stable anti-icing ability(<20 kPa after 20 icing-deicing cycles),and high electrical conductivity(18.5 mS/cm).Additionally,the CP hydrogels show fast and sensitive responsiveness and cycling stability and can attach directly to human skin to accurately detect both human motions and tiny physiological signals as a flexible wearable sensor.Collectively,this work significantly contributes a straightforward and efficient design strategy for the development of multifunctional hydrogels,broadening their application scenarios.展开更多
EuB_(6),a magnetic topological semimetal,has attracted considerable attention in recent years due to its rich intriguing physical properties,including a colossal negative magnetoresistance(CNMR)ratio exceeding-80%,a t...EuB_(6),a magnetic topological semimetal,has attracted considerable attention in recent years due to its rich intriguing physical properties,including a colossal negative magnetoresistance(CNMR)ratio exceeding-80%,a topological phase transition and a predicted quantum anomalous Hall effect(QAHE)approaching the two-dimensional(2D)limit.Yet,studies of the influence of the dimensionality approaching 2D on the electronic transport properties of EuB_(6) are still scarce.In this work,EuB_(6) thin sheets with thicknesses ranging from 35μm to 180μm were successfully fabricated through careful mechanical polishing of high-quality EuB_(6) single crystals.The reduced thickness,temperature and magnetic field have a strong influence on the electronic transport properties,including the CNMR and carrier concentration of EuB_(6) thin sheets.As the thickness of EuB_(6) thin sheets decreases from 180μm to 35μm,the magnetization transition temperature and the corresponding suppressing temperature of the Kondo effect decrease from 15.2 K to 10.9 K,while the CNMR ratio increases from-87.2%to-90.8%.Furthermore,the weak antilocalization effect transits to a weak localization effect and the carrier concentration increases by 9.4%at 30 K in a 35μm EuB_(6) thin sheet compared to the value reported for a 180μm thin sheet.Our findings demonstrate an obvious tunable effect of the reduced dimensionality on the transport properties of EuB_(6) along with the temperature and magnetic field,which could provide a route to exploring the QAHE near the 2D limit in EuB_(6) and other topological semimetals.展开更多
Vanadium-based transition metal chalcogenides VmXn(X=S,Se,Te)with their distinctive quantum effects,tunable magnetism,spin-orbit coupling,and high carrier mobility are a valuable platform to explore the interplay betw...Vanadium-based transition metal chalcogenides VmXn(X=S,Se,Te)with their distinctive quantum effects,tunable magnetism,spin-orbit coupling,and high carrier mobility are a valuable platform to explore the interplay between magnetism and electronic correlations,especially with tunable structural phases and magnetic properties through stoichiometric variations,making them ideal candidates for advanced device applications.Here,we report the synthesis of high-quality V_(5+x)S_(8)single crystals with different concentrations of self-intercalated vanadium.V_(5+x)S_(8)crystals show an antiferromagnetic behavior and a spin-flop-like transition below TN of 30.6 K.The high-quality V_(5+x)S_(8)single crystals exhibit a large negative magnetoresistance of 12.3%at 2 K.Interestingly,V_(5+x)S_(8)crystals show an obvious low-temperature resistance upturn that gradually levels off with the increasing magnetic field,attributed to the Kondo effect arising from the interaction between conduction electrons and embedded vanadium magnetic impurities.With increasing V doping,the antiferromagnetic interactions intensify,weakening the coupling between the local moments and conduction electrons,which in turn lowers the Kondo temperature(TK).Furthermore,the anomalous Hall effect is observed in V5.73S8,with an anomalous Hall conductivity(AHC)of 50.46 W^(-1)·cm^(-1)and anomalous Hall angle of 0.73%at 2 K.Our findings offer valuable insights into the mechanisms of the Kondo effect and anomalous Hall effect in self-intercalated transition metal chalcogenides with complex magnetism and electronic correlation effects.展开更多
As a representative of the third generation advanced high-strength steels(AHSSs),medium Mn steels(MMS)have broad development prospects in the field of automobile manufacturing.MMS with typical austenite reversion trea...As a representative of the third generation advanced high-strength steels(AHSSs),medium Mn steels(MMS)have broad development prospects in the field of automobile manufacturing.MMS with typical austenite reversion treatment have a soft duplex microstructure,i.e.ferrite+austenite,presenting a high ductility but a low yield strength.Here we show that a flash heating and cooling after austenite reversion treatment can replace the ferrite with strong martensite,which greatly enhances the yield strength of a 0.25C-4Mn steel by about 461–886 MPa.By adjusting the reversion temperature before the flash treatment,the C and Mn concentrations of reverted austenite can be altered,which determine the fraction of reverted austenite surviving the flash treatment.In addition,the mechanical stability of final retained austenite is also linked to the reversion temperature,resulting different work hardening behaviors due to transformation induced plasticity(TRIP)effect.By tweaking the reversion temperature before the flash treatment,an optimized combination of strength and ductility can be achieved.The micromechanical differences caused by the replacement of the matrix are also investigated via in-situ digital image correlation method.展开更多
Glioblastoma(GBM)is a highly infiltrative brain tumor.The treatment of GBM is challenging due to the existence of blood brain barrier,its highly invasive nature,and its heterogeneity.Given the limitations of conventio...Glioblastoma(GBM)is a highly infiltrative brain tumor.The treatment of GBM is challenging due to the existence of blood brain barrier,its highly invasive nature,and its heterogeneity.Given the limitations of conventional therapies,this Perspective explores the development trajectory of implantable devices,highlighting the advantages of current models.With the progression in research,these implantable devices certainly hold promising potential for GBM therapy.展开更多
