As a carrier to develop various marine resources, sea area is regulated as a kind of important resources through legislation by many coastal countries with a management system for the paid use of sea area. Since the e...As a carrier to develop various marine resources, sea area is regulated as a kind of important resources through legislation by many coastal countries with a management system for the paid use of sea area. Since the early 1990s, China has begun to implement the paid use and formed an institutional system comprised of three levels after developing it for more than two decades. From 2002 to 2015, the Chinese Government transferred the use right of sea area of 33,910 km2 by paid use and levied a total of 75.89 billion CNY (11.328 billion US dollars) of sea area use payment. Apart from this, the Government has gained rich experience in operating and managing the compensable use of sea area. After retrospectively analyzing the development history of paid use of China’s sea area, the research presents an institutional structure and the implementation of the management system for the paid use of sea area and the main problems therein. On this basis, management policies and feasible policy suggestions are proposed. Research results from this study can provide available references for other developing countries and emerging economies to apply and improve native management system for the paid use of sea area.展开更多
High-Entropy Alloys(HEAs)exhibit significant potential across multiple domains due to their unique properties.However,conventional research methodologies face limitations in composition design,property prediction,and ...High-Entropy Alloys(HEAs)exhibit significant potential across multiple domains due to their unique properties.However,conventional research methodologies face limitations in composition design,property prediction,and process optimization,characterized by low efficiency and high costs.The integration of Artificial Intelligence(AI)technologies has provided innovative solutions for HEAs research.This review presented a detailed overview of recent advancements in AI applications for structural modeling and mechanical property prediction of HEAs.Furthermore,it discussed the advantages of big data analytics in facilitating alloy composition design and screening,quality control,and defect prediction,as well as the construction and sharing of specialized material databases.The paper also addressed the existing challenges in current AI-driven HEAs research,including issues related to data quality,model interpretability,and cross-domain knowledge integration.Additionally,it proposed prospects for the synergistic development of AI-enhanced computational materials science and experimental validation systems.展开更多
</span><b><span style="font-family:Verdana;">Purpose</span></b></span></span><span style="font-family:Verdana;"><span style="font-family:Verd...</span><b><span style="font-family:Verdana;">Purpose</span></b></span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><b><span style="font-family:Verdana;">:</span></b></span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;"></b></span></span></span><span><span><span style="font-family:""> </span></span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;">The purpose of this article is </span></span></span><span><span><span style="font-family:""><span style="font-family:Verdana;">to investigate the clinical value of TB-IGRA</span><span style="font-family:Verdana;"> (Tuberculosis-Interferon </span><span style="font-family:Verdana;">Gamma Release Assay), PPD (Intradermal </span><span style="font-family:Verdana;">Terbuculin Test), TB-DNA-PCR (Tuberculosis-Deoxyribonucleic-Polymerase</span><span style="font-family:Verdana;"> Chain Reaction) and TB-Ab (Tuberculosis-Antibody) in diagnosing silicosis complicated with pulmonary tuberculosis. <b></span></span></span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><b><span style="font-family:Verdana;">Methods</span></b></span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><b><span style="font-family:Verdana;">:</span></b></span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;"></b></span></span></span><span><span><b><span style="font-family:""> </span></b></span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;">53 cases of suspected silicosis complicated with pulmonary tuberculosis were selected in the time span ranging from February 2017 to May 2019. TB-IGRA test, PPD test, TB-DNA-PCR and TB-Ab detection were performed. The sensitivity, specificity, positive predictive value and negative predictive value were calculated. </span></span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;"><b></span></span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><b><span