Experimental validation of laser intensity is particularly important for the study of fundamental physics at extremely high intensities.However,reliable diagnosis of the focal spot and peak intensity faces huge challe...Experimental validation of laser intensity is particularly important for the study of fundamental physics at extremely high intensities.However,reliable diagnosis of the focal spot and peak intensity faces huge challenges.In this work,we demonstrate for the firs time that the coherent radiation farfiel patterns from laser–foil interactions can serve as an in situ,real-time,and easy-to-implement diagnostic for an ultraintense laser focus.The laser-driven electron sheets,curved by the spatially varying laser fiel and leaving the targets at nearly the speed of light,produce doughnut-shaped patterns depending on the shapes of the focal spot and the absolute laser intensities.Assisted by particle-in-cell simulations,we can achieve measurements of the intensity and the focal spot,and provide immediate feedback to optimize the focal spots for extremely high intensity.展开更多
Aligned SnS nanowires arrays were grown via a simple chemical vapor deposition method.As-synthesized SnS nanowires are single crystals grown along the[111]direction.The single SnS nanowire based device showed excellen...Aligned SnS nanowires arrays were grown via a simple chemical vapor deposition method.As-synthesized SnS nanowires are single crystals grown along the[111]direction.The single SnS nanowire based device showed excellent response to near infrared lights with good responsivity of 267.9 A/W,high external quantum efficiency of 3.12×10^4%and fast response time.Photodetectors were built on the aligned SnS nanowire arrays,exhibiting a light on/off ratio of 3.6,and the response and decay time of 4.5 and 0.7 s,respectively,to 1064 nm light illumination.展开更多
This paper presented a novel millimeterwave channel measurement platform for the 6G intelligent railway.This platform used phased array antenna with 64 elements and can support instant bandwidth up to 1 GHz.Combined w...This paper presented a novel millimeterwave channel measurement platform for the 6G intelligent railway.This platform used phased array antenna with 64 elements and can support instant bandwidth up to 1 GHz.Combined with improved multi-tone sounding signals,the platform can enhance dynamic measurement capability in high-speed railway scenarios.We performed calibration works about frequency flatness,frequency offset and proved platform reliability with channel emulator based closed-loop verification.We also carried out field trials in high-speed railway carriage scenarios.Based on measurement results,we extracted channel characteristic parameters of path loss,power delay profile and delay spread to further verify the field measurement performance of the platform.展开更多
Model I quasi-static nonlinear fracture of aluminum foams is analyzed by considering the effect of microscopic heterogeneity. Firstly, a continuum constitutive model is adopted to account for the plastic compressibili...Model I quasi-static nonlinear fracture of aluminum foams is analyzed by considering the effect of microscopic heterogeneity. Firstly, a continuum constitutive model is adopted to account for the plastic compressibility of the metallic foams. The yield strain modeled by a two- parameter Weibull-type function is adopted in the constitutive model. Then, a modified cohesive zone model is established to characterize the fracture behavior of aluminum foams with a cohesive zone ahead of the initial crack. The tensile traction versus local crack opening displacement relation is employed to describe the softening characteristics of the material. And a Weibull statistical model for peak bridging stress within the fracture process zone is used for considering microscopic heterogeneity of aluminum foams. Lastly, the influence of stochastic parameters on the curve of stress-strain is given. Numerical examples are given to illustrate the numerical model presented in this paper and the effects of Weibull parameters and material properties on J-integral are discussed.展开更多
Dynamic fracture behavior of a Griffith crack along the interface of an adhesive bonded material under normal loading is studied. The singular integral equations are obtained by employing integral transformation and i...Dynamic fracture behavior of a Griffith crack along the interface of an adhesive bonded material under normal loading is studied. The singular integral equations are obtained by employing integral transformation and introducing dislocation density functions. By adopting Gauss-Jacobi integration formula, the problem is reduced to the solution of algebraic equations, and by collocation dots method. their solutions can be obtained Based on the parametric discussions presented in the paper, the following conclusions can be drawn： （1） Mode I dynamic stress intensity factor （DSIF） increases with increasing initial crack length and decreasing visco-elastic layer thickness, revealing distinct size effect; （2） The influence of the visco-elastic adhesive relaxation time on the DSIF should not be ignored.展开更多
Work function plays a significant role in surface chemistry. Local work function provides the information of local d/pole-d/pole interaction and charge distribution between adsorbates and substrate, highlighting the l...Work function plays a significant role in surface chemistry. Local work function provides the information of local d/pole-d/pole interaction and charge distribution between adsorbates and substrate, highlighting the local charge effect of the targeted spot which is normally smeared out in conventional average work function measurements. Chloroaluminum phthalocyanine （CIA1Pc）, an important optoelectronic molecule with a permanent dipole moment pointing from the Pc ring to the ending CI atom, adsorbed on Au（111） in either Cl-up or Cl-down configuration. Scanning tunneling microscopy/spectroscopy measurements revealed that at the centers of Cl-up and CI-down molecules, the local work functions changed oppositely with respect to the Au（111） substrate. At their Pc lobes, however, the local work functions unanimously increased due to charging effect of the indole lobes in the CIAIPc molecule.展开更多
