目的探讨多模式预康复策略对老年衰弱结直肠癌手术患者的功能状态及短期预后的影响。方法回顾性收集2021年1月—2023年6月接受手术治疗的老年衰弱结直肠癌患者的临床资料,所有患者均采用加速康复外科(enhanced recovery after surgery,E...目的探讨多模式预康复策略对老年衰弱结直肠癌手术患者的功能状态及短期预后的影响。方法回顾性收集2021年1月—2023年6月接受手术治疗的老年衰弱结直肠癌患者的临床资料,所有患者均采用加速康复外科(enhanced recovery after surgery,ERAS)路径管理,依据是否实行多模式预康复分为预康复组和对照组。采用1∶2倾向性评分匹配平衡组间基线差异所致的混杂偏倚,比较匹配后两组患者资料,卡钳值设为0.1。主要观察指标为术后4周6分钟步行距离(6-minute walk distance,6MWD);次要观察指标为衰弱指数(frail index,FI)、手术时间、术中出血量、术后并发症、术后住院时间、术后30 d再入院率/再手术率及术后90 d死亡率。结果本研究最终共纳入182例患者(上海交通大学医学院附属第九人民医院62例,临沂市人民医院61例,聊城市人民医院59例),预康复组31例,对照组151例。经1∶2匹配后成功匹配93例患者,预康复组31例,对照组62例。术后4周预康复组6MWD改善值大于对照组[(46.3±33.7)m vs(7.6±30.2)m,P=0.002],预康复组6MWD改善值>20 m的患者数占比多于对照组(55%vs 9.9%,P=0.033)。FI预康复组小于对照组(中位数2 vs 3,P=0.024)。两组间手术时间、并发症发生率、术后30 d再入院率/再手术率及术后90 d死亡率差异无统计学意义(P>0.05)。术后住院时间预康复组长于对照组[(14.0±4.3)d vs(11.3±4.2)d,P=0.007]。结论多模式预康复策略未增加围手术期风险,有助于改善老年衰弱结直肠癌患者术后功能状态,可能提高患者对手术应激的耐受性,从而使其更好地从ERAS中获益。展开更多
Flexible PANI-Polyethersulfone (PES) fibers were fabricated using the wet-spinning technique.PANI particles were uniformly distributed within the matrix and micropores formed by the phase separation of PES,which preve...Flexible PANI-Polyethersulfone (PES) fibers were fabricated using the wet-spinning technique.PANI particles were uniformly distributed within the matrix and micropores formed by the phase separation of PES,which prevented PANI particles aggregation and facilitated the formation of continuous ion transport channels.The experimental results reveals that the electrochemical performance of the fiber electrode material is optimal when the concentration of PES in the spinning solution is 15wt%.The assembled supercapacitor exhibits a commendable specific area capacitance of 162.75 mF·cm^(-2) at a current density of 0.5 mA·cm^(-2) and achieves an energy density of 14.47 mWh·cm^(-2) at a power density of 321.69 mW·cm^(-2).The capacitor retains 98.1% of its capacitance after 1 000 bending cycles.Therefore,the prepared fibers have good electrochemical properties and flexibility,and this simple and efficient preparation method is promising for the scalable production of flexible electrodes.展开更多
基金Funded by the Hubei Integrative Technology and Innovation Center for Advanced Fiberous Materials Open Fund (No.XC202425)。
文摘Flexible PANI-Polyethersulfone (PES) fibers were fabricated using the wet-spinning technique.PANI particles were uniformly distributed within the matrix and micropores formed by the phase separation of PES,which prevented PANI particles aggregation and facilitated the formation of continuous ion transport channels.The experimental results reveals that the electrochemical performance of the fiber electrode material is optimal when the concentration of PES in the spinning solution is 15wt%.The assembled supercapacitor exhibits a commendable specific area capacitance of 162.75 mF·cm^(-2) at a current density of 0.5 mA·cm^(-2) and achieves an energy density of 14.47 mWh·cm^(-2) at a power density of 321.69 mW·cm^(-2).The capacitor retains 98.1% of its capacitance after 1 000 bending cycles.Therefore,the prepared fibers have good electrochemical properties and flexibility,and this simple and efficient preparation method is promising for the scalable production of flexible electrodes.