style="font-family:Verdana;">Results</span></b></span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><b><span style="font-family:Verdana;">:</span></b></span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;"></b></span></span></span><span><span><span style="font-family:""> </span></span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;">Silicosis and pulmonary tuberculosis were diagnosed in 11 cases, with an incidence of 20.75%. The positive rates of TB-IGRA, PPD, TB-DNA-PCR and TB-Ab were 66.04%, 30.19%, 5.67% and 26.42%, respectively. The sensitivity was 90.91%, 81.82%, 27.27% and 54.55% respectively. The specificity was 42.86%, 80.95%, 100% and 80.95% respectively. The positive predictive values were 28.57%, 50%, 100% and 42.86% respectively. The negative predictive values were 94.44%, 91.89%, 84% and 87.18%. The positive rate, sensitivity and negative predictive value of TB-IGRA were the highest, while the specificity of TB-DNA-PCR was the highest yet with low positive rate, sensitivity and positive predictive value. </span></span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;"><b></span></span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><b><span style="font-family:Verdana;">Conclusion</span></b></span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><b><span style="font-family:Verdana;">:</span></b></span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;"></b></span></span></span><span><span><b><span style="font-family:""> </span></b></span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;">The positive rate and sensitivity of TB-IGRA were high, yet with poor specificity, so it was impossible to judge whether the cases belonged to active pulmonary tuberculosis. The combination of PPD and TB-DNA-PCR could improve the sensitivity, specificity and positive predictive value, and the diagnostic accuracy of active pulmonary tuberculosis, which showed satisfactory clinical value.展开更多
The authors apologize for the erroneous transcription of the average chemical composition data of Apollo lunar soil samples in Table 4.The difference in chemical composition between lunar regolith simulants and actual...The authors apologize for the erroneous transcription of the average chemical composition data of Apollo lunar soil samples in Table 4.The difference in chemical composition between lunar regolith simulants and actual lunar samples is an important indicator for evaluating their similarity.For comparison,Table 4 lists the chemical compositions of Apollo 12,Apollo 14,Apollo 15,Apollo 16,and other classic lunar regolith simulants.However,the Apollo lunar soil data in the original Table 4 contained errors,which have been corrected in this corrigendum.展开更多
Given the limitations of traditional hot extrusion methods in improving the microstructure and mechanical properties of magnesium(Mg)alloys,this paper attempts to treat AZ31 Mg alloy billet by pre-upsetting continuous...Given the limitations of traditional hot extrusion methods in improving the microstructure and mechanical properties of magnesium(Mg)alloys,this paper attempts to treat AZ31 Mg alloy billet by pre-upsetting continuous variable cross-section direct extrusion(U-CVCDE).The effects of dynamic recrystallization behavior and slip system activity on texture evolution and mechanical properties of CVCDE Mg alloys with different pre-upsetting amounts were systematically analyzed.The results indicate that the introduction of the pre-upsetting process promotes dynamic recrystallization during the CVCDE process.The recrystallization proportion shows a trend of first rising and then decreasing with the increase of the pre-upsetting amount.Among them,the proportion of recrystallization grains in the U2-CVCDE-formed structural parts is as high as 88.3%.The average grain sizes of U1-CVCDE,U2-CVCDE,and U3-CVCDE were 6.01μm,4.90μm,and10.45μm,respectively.In addition,following U-CVCDE,the pyramidal slip of each forming component consistently maintains a high level of activation and opening and dominates,making more grains deflect in the axial extrusion direction of C to varying degrees,which is conducive to the uniform distribution of stress in more grains during plastic deformation.The synergistic effect of dynamic recrystallization behavior and the high activity of the pyramidal slip system significantly weakened the(0001)basal texture strength,and the maximum basal texture strength showed a gradually decreasing trend,among which the base surface texture strength of U3-CVCDE formed parts was only 9.9.The U-CVCDE process is employed to achieve deep modification of Mg alloy,and excellent comprehensive mechanical properties are obtained;among them,the yield and tensile strength of U2-CVCDE are as high as 243.4 MPa and 317.5 MPa,respectively,and the elongation after breaking is up to 21.3%.This study introduces a practical new idea for investigating the extrusion forming technology of high-performance Mg alloys.展开更多