Surface-enhanced Raman spectroscopy(SERS),as a great potential label-free tool in metabolite detection,offers a strategy for rapid bacterial identification.However,it still lacks experimentally supported spectral inte...Surface-enhanced Raman spectroscopy(SERS),as a great potential label-free tool in metabolite detection,offers a strategy for rapid bacterial identification.However,it still lacks experimentally supported spectral interpretation at the metabolite level for complex biosamples.We present a SERS-based method for reliable bacterial intracellular metabolic profiling using plasmonic colloids with high rapidness and costefficiency.A convolutional neural network model was constructed to accurately classify eight types of bacteria with an overall accuracy as high as 90.44%and identify the key spectral features for classification by Shapley Additive Explanations.Molecule-level interpretation of the SERS metabolic profiles has been further realized in combination with laser desorption/ionization mass spectrometry,evidencing the primary metabolite contribution to the bacterial spectral signatures and molecule-level distinctions among different bacterial types.We provide insights into the mechanism of bacterial identification by label-free SERS and pave the way for interpretable SERS diagnostic tools for various diseases.展开更多
As a computer vision task,object detection algorithms can be applied to various real-world sce-narios.However,efficient algorithms often come with a large number of parameters and high computational complexity.To meet...As a computer vision task,object detection algorithms can be applied to various real-world sce-narios.However,efficient algorithms often come with a large number of parameters and high computational complexity.To meet the demand for high-performance object detection algorithms on mobile devices and embedded devices with limited computational resources,we propose a new lightweight object detection algorithm called DLE-YOLO.Firstly,we design a novel backbone called dual-branch lightweight excitation network(DLEN)for feature extraction,which is mainly constructed by dual-branch lightweight excitation units(DLEU).DLEU is stacked with different numbers of dual-branch lightweight excitation blocks(DLEB),which can extract comprehensive features and integrate information between different channels of features.Secondly,in order to enhance the network to capture key feature information in the regions of interest,the attention model HS-coordinate attention(HS-CA)is introduced into the network.Thirdly,the localization loss utilizes SIoU loss to further optimize the accuracy of the bounding box.Our method achieves a mAP value of 46.0%on the MS-COCO dataset,which is a 2%mAP improvement compared to the baseline YOLOv5-m,while bringing a 19.3%reduction in parameter count and a 12.9%decrease in GFLOPs.Furthermore,our method outperforms some advanced lightweight object detection algorithms,validating the effectiveness of our approach.展开更多
Emergency communication in forested environments encounters extremely complex propagation conditions,whose channel characteristics cannot be accurately captured by conventional models designed for urban scenarios.This...Emergency communication in forested environments encounters extremely complex propagation conditions,whose channel characteristics cannot be accurately captured by conventional models designed for urban scenarios.This paper conducts field measurements and modeling for 380 MHz vehicle-to-infrastructure(V2I)links in the primeval forest of the Greater Khingan Mountains.Through joint analysis of large-scale and small-scale channel characteristics,we systematically reveal the signal attenuation,fading mechanisms,and delay spread behavior in such environments.Results indicate that for path loss modeling,the Alpha-Beta model outperforms the Close-In model in characterizing the rapid attenuation in dense foliage.Small-scale fading is predominantly Rayleigh-distributed,while Ricean fading only dominates in the initial stage,with its K-factor decreasing significantly as distance increases.The root mean square(RMS)delay spread ranges from 0 to 450 ns,follows a log-normal distribution,and is markedly larger than in urban scenarios.Based on these observations,a parametric tapped-delay-line(TDL)model is developed,effectively quantifying multipath delay,power decay,and fading characteristics.The proposed model can reproduce realistic propagation features in simulations,offering theoretical support for emergency communication system planning and optimization,as well as engineering guidance for enhancing communication reliability and coverage in disaster rescue scenarios.展开更多
Currently three major problems seriously limit the practical application of can-cer photodynamic therapy(PDT):(i)the hypoxic tumor microenvironment(TME);(ii)low generation efficiency of toxic reactive oxygen species(R...Currently three major problems seriously limit the practical application of can-cer photodynamic therapy(PDT):(i)the hypoxic tumor microenvironment(TME);(ii)low generation efficiency of toxic reactive oxygen species(ROS)in aggre-gates and(iii)shallow tissue penetration depth of excitation light.Very limited approaches are available for addressing all the above three problems with a single design.Herein,a rational“three birds with one stone”molecular and nanoengi-neering strategy is demonstrated:a photodynamic nanoplatform U-Ir@PAA-ABS based on the covalent combination of lanthanide-doped upconversion nanoparti-cles(UCNPs)and an AIE-active dinuclear Ir(III)complex provides a low oxygen concentration-dependent type-I photochemical process upon 980 nm irradiation by Föster resonance energy transfer(FRET).U-Ir@PAA-ABS targets mitochondria and has excellent phototoxicity even in severe hypoxia environments upon 980 nm irradiation,inducing a dual-mode cell death mechanism by apoptosis and ferropto-sis.Taken together,the in vitro and in vivo results demonstrate a successful strategy for improving the efficacy of PDT against hypoxic tumors.展开更多
