In this paper,we first generalize the constant dimension and orbit codes over finite fields to the constant rank and orbit codes over finite chain rings.Then we provide a relationship between constant rank codes over ...In this paper,we first generalize the constant dimension and orbit codes over finite fields to the constant rank and orbit codes over finite chain rings.Then we provide a relationship between constant rank codes over finite chain rings and constant dimension codes over the residue fields.In particular,we prove that an orbit submodule code over a finite chain ring is a constant rank code.Finally,for special finite chain ring F_(q)+γF_(q),we define a Gray mapφfrom(F_(q)+γF_(q))^(n)to F^(2n)_(q),and by using cyclic codes over F_(q)+γF_(q),we obtain a method of constructing an optimum distance constant dimension code over F_(q).展开更多
文摘头颈部鳞状细胞癌(head and neck squamous cell carcinoma,HNSCC)是头颈部肿瘤最为常见的一种类型,其治疗效果及患者的预后并不理想,随着抗表皮生长因子受体(epidermal growth factor receptor,EGFR)单抗和免疫检查点抑制剂(immune checkpoint inhibitors,ICIs)的广泛应用,HNSCC患者的生存期虽有所延长但仍存在较大的改善空间。近年来多项研究提示,抗EGFR单抗联合ICIs治疗可带来良好的效果及安全性,已获得美国国立综合癌症网络(National Comprehensive Cancer Network,NCCN)和中国临床肿瘤学会(Chinese Society of Clinical Oncology,CSCO)等发布的权威性指南推荐。然而,抗EGFR单抗联合ICIs治疗方案的应用仍处于早期探索阶段,如何在临床中规范使用仍存在诸多待解答的问题,包括其协同作用机制、在不同类型患者中的治疗价值及安全性等。CSCO头颈肿瘤专家委员会组织专家基于循证医学证据及临床实践探索,经过多轮讨论,最终形成《抗EGFR单抗联合免疫检查点抑制剂治疗头颈部鳞状细胞癌专家共识(2025年版)》,对抗EGFR单抗与ICIs联合治疗的作用机制、分层治疗、在特殊人群中的应用及安全性等方面提出指导建议。本共识已在国际实践指南注册与透明化平台(Practice guideline REgistration for transPAREncy,PREPARE)上注册,注册号为PREPARE-2025CN666。期望本共识能够为临床医师提供更为明确和实用的指导,进一步推动该联合方案在临床实践中的合理应用,为HNSCC患者提供更多的治疗选择。
基金Supported by Research Funds of Hubei Province(D20144401,Q20174503)。
文摘In this paper,we first generalize the constant dimension and orbit codes over finite fields to the constant rank and orbit codes over finite chain rings.Then we provide a relationship between constant rank codes over finite chain rings and constant dimension codes over the residue fields.In particular,we prove that an orbit submodule code over a finite chain ring is a constant rank code.Finally,for special finite chain ring F_(q)+γF_(q),we define a Gray mapφfrom(F_(q)+γF_(q))^(n)to F^(2n)_(q),and by using cyclic codes over F_(q)+γF_(q),we obtain a method of constructing an optimum distance constant dimension code over F_(q).