BACKGROUND Due to their significantly lower incidence than colorectal polyps and macroscopic features resembling those of hyperplastic polyps,rectal neuroendocrine tumors(rNETs)are frequently misdiagnosed and resected...BACKGROUND Due to their significantly lower incidence than colorectal polyps and macroscopic features resembling those of hyperplastic polyps,rectal neuroendocrine tumors(rNETs)are frequently misdiagnosed and resected as polyps.To date,no reports have been written on the application of artificial intelligence for assisting in the white-light endoscopy of rNETs.AIM To establish a neuroendocrine tumor lesion detection algorithm based on the YOLOv7 model and evaluate the performance of the algorithm in identifying neuroendocrine tumors.METHODS In total,137748 white-light endoscopic images were collected in this study,including 2232 images of rNET,4429 images of submucosal lesions other than rNET,42563 images of polyps,and 88593 images of normal mucosa.All the images were randomly divided into a training set,a validation set,and a test set.To evaluate the ability of the algorithm to diagnose rNETs,we selected 1578 images to form the test set.The performance of the algorithm was compared with that of endoscopists at different levels.RESULTS The accuracy of the algorithm in identifying rNET from all the images was 97.8%,the sensitivity was 72.6%,the specificity was 99.7%,the positive predictive value was 93.9%,and the negative predictive value was 98.1%.CONCLUSION Our model,which was based on YOLOv7,could effectively detect rNET lesions,which was better than that of most endoscopists.展开更多
This paper systematically analyzed the development status of sheep industry in Lubei region,and comprehensively expounded the scale and distribution of key industries,breed resources and genetic characteristics,feedin...This paper systematically analyzed the development status of sheep industry in Lubei region,and comprehensively expounded the scale and distribution of key industries,breed resources and genetic characteristics,feeding management status,disease prevention and control and veterinary services,and sheep product processing and sales.The research shows that the sheep industry in Lubei region has formed a certain scale,but there are some problems such as intensified resource and environmental constraints,unreasonable industrial structure,insufficient scientific and technological innovation capacity and market competitiveness to be improved.In view of these problems,this paper put forward some countermeasures and suggestions to promote the high-quality development of the industry,including establishing forage and feed system,promoting the adjustment and optimization of industrial structure,strengthening scientific and technological innovation and talent cultivation and introduction,and enhancing brand influence and market competitiveness,providing useful reference for the sustainable development of sheep industry in Lubei region.展开更多
BACKGROUND Schizophrenia(SZ),a chronic and widespread brain disorder,presents with complex etiology and pathogenesis that remain inadequately understood.Despite the absence of a universally recognized endophenotype,pe...BACKGROUND Schizophrenia(SZ),a chronic and widespread brain disorder,presents with complex etiology and pathogenesis that remain inadequately understood.Despite the absence of a universally recognized endophenotype,peripheral blood mononuclear cells(PBMCs)serve as a robust model for investigating intracellular alterations linked to SZ.AIM To preliminarily investigate potential pathogenic mechanisms and identify novel biomarkers for SZ.METHODS PBMCs from SZ patients were subjected to integrative transcriptomic and proteomic analyses to uncover differentially expressed genes(DEGs)and differentially expressed proteins while mapping putative disease-associated signaling pathways.Key findings were validated using western blot(WB)and real-time fluorescence quantitative PCR(RT-qPCR).RNAi-lentivirus was employed to transfect rat hippocampal CA1 neurons in vitro,with subsequent verification of target gene expression via RT-qPCR.The levels of neuronal conduction proteins,including calmodulin-dependent protein kinase II(caMKII),CREB,and BDNF,were assessed through WB.Apoptosis was quantified by flow cytometry,while cell proliferation and viability were evaluated using the Cell Counting Kit-8 assay.RESULTS The integration of transcriptomic and proteomic analyses identified 6079 co-expressed genes,among which 25 DEGs were significantly altered between the SZ group and healthy