Entomopathogenic fungi are protected by a cell wall with dynamic structure for adapting to various environmental conditions.β-1,3-Glucan recognition proteins activate the innate immune system of insects by recognizin...Entomopathogenic fungi are protected by a cell wall with dynamic structure for adapting to various environmental conditions.β-1,3-Glucan recognition proteins activate the innate immune system of insects by recognizing surface molecules of fungi.However,the associations between pathogenicity and the different components of entomopathogenic fungal cell walls remain unclear.Three Beauveria bassiana strains were selected that have significantly differing virulence against Bombyx mori.The molecular mechanisms underlying the immune response in B.mori were investigated using RNA sequencing,which revealed differences in the immune response to different B.bassiana strains at 12 h post-infection.Immunofluorescence assays revealed thatβ-1,3-glucan content had an opposite trend to that of fungal virulence.β-1,3-Glucan injection upregulated BmβGRP4 expression and significantly reduced the virulence of the high-virulence strain but not that of the medium-virulence or low-virulence strains.BmβGRP4 silencing in B.mori with RNA interference resulted in the opposite virulence pattern,indicating that the virulence of B.bassiana was affected by the cell walls’content ofβ-1,3-glucan,which could be recognized by BmβGRP4.Furthermore,interference with the gene CnA(calcineurin catalytic A subunit)involved inβ-1,3-glucan synthesis eliminated differences in virulence between B.bassiana strains.These results indicate that strains of a single species of pathogenic fungi that have differing cell wall components are recognized differently by the innate immune system of B.mori.展开更多
The conventional Hall effect is linearly proportional to the field component or magnetization component perpendicular to a film. Despite the increasing theoretical proposals on the Hall effect to the in-plane field or...The conventional Hall effect is linearly proportional to the field component or magnetization component perpendicular to a film. Despite the increasing theoretical proposals on the Hall effect to the in-plane field or magnetization in various special systems induced by the Berry curvature, such an unconventional Hall effect has only been experimentally reported in Weyl semimetals and in a heterodimensional superlattice. Here, we report an unambiguous experimental observation of the antisymmetric planar Hall effect(APHE) with respect to the in-plane magnetic field in centrosymmetric rutile RuO_(2) and IrO_(2) single-crystal films. The measured Hall resistivity is found to be linearly proportional to the component of the applied in-plane magnetic field along a particular crystal axis and to be independent of the current direction or temperature. Both the experimental observations and theoretical calculations confirm that the APHE in rutile oxide films is induced by the Lorentz force. Our findings can be generalized to ferromagnetic materials for the discovery of anomalous Hall effects and quantum anomalous Hall effects induced by in-plane magnetization. In addition to significantly expanding knowledge of the Hall effect, this work opens the door to explore new members in the Hall effect family.展开更多
We report the generation of polarization-entangled photon pairs in the 1550 nm band by pumping an uneven nonlinear interferometer loop with two orthogonally polarized counterpropagating pump pulses.The uneven nonlinea...We report the generation of polarization-entangled photon pairs in the 1550 nm band by pumping an uneven nonlinear interferometer loop with two orthogonally polarized counterpropagating pump pulses.The uneven nonlinear interferometer,providing a more ideal interference pattern due to the elimination of secondary maxima,consists of four pieces of dispersion-shifted fibers sandwiched with three pieces of standard single-mode fibers,and the lengths of the nonlinear fibers follow the binomial distribution.The mode number of the photon pairs deduced from the measured joint spectrum is∼1.03.The collection efficiency of the photon pairs is found to be∼94%(after background noise correction).The directly measured visibility of two-photon interference of the polarization-entangled photon pairs is∼92%,while no interference is observed in the direct detection of either the signal or idler photons.展开更多
Solid tumor cells live in a highly dynamic mechanical microenvironment.How the extracellular-matrix-generated mechanotransduction regulates tumor cell development and differentiation remains an enigma.Here,we show tha...Solid tumor cells live in a highly dynamic mechanical microenvironment.How the extracellular-matrix-generated mechanotransduction regulates tumor cell development and differentiation remains an enigma.Here,we show that a low mechanical force generated from the soft matrix induces dedifferentiation of moderately stiff tumor cells to soft stem-cell-like cells.Mechanistically,integrin?was identified to transduce mechano-signaling to trigger tumor cell dedifferentiation by recruiting RhoGDI1 to inactivate RhoA and subsequently Yes-associated protein(YAP).YAP inactivation relieved the inhibition of v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog G(MAFG),allowing MAFG to transactivate the stemness genes NANOG,SOX2,and NESTIN.Inactivation also restoredβ8 expression,thereby forming a closed mechanical loop.Importantly,MAFG expression is correlated with worse prognosis.Our findings provide mechanical insights into the regulation of tumor cell dedifferentiation,which has therapeutic implications for exploring innovative strategies to attack malignancies.展开更多
Managing Editor:Peng Lyu Primary bone marrow lymphoma(PBML)is a rare lymphoma accounting for 1.23%of non-Hodgkin lymphoma(NHL)cases.It is characterized by tumor cells invading only the bone marrow without systemic lym...Managing Editor:Peng Lyu Primary bone marrow lymphoma(PBML)is a rare lymphoma accounting for 1.23%of non-Hodgkin lymphoma(NHL)cases.It is characterized by tumor cells invading only the bone marrow without systemic lymphadenopathy or extranodal organ involvement.Owing to the lack of standardized treatment regimens,most patients are treated using rituximab with cyclophosphamide,doxorubicin,vincristine,and prednisone(R-CHOP)regimens;however,their efficacy needs to be further investigated.展开更多
