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MewCDNet: A Wavelet-Based Multi-Scale Interaction Network for Efficient Remote Sensing Building Change Detection
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作者 Jia Liu Hao chen +5 位作者 Hang Gu Yushan Pan haoran chen Erlin Tian Min Huang Zuhe Li 《Computers, Materials & Continua》 2026年第1期687-710,共24页
Accurate and efficient detection of building changes in remote sensing imagery is crucial for urban planning,disaster emergency response,and resource management.However,existing methods face challenges such as spectra... Accurate and efficient detection of building changes in remote sensing imagery is crucial for urban planning,disaster emergency response,and resource management.However,existing methods face challenges such as spectral similarity between buildings and backgrounds,sensor variations,and insufficient computational efficiency.To address these challenges,this paper proposes a novel Multi-scale Efficient Wavelet-based Change Detection Network(MewCDNet),which integrates the advantages of Convolutional Neural Networks and Transformers,balances computational costs,and achieves high-performance building change detection.The network employs EfficientNet-B4 as the backbone for hierarchical feature extraction,integrates multi-level feature maps through a multi-scale fusion strategy,and incorporates two key modules:Cross-temporal Difference Detection(CTDD)and Cross-scale Wavelet Refinement(CSWR).CTDD adopts a dual-branch architecture that combines pixel-wise differencing with semanticaware Euclidean distance weighting to enhance the distinction between true changes and background noise.CSWR integrates Haar-based Discrete Wavelet Transform with multi-head cross-attention mechanisms,enabling cross-scale feature fusion while significantly improving edge localization and suppressing spurious changes.Extensive experiments on four benchmark datasets demonstrate MewCDNet’s superiority over comparison methods:achieving F1 scores of 91.54%on LEVIR,93.70%on WHUCD,and 64.96%on S2Looking for building change detection.Furthermore,MewCDNet exhibits optimal performance on the multi-class⋅SYSU dataset(F1:82.71%),highlighting its exceptional generalization capability. 展开更多
关键词 Remote sensing change detection deep learning wavelet transform MULTI-SCALE
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Diagnosis of focal spots at relativistic intensity utilizing coherent radiation from laser-driven flying electron sheets
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作者 Shirui Xu Zhuo Pan +22 位作者 Ying Gao Jiarui Zhao Shiyou chen Zhusong Mei Xun chen Ziyang Peng Xuan Liu Yulan Liang Tianqi Xu Tan Song Qingfan Wu Yujia Zhang Zhipeng Liu Zihao Zhang haoran chen Qihang Han Jundong Shen chenghao Hua Kun Zhu Yanying Zhao chen Lin Xueqing Yan Wenjun Ma 《Matter and Radiation at Extremes》 2025年第2期16-23,共8页
Experimental validation of laser intensity is particularly important for the study of fundamental physics at extremely high intensities.However,reliable diagnosis of the focal spot and peak intensity faces huge challe... Experimental validation of laser intensity is particularly important for the study of fundamental physics at extremely high intensities.However,reliable diagnosis of the focal spot and peak intensity faces huge challenges.In this work,we demonstrate for the firs time that the coherent radiation farfiel patterns from laser–foil interactions can serve as an in situ,real-time,and easy-to-implement diagnostic for an ultraintense laser focus.The laser-driven electron sheets,curved by the spatially varying laser fiel and leaving the targets at nearly the speed of light,produce doughnut-shaped patterns depending on the shapes of the focal spot and the absolute laser intensities.Assisted by particle-in-cell simulations,we can achieve measurements of the intensity and the focal spot,and provide immediate feedback to optimize the focal spots for extremely high intensity. 展开更多
关键词 diagnosis focal spot peak intensity laser foil interactions laser fi coherent radiation farfiel patterns laser driven electron sheets experimental validation laser intensity focal spot coherent radiation
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Sub-diffraction-limited focusing laser pulses at ultrahigh intensity via near-critical-density hollow plasma fibers
