Owing to their low toxicity and remarkable stability, perovskites based on antimony and bismuth have garnered significant interest in recent years. However, A_(3)B_(2)X_(9) perovskite materials derived from antimony a...Owing to their low toxicity and remarkable stability, perovskites based on antimony and bismuth have garnered significant interest in recent years. However, A_(3)B_(2)X_(9) perovskite materials derived from antimony and bismuth face several challenges, including excessively wide band gaps, elevated defect densities, and suboptimal film quality, all of which hinder advancements in device efficiency. While extensive studies have been undertaken to investigate the effects of modulating the A-site and X-site elements in lead-free A_(3)B_(2)X_(9) perovskites, there remains a notable scarcity of reports addressing the impact of modifications to the B-site element. In this study, we investigated the alloying of antimony and bismuth within the 2D Cs_(3)B_(2)I_(6)Br_(3) perovskite. By systematically varying the ratios of two elements, we found that the incorporation of both antimony and bismuth at the B-site significantly enhances the quality of the perovskite films. Our findings indicate that a 1 : 1 ratio of antimony to bismuth produces the densest films, the highest photoluminescence intensity, and superior photovoltaic performance. Ultimately,the devices fabricated using this optimal ratio achieved an open-circuit voltage(VOC) of 1.01 V and a power conversion efficiency(PCE) of 0.645%.展开更多
阐述初中英语“教—学—评”一体化的内涵,并以牛津沪教版初中《英语》九年级(上)Module 4A taste of literature Unit 7 The Adventures of Tom Sawyer的写作课为例,探讨如何在英语教学与劳动教育相结合的过程中实施“教—学—评”一...阐述初中英语“教—学—评”一体化的内涵,并以牛津沪教版初中《英语》九年级(上)Module 4A taste of literature Unit 7 The Adventures of Tom Sawyer的写作课为例,探讨如何在英语教学与劳动教育相结合的过程中实施“教—学—评”一体化。研究发现,在劳动教育背景下,通过真实劳动任务驱动英语学习,结合多样化的评价方式,能够有效促进学生语言能力与劳动素养的全面发展。进一步提出在初中英语教学中实施“教—学—评”一体化的具体建议,包括设计劳动任务情境、优化评价工具及利用信息化技术支持教学等。展开更多
Background:Breast cancer remains a leading cause of morbidity and mortality among women worldwide,with significant geographic disparities in its impact.While human epidermal growth factor receptor 2(HER2)-targeted the...Background:Breast cancer remains a leading cause of morbidity and mortality among women worldwide,with significant geographic disparities in its impact.While human epidermal growth factor receptor 2(HER2)-targeted therapies,such as trastuzumab,have improved outcomes for HER2-positive breast cancer,challenges like therapy resistance persist,highlighting the need for novel treatments.Recent developments in antibody-drug conjugates(ADCs),particularly disitamab vedotin(RC48),show promising efficacy in targeting both HER2-positive and HER2-low expression tumors,warranting further investigation through real-world studies to assess its broader clinical applicability.Method:This retrospective,multicenter observational study evaluated the real-world efficacy and safety of RC48 in patients with HER2-positive or HER2-low breast cancer across three medical centers in China.Patient demographic characteristics,treatment patterns,sequential use of ADCs,and treatment-related adverse events were recorded and analyzed.Result:The median progression-free survival(mPFS)for the overall population(n 96)was=4.31 months,with HER2-positive patients demonstrating significantly longer mPFS(5.26 months)compared to HER2-low patients(3.45 months;p<0.044),while subgroup analyses revealed no significant differences in mPFS based on=estrogen receptor(ER),progesterone receptor(PR),or hormone receptor(HR)status.Safety data indicated that adverse events were consistent with prior reports,with no new safety concerns identified during the study period.Conclusion:This real-world study demonstrates the efficacy of RC48 in both HER2-positive and HER2-low breast cancer.Notably,combination therapy significantly improved outcomes in HER2-low patients.展开更多
The<001>orientation of the Goss texture aligned with the rolling direction is the most easily magnetized direction,effectively enhancing the magnetic properties of non-oriented silicon steel.In the present study...The<001>orientation of the Goss texture aligned with the rolling direction is the most easily magnetized direction,effectively enhancing the magnetic properties of non-oriented silicon steel.In the present study,an ultra-thin high-silicon sheet of 0.2 mm with a strong Goss texture was successfully fabricated using a two-stage rolling method,achieving superior magnetic properties.The combination of suitable primary rolling reduction and intermediate annealing proved beneficial in promoting the formation of Goss texture.Electron back scatter diffraction(EBSD)was used to characterize micro-shear bands within deformed grains of secondary rolled sheets.Observations revealed that the recrystallized Goss nucleus originated from the Goss substructure of shear bands within deformed{111}<112>grains during the initial stages