Accurate and efficient detection of building changes in remote sensing imagery is crucial for urban planning,disaster emergency response,and resource management.However,existing methods face challenges such as spectra...Accurate and efficient detection of building changes in remote sensing imagery is crucial for urban planning,disaster emergency response,and resource management.However,existing methods face challenges such as spectral similarity between buildings and backgrounds,sensor variations,and insufficient computational efficiency.To address these challenges,this paper proposes a novel Multi-scale Efficient Wavelet-based Change Detection Network(MewCDNet),which integrates the advantages of Convolutional Neural Networks and Transformers,balances computational costs,and achieves high-performance building change detection.The network employs EfficientNet-B4 as the backbone for hierarchical feature extraction,integrates multi-level feature maps through a multi-scale fusion strategy,and incorporates two key modules:Cross-temporal Difference Detection(CTDD)and Cross-scale Wavelet Refinement(CSWR).CTDD adopts a dual-branch architecture that combines pixel-wise differencing with semanticaware Euclidean distance weighting to enhance the distinction between true changes and background noise.CSWR integrates Haar-based Discrete Wavelet Transform with multi-head cross-attention mechanisms,enabling cross-scale feature fusion while significantly improving edge localization and suppressing spurious changes.Extensive experiments on four benchmark datasets demonstrate MewCDNet’s superiority over comparison methods:achieving F1 scores of 91.54%on LEVIR,93.70%on WHUCD,and 64.96%on S2Looking for building change detection.Furthermore,MewCDNet exhibits optimal performance on the multi-class⋅SYSU dataset(F1:82.71%),highlighting its exceptional generalization capability.展开更多
Probiotic is a promising nutritional intervention for the prevention and alleviation of type 2 diabetes (T2DM).In this study,the remission potential of a multi-species probiotic (Lactobacillus acidophilus NCFM,Lactoba...Probiotic is a promising nutritional intervention for the prevention and alleviation of type 2 diabetes (T2DM).In this study,the remission potential of a multi-species probiotic (Lactobacillus acidophilus NCFM,Lactobacillus rhamnosus GG,Bifidobacterium lactis HN019 and Streptococcus thermophilus ST447) and its fermented yoghurt on the symptoms of high fat diet and streptozotocin induced T2DM mice were investigated,and the underlying mechanisms were elucidated.Multi-species probiotic and probiotic yoghurt elicited similar but varying efficacy in decreasing the body weight loss,improving organ weight,glucose tolerance and insulin resistance,regulating the levels of blood glucose,HbA1c,insulin and lipid as well as protecting the pancreatic islets.Their tangible antidiabetic effects may be ascribed to the mutual promotion between the repair of the intestinal barrier/permeability and the optimization of gut microbiota structure.Furthermore,the intestinal flora-short chain fatty acids-intestinal hormones/inflammatory pathway was activated and thereby conferring healthy benefits to the host.This proposed probiotic combination appears to provide a viable approach to alleviate T2DM.展开更多
Stretchable ultraviolet photodetectors with fast response have wide applications in wearable electronics and implantable biomedical devices. However, most of the conventional binary oxide nanowires based photodetector...Stretchable ultraviolet photodetectors with fast response have wide applications in wearable electronics and implantable biomedical devices. However, most of the conventional binary oxide nanowires based photodetectors exhibit slow response due to the presence of a large number of surface defects related to trapping centers. Herein, with interlaced SnO2-CdS nanowire films as the sensing materials, we fabricated stretchable ultraviolet photodetectors with significantly improved response speed via a multiple lithographic filtration method. Systematic investigations reveal that the interlaced-nanowire based photodetectors have lower dark current and much higher response speed(more than 100 times) compared with pure SnO2 nanowire based photodetectors. The relevant carrier generation and transport mechanism were also discussed. In addition, due to the formation of waved wrinkles on the surface of the nanowires/PDMS layer during the prestretching cycles, the SnO2-CdS interlaced nanowire photodetectors display excellent electrical stability and stretching cyclability within 50% strain, without obvious performance degradation even after 150 stretching cycles. As a simple and effective strategy to fabricate stretchable ultraviolet photodetectors with high response speed, the interlacednanowire structure can also be applied to other nanowire pairs, like ZnO-CdS interlaced-nanowires. Our method provides a versatile way to fabricate fast speed ultraviolet photodetectors by using interlaced metal oxide nanowires-CdS nanowires structures, which is potential in future stretchable and wearable optoelectronic devices.展开更多
基金supported by the Guangdong High Level Innovation Research Institute(Grant No.2021B0909050006)the National Grand Instrument Project(Grant No.2019YFF01014402)+1 种基金the National Natural Science Foundation of China(Grant No.12205008)support from the National Science Fund for Distinguished Young Scholars(Grant No.12225501)。
文摘Experimental validation of laser intensity is particularly important for the study of fundamental physics at extremely high intensities.However,reliable diagnosis of the focal spot and peak intensity faces huge challenges.In this work,we demonstrate for the firs time that the coherent radiation farfiel patterns from laser–foil interactions can serve as an in situ,real-time,and easy-to-implement diagnostic for an ultraintense laser focus.The laser-driven electron sheets,curved by the spatially varying laser fiel and leaving the targets at nearly the speed of light,produce doughnut-shaped patterns depending on the shapes of the focal spot and the absolute laser intensities.Assisted by particle-in-cell simulations,we can achieve measurements of the intensity and the focal spot,and provide immediate feedback to optimize the focal spots for extremely high intensity.