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作者 Tianqi Xu Zhuo Pan +12 位作者 Ying Gao Yulan Liang Shirui Xu Qingfan Wu Tan Song Yujia Zhang haoran chen Qihang Han chenghao Hua Ziyang Peng Ke chen Xuan Liu Wenjun Ma 《Advanced Photonics Nexus》 2025年第6期64-71,共8页
Ultra-intense electromagnetic fields exceeding 10^(23)W∕cm^(2)are enabling breakthroughs in compact laser-driven particle accelerators and revealing new quantum electrodynamics(QED)phenomena.However,conventional lase... Ultra-intense electromagnetic fields exceeding 10^(23)W∕cm^(2)are enabling breakthroughs in compact laser-driven particle accelerators and revealing new quantum electrodynamics(QED)phenomena.However,conventional laser-focusing methods face considerable engineering challenges and require substantial costs.Focusing schemes utilizing plasma optics can produce sub-micrometer focus spots beyond the diffraction limit and substantially enhance the peak intensity;however,owing to significant energy dissipation,they may fail to simultaneously increase the laser fluence.To address these challenges,we propose a focusing scheme employing a near-critical-density hollow plasma fiber(HPF)that utilizes graded refractive index dynamics to boost both laser peak intensity and fluence at the same time.Three-dimensional particle-in-cell simulations demonstrate the HPF’s capability to focus a 4.5-μm-diameter Gaussian beam to a sub-diffraction-limited 0.6-μm-diameter spot.The peak intensity and laser fluence can be enhanced by factors of 22 and 10,respectively,marking a substantial improvement over existing plasma-based focusing schemes.Furthermore,the proposed scheme exhibits wide-range parameter adaptation and high robustness,making it suitable for direct implementation in PW-class ultra-intense laser experiments. 展开更多
关键词 plasma optics laser focusing intensity enhancement
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碳点增敏的流动注射化学发光法测定食品中二氧化硫的含量 被引量:4
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作者 曹烁 曾鸿林 +4 位作者 周佳欣 邵思远 刘丰睿 陈浩然 陈芳 《大学化学》 CAS 2023年第2期170-176,共7页
二氧化硫的检测对于食品安全保障具有重要意义。采用酸性高锰酸钾-亚硫酸盐化学发光体系,以碳点(Carbon Dots,CDs)为增敏剂,结合流动注射技术(Flow Injection Analysis,FIA)建立了一种用于检测食品中二氧化硫含量的简便方法。在优化的... 二氧化硫的检测对于食品安全保障具有重要意义。采用酸性高锰酸钾-亚硫酸盐化学发光体系,以碳点(Carbon Dots,CDs)为增敏剂,结合流动注射技术(Flow Injection Analysis,FIA)建立了一种用于检测食品中二氧化硫含量的简便方法。在优化的实验条件下,该方法的线性范围为1.0×10^(-5)–3.0×10^(-4) mol·L^(-1),检出限为7.79×10^(-6) mol·L^(-1)。该实验适合作为本科生仪器分析课程的教学实验,帮助学生掌握化学发光、流动注射分析技术的原理及应用,学习科学研究的基本方法,提高思考能力。 展开更多
关键词 流动注射 化学发光 碳点 二氧化硫 食品分析
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血小板淋巴细胞比值作为非小细胞肺癌预后因素的meta分析 被引量:14
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作者 陈浩然 薛昊 +3 位作者 刘文静 吴方方 王一托 高红军 《中国肺癌杂志》 CAS CSCD 北大核心 2019年第5期289-298,共10页
背景与目的目前研究显示,血小板淋巴细胞比值(platelet lymphocyte ratio, PLR)在肾细胞癌、食管癌、胃癌、肝癌以及结肠癌中均有重要的预后价值。本研究旨在通过meta分析,评估PLR对非小细胞肺癌(nonsmall cell lung cancer, NSCLC)患... 背景与目的目前研究显示,血小板淋巴细胞比值(platelet lymphocyte ratio, PLR)在肾细胞癌、食管癌、胃癌、肝癌以及结肠癌中均有重要的预后价值。本研究旨在通过meta分析,评估PLR对非小细胞肺癌(nonsmall cell lung cancer, NSCLC)患者的预后价值。方法使用计算机电子系统对PubMed、EMBASE、Web of Science、Medline、Cochrane Library、中国知网、中国生物医学文献数据库、维普、万方数据库进行系统文献检索,查阅研究PLR与总生存期(overall survival, OS)和无病生存期(disease-free survival, DFS)之间关联的文献。提取每个符合条件的研究数据,使用风险比率(hazard risk, HR)和95%置信区间(95%confidence interval, 95%CI)进行系统评价分析以评估PLR的预后价值,检索时限为建库至2018年11月。结果我们共纳入15篇研究文献涉及5524名患者进行系统评价分析。Meta分析结果显示:较高PLR组的OS明显低于较低PLR组的OS(HR=1.69, 95%CI:1.45-1.97, P<0.000,01, I^2=46.2%,P异质性=0.026);较高PLR组的DFS明显低于较低PLR组的DFS(HR=1.41, 95%CI:1.14-1.74, P=0.001, I^2=46.2%, P异质性=0.026)。亚组分析显示,按种族、样本大小、PLR临界值和治疗方法分组后,PLR较高组的OS仍明显低于PLR较低组(P<0.05)。结论 PLR增高与NSCLC患者预后不良有关,因此PLR可能作为NSCLC患者重要的生物预测标记,但其临床应用仍需要未来通过更多的研究来验证。 展开更多
关键词 肺肿瘤 血小板与淋巴细胞比值 META分析 总生存期 无病生存期
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Growth of aligned SnS nanowire arrays for near infrared photodetectors 被引量:3
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作者 Guozhen Shen haoran chen Zheng Lou 《Journal of Semiconductors》 EI CAS CSCD 2020年第4期95-100,共6页
Aligned SnS nanowires arrays were grown via a simple chemical vapor deposition method.As-synthesized SnS nanowires are single crystals grown along the[111]direction.The single SnS nanowire based device showed excellen... Aligned SnS nanowires arrays were grown via a simple chemical vapor deposition method.As-synthesized SnS nanowires are single crystals grown along the[111]direction.The single SnS nanowire based device showed excellent response to near infrared lights with good responsivity of 267.9 A/W,high external quantum efficiency of 3.12×10^4%and fast response time.Photodetectors were built on the aligned SnS nanowire arrays,exhibiting a light on/off ratio of 3.6,and the response and decay time of 4.5 and 0.7 s,respectively,to 1064 nm light illumination. 展开更多