of recrystallization.The influence of stored energy and grain size on texture evolution was thoroughly investigated using quasi-in situ EBSD during recrystallization.In the initial stages,large deformed{111}<112>and near{111}<112>grains with high stored energy facilitated nucleation and growth of Goss and near-Goss grains within shear bands and reduced grain boundary nucleation.In the later stages,large deformed grains with low stored energy underwent a strain-induced grain boundary migration mechanism to nucleate.During the recrystallization,many recrystallized Goss and near-Goss grains clustered together,with Goss grains rotating towards near-Goss orientation.The resulting annealed ultra-thin 0.2 mm sheet with a pronounced Goss texture exhibited superior magnetic properties.展开更多
Leachate sludge,a byproduct of municipal solid waste leachate treated through biochemical processes,is characterized by high water content(761.1%)and significant organic matter content(71.2%).Cement that is commonly u...Leachate sludge,a byproduct of municipal solid waste leachate treated through biochemical processes,is characterized by high water content(761.1%)and significant organic matter content(71.2%).Cement that is commonly used for solidifying leachate sludge has shown limited effectiveness.To address this issue,an alkali-activated ground-granulated blast-furnace slag(GGBS)geopolymer blended with polypropylene fibers was developed to solidify leachate sludge.Moreover,unconfined compressive strength(UCS),immersion,as well as X-ray diffraction(XRD),Fourier transform infrared spectroscopy(FTIR),and scanning electron microscope(SEM)tests were conducted to investigate the solidification effect and mechanism of the GGBS-based geopolymer and fibers on leachate sludge.The results showed that:the 28-d UCS of the solidified sludge with 20%and 30%GGBS is 0.35 MPa and 1.85 MPa,and decreases to 0.18 MPa and 1.13 MPa,respectively,after soaked in water for 28 d.Notably,the UCS of the solidified sludge with 30%GGBS satisfied the strength requirement of roadbed materials.Polypropylene fibers significantly enhanced the strength,ductility and water stability of the solidified sludge,with an optimal fiber content of 0.3%.Alkali-activated GGBS geopolymer generated three-dimensional,cross-linked geopolymeric gels within the solidified sludge,cementing sludge particles and filling intergranular pores to form a stable cementitious structure,thereby achieving effective solidification.Furthermore,incorporating polypropylene fibers improved the bonding and anchoring effect between fiber and solidified sludge,constrained lateral deformation of the solidified sludge,restricted crack propagation,and enhanced engineering performance of the solidified leachate sludge.展开更多
基金financially supported by the Natural Science Foundation of Zhejiang Province, China (Grant No. LQ22F040001)China Postdoctoral Science Foundation (Grant No. 2022M723281)Science and Technology Planning Project of Shaoxing City (Grant No. 2023B41006)。
文摘Owing to their low toxicity and remarkable stability, perovskites based on antimony and bismuth have garnered significant interest in recent years. However, A_(3)B_(2)X_(9) perovskite materials derived from antimony and bismuth face several challenges, including excessively wide band gaps, elevated defect densities, and suboptimal film quality, all of which hinder advancements in device efficiency. While extensive studies have been undertaken to investigate the effects of modulating the A-site and X-site elements in lead-free A_(3)B_(2)X_(9) perovskites, there remains a notable scarcity of reports addressing the impact of modifications to the B-site element. In this study, we investigated the alloying of antimony and bismuth within the 2D Cs_(3)B_(2)I_(6)Br_(3) perovskite. By systematically varying the ratios of two elements, we found that the incorporation of both antimony and bismuth at the B-site significantly enhances the quality of the perovskite films. Our findings indicate that a 1 : 1 ratio of antimony to bismuth produces the densest films, the highest photoluminescence intensity, and superior photovoltaic performance. Ultimately,the devices fabricated using this optimal ratio achieved an open-circuit voltage(VOC) of 1.01 V and a power conversion efficiency(PCE) of 0.645%.
文摘阐述初中英语“教—学—评”一体化的内涵,并以牛津沪教版初中《英语》九年级(上)Module 4A taste of literature Unit 7 The Adventures of Tom Sawyer的写作课为例,探讨如何在英语教学与劳动教育相结合的过程中实施“教—学—评”一体化。研究发现,在劳动教育背景下,通过真实劳动任务驱动英语学习,结合多样化的评价方式,能够有效促进学生语言能力与劳动素养的全面发展。进一步提出在初中英语教学中实施“教—学—评”一体化的具体建议,包括设计劳动任务情境、优化评价工具及利用信息化技术支持教学等。
基金funded by the medical and health category of the Science and Technology Project of Shantou(No.230509116495542,Wu Haoming)National Natural Science Foundation of China(NSFC)Cultivation Project of the Cancer Hospital of Shantou University Medical College(No.2024GP002,Wu Haoming)National Natural Science Foundation of China(82203130,Ye Feng).