基金National Natural Science Foundation of China(61625404,61888102).
文摘Aligned SnS nanowires arrays were grown via a simple chemical vapor deposition method.As-synthesized SnS nanowires are single crystals grown along the[111]direction.The single SnS nanowire based device showed excellent response to near infrared lights with good responsivity of 267.9 A/W,high external quantum efficiency of 3.12×10^4%and fast response time.Photodetectors were built on the aligned SnS nanowire arrays,exhibiting a light on/off ratio of 3.6,and the response and decay time of 4.5 and 0.7 s,respectively,to 1064 nm light illumination.
基金supported in part by the Fundamental Research Funds for the Central Universities under Grant 2022JBQY004,2022JBZY018 and 2022JBXT001in part by the Basic Research Project of Jiangsu Province Frontier Leading Technology under Grant BK20212002.
文摘This paper presented a novel millimeterwave channel measurement platform for the 6G intelligent railway.This platform used phased array antenna with 64 elements and can support instant bandwidth up to 1 GHz.Combined with improved multi-tone sounding signals,the platform can enhance dynamic measurement capability in high-speed railway scenarios.We performed calibration works about frequency flatness,frequency offset and proved platform reliability with channel emulator based closed-loop verification.We also carried out field trials in high-speed railway carriage scenarios.Based on measurement results,we extracted channel characteristic parameters of path loss,power delay profile and delay spread to further verify the field measurement performance of the platform.
基金supported by the National Basic Research Program of China(No.2006CB601205)the National Natural Science Foundation of China(No.10672027)the Key Project of National Natural Science Foundation of China(No.90816025)
文摘Model I quasi-static nonlinear fracture of aluminum foams is analyzed by considering the effect of microscopic heterogeneity. Firstly, a continuum constitutive model is adopted to account for the plastic compressibility of the metallic foams. The yield strain modeled by a two- parameter Weibull-type function is adopted in the constitutive model. Then, a modified cohesive zone model is established to characterize the fracture behavior of aluminum foams with a cohesive zone ahead of the initial crack. The tensile traction versus local crack opening displacement relation is employed to describe the softening characteristics of the material. And a Weibull statistical model for peak bridging stress within the fracture process zone is used for considering microscopic heterogeneity of aluminum foams. Lastly, the influence of stochastic parameters on the curve of stress-strain is given. Numerical examples are given to illustrate the numerical model presented in this paper and the effects of Weibull parameters and material properties on J-integral are discussed.
基金supported by the National Basic Research Program of China(2006CB601205)the National Natural Science Foundation of China(10672027)the National Outstanding Young Scientist of China (50625414)
文摘Dynamic fracture behavior of a Griffith crack along the interface of an adhesive bonded material under normal loading is studied. The singular integral equations are obtained by employing integral transformation and introducing dislocation density functions. By adopting Gauss-Jacobi integration formula, the problem is reduced to the solution of algebraic equations, and by collocation dots method. their solutions can be obtained Based on the parametric discussions presented in the paper, the following conclusions can be drawn： （1） Mode I dynamic stress intensity factor （DSIF） increases with increasing initial crack length and decreasing visco-elastic layer thickness, revealing distinct size effect; （2） The influence of the visco-elastic adhesive relaxation time on the DSIF should not be ignored.
基金supported by National Natural Science Foundation of China(Nos. 91527303, 21333001,21373020, 61321001)MOST(Nos.2013CB933404,2014CB239302),China
文摘Work function plays a significant role in surface chemistry. Local work function provides the information of local d/pole-d/pole interaction and charge distribution between adsorbates and substrate, highlighting the local charge effect of the targeted spot which is normally smeared out in conventional average work function measurements. Chloroaluminum phthalocyanine （CIA1Pc）, an important optoelectronic molecule with a permanent dipole moment pointing from the Pc ring to the ending CI atom, adsorbed on Au（111） in either Cl-up or Cl-down configuration. Scanning tunneling microscopy/spectroscopy measurements revealed that at the centers of Cl-up and CI-down molecules, the local work functions changed oppositely with respect to the Au（111） substrate. At their Pc lobes, however, the local work functions unanimously increased due to charging effect of the indole lobes in the CIAIPc molecule.
基金the financial support from the National Key Research and Development Program of China(Grant No.2024YFF1502600)the Fundamental Research Funds for the Central Universities(Grant Nos.YG2024LC09 and YG2025ZD25)+4 种基金the National Natural Science Foundation of China(Grant Nos.82272054 and 623B2070)the Science and Technology Commission of Shanghai Municipality(Grant Nos.24DIPA00300,24490710800,and 24490790900)the Pujiang Program of Shanghai Magnolia Talent Plan(Grant No.24PJA043)the Shanghai Key Laboratory of Gynecologic Oncology,the Sichuan Science and Technology Program(Grant No.2024ZYD0112)the Start-up Program for New Teachers of Shanghai Jiao Tong University(Grant No.AF0820138)。
文摘Surface-enhanced Raman spectroscopy(SERS),as a great potential label-free tool in metabolite detection,offers a strategy for rapid bacterial identification.However,it still lacks experimentally supported spectral interpretation at the metabolite level for complex biosamples.We present a SERS-based method for reliable bacterial intracellular metabolic profiling using plasmonic colloids with high rapidness and costefficiency.A convolutional neural network model was constructed to accurately classify eight types of bacteria with an overall accuracy as high as 90.44%and identify the key spectral features for classification by Shapley Additive Explanations.Molecule-level interpretation of the SERS metabolic profiles has been further realized in combination with laser desorption/ionization mass spectrometry,evidencing the primary metabolite contribution to the bacterial spectral signatures and molecule-level distinctions among different bacterial types.We provide insights into the mechanism of bacterial identification by label-free SERS and pave the way for interpretable SERS diagnostic tools for various diseases.