关键词 PHOTODETECTORS NANOWIRES INFRARED ALIGNED
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A Novel Millimeter-Wave Channel Measurement Platform for 6G Intelligent Railway Scenarios 被引量:1
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作者 Dan Fei chen chen +4 位作者 Peng Zheng Dongsheng Zhang Jingya Yang haoran chen Bo Ai 《China Communications》 SCIE CSCD 2022年第11期60-73,共14页
This paper presented a novel millimeterwave channel measurement platform for the 6G intelligent railway.This platform used phased array antenna with 64 elements and can support instant bandwidth up to 1 GHz.Combined w... This paper presented a novel millimeterwave channel measurement platform for the 6G intelligent railway.This platform used phased array antenna with 64 elements and can support instant bandwidth up to 1 GHz.Combined with improved multi-tone sounding signals,the platform can enhance dynamic measurement capability in high-speed railway scenarios.We performed calibration works about frequency flatness,frequency offset and proved platform reliability with channel emulator based closed-loop verification.We also carried out field trials in high-speed railway carriage scenarios.Based on measurement results,we extracted channel characteristic parameters of path loss,power delay profile and delay spread to further verify the field measurement performance of the platform. 展开更多
关键词 6G MILLIMETER-WAVE channel measurement phased array antenna high-speed railway
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STOCHASTIC ELASTO-PLASTIC FRACTURE ANALYSIS OF ALUMINUM FOAMS
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作者 Shiyong Sun haoran chen +1 位作者 Xiaozhi Hu Zhanjun Wu 《Acta Mechanica Solida Sinica》 SCIE EI 2009年第3期276-282,共7页
Model I quasi-static nonlinear fracture of aluminum foams is analyzed by considering the effect of microscopic heterogeneity. Firstly, a continuum constitutive model is adopted to account for the plastic compressibili... Model I quasi-static nonlinear fracture of aluminum foams is analyzed by considering the effect of microscopic heterogeneity. Firstly, a continuum constitutive model is adopted to account for the plastic compressibility of the metallic foams. The yield strain modeled by a two- parameter Weibull-type function is adopted in the constitutive model. Then, a modified cohesive zone model is established to characterize the fracture behavior of aluminum foams with a cohesive zone ahead of the initial crack. The tensile traction versus local crack opening displacement relation is employed to describe the softening characteristics of the material. And a Weibull statistical model for peak bridging stress within the fracture process zone is used for considering microscopic heterogeneity of aluminum foams. Lastly, the influence of stochastic parameters on the curve of stress-strain is given. Numerical examples are given to illustrate the numerical model presented in this paper and the effects of Weibull parameters and material properties on J-integral are discussed. 展开更多
关键词 aluminum foams cohesive zone model continuum constitutive model fracture Weibull distributions J-INTEGRAL
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Dynamic fracture analysis of adhesive bonded material under normal loading
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作者 Yanhong Cai haoran chen Xiaozhi Hu 《Acta Mechanica Sinica》 SCIE EI CAS CSCD 2010年第1期107-112,共6页
Dynamic fracture behavior of a Griffith crack along the interface of an adhesive bonded material under normal loading is studied. The singular integral equations are obtained by employing integral transformation and i... Dynamic fracture behavior of a Griffith crack along the interface of an adhesive bonded material under normal loading is studied. The singular integral equations are obtained by employing integral transformation and introducing dislocation density functions. By adopting Gauss-Jacobi integration formula, the problem is reduced to the solution of algebraic equations, and by collocation dots method. their solutions can be obtained Based on the parametric discussions presented in the paper, the following conclusions can be drawn: (1) Mode I dynamic stress intensity factor (DSIF) increases with increasing initial crack length and decreasing visco-elastic layer thickness, revealing distinct size effect; (2) The influence of the visco-elastic adhesive relaxation time on the DSIF should not be ignored. 展开更多