Loss-of-function variants in CSDE1 have been strongly linked to neuropsychiatric disorders,yet the precise role of CSDE1 in neurogenesis remains elusive.In this study,we demonstrate that knockout of Csde1 during corti...Loss-of-function variants in CSDE1 have been strongly linked to neuropsychiatric disorders,yet the precise role of CSDE1 in neurogenesis remains elusive.In this study,we demonstrate that knockout of Csde1 during cortical development in mice results in impaired neural progenitor proliferation,leading to abnormal cortical lamination and embryonic lethality.Transcriptomic analysis revealed that Csde1 upregulates the transcription of genes involved in the cell cycle network.Applying a dual thymidine-labelling approach,we further revealed prolonged cell cycle durations of neuronal progenitors in Csde1-knockout mice,with a notable extension of the G1 phase.Intersection with CLIP-seq data demonstrated that Csde1 binds to the 3′untranslated region(UTR)of mRNA transcripts encoding cell cycle genes.Particularly,we uncovered that Csde1 directly binds to the 3′UTR of mRNA transcripts encoding Cdk6,a pivotal gene in regulating the transition from the G1 to S phases of the cell cycle,thereby maintaining its stability.Collectively,this study elucidates Csde1 as a novel regulator of Cdk6,sheds new light on its critical roles in orchestrating brain development,and underscores how mutations in Csde1 may contribute to the pathogenesis of neuropsychiatric disorders.展开更多
Objective:The aim of this study was to evaluate the synergistic effect of eye care and drug therapy in patients with dry eye.Methods:A total of 59 patients with dry eye diagnosed and treated in our hospital were rando...Objective:The aim of this study was to evaluate the synergistic effect of eye care and drug therapy in patients with dry eye.Methods:A total of 59 patients with dry eye diagnosed and treated in our hospital were randomly divided into the reference group(29 cases)and the experimental group(30 cases).Patients in the reference group received only the usual medication,while the experimental group received additional eye care.The treatment response and the improvement of quality of life were evaluated by comparing the treatment excellence rate,quality of life score,and nursing satisfaction score of the two groups.Results:The rate of excellent treatment in the experimental group was 93.33%,which was significantly higher than that in the reference group(68.97%)(P=0.013).The quality of life scores in social function,psychological function and physiological function of the experimental group were significantly higher than those of the reference group(P<0.003),the nursing satisfaction score and symptom score were also improved more significantly(P<0.003),and the SAS score was decreased more(P<0.003).Conclusion:The synergistic effect of comprehensive eye care and drug therapy on patients with dry eye can significantly improve the rate of good treatment and quality of life score,increase the nursing satisfaction of patients,and have potential benefits to improve psychological status,providing an effective way for the management of dry eye.展开更多
Ising superconductivity, induced by the strong spin–orbit coupling(SOC) and inversion symmetry breaking, can lead to the in-plane upper critical field exceeding the Pauli limit and hold significant potential for adva...Ising superconductivity, induced by the strong spin–orbit coupling(SOC) and inversion symmetry breaking, can lead to the in-plane upper critical field exceeding the Pauli limit and hold significant potential for advancing the study of topological superconductivity. However, the enhancement of Ising superconductivity is still a challenging problem, important for engineering Majorana fermions and exploring topological quantum computing. In this study, we investigated the superconducting properties of a series of van der Waals NbSe_(2-x)Te_(x) nanosheets. The Ising superconductivity in NbSe_(2-x)Te_(x) nanosheets can be significantly enhanced by the substitution of Te, an element with strong SOC. The fitted in-plane upper critical field of Nb Se_(1.5)Te_(0.5) nanosheets at absolute zero temperature reaches up to 3.2 times the Pauli limit. Angular dependence of magnetoresistance measurements reveals a distinct two-fold rotational symmetry in the superconducting transition region, highlighting the role of strong SOC. In addition, the fitting results of the Berezinskii–Kosterlitz–Thouless(BKT) transition and the two-dimensional(2D) Tinkham formula provide strong evidence for 2D superconductivity. These findings offer new perspectives for the design and modulation of the Ising superconducting state and pave the way for their potential applications in topological superconductivity and quantum technologies.展开更多
Diseases associated with bacterial infection,especially those caused by gram-negative bacteria,have been posing a serious threat to human health.Photodynamic therapy based on aggregation-induced emission(AIE)photosens...Diseases associated with bacterial infection,especially those caused by gram-negative bacteria,have been posing a serious threat to human health.Photodynamic therapy based on aggregation-induced emission(AIE)photosensitizer have recently emerged and provided a promising approach for bacterial discrimination and efficient photodynamic antimicrobial applications.However,they often suffer from the shorter excitation wavelength and lower molar extinction coefficients in the visible region,severely limiting their further applications.Herein,three novel BF_(2)-curcuminoid-based AIE photosensitizers,TBBC,TBC and TBBC-C8,have been rationally designed and successfully developed,in which OCH_(3)-and OC_(8)H_(17)-substituted tetraphenylethene(TPE)groups serve as both electron donor(D)and AIE active moieties,BF_(2)bdk group functions as electron acceptor(A),and styrene(or ethylene)group asπ-bridge in this D-π-A-π-D system,respectively.As expected,these resulting BF_(2)-curcuminoids presented solvent-dependent photophysical properties with large molar extinction coefficients in solutions and excellent AIE properties.Notably,TBBC showed an effective singlet oxygen generation efficiency thanks to the smaller singlet-triplet energy gap(△E_(ST)),and remarkable photostability under green light exposure at 530nm(8.9 mW/cm^(2)).More importantly,TBBC was demonstrated effectiveness in selective staining and photodynamic killing of Escherichia coli(E.coli)in vitro probably due to its optimal molecular size compared with TBC and TBBC-C8.Therefore,TBBC will have great potential as a novel AIE photosensitizer to apply in the discrimination and selective sterilization between Gram-positive and Gram-negative bacteria.展开更多