文摘Background:Breast cancer remains a leading cause of morbidity and mortality among women worldwide,with significant geographic disparities in its impact.While human epidermal growth factor receptor 2(HER2)-targeted therapies,such as trastuzumab,have improved outcomes for HER2-positive breast cancer,challenges like therapy resistance persist,highlighting the need for novel treatments.Recent developments in antibody-drug conjugates(ADCs),particularly disitamab vedotin(RC48),show promising efficacy in targeting both HER2-positive and HER2-low expression tumors,warranting further investigation through real-world studies to assess its broader clinical applicability.Method:This retrospective,multicenter observational study evaluated the real-world efficacy and safety of RC48 in patients with HER2-positive or HER2-low breast cancer across three medical centers in China.Patient demographic characteristics,treatment patterns,sequential use of ADCs,and treatment-related adverse events were recorded and analyzed.Result:The median progression-free survival(mPFS)for the overall population(n 96)was=4.31 months,with HER2-positive patients demonstrating significantly longer mPFS(5.26 months)compared to HER2-low patients(3.45 months;p<0.044),while subgroup analyses revealed no significant differences in mPFS based on=estrogen receptor(ER),progesterone receptor(PR),or hormone receptor(HR)status.Safety data indicated that adverse events were consistent with prior reports,with no new safety concerns identified during the study period.Conclusion:This real-world study demonstrates the efficacy of RC48 in both HER2-positive and HER2-low breast cancer.Notably,combination therapy significantly improved outcomes in HER2-low patients.
基金financially supported by the project for the full-time introduction of national high-level innovative technological talents in Hebei province(No.2024HBQZY CXY039)the Funds for Creative Research Groups of China(No.51921001)the Key R&D Program of Jiangxi Province of China(No.20212BBE51019)。
文摘The<001>orientation of the Goss texture aligned with the rolling direction is the most easily magnetized direction,effectively enhancing the magnetic properties of non-oriented silicon steel.In the present study,an ultra-thin high-silicon sheet of 0.2 mm with a strong Goss texture was successfully fabricated using a two-stage rolling method,achieving superior magnetic properties.The combination of suitable primary rolling reduction and intermediate annealing proved beneficial in promoting the formation of Goss texture.Electron back scatter diffraction(EBSD)was used to characterize micro-shear bands within deformed grains of secondary rolled sheets.Observations revealed that the recrystallized Goss nucleus originated from the Goss substructure of shear bands within deformed{111}<112>grains during the initial stages of recrystallization.The influence of stored energy and grain size on texture evolution was thoroughly investigated using quasi-in situ EBSD during recrystallization.In the initial stages,large deformed{111}<112>and near{111}<112>grains with high stored energy facilitated nucleation and growth of Goss and near-Goss grains within shear bands and reduced grain boundary nucleation.In the later stages,large deformed grains with low stored energy underwent a strain-induced grain boundary migration mechanism to nucleate.During the recrystallization,many recrystallized Goss and near-Goss grains clustered together,with Goss grains rotating towards near-Goss orientation.The resulting annealed ultra-thin 0.2 mm sheet with a pronounced Goss texture exhibited superior magnetic properties.
基金financially supported by the National Natural Science Foundation of China(Grant No.52078142).
文摘Leachate sludge,a byproduct of municipal solid waste leachate treated through biochemical processes,is characterized by high water content(761.1%)and significant organic matter content(71.2%).Cement that is commonly used for solidifying leachate sludge has shown limited effectiveness.To address this issue,an alkali-activated ground-granulated blast-furnace slag(GGBS)geopolymer blended with polypropylene fibers was developed to solidify leachate sludge.Moreover,unconfined compressive strength(UCS),immersion,as well as X-ray diffraction(XRD),Fourier transform infrared spectroscopy(FTIR),and scanning electron microscope(SEM)tests were conducted to investigate the solidification effect and mechanism of the GGBS-based geopolymer and fibers on leachate sludge.The results showed that:the 28-d UCS of the solidified sludge with 20%and 30%GGBS is 0.35 MPa and 1.85 MPa,and decreases to 0.18 MPa and 1.13 MPa,respectively,after soaked in water for 28 d.Notably,the UCS of the solidified sludge with 30%GGBS satisfied the strength requirement of roadbed materials.Polypropylene fibers significantly enhanced the strength,ductility and water stability of the solidified sludge,with an optimal fiber content of 0.3%.Alkali-activated GGBS geopolymer generated three-dimensional,cross-linked geopolymeric gels within the solidified sludge,cementing sludge particles and filling intergranular pores to form a stable cementitious structure,thereby achieving effective solidification.Furthermore,incorporating polypropylene fibers improved the bonding and anchoring effect between fiber and solidified sludge,constrained lateral deformation of the solidified sludge,restricted crack propagation,and enhanced engineering performance of the solidified leachate sludge.