基金funded in part by the National Natural Science Foundation of China(62372355,61972305,61871308)in part by the Natural Science Basic Research Program of Shaanxi(2023-JC-zD-39,2024JC-YBMS-520)in part by the Key Research and Development Program of Shaanxi(2021ZDLGY02-03).
文摘As a computer vision task,object detection algorithms can be applied to various real-world sce-narios.However,efficient algorithms often come with a large number of parameters and high computational complexity.To meet the demand for high-performance object detection algorithms on mobile devices and embedded devices with limited computational resources,we propose a new lightweight object detection algorithm called DLE-YOLO.Firstly,we design a novel backbone called dual-branch lightweight excitation network(DLEN)for feature extraction,which is mainly constructed by dual-branch lightweight excitation units(DLEU).DLEU is stacked with different numbers of dual-branch lightweight excitation blocks(DLEB),which can extract comprehensive features and integrate information between different channels of features.Secondly,in order to enhance the network to capture key feature information in the regions of interest,the attention model HS-coordinate attention(HS-CA)is introduced into the network.Thirdly,the localization loss utilizes SIoU loss to further optimize the accuracy of the bounding box.Our method achieves a mAP value of 46.0%on the MS-COCO dataset,which is a 2%mAP improvement compared to the baseline YOLOv5-m,while bringing a 19.3%reduction in parameter count and a 12.9%decrease in GFLOPs.Furthermore,our method outperforms some advanced lightweight object detection algorithms,validating the effectiveness of our approach.
基金funded by the National Key Research and Development Program of China under Grants 2023YFC3011500 and 2024YFC3016000.
文摘Emergency communication in forested environments encounters extremely complex propagation conditions,whose channel characteristics cannot be accurately captured by conventional models designed for urban scenarios.This paper conducts field measurements and modeling for 380 MHz vehicle-to-infrastructure(V2I)links in the primeval forest of the Greater Khingan Mountains.Through joint analysis of large-scale and small-scale channel characteristics,we systematically reveal the signal attenuation,fading mechanisms,and delay spread behavior in such environments.Results indicate that for path loss modeling,the Alpha-Beta model outperforms the Close-In model in characterizing the rapid attenuation in dense foliage.Small-scale fading is predominantly Rayleigh-distributed,while Ricean fading only dominates in the initial stage,with its K-factor decreasing significantly as distance increases.The root mean square(RMS)delay spread ranges from 0 to 450 ns,follows a log-normal distribution,and is markedly larger than in urban scenarios.Based on these observations,a parametric tapped-delay-line(TDL)model is developed,effectively quantifying multipath delay,power decay,and fading characteristics.The proposed model can reproduce realistic propagation features in simulations,offering theoretical support for emergency communication system planning and optimization,as well as engineering guidance for enhancing communication reliability and coverage in disaster rescue scenarios.
基金NSFC,Grant/Award Numbers:52073045,51773195Key Scientific and Technological Project of Jilin Province,Grant/Award Number:20190701010GH+2 种基金Development and Reform Commission of Jilin Province,Grant/Award Number:2020C035-5Changchun Science and Technology Bureau,Grant/Award Number:21ZGY19EPSRC,Grant/Award Number:EP/L02621X/1。
文摘Currently three major problems seriously limit the practical application of can-cer photodynamic therapy(PDT):(i)the hypoxic tumor microenvironment(TME);(ii)low generation efficiency of toxic reactive oxygen species(ROS)in aggre-gates and(iii)shallow tissue penetration depth of excitation light.Very limited approaches are available for addressing all the above three problems with a single design.Herein,a rational“three birds with one stone”molecular and nanoengi-neering strategy is demonstrated:a photodynamic nanoplatform U-Ir@PAA-ABS based on the covalent combination of lanthanide-doped upconversion nanoparti-cles(UCNPs)and an AIE-active dinuclear Ir(III)complex provides a low oxygen concentration-dependent type-I photochemical process upon 980 nm irradiation by Föster resonance energy transfer(FRET).U-Ir@PAA-ABS targets mitochondria and has excellent phototoxicity even in severe hypoxia environments upon 980 nm irradiation,inducing a dual-mode cell death mechanism by apoptosis and ferropto-sis.Taken together,the in vitro and in vivo results demonstrate a successful strategy for improving the efficacy of PDT against hypoxic tumors.
基金This work was supported by National Science Foundation of China(Grant No.32102274)Natural Science Foundation of the Anhui Higher Education Institutions(KJ2020A0129,YJS20210237).
