摘要
新型冠状病毒感染(Coronavirus disease 2019,COVID-19)是由新型冠状病毒(SARS-CoV-2)引起的全球暴发性传染病,严重危害人类的生命安全。为了遏制新型冠状病毒感染,研究学者致力于研发抗病毒药物。为快速直接评价抗新冠病毒药物的有效性,研究构建了多种新冠病毒的新型报告系统。本文综述了基于目前新冠病毒两种蛋白酶(Mpro和PLpro)切割功能的报告系统相关研究进展,及其在抗病毒药物研发中的应用。
Coronavirus disease 2019(COVID-19),a disease caused by SARS-CoV-2,has given rise to a global pandemic and posed great threats to human health and safety.In response to this,the researchers have been actively engaged in the development of antiviral drugs to contain COVID-19 infections.A variety of new Covid-19 reporter systems have been developed for rapid and direct evaluation of the efficacy of anti-SARS-CoV-2 drugs.Herein,the progress of the reporter system based on the cleavage function of two proteases,Mpro and PLpro,of SARS-CoV-2 was reviewed and its applications in the research and development of antiviral drugs was discussed.
作者
董豹
陈月红
冯烨
姜涛
DONG Bao;CHEN Yuehong;FENG Ye;JIANG Tao(School of Basic Medical Sciences,Anhui Medical University,Hefei 230032,China;State Key Laboratory of Pathogen and Biosecurity,Academy of Military Medical Sciences,Academy of Military Sciences,Beijing 100071,China)
出处
《病毒学报》
北大核心
2025年第1期211-221,共11页
Chinese Journal of Virology
基金
病原微生物生物安全全国重点实验室面上项目(项目号:SKLPBS2209,SKLPBS2120)。