BACKGROUND Diabetic retinopathy(DR)is a major cause of visual impairment and blindness.However,the current DR biomarkers are insufficient for accurately predicting its onset.AIM To identify a novel marker for predicti...BACKGROUND Diabetic retinopathy(DR)is a major cause of visual impairment and blindness.However,the current DR biomarkers are insufficient for accurately predicting its onset.AIM To identify a novel marker for predicting the risk of developing DR in patients with type 2 diabetes mellitus(T2DM).METHODS We conducted a cross-sectional study involving 6993 hospitalized T2DM patients between 2013 and 2020.Patients were divided into two groups:The DR group and the non-DR group.Data were analyzed using univariate,correlation,multivariate,subgroup,and receiver operating characteristic curve analyses.RESULTS Total bilirubin,indirect bilirubin(IBIL),and direct bilirubin were negatively correlated with the risk of developing DR(P<0.001).Moreover,these three factors were all positively correlated with clinical indicators related to DR,including the estimated glomerular filtration rate,the albumin/creatinine ratio,and the 1,25-dihydroxyvitamin D3 level(P<0.001).After adjusting for multiple variables,greater IBIL levels remained independently associated with a lower risk of developing DR(odds ratio=0.500;95%confidence interval:0.363-0.686;P<0.001).The optimal IBIL cutoff point for predicting the risk of DR in male patients with elevated diastolic blood pressure was 0.655μmol/dL(area under the curve=0.662).CONCLUSION These findings suggest that IBIL could be a valuable biomarker for predicting DR risk,offering a noninvasive,cost-effective,and readily available clinical tool for the early identification of high-risk patients.Future multicenter and longitudinal studies are warranted to validate these findings and further explore the biological mechanisms underlying the protective role of IBIL in DR.展开更多
One effective approach to strike the balance between ionic conductivity and mechanical strength in polymer electrolytes involves the design of a coupled polymer molecular structure comprising both rigid and flexible p...One effective approach to strike the balance between ionic conductivity and mechanical strength in polymer electrolytes involves the design of a coupled polymer molecular structure comprising both rigid and flexible phases.Nevertheless,the regulation of intermolecular interactions between plasticizers and rigid and flexible phases has been largely overlooked.Here,an intermolecular interaction engineering strategy is carried out with well-chosen dual-plasticize within qua si-sol id-state polymer electrolytes(QSPEs).Succinonitrile exhibits a stronger affinity towards rigid phase hydrogenated nitrile butadiene rubber(HNBR),while propene carbonate demonstrates a stronger affinity towards flexible segments poly(propylene carbonate)(PPC).This tailored intermolecular interaction engineering allows for differential plasticization of the polymer's rigid and flexible phases,thereby achieving a balance between ionic conductivity and mechanical strength.The QSPE have both higher ionic conductivity(1.04×10^(-4)S cm^(-1)at 30℃),t_(Li+)(0.55),and tensile strength(0.76 MPa).Li//Li symmetric cells maintaining performance over1100 h at 0.1 mA cm^(-2)and Li//LiFePO_(4)cells retaining 85.0%capacity after 700 cycles at 1.0 C.It is a unique angle to employ intermolecular interaction engineering in QSPEs through dual-plasticizer approach combined with CO_(2)-based polymer materials.This sustainable strategy combining dual-plasticizer engineering with CO_(2)-based polymers,offers insights for designing high-performance,eco-friendly lithium metal batteries.展开更多
Two-dimensional van der Waals(vdW)magnetic materials,characterized by their tunable magnetism,spin transport properties,and remarkable quantum effects,provide significant promise for the development of efficient,low-p...Two-dimensional van der Waals(vdW)magnetic materials,characterized by their tunable magnetism,spin transport properties,and remarkable quantum effects,provide significant promise for the development of efficient,low-power spintronic devices.Intriguingly,the rare earth tritelluride(RTe3)materials have attracted great attention due to their unique magnetic structure,exotic electronic properties,multiple charge density wave(CDW),and superconductivity under pressure.Here,we report the successful synthesis of high-quality DyTe_(3)single crystals using a self-flux method.DyTe_(3)shows an antiferromagnetic transition at 4.5 K and demonstrates the magnetic field-induced ferromagnetism.The high-quality DyTe_(3)single crystal demonstrates outstanding transport properties,featuring a high carrier mobility of approximately1.4×10^(4)cm^(2)·V^(-1)·s^(-1)and large linear magnetoresistance of 1300%.Furthermore,distinct Shubnikov-de Haas(SdH)oscillations are observed in DyTe_(3),revealing a small Fermi pocket and an effective mass of 0.24 me.Remarkably,the unconventional in-plane negative magnetoresistances appear along the a-axis below 2 T and c-axis until 9 T from 2 K to17 K,which are attributed to the complex helimagnetic structures caused by CDW coupling and weak single-ion anisotropy.Our findings offer a significant platform for understanding the complex magnetoresistance behavior and quantum transport effects in RTe3-type materials,holding great promise for advancing applications in electronic and spintronic devices.展开更多
基金National Key R&D Program of China(2022YFB2602900)R&D Fund Project of China Academy of Railway Sciences Corporation Limited(2021YJ084)+2 种基金Project of Science and Technology R&D Program of China Railway(2016G002-K)R&D Fund Project of China Railway Major Bridge Reconnaissance&Design Institute Co.,Ltd.(2021)R&D Fund Project of China Railway Shanghai Group(2021141).