文摘Entomopathogenic fungi are protected by a cell wall with dynamic structure for adapting to various environmental conditions.β-1,3-Glucan recognition proteins activate the innate immune system of insects by recognizing surface molecules of fungi.However,the associations between pathogenicity and the different components of entomopathogenic fungal cell walls remain unclear.Three Beauveria bassiana strains were selected that have significantly differing virulence against Bombyx mori.The molecular mechanisms underlying the immune response in B.mori were investigated using RNA sequencing,which revealed differences in the immune response to different B.bassiana strains at 12 h post-infection.Immunofluorescence assays revealed thatβ-1,3-glucan content had an opposite trend to that of fungal virulence.β-1,3-Glucan injection upregulated BmβGRP4 expression and significantly reduced the virulence of the high-virulence strain but not that of the medium-virulence or low-virulence strains.BmβGRP4 silencing in B.mori with RNA interference resulted in the opposite virulence pattern,indicating that the virulence of B.bassiana was affected by the cell walls’content ofβ-1,3-glucan,which could be recognized by BmβGRP4.Furthermore,interference with the gene CnA(calcineurin catalytic A subunit)involved inβ-1,3-glucan synthesis eliminated differences in virulence between B.bassiana strains.These results indicate that strains of a single species of pathogenic fungi that have differing cell wall components are recognized differently by the innate immune system of B.mori.
基金supported by the National Key Research and Development Program of China (2022YFA1403300)the National Natural Science Foundation of China (11974079, 12274083, 12221004, 12174028, 52231007, 51725101, and 11727807)+2 种基金the Shanghai Municipal Science and Technology Major Project (2019SHZDZX01)the Shanghai Municipal Science and Technology Basic Research Project (22JC1400200 and 23dz2260100)the National Key Research and Development Program of China (2021YFA1200600 and 2018YFA0209100)。
文摘The conventional Hall effect is linearly proportional to the field component or magnetization component perpendicular to a film. Despite the increasing theoretical proposals on the Hall effect to the in-plane field or magnetization in various special systems induced by the Berry curvature, such an unconventional Hall effect has only been experimentally reported in Weyl semimetals and in a heterodimensional superlattice. Here, we report an unambiguous experimental observation of the antisymmetric planar Hall effect(APHE) with respect to the in-plane magnetic field in centrosymmetric rutile RuO_(2) and IrO_(2) single-crystal films. The measured Hall resistivity is found to be linearly proportional to the component of the applied in-plane magnetic field along a particular crystal axis and to be independent of the current direction or temperature. Both the experimental observations and theoretical calculations confirm that the APHE in rutile oxide films is induced by the Lorentz force. Our findings can be generalized to ferromagnetic materials for the discovery of anomalous Hall effects and quantum anomalous Hall effects induced by in-plane magnetization. In addition to significantly expanding knowledge of the Hall effect, this work opens the door to explore new members in the Hall effect family.
基金supported by the National Natural Science Foundation of China (Nos.12074283,91836302,11874279,and 62305240)
文摘We report the generation of polarization-entangled photon pairs in the 1550 nm band by pumping an uneven nonlinear interferometer loop with two orthogonally polarized counterpropagating pump pulses.The uneven nonlinear interferometer,providing a more ideal interference pattern due to the elimination of secondary maxima,consists of four pieces of dispersion-shifted fibers sandwiched with three pieces of standard single-mode fibers,and the lengths of the nonlinear fibers follow the binomial distribution.The mode number of the photon pairs deduced from the measured joint spectrum is∼1.03.The collection efficiency of the photon pairs is found to be∼94%(after background noise correction).The directly measured visibility of two-photon interference of the polarization-entangled photon pairs is∼92%,while no interference is observed in the direct detection of either the signal or idler photons.
基金supported by National Natural Science Foundation of China grant nos.82388201 to B.H.and 82003145 to J.L.Haihe Laboratory of Cell Ecosystem Innovation Fund grant no.22HHXBSS00009 to B.H.+1 种基金National Key Research and Development Program of China grant no.2022YFA1206000CAMS Innovation Fund for Medical Sciences(CIFMS)grant nos.2021-I2M-1-021 and 2022-I2M-JB-008 to B.H.
文摘Solid tumor cells live in a highly dynamic mechanical microenvironment.How the extracellular-matrix-generated mechanotransduction regulates tumor cell development and differentiation remains an enigma.Here,we show that a low mechanical force generated from the soft matrix induces dedifferentiation of moderately stiff tumor cells to soft stem-cell-like cells.Mechanistically,integrin?was identified to transduce mechano-signaling to trigger tumor cell dedifferentiation by recruiting RhoGDI1 to inactivate RhoA and subsequently Yes-associated protein(YAP).YAP inactivation relieved the inhibition of v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog G(MAFG),allowing MAFG to transactivate the stemness genes NANOG,SOX2,and NESTIN.Inactivation also restoredβ8 expression,thereby forming a closed mechanical loop.Importantly,MAFG expression is correlated with worse prognosis.Our findings provide mechanical insights into the regulation of tumor cell dedifferentiation,which has therapeutic implications for exploring innovative strategies to attack malignancies.
基金This work was supported by the New Technology and New Business Support Projects of The Second Medical Center of PLA General Hospital(No.XYW-202107)the Army Health Care Special Project(No.23BJZ25).