关键词 Adhesive bonded material Interface crackDynamic stress intensity factor Integral transformationSingular integral equation
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Dipole and charge effects of chloroaluminum phthalocyanine revealed by local work function measurements at sub-molecular level
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作者 Huanjun Song Na Li +6 位作者 Hao Zhu Zhantao Peng Wenhui Zhao haoran chen Wei chen Yongfeng Wang Kai Wua 《Chinese Chemical Letters》 SCIE CAS CSCD 2018年第3期429-432,共4页
Work function plays a significant role in surface chemistry. Local work function provides the information of local d/pole-d/pole interaction and charge distribution between adsorbates and substrate, highlighting the l... Work function plays a significant role in surface chemistry. Local work function provides the information of local d/pole-d/pole interaction and charge distribution between adsorbates and substrate, highlighting the local charge effect of the targeted spot which is normally smeared out in conventional average work function measurements. Chloroaluminum phthalocyanine (CIA1Pc), an important optoelectronic molecule with a permanent dipole moment pointing from the Pc ring to the ending CI atom, adsorbed on Au(111) in either Cl-up or Cl-down configuration. Scanning tunneling microscopy/spectroscopy measurements revealed that at the centers of Cl-up and CI-down molecules, the local work functions changed oppositely with respect to the Au(111) substrate. At their Pc lobes, however, the local work functions unanimously increased due to charging effect of the indole lobes in the CIAIPc molecule. 展开更多
关键词 Chloroaluminum phthalocyanine Local work function Dipole orientation Scanning tunneling microscopy Surface dipole
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Solving Mathematical Problems using Large Language Models:A Survey
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作者 Feijuan He Han Lai +4 位作者 Jiaqi Liu Bo Wang haoran chen Haohan Liu chenxi Zhang 《Data Intelligence》 2025年第4期907-946,共40页
Large Language Models(LLMs)exhibit impressive performance across various Natural Language Processing(NLP)tasks due to their robust contextual understanding,content generation and few/zero-shot learning abilities.Howev... Large Language Models(LLMs)exhibit impressive performance across various Natural Language Processing(NLP)tasks due to their robust contextual understanding,content generation and few/zero-shot learning abilities.However,LLMs still show significant limitations while handling with mathematical problems that require complex reasoning skills and interpretable solving processes.Consequently,a series of research efforts have been made in solving mathematical problems using Large Language Models(SMP-LLM).This survey provides a comprehensive review of such endeavors.First,we introduce a two-layer classification system for SMP-LLM:at the primary layer,we categorize extant researches into four classes of solution methods,including:fine-tuning,prompt engineering,collaboration with symbolic solvers,and collaboration with evaluators/validators.At the second layer,we classify mathematical problems into four categories:math word problem,geometry problem,theorem proving,and combinatorial optimization problem.This classification system finds the correlation between solution methods and the categories of mathematical problems.Second,we analyzed typical research works under of each method,and summarized their strengths and weaknesses.Third,we elucidate current mainstream datasets for solving mathematical problems and analyzed how these datasets promote SMP-LLM research from different perspectives.Finally,summarize the challenges that SMP-LLM are facing and highlighted four research directions:geometric analysis,comprehension,and generation of mathematical expressions,indirect reasoning and benchmarks for evaluating mathematical ability.We hope that this survey can provide useful references for researchers interested in SMP-LLM. 展开更多
关键词 Large language models Mathematical problems Fine-tuning Prompt engineering Symbolic solvers Evaluators Validators SURVEY Knowledge graph
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Bacterial identification by metabolite-level interpretable surface-enhanced Raman spectroscopy