controls.Notably,haptoglobin(HP),lactotransferrin(LTF),and SERPING1 exhibited marked upregulation.KEGG pathway enrichment analysis implicated neuroactive ligand-receptor interaction pathways in disease pathogenesis.Clinical sample validation demonstrated elevated protein and mRNA levels of HP,LTF,and SERPING1 in the SZ group compared to controls.WB analysis of all clinical samples further corroborated the significant upregulation of SERPING1.In hippocampal CA1 neurons transfected with lentivirus,reduced SERPING1 expression was accompanied by increased levels of CaMKII,CREB,and BDNF,enhanced cell viability,and reduced apoptosis.CONCLUSION SERPING1 may suppress neural cell proliferation in SZ patients via modulation of the CaMKII-CREB-BDNF signaling pathway.展开更多
The effects of synthesis conditions,especially the heating rate,on the reaction kinetics of Ni-rich cathodes were systematically studied.The growth rate of Ni-rich oxide increases continuously as the heating rate incr...The effects of synthesis conditions,especially the heating rate,on the reaction kinetics of Ni-rich cathodes were systematically studied.The growth rate of Ni-rich oxide increases continuously as the heating rate increases.Ab initio molecular dynamics simulations demonstrate that a high heating rate induces anabatic oscillations,indicating a decrease in thermodynamic stability and a tendency for the crystal surface to undergo reconstruction.The presence of an intermediate phase at the grain boundary amplifies atomic migration-induced interface fusion and consequently augments crystal growth kinetics.However,the excessively high heating rate aggravates the Li+/Ni2+mixing in the Ni-rich cathode.The single-crystal Ni-rich cathode exhibits enhanced structural/thermal stability but a decreased specific capacity and rate performance compared with its polycrystalline counterpart.展开更多
Lanthanum ferrite is a representative perovskite-structured rare earth-based bimetallic oxide,which has been widely studied in magnetic materials,sensors,catalysts and batteries.Herein,we designed and prepared polyoxo...Lanthanum ferrite is a representative perovskite-structured rare earth-based bimetallic oxide,which has been widely studied in magnetic materials,sensors,catalysts and batteries.Herein,we designed and prepared polyoxometalate electron acceptor decorated LaFeO_(3)gas-sensitive composite materials with one-dimensional nanoribbons morphology by electrospinning.The effects of different mass fraction of Keggin type phosphotungstic acid(PW_(12)) on the gas-sensitive properties of LaFeO_(3)nanoribbons were investigated.The results show that the response value of LaFeO_(3)/PW_(12)sensor to acetone gas first increases and then decreases with the increase of PW_(12)content.The LaFeO_(3)/3%PW_(12)sensor exhibits a maximum response of 3.35-5 ppm acetone at 250℃,a 2.6 times increase in response value and a 90℃reduction in operating temperature compared to pure LaFeO_(3)nanoribbons.The LaFeO_(3)/3%PW_(12)sensor exhibits good linear relation in ppb-level concentrations and the lowest detection concentration is100 ppb.The sensors also show good repeatability in 6 tests and excellent long-term stability in 30 d.The improvement of the gas sensitive properties of the composite can be attributed to the synergistic effect between the two components.As an electron acceptor,PW_(12) promotes carrier migration between PW_(12)and LaFeO_(3),thereby improving the gas sensing performance of LaFeO_(3).This work promotes the practical application of polyoxometalate to promote rare earth-based gas sensitive materials in sensing field.展开更多
This study systematically investigates the unusual tensile mechanical behavior of Mg-RE solid solution(SS)alloys,exhibiting anomalous tensile strengths(ATS)and an enhanced strain-hardening rate at high temperature.Bot...This study systematically investigates the unusual tensile mechanical behavior of Mg-RE solid solution(SS)alloys,exhibiting anomalous tensile strengths(ATS)and an enhanced strain-hardening rate at high temperature.Both the peak ultimate tensile strength(UTS)and tensile yield strength(TYS)values occur at 150-200℃,which are 12-50%higher compared to those at room temperature(RT).Meanwhile,the strain-hardening rate increases with the temperature rising from RT to 200℃ during the plastic deformation process.The results reveal that the formation of stacking faults(SFs)and the locking of dislocations,particularly immobile (c) partial dislocations,enhance resistance to plastic deformation,leading to higher strengths at high temperature.Furthermore,the interactivity between SFs and (c+a) dislocations intensify with rising of temperature.The presence of RE atoms in the SS plays a critical role in this unique mechanical behavior,as they preferentially occupy non-basal planes rather than basal planes,thereby reducing the stacking fault(SF)formation energy.This study provides new insights into the high-temperature strengthening mechanisms of Mg-RE based alloys,offering potential guidance for the design of advanced lightweight materials with superior mechanical properties.展开更多