文摘Managing Editor:Peng Lyu Primary bone marrow lymphoma(PBML)is a rare lymphoma accounting for 1.23%of non-Hodgkin lymphoma(NHL)cases.It is characterized by tumor cells invading only the bone marrow without systemic lymphadenopathy or extranodal organ involvement.Owing to the lack of standardized treatment regimens,most patients are treated using rituximab with cyclophosphamide,doxorubicin,vincristine,and prednisone(R-CHOP)regimens;however,their efficacy needs to be further investigated.
基金supported by the Henan Province Key R&D Project under Grant 241111210400the Henan Provincial Science and Technology Research Project under Grants 252102211047,252102211062,252102211055 and 232102210069+2 种基金the Jiangsu Provincial Scheme Double Initiative Plan JSS-CBS20230474,the XJTLU RDF-21-02-008the Science and Technology Innovation Project of Zhengzhou University of Light Industry under Grant 23XNKJTD0205the Higher Education Teaching Reform Research and Practice Project of Henan Province under Grant 2024SJGLX0126。
文摘Accurate and efficient detection of building changes in remote sensing imagery is crucial for urban planning,disaster emergency response,and resource management.However,existing methods face challenges such as spectral similarity between buildings and backgrounds,sensor variations,and insufficient computational efficiency.To address these challenges,this paper proposes a novel Multi-scale Efficient Wavelet-based Change Detection Network(MewCDNet),which integrates the advantages of Convolutional Neural Networks and Transformers,balances computational costs,and achieves high-performance building change detection.The network employs EfficientNet-B4 as the backbone for hierarchical feature extraction,integrates multi-level feature maps through a multi-scale fusion strategy,and incorporates two key modules:Cross-temporal Difference Detection(CTDD)and Cross-scale Wavelet Refinement(CSWR).CTDD adopts a dual-branch architecture that combines pixel-wise differencing with semanticaware Euclidean distance weighting to enhance the distinction between true changes and background noise.CSWR integrates Haar-based Discrete Wavelet Transform with multi-head cross-attention mechanisms,enabling cross-scale feature fusion while significantly improving edge localization and suppressing spurious changes.Extensive experiments on four benchmark datasets demonstrate MewCDNet’s superiority over comparison methods:achieving F1 scores of 91.54%on LEVIR,93.70%on WHUCD,and 64.96%on S2Looking for building change detection.Furthermore,MewCDNet exhibits optimal performance on the multi-class⋅SYSU dataset(F1:82.71%),highlighting its exceptional generalization capability.
基金financially supported by the Key Special Projects of the Ministry of Science and Technology(SQ2020YFF0419518)China Scholarship Council(no.202006120438,Beijing).
文摘Probiotic is a promising nutritional intervention for the prevention and alleviation of type 2 diabetes (T2DM).In this study,the remission potential of a multi-species probiotic (Lactobacillus acidophilus NCFM,Lactobacillus rhamnosus GG,Bifidobacterium lactis HN019 and Streptococcus thermophilus ST447) and its fermented yoghurt on the symptoms of high fat diet and streptozotocin induced T2DM mice were investigated,and the underlying mechanisms were elucidated.Multi-species probiotic and probiotic yoghurt elicited similar but varying efficacy in decreasing the body weight loss,improving organ weight,glucose tolerance and insulin resistance,regulating the levels of blood glucose,HbA1c,insulin and lipid as well as protecting the pancreatic islets.Their tangible antidiabetic effects may be ascribed to the mutual promotion between the repair of the intestinal barrier/permeability and the optimization of gut microbiota structure.Furthermore,the intestinal flora-short chain fatty acids-intestinal hormones/inflammatory pathway was activated and thereby conferring healthy benefits to the host.This proposed probiotic combination appears to provide a viable approach to alleviate T2DM.
基金supported by the National Natural Science Foundation of China(61625404,61888102 and 61574132)the Key Research Program of Frontier Sciences,CAS(QYZDY-SSWJWC004)
文摘Stretchable ultraviolet photodetectors with fast response have wide applications in wearable electronics and implantable biomedical devices. However, most of the conventional binary oxide nanowires based photodetectors exhibit slow response due to the presence of a large number of surface defects related to trapping centers. Herein, with interlaced SnO2-CdS nanowire films as the sensing materials, we fabricated stretchable ultraviolet photodetectors with significantly improved response speed via a multiple lithographic filtration method. Systematic investigations reveal that the interlaced-nanowire based photodetectors have lower dark current and much higher response speed(more than 100 times) compared with pure SnO2 nanowire based photodetectors. The relevant carrier generation and transport mechanism were also discussed. In addition, due to the formation of waved wrinkles on the surface of the nanowires/PDMS layer during the prestretching cycles, the SnO2-CdS interlaced nanowire photodetectors display excellent electrical stability and stretching cyclability within 50% strain, without obvious performance degradation even after 150 stretching cycles. As a simple and effective strategy to fabricate stretchable ultraviolet photodetectors with high response speed, the interlacednanowire structure can also be applied to other nanowire pairs, like ZnO-CdS interlaced-nanowires. Our method provides a versatile way to fabricate fast speed ultraviolet photodetectors by using interlaced metal oxide nanowires-CdS nanowires structures, which is potential in future stretchable and wearable optoelectronic devices.