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作者 haoran chen Ruike Zhao +5 位作者 Xinyuan Bi Nan Shen Xi Mo Yue Tao Zhou chen Jian Ye 《Advanced Photonics》 2025年第4期126-138,共13页
Surface-enhanced Raman spectroscopy(SERS),as a great potential label-free tool in metabolite detection,offers a strategy for rapid bacterial identification.However,it still lacks experimentally supported spectral inte... Surface-enhanced Raman spectroscopy(SERS),as a great potential label-free tool in metabolite detection,offers a strategy for rapid bacterial identification.However,it still lacks experimentally supported spectral interpretation at the metabolite level for complex biosamples.We present a SERS-based method for reliable bacterial intracellular metabolic profiling using plasmonic colloids with high rapidness and costefficiency.A convolutional neural network model was constructed to accurately classify eight types of bacteria with an overall accuracy as high as 90.44%and identify the key spectral features for classification by Shapley Additive Explanations.Molecule-level interpretation of the SERS metabolic profiles has been further realized in combination with laser desorption/ionization mass spectrometry,evidencing the primary metabolite contribution to the bacterial spectral signatures and molecule-level distinctions among different bacterial types.We provide insights into the mechanism of bacterial identification by label-free SERS and pave the way for interpretable SERS diagnostic tools for various diseases. 展开更多
关键词 surface-enhanced Raman spectroscopy METABOLITE pathogenic bacteria DIAGNOSIS SERSome
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DLE-YOLO:An efficient object detection algorithm with dual-branch lightweight excitation network
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作者 Peitao cheng Xuanjiao Lei +1 位作者 haoran chen Xiumei Wang 《Journal of Information and Intelligence》 2025年第2期91-102,共12页
As a computer vision task,object detection algorithms can be applied to various real-world sce-narios.However,efficient algorithms often come with a large number of parameters and high computational complexity.To meet... As a computer vision task,object detection algorithms can be applied to various real-world sce-narios.However,efficient algorithms often come with a large number of parameters and high computational complexity.To meet the demand for high-performance object detection algorithms on mobile devices and embedded devices with limited computational resources,we propose a new lightweight object detection algorithm called DLE-YOLO.Firstly,we design a novel backbone called dual-branch lightweight excitation network(DLEN)for feature extraction,which is mainly constructed by dual-branch lightweight excitation units(DLEU).DLEU is stacked with different numbers of dual-branch lightweight excitation blocks(DLEB),which can extract comprehensive features and integrate information between different channels of features.Secondly,in order to enhance the network to capture key feature information in the regions of interest,the attention model HS-coordinate attention(HS-CA)is introduced into the network.Thirdly,the localization loss utilizes SIoU loss to further optimize the accuracy of the bounding box.Our method achieves a mAP value of 46.0%on the MS-COCO dataset,which is a 2%mAP improvement compared to the baseline YOLOv5-m,while bringing a 19.3%reduction in parameter count and a 12.9%decrease in GFLOPs.Furthermore,our method outperforms some advanced lightweight object detection algorithms,validating the effectiveness of our approach. 展开更多
关键词 Object detection Lightweight network Attention mechanism Loss function
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Channel Measurement and Modeling for 380 MHz V2I Emergency Communications in Forested Scenarios
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作者 Rong Yuan Wenchi cheng +4 位作者 Wei Guo Dan Fei haoran chen Yayun Ao Yudong Fang 《Journal of Communications and Information Networks》 2025年第3期276-286,共11页