The unique oxygen stacking sequence of O2-type structures restricts the irreversible transition metal movement into Li vacancies for the delithiated Li-rich layered oxides(LLOs)and maintains outstanding voltage stabil...The unique oxygen stacking sequence of O2-type structures restricts the irreversible transition metal movement into Li vacancies for the delithiated Li-rich layered oxides(LLOs)and maintains outstanding voltage stability.However,the ion-exchange synthesis promotes the Mn-ion valence reduction and aggravates the Jahn-Teller(J-T)distortion alongside disproportionation.Since the main oxidation state of the Mn ions is+4 in the traditional O3-type LLOs,synergistic effects of the O2-type and O3-type structures are expected in the O2/O3 diphasic Li-rich material.Herein,O2/O3 biphasic intergrowth LLOs were rationally designed,and the synergic optimization of the biphasic structure was planned to retard the J-T effect.The O2/O3 intergrowth nature was confirmed,and the percentages of the O2 and O3 phases were 56%and 44%,respectively.Density functional theory calculations demonstrated that the Mn^(2+)(EC)sheath had a remarkably lower energy barrier than the Li^(+)(EC)sheath.This finding suggests that Mn^(2+)ions that are dissolved into the electrolyte accelerate the electrolyte oxidization,so the deposition of the cathode electrolyte interface for pristine O2-LLOs causes a high electrochemical impedance.The designed O2/O3 biphasic LLOs boost the capacity stability and suppress the voltage drop upon repeated Li^(+)de-intercalation.The phase regulation strategy offers great potential for developing low-cost LLOs with enhanced structural stability for advanced Li-ion batteries.展开更多
Introducing ligand into the surface of gold(Au)-based catalyst has been recognized as an efficient strategy to enhance the performance of catalyst in acetylene hydrochlorination reaction.However,due to the multifactor...Introducing ligand into the surface of gold(Au)-based catalyst has been recognized as an efficient strategy to enhance the performance of catalyst in acetylene hydrochlorination reaction.However,due to the multifactorial deactivation,the usage of single type of ligand has limitations on the performance improvement.In this work,two types of ligands including a molecular 2-methylimidazole and an ionic cetrimonium are selected to protect Au^(n+)species.After kinetics analysis,advanced characterization,and density functional theory simulation,we demonstrate the optimal interaction model between two ligands and Au species:Two 2-methylimidazole molecules are coordinated with high-valent Au species while cetrimonium is interacted via electrostatic interaction.Except the synergistic effect in the decrease of Au species reduction and agglomeration,the existence of molecular ligand greatly increases the adsorption of hydrogen chloride while the ionic ligand significantly inhibits the deposition of coke.Due to the positive effect of dual-ligands,we achieved 97.1%of acetylene conversion and 0.29 h^(−1) of deactivation rate under high gas hourly space velocity of acetylene.This work establishes a foundation to explore the property-activity relationships in Au-based catalyst via ligand engineering.展开更多
文摘As a carrier to develop various marine resources, sea area is regulated as a kind of important resources through legislation by many coastal countries with a management system for the paid use of sea area. Since the early 1990s, China has begun to implement the paid use and formed an institutional system comprised of three levels after developing it for more than two decades. From 2002 to 2015, the Chinese Government transferred the use right of sea area of 33,910 km2 by paid use and levied a total of 75.89 billion CNY (11.328 billion US dollars) of sea area use payment. Apart from this, the Government has gained rich experience in operating and managing the compensable use of sea area. After retrospectively analyzing the development history of paid use of China’s sea area, the research presents an institutional structure and the implementation of the management system for the paid use of sea area and the main problems therein. On this basis, management policies and feasible policy suggestions are proposed. Research results from this study can provide available references for other developing countries and emerging economies to apply and improve native management system for the paid use of sea area.