文摘Purpose–The bridge expansion joint(BEJ)is a key device for accommodating spatial displacement at the beam end,and for providing vertical support for running trains passing over the gap between the main bridge and the approach bridge.For long-span railway bridges,it must also be coordinated with rail expansion joint(REJ),which is necessary to accommodate the expansion and contraction of,and reducing longitudinal stress in,the rails.The main aim of this study is to present analysis of recent developments in the research and application of BEJs in high-speed railway(HSR)long-span bridges in China,and to propose a performance-based integral design method for BEJs used with REJs,from both theoretical and engineering perspectives.Design/methodology/approach–The study first presents a summary on the application and maintenance of BEJs in HSR long-span bridges in China representing an overview of their state of development.Results of a survey of typical BEJ faults were analyzed,and field testing was conducted on a railway cable-stayed bridge in order to obtain information on the major mechanical characteristics of its BEJ under train load.Based on the above,a performance-based integral design method for BEJs with maximum expansion range 1600 mm(±800 mm),was proposed,covering all stages from overall conceptual design to consideration of detailed structural design issues.The performance of the novel BEJ design thus derived was then verified via theoretical analysis under different scenarios,full-scale model testing,and field testing and commissioning.Findings–Two major types of BEJs,deck-type and through-type,are used in HSR long-span bridges in China.Typical BEJ faults were found to mainly include skewness of steel sleepers at the bridge gap,abnormally large longitudinal frictional resistance,and flexural deformation of the scissor mechanisms.These faults influence BEJ functioning,and thus adversely affect track quality and train running performance at the beam end.Due to their simple and integral structure,deck-type BEJs with expansion range 1200 mm(±600 mm)or less have been favored as a solution offering improved operational conditions,and have emerged as a standard design.However,when the expansion range exceeds the above-mentioned value,special design work becomes necessary.Therefore,based on engineering practice,a performance-based integral design method for BEJs used with REJs was proposed,taking into account four major categories of performance requirements,i.e.,mechanical characteristics,train running quality,durability and insulation performance.Overall BEJ design must mainly consider component strength and the overall stiffness of BEJ;the latter factor in particular has a decisive influence on train running performance at the beam end.Detailed BEJ structural design must stress minimization of the frictional resistance of its sliding surface.The static and dynamic performance of the newlydesigned BEJ with expansion range 1600 mm have been confirmed to be satisfactory,via numerical simulation,full-scale model testing,and field testing and commissioning.Originality/value–This research provides a broad overview of the status of BEJs with large expansion range in HSR long-span bridges in China,along with novel insights into their design.
基金supported by the National Natural Science Foundation of China(No.52271089)the financial support from the C hina Postdoctoral Science Foundation(No.2023M732192)。
文摘This work reveals the significant effects of cobalt(Co)on the microstructure and impact toughness of as-quenched highstrength steels by experimental characterizations and thermo-kinetic analyses.The results show that the Co-bearing steel exhibits finer blocks and a lower ductile-brittle transition temperature than the steel without Co.Moreover,the Co-bearing steel reveals higher transformation rates at the intermediate stage with bainite volume fraction ranging from around 0.1 to 0.6.The improved impact toughness of the Co-bearing steel results from the higher dense block boundaries dominated by the V1/V2 variant pair.Furthermore,the addition of Co induces a larger transformation driving force and a lower bainite start temperature(BS),thereby contributing to the refinement of blocks and the increase of the V1/V2 variant pair.These findings would be instructive for the composition,microstructure design,and property optimization of high-strength steels.
基金supported by the grants from the Major State Basic Research Development Program of China(2012CB517902 and 2012CB517904)National Key Technology Research and Development Program of China(2012BAI03B00)+3 种基金Special Research Program of National Health and Family Planning Commission of China(201302002)International S&T Cooperation Program of China(2011DFA30670)National Natural Science Foundation of China(31571357/31771404)supported in part by research funding from AstraZeneca Innovation Center China and Wenzhou Medical University
文摘Autism spectrum disorder (ASD) is a neurodevelopmental disorder with considerable clinical and genetic heterogeneity.In this study,we identified all classes of genomic variants from whole-genome sequencing (WGS) dataset of 32 Chinese trios with ASD,including de novo mutations,inherited variants,copy number variants (CNVs) and genomic structural variants.A higher mutation rate (Poisson test,P<2.2×10^(-16)) in exonic (1.37×10^(-8)) and 3'-UTR regions (1.42×10^(-8)) was revealed in comparison with that of whole genome (1.05×10^(-8)).Using an integrated model,we identified 87 potentially risk genes (P<0.01) from 4832 genes harboring various rare deleterious variants,including CHD8 and NRXN2,implying that the disorders may be in favor to multiple-hit.In particular,frequent rare inherited mutations of several microcephaly-associated genes (ASPM,WDR62,and ZNF335)were found in ASD.In chromosomal structure analyses,we found four de novo CNVs and one de novo chromosomal rearrangement event,including a de novo duplication of UBE3A-containing region at 15q11.2-q13.1,which causes Angelman syndrome and microcephaly,and a disrupted TNR due to de novo chromosomal translocation t (1;5) (q25.1;q33.2).Taken together,our results suggest that abnormalities of centrosomal function and chromatin remodeling of the microcephaly-associated genes may be implicated in pathogenesis of ASD.Adoption of WGS as a new yet efficient technique to illustrate the full genetic spectrum in complex disorders,such as ASD,could provide novel insights into pathogenesis,diagnosis and treatment.
文摘The objective of this work is to explore how to realize the homogenization of emergency clinical decision, and it means that patients receive the same effect of clinical decisions and the treatment in a different hospital. In order to achieve that, emergency doctors should first have the same clinical thinking and thinking mode which is the biggest challenge for homogenization of emergency clinical decision. The task of emergency medicine is to give priority to the treatment of critically ill patients, so step-down thinking of “excluding life-threatening symptoms first” is the basis, the preemptive thinking is the means, and Process thinking is the key of homogenization;The initial diagnosis and treatment mode of symptom-oriented is the starting point for emergency decision;establishing a unified “checklist” can not only broaden the lateral thinking of emergency doctors, but also unify the thinking of differential diagnosis of emergency;dynamic observation should run through the whole diagnosis and treatment process, which is necessary for the homogenization of emergency decision.