Emergency communication in forested environments encounters extremely complex propagation conditions,whose channel characteristics cannot be accurately captured by conventional models designed for urban scenarios.This... Emergency communication in forested environments encounters extremely complex propagation conditions,whose channel characteristics cannot be accurately captured by conventional models designed for urban scenarios.This paper conducts field measurements and modeling for 380 MHz vehicle-to-infrastructure(V2I)links in the primeval forest of the Greater Khingan Mountains.Through joint analysis of large-scale and small-scale channel characteristics,we systematically reveal the signal attenuation,fading mechanisms,and delay spread behavior in such environments.Results indicate that for path loss modeling,the Alpha-Beta model outperforms the Close-In model in characterizing the rapid attenuation in dense foliage.Small-scale fading is predominantly Rayleigh-distributed,while Ricean fading only dominates in the initial stage,with its K-factor decreasing significantly as distance increases.The root mean square(RMS)delay spread ranges from 0 to 450 ns,follows a log-normal distribution,and is markedly larger than in urban scenarios.Based on these observations,a parametric tapped-delay-line(TDL)model is developed,effectively quantifying multipath delay,power decay,and fading characteristics.The proposed model can reproduce realistic propagation features in simulations,offering theoretical support for emergency communication system planning and optimization,as well as engineering guidance for enhancing communication reliability and coverage in disaster rescue scenarios. 展开更多
关键词 channel measurement emergency rescue forested scenario characteristic analysis
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Photonic chip-based optical frequency division with PZT-integrated soliton microcombs
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作者 RUXUAN LIU MARK W.HARRINGTON +17 位作者 SHUMAN SUN FATEMEHSADAT TABATABAEI SAMIN HANIFI MEITING SONG KAIKAI LIU JIAWEI WANG haoran chen ZIJIAO YANG BEIchen WANG FATEME MAJDI PAUL A.MORTON KARL D.NELSON STEVEN M.BOWERS ANDREAS BELING RYAN Q.RUDY IAIN M.KIERZEWSKI DANIEL J.BLUMENTHAL XU YI 《Photonics Research》 2026年第2期621-625,共5页
Optical frequency division(OFD)produces low-noise microwave and millimeter-wave(mmWave)signals by transferring the exceptional stability of optical references to electronic frequency domains.Recent developments in int... Optical frequency division(OFD)produces low-noise microwave and millimeter-wave(mmWave)signals by transferring the exceptional stability of optical references to electronic frequency domains.Recent developments in integrated optical references and soliton microcombs have paved the way for miniaturizing OFD oscillators to chip scale.Critical to this realization is a rapid tunable frequency comb that is stabilized to the optical references,thereby coherently linking optical and electronic frequencies.In this work,we advance the on-chip OFD technology using an integrated high-speed lead zirconate titanate(PZT)stress-optic actuator on the SiN soliton microcomb resonator.The integrated PZT actuator tunes the resonance frequency of the soliton-generating microresonator with a bandwidth exceeding 10s MHz and thus adjusts the soliton repetition rate.Optical frequency division and low-noise mmWave generation are demonstrated by feedback control of the soliton repetition rate through the integrated PZT-actuator,and the soliton microcomb is stabilized to a pair of reference lasers that are locked to an integrated 4 m SiN coil reference cavity.Our approach provides a fast,versatile,and integrated control mechanism for OFD oscillators and their applications in advanced communications,sensing,and precise timing. 展开更多
关键词 optical frequency division ofd produces soliton microcombs transferring exceptional stability optical references electronic frequency domainsrecent optical referencesthereby integrated optical references optical frequency division PZT integrated soliton microcombs ofd oscillators
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Rationally reconstructing the surface microstructure of a chemical bath deposited electron transport layer for efficient and stable perovskite solar cells
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作者 Xinxuan Yang Lexin Wang +9 位作者 Meihan Liu Jiahui Jin Lili Yang Lin Fan Maobin Wei Huilian Liu haoran chen Jinghai Yang Yulei Chang Fengyou Wang 《Inorganic Chemistry Frontiers》 2024年第22期7910-7920,共11页