文摘High-Entropy Alloys(HEAs)exhibit significant potential across multiple domains due to their unique properties.However,conventional research methodologies face limitations in composition design,property prediction,and process optimization,characterized by low efficiency and high costs.The integration of Artificial Intelligence(AI)technologies has provided innovative solutions for HEAs research.This review presented a detailed overview of recent advancements in AI applications for structural modeling and mechanical property prediction of HEAs.Furthermore,it discussed the advantages of big data analytics in facilitating alloy composition design and screening,quality control,and defect prediction,as well as the construction and sharing of specialized material databases.The paper also addressed the existing challenges in current AI-driven HEAs research,including issues related to data quality,model interpretability,and cross-domain knowledge integration.Additionally,it proposed prospects for the synergistic development of AI-enhanced computational materials science and experimental validation systems.
文摘</span><b><span style="font-family:Verdana;">Purpose</span></b></span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><b><span style="font-family:Verdana;">:</span></b></span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;"></b></span></span></span><span><span><span style="font-family:""> </span></span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;">The purpose of this article is </span></span></span><span><span><span style="font-family:""><span style="font-family:Verdana;">to investigate the clinical value of TB-IGRA</span><span style="font-family:Verdana;"> (Tuberculosis-Interferon </span><span style="font-family:Verdana;">Gamma Release Assay), PPD (Intradermal </span><span style="font-family:Verdana;">Terbuculin Test), TB-DNA-PCR (Tuberculosis-Deoxyribonucleic-Polymerase</span><span style="font-family:Verdana;"> Chain Reaction) and TB-Ab (Tuberculosis-Antibody) in diagnosing silicosis complicated with pulmonary tuberculosis. <b></span></span></span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><b><span style="font-family:Verdana;">Methods</span></b></span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><b><span style="font-family:Verdana;">:</span></b></span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;"></b></span></span></span><span><span><b><span style="font-family:""> </span></b></span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;">53 cases of suspected silicosis complicated with pulmonary tuberculosis were selected in the time span ranging from February 2017 to May 2019. TB-IGRA test, PPD test, TB-DNA-PCR and TB-Ab detection were performed. The sensitivity, specificity, positive predictive value and negative predictive value were calculated. </span></span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;"><b></span></span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><b><span style="font-family:Verdana;">Results</span></b></span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><b><span style="font-family:Verdana;">:</span></b></span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;"></b></span></span></span><span><span><span style="font-family:""> </span></span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;">Silicosis and pulmonary tuberculosis were diagnosed in 11 cases, with an incidence of 20.75%. The positive rates of TB-IGRA, PPD, TB-DNA-PCR and TB-Ab were 66.04%, 30.19%, 5.67% and 26.42%, respectively. The sensitivity was 90.91%, 81.82%, 27.27% and 54.55% respectively. The specificity was 42.86%, 80.95%, 100% and 80.95% respectively. The positive predictive values were 28.57%, 50%, 100% and 42.86% respectively. The negative predictive values were 94.44%, 91.89%, 84% and 87.18%. The positive rate, sensitivity and negative predictive value of TB-IGRA were the highest, while the specificity of TB-DNA-PCR was the highest yet with low positive rate, sensitivity and positive predictive value. </span></span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;"><b></span></span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><b><span style="font-family:Verdana;">Conclusion</span></b></span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><b><span style="font-family:Verdana;">:</span></b></span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;"></b></span></span></span><span><span><b><span style="font-family:""> </span></b></span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;">The positive rate and sensitivity of TB-IGRA were high, yet with poor specificity, so it was impossible to judge whether the cases belonged to active pulmonary tuberculosis. The combination of PPD and TB-DNA-PCR could improve the sensitivity, specificity and positive predictive value, and the diagnostic accuracy of active pulmonary tuberculosis, which showed satisfactory clinical value.