文摘<strong>Objective</strong><span style="font-family:;" "=""><span style="font-family:Verdana;"><strong>: </strong>To evaluate the clinical value of transcranial color Doppler ultrasound (TCCD) in assessing cerebral function after cardiopulmonary resuscitation (CPR). </span><b><span style="font-family:Verdana;">Methods</span></b><span style="font-family:Verdana;">: A prospective study was conducted in 52 patients with cardiac arrest treated by CPR from January 2018 to January 2020, and its clinical data were analyzed</span></span><span style="font-family:Verdana;">. </span><span style="font-family:;" "=""><span style="font-family:Verdana;">According to classification of cerebral performance category (CPC), 31 cases (CPC grade 1 - 2) were selected in the good prognosis group and 21 cases (CPC grade 3 - 5) in the poor prognosis group. The cerebral blood flow was measured by transcranial Doppler ultrasound (TCCD) 24 h after CPR, and the differences were compared between the two groups in stroke index, diastolic blood flow velocity (Vd), systolic peak blood flow velocity (Vs) and mean peak blood flow velocity (Vm). The ROC curve of cerebral blood flow after CPR was drawn to predict the prognosis of brain function. </span><b><span style="font-family:Verdana;">Results</span></b><span style="font-family:Verdana;">: The data showed that the pulsatility index of middle cerebral artery of the poor prognosis group decreased within 24 h</span></span><span style="font-family:Verdana;">;</span><span style="font-family:Verdana;">the difference between the two groups was statistically significant (p < 0.05);the Vd, Vs, Vm increased in the good prognosis group</span><span style="font-family:Verdana;">;</span><span style="font-family:;" "=""><span style="font-family:Verdana;">the difference between the two groups was statistically significant (p < 0.05). The ROC curve of cerebral blood flow after CPR was drawn to predict the prognosis of brain function, and the results showed that the area under the curve and the optimal critical value of cerebral blood flow were 0.731 and 5.69. The sensitivity and specificity were 67.3% and 79.1% respectively. </span><b><span style="font-family:Verdana;">Conclusion</span></b><span style="font-family:Verdana;">: The cerebral blood flow increase in the early stage of successful CPR is positively correlated with the prognosis of cerebral functional resuscitation. Monitoring intracranial blood flow after CPR by TCCD has clinical value to evaluate prognosis of brain function.</span></span>
文摘Since the Industrial Revolution,humanity’s extensive burning of fossil fuels(coal,oil,and natural gas)has led to a continuous rise in the concentration of greenhouse gases,such as carbon dioxide(CO_(2)),in the atmosphere.According to data from the World Meteorological Organization(WMO),the global average CO_(2) concentration in 2023 exceeded 420×10^(−6),reaching the highest level in the past 800000 years.This has led to the increasing frequency of extreme climate events-such as glacier melting,sea-level rise,heatwaves,droughts,floods,and hurricanes-posing a severe threat to ecosystems and human society.
基金supported by the National Key Research&Development Projects of China(Grant No.2022YFA1204100)National Natural Science Foundation of China(Grant No.62488201)+1 种基金CAS Project for Young Scientists in Basic Research(YSBR-003)the Innovation Program of Quantum Science and Technology(2021ZD0302700)。
文摘As a typical in-memory computing hardware design, nonvolatile ternary content-addressable memories(TCAMs) enable the logic operation and data storage for high throughout in parallel big data processing. However,TCAM cells based on conventional silicon-based devices suffer from structural complexity and large footprintlimitations. Here, we demonstrate an ultrafast nonvolatile TCAM cell based on the MoTe2/hBN/multilayergraphene (MLG) van der Waals heterostructure using a top-gated partial floating-gate field-effect transistor(PFGFET) architecture. Based on its ambipolar transport properties, the carrier type in the source/drain andcentral channel regions of the MoTe2 channel can be efficiently tuned by the control gate and top gate, respectively,enabling the reconfigurable operation of the device in either memory or FET mode. When working inthe memory mode, it achieves an ultrafast 60 ns programming/erase speed with a current on-off ratio of ∼105,excellent retention capability, and robust endurance. When serving as a reconfigurable transistor, unipolar p-typeand n-type FETs are obtained by adopting ultrafast 60 ns control-gate voltage pulses with different polarities.The monolithic integration of memory and logic within a single device enables the content-addressable memory(CAM) functionality. Finally, by integrating two PFGFETs in parallel, a TCAM cell with a high current ratioof ∼10^(5) between the match and mismatch states is achieved without requiring additional peripheral circuitry.These results provide a promising route for the design of high-performance TCAM devices for future in-memorycomputing applications.
文摘Alterations in the mesenchymal-epithelial transition factor(MET)gene are critical drivers of non-small cell lung cancer(NSCLC).In recent years advances in precision therapies targeting MET alterations have significantly expanded treatment options for NSCLC patients.These alterations include MET exon 14 skipping mutations(MET exon 14 skipping),MET gene amplifications,MET point mutations(primarily kinase domain mutations),and MET protein overexpression.Accurate identification of these alterations and appropriate selection of patient populations and targeted therapies are essential for improving clinical outcomes.The East China Lung Cancer Group,Youth Committee(ECLUNG YOUNG,Yangtze River Delta Lung Cancer Cooperation Group)has synthesized insights from China’s innovative drug development landscape and clinical practice to formulate an expert consensus on the diagnosis and treatment of NSCLC patients with MET alterations.This consensus addresses key areas,such as optimal testing timing,testing methods,testing strategies,quality control measures,and treatment approaches.By offering standardized recommendations,this guidance aims to streamline diagnostic and therapeutic processes and enhance clinical decision-making for NSCLC with MET alterations.
基金financial support from the Guangdong Basic and Applied Basic Research Foundation(No.2023A1515012218)Macao Science and Technology Development Fund(Nos.FDCT 0009/2020/AMJ,0027/2023/RIB1)+1 种基金National Natural Science Foundation of China(No.32301104)Fundamental Research Funds for the Central Universities,Sun Yat-sen University(No.23ptpy165).
