[目的]通过分析针刀治疗腰椎间盘突出症(LDH)的随机对照试验(RCT)结局指标使用现状,为构建该领域核心指标集提供循证医学依据。[方法]全面检索2005年1月至2024年9月PubMed、Web of Science、Cochrane Library、EMbase、中国知网、维普...[目的]通过分析针刀治疗腰椎间盘突出症(LDH)的随机对照试验(RCT)结局指标使用现状,为构建该领域核心指标集提供循证医学依据。[方法]全面检索2005年1月至2024年9月PubMed、Web of Science、Cochrane Library、EMbase、中国知网、维普网、万方数据知识服务平台、SinoMed、ClinicalTrials.gov、CHiCTR和ITMCTR中所有有关针刀治疗LDH的RCT,通过提取、归纳和分析相关结局指标,制定针刀治疗LDH的指标域。[结果]最终纳入369篇RCT,样本总量40430例,涉及107种不同的结局指标,累计出现1092次。结局指标以症状/体征最多(75.46%),其次是理化检查(18.41%)、生活质量评价(2.56%)、安全性评价(2.56%)、远期疗效(1.37%)、中医证候(1.28%)、患者满意度(0.64%)和经济学评估(0.18%)。结果表明当前针刀治疗LDH的RCT结局指标应用普遍存在主/次结局指标未区分、缺乏客观性、过度关注短期疗效、经济学指标缺乏、生活质量未受重视和安全性评价关注度低的问题。[结论]建议研究者构建针刀治疗LDH的核心指标集,以此增进针刀治疗LDH研究设计的规范性、结局指标选定的合理性以及研究结论的可靠性。展开更多
The zigzag nitrogen chain,similar to the Ch-N structure,has long been considered as a potential high-energy-density structure.However,all the previously predicted zigzag N-chain structures,similar to Ch-N,exhibited im...The zigzag nitrogen chain,similar to the Ch-N structure,has long been considered as a potential high-energy-density structure.However,all the previously predicted zigzag N-chain structures,similar to Ch-N,exhibited imaginary frequencies in their phonon spectra at 0 GPa.Here,we conducted a systematic investigation of P-N compounds using first-principles calculations,uncovering a series of structurally similar stable phases,C2/m-PN_(x)(x=6,8,10,12,and 14),in which N forms zigzag N chains similar to those in Ch-N.In P-N compounds,the longest zigzag N-chain,which can theoretically remain stable under ambient pressure,is the N-chain composed of 14 N atoms in C2/m-PN14.If the N-chain continues to grow,imaginary interchain vibrational frequencies arise in the system.Notably,N chains with an even number of atoms were more likely to be energetically favorable.The five C2/m-PN_(x) phases and one metastable phase(R-PN_(6))exhibited remarkable stability and excellent detonability at ambient pressure,indicating that they are promising candidates for high-energy-density materials.In addition,R-PN_(6) was the first structure to stabilize the N_(6) ring through covalent bonding,with the covalent network contributing to its high hardness(47.59 GPa).展开更多
文摘[目的]通过分析针刀治疗腰椎间盘突出症(LDH)的随机对照试验(RCT)结局指标使用现状,为构建该领域核心指标集提供循证医学依据。[方法]全面检索2005年1月至2024年9月PubMed、Web of Science、Cochrane Library、EMbase、中国知网、维普网、万方数据知识服务平台、SinoMed、ClinicalTrials.gov、CHiCTR和ITMCTR中所有有关针刀治疗LDH的RCT,通过提取、归纳和分析相关结局指标,制定针刀治疗LDH的指标域。[结果]最终纳入369篇RCT,样本总量40430例,涉及107种不同的结局指标,累计出现1092次。结局指标以症状/体征最多(75.46%),其次是理化检查(18.41%)、生活质量评价(2.56%)、安全性评价(2.56%)、远期疗效(1.37%)、中医证候(1.28%)、患者满意度(0.64%)和经济学评估(0.18%)。结果表明当前针刀治疗LDH的RCT结局指标应用普遍存在主/次结局指标未区分、缺乏客观性、过度关注短期疗效、经济学指标缺乏、生活质量未受重视和安全性评价关注度低的问题。[结论]建议研究者构建针刀治疗LDH的核心指标集,以此增进针刀治疗LDH研究设计的规范性、结局指标选定的合理性以及研究结论的可靠性。
基金supported by the Anhui Provincial Natural Science Foundation (Grant No.2508085J006)CASHIPS Director's Fund (Grant No.YZJJ202207-CX)。
文摘The zigzag nitrogen chain,similar to the Ch-N structure,has long been considered as a potential high-energy-density structure.However,all the previously predicted zigzag N-chain structures,similar to Ch-N,exhibited imaginary frequencies in their phonon spectra at 0 GPa.Here,we conducted a systematic investigation of P-N compounds using first-principles calculations,uncovering a series of structurally similar stable phases,C2/m-PN_(x)(x=6,8,10,12,and 14),in which N forms zigzag N chains similar to those in Ch-N.In P-N compounds,the longest zigzag N-chain,which can theoretically remain stable under ambient pressure,is the N-chain composed of 14 N atoms in C2/m-PN14.If the N-chain continues to grow,imaginary interchain vibrational frequencies arise in the system.Notably,N chains with an even number of atoms were more likely to be energetically favorable.The five C2/m-PN_(x) phases and one metastable phase(R-PN_(6))exhibited remarkable stability and excellent detonability at ambient pressure,indicating that they are promising candidates for high-energy-density materials.In addition,R-PN_(6) was the first structure to stabilize the N_(6) ring through covalent bonding,with the covalent network contributing to its high hardness(47.59 GPa).