In perovskite solar cells(PSCs),chemical bath deposition(CBD)is promising as the core technique for preparing a commercial electron transport layer(ETL)because the film prepared by CBD exhibits excellent uniform and c... In perovskite solar cells(PSCs),chemical bath deposition(CBD)is promising as the core technique for preparing a commercial electron transport layer(ETL)because the film prepared by CBD exhibits excellent uniform and conformal coverage of the substrate.However,metal oxide(MO_(x))films prepared through CBD often have defects on the surface like oxygen vacancies and hydroxyl that limit the PSCs efficiency and degrade the long-term stability. 展开更多
关键词 perovskite solar cells surface microstructure hydroxyl perovskite solar cells pscs chemical bath deposition cbd chemical bath deposition commercial electron transport layer etl electron transport layer oxygen vacancies
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Lotus seed protein ameliorates hepatic lipid metabolic disorders in high-fat diet-fed mice via activating the PPARαsignaling pathway
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作者 haoran chen Hongzheng Lu +2 位作者 Zhenling Lang Baodong Zheng Shaoxiao Zeng 《Food Bioscience》 2024年第5期4085-4097,共13页
Obesity,one of the prevalent chronic diseases globally,is a serious threat to human health.Dietary natural compounds intervention is an effective means to alleviate obesity.The objective of this study was to investiga... Obesity,one of the prevalent chronic diseases globally,is a serious threat to human health.Dietary natural compounds intervention is an effective means to alleviate obesity.The objective of this study was to investigate the potential protective role of lotus seed protein(LSP)against obesity.The results of amino acid composition analysis indicated that LSP possessed a well-balanced distribution of amino acids and was rich in branched-chain amino acids(BCAAs).Meanwhile,LSP exhibited better ABTS radical scavenging,DPPH radical scavenging,hydroxyl radical scavenging,and Fe^(2+)chelating ability in vitro.In vivo,LSP intervention remarkably alleviated body weight gain,organ index gain,dyslipidemia,and hepatic lipid deposition in high-fat diet(HFD)-fed mice.Meanwhile,LSP enhanced hepatic antioxidant enzyme activities(superoxide dismutase(SOD)and catalase(CAT))and decreased malondialdehyde(MDA)levels,subsequently alleviated liver injury.In addition,LSP intervention significantly improved insulin sensitivity and glucose tolerance in obese mice,thereby alleviating hyperglycemia and insulin resistance.At the molecular level,LSP intervention up-regulated the mRNA and protein expression of fatty acid oxidation-related genes(FATP1,CPT-1a,ACOX1)and down-regulated the mRNA and protein expression of lipid synthesis-related genes(SREBP-1c,ACC,SCD-1,FASN)by activating the PPARαsignaling pathway,thereby promoting hepatic fatty acid oxidation and reducing lipogenesis.These results demonstrate that LSP has the potential as a dietary supplementation to prevent and ameliorate obesity. 展开更多
关键词 Obesity Lotus seed protein Lipid deposition PPARα
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“Three birds with one stone”nanoplatform:Efficient near-infrared-triggered type-I AIE photosensitizer for mitochondria-targeted photodynamic therapy against hypoxic tumors 被引量:7
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作者 Shengnan Liu Yu Pei +6 位作者 Yan Sun Ziwei Wang haoran chen Dongxia Zhu Martin R.Bryce Ben Zhong Tang Yulei Chang 《Aggregate》 EI CAS 2024年第4期279-293,共15页
Currently three major problems seriously limit the practical application of can-cer photodynamic therapy(PDT):(i)the hypoxic tumor microenvironment(TME);(ii)low generation efficiency of toxic reactive oxygen species(R... Currently three major problems seriously limit the practical application of can-cer photodynamic therapy(PDT):(i)the hypoxic tumor microenvironment(TME);(ii)low generation efficiency of toxic reactive oxygen species(ROS)in aggre-gates and(iii)shallow tissue penetration depth of excitation light.Very limited approaches are available for addressing all the above three problems with a single design.Herein,a rational“three birds with one stone”molecular and nanoengi-neering strategy is demonstrated:a photodynamic nanoplatform U-Ir@PAA-ABS based on the covalent combination of lanthanide-doped upconversion nanoparti-cles(UCNPs)and an AIE-active dinuclear Ir(III)complex provides a low oxygen concentration-dependent type-I photochemical process upon 980 nm irradiation by Föster resonance energy transfer(FRET).U-Ir@PAA-ABS targets mitochondria and has excellent phototoxicity even in severe hypoxia environments upon 980 nm irradiation,inducing a dual-mode cell death mechanism by apoptosis and ferropto-sis.Taken together,the in vitro and in vivo results demonstrate a successful strategy for improving the efficacy of PDT against hypoxic tumors. 展开更多