文摘Hydrogel-based flexible sensors are emerging as ideal candidates for wearable devices and soft robotics.However,most current hydrogels possess limited physicochemical properties,which hinder their practical application in long-term and complex scenarios.Herein,inspired by the unique structure of the barnacle,we design multifunctional poly(DMAPA-co-PHEA)hydrogels(CP hydrogels)by employing multiple physical crosslinks in the presence of Ag nanoparticles and NaCl additives.Owing to the synergistic effect of cation-πinteractions,hydrophobic interactions,and ionic bonds,the CP hydrogels exhibit high stretchability(strain up to 1430%),strong adhesion(22.8 kPa),satisfactory antibacterial activity,stable anti-icing ability(<20 kPa after 20 icing-deicing cycles),and high electrical conductivity(18.5 mS/cm).Additionally,the CP hydrogels show fast and sensitive responsiveness and cycling stability and can attach directly to human skin to accurately detect both human motions and tiny physiological signals as a flexible wearable sensor.Collectively,this work significantly contributes a straightforward and efficient design strategy for the development of multifunctional hydrogels,broadening their application scenarios.
基金Project supported by the National Key R&D Program of China(Grant No.2022YFA1204100)the National Natural Science Foundation of China(Grant No.62488201)+1 种基金the Chinese Academy of Sciences(Grant Nos.XDB33030000 and YSBR-053)Innovation Program of Quantum Science and Technology(Grant No.2021ZD0302700)。
文摘EuB_(6),a magnetic topological semimetal,has attracted considerable attention in recent years due to its rich intriguing physical properties,including a colossal negative magnetoresistance(CNMR)ratio exceeding-80%,a topological phase transition and a predicted quantum anomalous Hall effect(QAHE)approaching the two-dimensional(2D)limit.Yet,studies of the influence of the dimensionality approaching 2D on the electronic transport properties of EuB_(6) are still scarce.In this work,EuB_(6) thin sheets with thicknesses ranging from 35μm to 180μm were successfully fabricated through careful mechanical polishing of high-quality EuB_(6) single crystals.The reduced thickness,temperature and magnetic field have a strong influence on the electronic transport properties,including the CNMR and carrier concentration of EuB_(6) thin sheets.As the thickness of EuB_(6) thin sheets decreases from 180μm to 35μm,the magnetization transition temperature and the corresponding suppressing temperature of the Kondo effect decrease from 15.2 K to 10.9 K,while the CNMR ratio increases from-87.2%to-90.8%.Furthermore,the weak antilocalization effect transits to a weak localization effect and the carrier concentration increases by 9.4%at 30 K in a 35μm EuB_(6) thin sheet compared to the value reported for a 180μm thin sheet.Our findings demonstrate an obvious tunable effect of the reduced dimensionality on the transport properties of EuB_(6) along with the temperature and magnetic field,which could provide a route to exploring the QAHE near the 2D limit in EuB_(6) and other topological semimetals.
基金supported by the National Key R&D Program of China(Grant No.2022YFA1204100)the National Natural Science Foundation of China(Grant Nos.62488201 and 1240041502)+2 种基金the CAS Project for Young Scientists in Basic Research(Grant No.YSBR-003)the Chinese Academy of Sciences(Grant No.XDB33030100)the Innovation Program of Quantum Science and Technology(Grant No.2021ZD0302700).
文摘Vanadium-based transition metal chalcogenides VmXn(X=S,Se,Te)with their distinctive quantum effects,tunable magnetism,spin-orbit coupling,and high carrier mobility are a valuable platform to explore the interplay between magnetism and electronic correlations,especially with tunable structural phases and magnetic properties through stoichiometric variations,making them ideal candidates for advanced device applications.Here,we report the synthesis of high-quality V_(5+x)S_(8)single crystals with different concentrations of self-intercalated vanadium.V_(5+x)S_(8)crystals show an antiferromagnetic behavior and a spin-flop-like transition below TN of 30.6 K.The high-quality V_(5+x)S_(8)single crystals exhibit a large negative magnetoresistance of 12.3%at 2 K.Interestingly,V_(5+x)S_(8)crystals show an obvious low-temperature resistance upturn that gradually levels off with the increasing magnetic field,attributed to the Kondo effect arising from the interaction between conduction electrons and embedded vanadium magnetic impurities.With increasing V doping,the antiferromagnetic interactions intensify,weakening the coupling between the local moments and conduction electrons,which in turn lowers the Kondo temperature(TK).Furthermore,the anomalous Hall effect is observed in V5.73S8,with an anomalous Hall conductivity(AHC)of 50.46 W^(-1)·cm^(-1)and anomalous Hall angle of 0.73%at 2 K.Our findings offer valuable insights into the mechanisms of the Kondo effect and anomalous Hall effect in self-intercalated transition metal chalcogenides with complex magnetism and electronic correlation effects.
基金National Key R&D Program of China(Grant Nos.2022YFE0110800 and 2022YFB3705300)the National Natural Science Foundation of China(Grant Nos.52104380 and 52171123)for grant and financial support.
文摘As a representative of the third generation advanced high-strength steels(AHSSs),medium Mn steels(MMS)have broad development prospects in the field of automobile manufacturing.MMS with typical austenite reversion treatment have a soft duplex microstructure,i.e.ferrite+austenite,presenting a high ductility but a low yield strength.Here we show that a flash heating and cooling after austenite reversion treatment can replace the ferrite with strong martensite,which greatly enhances the yield strength of a 0.25C-4Mn steel by about 461–886 MPa.By adjusting the reversion temperature before the flash treatment,the C and Mn concentrations of reverted austenite can be altered,which determine the fraction of reverted austenite surviving the flash treatment.In addition,the mechanical stability of final retained austenite is also linked to the reversion temperature,resulting different work hardening behaviors due to transformation induced plasticity(TRIP)effect.By tweaking the reversion temperature before the flash treatment,an optimized combination of strength and ductility can be achieved.The micromechanical differences caused by the replacement of the matrix are also investigated via in-situ digital image correlation method.
基金financially supported by the National Natural Science Foundation of China(U23A20591 and 52273158).
文摘Glioblastoma(GBM)is a highly infiltrative brain tumor.The treatment of GBM is challenging due to the existence of blood brain barrier,its highly invasive nature,and its heterogeneity.Given the limitations of conventional therapies,this Perspective explores the development trajectory of implantable devices,highlighting the advantages of current models.With the progression in research,these implantable devices certainly hold promising potential for GBM therapy.
基金supported by STI 2030-Major Project(2021ZD0201704)the National Natural Science Foundation of China(32271141,82222025,82130043,82330035,82361138573,82160219,and 82401388)+3 种基金Hunan Provincial Grants(2023SK2084,2023RC1020,2023SK2114,2021SK1010,and 2024JJ6545)China Postdoctoral Science Foundation(2023M733969)Postdoctoral Fellowship Program of China Postdoctoral Science Foundation(GZB20230875)National Key Research and Development Program of China(2021YFA0805200)。
文摘Loss-of-function variants in CSDE1 have been strongly linked to neuropsychiatric disorders,yet the precise role of CSDE1 in neurogenesis remains elusive.In this study,we demonstrate that knockout of Csde1 during cortical development in mice results in impaired neural progenitor proliferation,leading to abnormal cortical lamination and embryonic lethality.Transcriptomic analysis revealed that Csde1 upregulates the transcription of genes involved in the cell cycle network.Applying a dual thymidine-labelling approach,we further revealed prolonged cell cycle durations of neuronal progenitors in Csde1-knockout mice,with a notable extension of the G1 phase.Intersection with CLIP-seq data demonstrated that Csde1 binds to the 3′untranslated region(UTR)of mRNA transcripts encoding cell cycle genes.Particularly,we uncovered that Csde1 directly binds to the 3′UTR of mRNA transcripts encoding Cdk6,a pivotal gene in regulating the transition from the G1 to S phases of the cell cycle,thereby maintaining its stability.Collectively,this study elucidates Csde1 as a novel regulator of Cdk6,sheds new light on its critical roles in orchestrating brain development,and underscores how mutations in Csde1 may contribute to the pathogenesis of neuropsychiatric disorders.
文摘Objective:The aim of this study was to evaluate the synergistic effect of eye care and drug therapy in patients with dry eye.Methods:A total of 59 patients with dry eye diagnosed and treated in our hospital were randomly divided into the reference group(29 cases)and the experimental group(30 cases).Patients in the reference group received only the usual medication,while the experimental group received additional eye care.The treatment response and the improvement of quality of life were evaluated by comparing the treatment excellence rate,quality of life score,and nursing satisfaction score of the two groups.Results:The rate of excellent treatment in the experimental group was 93.33%,which was significantly higher than that in the reference group(68.97%)(P=0.013).The quality of life scores in social function,psychological function and physiological function of the experimental group were significantly higher than those of the reference group(P<0.003),the nursing satisfaction score and symptom score were also improved more significantly(P<0.003),and the SAS score was decreased more(P<0.003).Conclusion:The synergistic effect of comprehensive eye care and drug therapy on patients with dry eye can significantly improve the rate of good treatment and quality of life score,increase the nursing satisfaction of patients,and have potential benefits to improve psychological status,providing an effective way for the management of dry eye.
基金Project supported by the National Natural Science Foundation of China (Grant Nos. 62488201 and 1240041502)the China Postdoctoral Science Foundation (Grant No. 2024T170990)+2 种基金the National Key R&D Program of China (Grant No. 2022YFA1204100)the Chinese Academy of Sciences (Grant No. XDB33030100)the Innovation Program of Quantum Science and Technology (Grant No. 2021ZD0302700)。
文摘Ising superconductivity, induced by the strong spin–orbit coupling(SOC) and inversion symmetry breaking, can lead to the in-plane upper critical field exceeding the Pauli limit and hold significant potential for advancing the study of topological superconductivity. However, the enhancement of Ising superconductivity is still a challenging problem, important for engineering Majorana fermions and exploring topological quantum computing. In this study, we investigated the superconducting properties of a series of van der Waals NbSe_(2-x)Te_(x) nanosheets. The Ising superconductivity in NbSe_(2-x)Te_(x) nanosheets can be significantly enhanced by the substitution of Te, an element with strong SOC. The fitted in-plane upper critical field of Nb Se_(1.5)Te_(0.5) nanosheets at absolute zero temperature reaches up to 3.2 times the Pauli limit. Angular dependence of magnetoresistance measurements reveals a distinct two-fold rotational symmetry in the superconducting transition region, highlighting the role of strong SOC. In addition, the fitting results of the Berezinskii–Kosterlitz–Thouless(BKT) transition and the two-dimensional(2D) Tinkham formula provide strong evidence for 2D superconductivity. These findings offer new perspectives for the design and modulation of the Ising superconducting state and pave the way for their potential applications in topological superconductivity and quantum technologies.
基金National Natural Science Foundation of China(No.32101150)Key Scientific Research Project of Higher Education of Henan Province(No.22A430007)+2 种基金Natural Science Foundation of Henan Province(No.222300420501)the Science and Technology Project of Henan Province(No.242102230119)Innovation and Entrepreneurship Training Program for College students in China(No.202310482001).
文摘Diseases associated with bacterial infection,especially those caused by gram-negative bacteria,have been posing a serious threat to human health.Photodynamic therapy based on aggregation-induced emission(AIE)photosensitizer have recently emerged and provided a promising approach for bacterial discrimination and efficient photodynamic antimicrobial applications.However,they often suffer from the shorter excitation wavelength and lower molar extinction coefficients in the visible region,severely limiting their further applications.Herein,three novel BF_(2)-curcuminoid-based AIE photosensitizers,TBBC,TBC and TBBC-C8,have been rationally designed and successfully developed,in which OCH_(3)-and OC_(8)H_(17)-substituted tetraphenylethene(TPE)groups serve as both electron donor(D)and AIE active moieties,BF_(2)bdk group functions as electron acceptor(A),and styrene(or ethylene)group asπ-bridge in this D-π-A-π-D system,respectively.As expected,these resulting BF_(2)-curcuminoids presented solvent-dependent photophysical properties with large molar extinction coefficients in solutions and excellent AIE properties.Notably,TBBC showed an effective singlet oxygen generation efficiency thanks to the smaller singlet-triplet energy gap(△E_(ST)),and remarkable photostability under green light exposure at 530nm(8.9 mW/cm^(2)).More importantly,TBBC was demonstrated effectiveness in selective staining and photodynamic killing of Escherichia coli(E.coli)in vitro probably due to its optimal molecular size compared with TBC and TBBC-C8.Therefore,TBBC will have great potential as a novel AIE photosensitizer to apply in the discrimination and selective sterilization between Gram-positive and Gram-negative bacteria.