关键词 hypoxia tumor iridium complex nanoplatform near-infrared photosensitizer photodynamic therapy type-I photosensitizer
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Antidiabetic effects of multi-species probiotic and its fermented milk in mice via restoring gut microbiota and intestinal barrier 被引量:7
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作者 Yuxiang Gu Xing Li +4 位作者 haoran chen Yue Sun Lin Yang Ying Ma Eric Chun Yong Chan 《Food Bioscience》 SCIE 2022年第3期316-326,共11页
Probiotic is a promising nutritional intervention for the prevention and alleviation of type 2 diabetes (T2DM).In this study,the remission potential of a multi-species probiotic (Lactobacillus acidophilus NCFM,Lactoba... Probiotic is a promising nutritional intervention for the prevention and alleviation of type 2 diabetes (T2DM).In this study,the remission potential of a multi-species probiotic (Lactobacillus acidophilus NCFM,Lactobacillus rhamnosus GG,Bifidobacterium lactis HN019 and Streptococcus thermophilus ST447) and its fermented yoghurt on the symptoms of high fat diet and streptozotocin induced T2DM mice were investigated,and the underlying mechanisms were elucidated.Multi-species probiotic and probiotic yoghurt elicited similar but varying efficacy in decreasing the body weight loss,improving organ weight,glucose tolerance and insulin resistance,regulating the levels of blood glucose,HbA1c,insulin and lipid as well as protecting the pancreatic islets.Their tangible antidiabetic effects may be ascribed to the mutual promotion between the repair of the intestinal barrier/permeability and the optimization of gut microbiota structure.Furthermore,the intestinal flora-short chain fatty acids-intestinal hormones/inflammatory pathway was activated and thereby conferring healthy benefits to the host.This proposed probiotic combination appears to provide a viable approach to alleviate T2DM. 展开更多
关键词 Type 2 diabetes Probiotic Probiotic yoghurt Gut microbiota Intestinal barrier INFLAMMATION
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Stretchable SnO2-CdS interlaced-nanowire film ultraviolet photodetectors 被引量:7
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作者 Ludong Li Zheng Lou +2 位作者 haoran chen Ruilong Shi Guozhen Shen 《Science China Materials》 SCIE EI CSCD 2019年第8期1139-1150,共12页
Stretchable ultraviolet photodetectors with fast response have wide applications in wearable electronics and implantable biomedical devices. However, most of the conventional binary oxide nanowires based photodetector... Stretchable ultraviolet photodetectors with fast response have wide applications in wearable electronics and implantable biomedical devices. However, most of the conventional binary oxide nanowires based photodetectors exhibit slow response due to the presence of a large number of surface defects related to trapping centers. Herein, with interlaced SnO2-CdS nanowire films as the sensing materials, we fabricated stretchable ultraviolet photodetectors with significantly improved response speed via a multiple lithographic filtration method. Systematic investigations reveal that the interlaced-nanowire based photodetectors have lower dark current and much higher response speed(more than 100 times) compared with pure SnO2 nanowire based photodetectors. The relevant carrier generation and transport mechanism were also discussed. In addition, due to the formation of waved wrinkles on the surface of the nanowires/PDMS layer during the prestretching cycles, the SnO2-CdS interlaced nanowire photodetectors display excellent electrical stability and stretching cyclability within 50% strain, without obvious performance degradation even after 150 stretching cycles. As a simple and effective strategy to fabricate stretchable ultraviolet photodetectors with high response speed, the interlacednanowire structure can also be applied to other nanowire pairs, like ZnO-CdS interlaced-nanowires. Our method provides a versatile way to fabricate fast speed ultraviolet photodetectors by using interlaced metal oxide nanowires-CdS nanowires structures, which is potential in future stretchable and wearable optoelectronic devices. 展开更多
关键词 stretchable electronics interlaced-nanowire structure nanowire photodetectors SnO2-CdS
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