基金Supported by Natural Science Foundation of Shaanxi Province,No.2024JC-YBQN-0828 and No.2024JC-YBMS-765Clinical Research Award of the First Affiliated Hospital of Xi'an Jiaotong University,No.XJTU1AF-CRF-2022-036National Innovation Center for Advanced Medical Devices,No.NMED2023AGP-013.
文摘BACKGROUND Diabetic retinopathy(DR)is a major cause of visual impairment and blindness.However,the current DR biomarkers are insufficient for accurately predicting its onset.AIM To identify a novel marker for predicting the risk of developing DR in patients with type 2 diabetes mellitus(T2DM).METHODS We conducted a cross-sectional study involving 6993 hospitalized T2DM patients between 2013 and 2020.Patients were divided into two groups:The DR group and the non-DR group.Data were analyzed using univariate,correlation,multivariate,subgroup,and receiver operating characteristic curve analyses.RESULTS Total bilirubin,indirect bilirubin(IBIL),and direct bilirubin were negatively correlated with the risk of developing DR(P<0.001).Moreover,these three factors were all positively correlated with clinical indicators related to DR,including the estimated glomerular filtration rate,the albumin/creatinine ratio,and the 1,25-dihydroxyvitamin D3 level(P<0.001).After adjusting for multiple variables,greater IBIL levels remained independently associated with a lower risk of developing DR(odds ratio=0.500;95%confidence interval:0.363-0.686;P<0.001).The optimal IBIL cutoff point for predicting the risk of DR in male patients with elevated diastolic blood pressure was 0.655μmol/dL(area under the curve=0.662).CONCLUSION These findings suggest that IBIL could be a valuable biomarker for predicting DR risk,offering a noninvasive,cost-effective,and readily available clinical tool for the early identification of high-risk patients.Future multicenter and longitudinal studies are warranted to validate these findings and further explore the biological mechanisms underlying the protective role of IBIL in DR.
基金supported by the National Key Research and Development Program(2019YFA0705701)National Natural Science Foundation of China(22075329,22008267,21978332 and 22179149)+1 种基金Research and Development Project of Henan Academy Sciences China(232018002)Guangdong Basic and Applied Basic Research Foundation(2021A1515010731)。
文摘One effective approach to strike the balance between ionic conductivity and mechanical strength in polymer electrolytes involves the design of a coupled polymer molecular structure comprising both rigid and flexible phases.Nevertheless,the regulation of intermolecular interactions between plasticizers and rigid and flexible phases has been largely overlooked.Here,an intermolecular interaction engineering strategy is carried out with well-chosen dual-plasticize within qua si-sol id-state polymer electrolytes(QSPEs).Succinonitrile exhibits a stronger affinity towards rigid phase hydrogenated nitrile butadiene rubber(HNBR),while propene carbonate demonstrates a stronger affinity towards flexible segments poly(propylene carbonate)(PPC).This tailored intermolecular interaction engineering allows for differential plasticization of the polymer's rigid and flexible phases,thereby achieving a balance between ionic conductivity and mechanical strength.The QSPE have both higher ionic conductivity(1.04×10^(-4)S cm^(-1)at 30℃),t_(Li+)(0.55),and tensile strength(0.76 MPa).Li//Li symmetric cells maintaining performance over1100 h at 0.1 mA cm^(-2)and Li//LiFePO_(4)cells retaining 85.0%capacity after 700 cycles at 1.0 C.It is a unique angle to employ intermolecular interaction engineering in QSPEs through dual-plasticizer approach combined with CO_(2)-based polymer materials.This sustainable strategy combining dual-plasticizer engineering with CO_(2)-based polymers,offers insights for designing high-performance,eco-friendly lithium metal batteries.
基金Project supported by the National Natural Science Foundation of China(Grant Nos.62488201 and 1240041502)the Ministry of Science and Technology of China(Grant No.2022YFA1204100)+1 种基金the Chinese Academy of Sciences(Grant No.XDB33030100)the Innovation Program of Quantum Science and Technology(Grant No.2021ZD0302700)。
文摘Two-dimensional van der Waals(vdW)magnetic materials,characterized by their tunable magnetism,spin transport properties,and remarkable quantum effects,provide significant promise for the development of efficient,low-power spintronic devices.Intriguingly,the rare earth tritelluride(RTe3)materials have attracted great attention due to their unique magnetic structure,exotic electronic properties,multiple charge density wave(CDW),and superconductivity under pressure.Here,we report the successful synthesis of high-quality DyTe_(3)single crystals using a self-flux method.DyTe_(3)shows an antiferromagnetic transition at 4.5 K and demonstrates the magnetic field-induced ferromagnetism.The high-quality DyTe_(3)single crystal demonstrates outstanding transport properties,featuring a high carrier mobility of approximately1.4×10^(4)cm^(2)·V^(-1)·s^(-1)and large linear magnetoresistance of 1300%.Furthermore,distinct Shubnikov-de Haas(SdH)oscillations are observed in DyTe_(3),revealing a small Fermi pocket and an effective mass of 0.24 me.Remarkably,the unconventional in-plane negative magnetoresistances appear along the a-axis below 2 T and c-axis until 9 T from 2 K to17 K,which are attributed to the complex helimagnetic structures caused by CDW coupling and weak single-ion anisotropy.Our findings offer a significant platform for understanding the complex magnetoresistance behavior and quantum transport effects in RTe3-type materials,holding great promise for advancing applications in electronic and spintronic devices.