文摘The authors apologize for the erroneous transcription of the average chemical composition data of Apollo lunar soil samples in Table 4.The difference in chemical composition between lunar regolith simulants and actual lunar samples is an important indicator for evaluating their similarity.For comparison,Table 4 lists the chemical compositions of Apollo 12,Apollo 14,Apollo 15,Apollo 16,and other classic lunar regolith simulants.However,the Apollo lunar soil data in the original Table 4 contained errors,which have been corrected in this corrigendum.
基金financially supported by the National Natural Science Foundation of China(No.52475341)the Natural Science Foundation of Heilongjiang Province(No.JQ2022E004)。
文摘Given the limitations of traditional hot extrusion methods in improving the microstructure and mechanical properties of magnesium(Mg)alloys,this paper attempts to treat AZ31 Mg alloy billet by pre-upsetting continuous variable cross-section direct extrusion(U-CVCDE).The effects of dynamic recrystallization behavior and slip system activity on texture evolution and mechanical properties of CVCDE Mg alloys with different pre-upsetting amounts were systematically analyzed.The results indicate that the introduction of the pre-upsetting process promotes dynamic recrystallization during the CVCDE process.The recrystallization proportion shows a trend of first rising and then decreasing with the increase of the pre-upsetting amount.Among them,the proportion of recrystallization grains in the U2-CVCDE-formed structural parts is as high as 88.3%.The average grain sizes of U1-CVCDE,U2-CVCDE,and U3-CVCDE were 6.01μm,4.90μm,and10.45μm,respectively.In addition,following U-CVCDE,the pyramidal slip of each forming component consistently maintains a high level of activation and opening and dominates,making more grains deflect in the axial extrusion direction of C to varying degrees,which is conducive to the uniform distribution of stress in more grains during plastic deformation.The synergistic effect of dynamic recrystallization behavior and the high activity of the pyramidal slip system significantly weakened the(0001)basal texture strength,and the maximum basal texture strength showed a gradually decreasing trend,among which the base surface texture strength of U3-CVCDE formed parts was only 9.9.The U-CVCDE process is employed to achieve deep modification of Mg alloy,and excellent comprehensive mechanical properties are obtained;among them,the yield and tensile strength of U2-CVCDE are as high as 243.4 MPa and 317.5 MPa,respectively,and the elongation after breaking is up to 21.3%.This study introduces a practical new idea for investigating the extrusion forming technology of high-performance Mg alloys.
基金Supported by the Municipal Key Science and Technology Program of Leshan,No.23SZD039National Natural Science Foundation of China,No.82470539.
文摘BACKGROUND Due to their significantly lower incidence than colorectal polyps and macroscopic features resembling those of hyperplastic polyps,rectal neuroendocrine tumors(rNETs)are frequently misdiagnosed and resected as polyps.To date,no reports have been written on the application of artificial intelligence for assisting in the white-light endoscopy of rNETs.AIM To establish a neuroendocrine tumor lesion detection algorithm based on the YOLOv7 model and evaluate the performance of the algorithm in identifying neuroendocrine tumors.METHODS In total,137748 white-light endoscopic images were collected in this study,including 2232 images of rNET,4429 images of submucosal lesions other than rNET,42563 images of polyps,and 88593 images of normal mucosa.All the images were randomly divided into a training set,a validation set,and a test set.To evaluate the ability of the algorithm to diagnose rNETs,we selected 1578 images to form the test set.The performance of the algorithm was compared with that of endoscopists at different levels.RESULTS The accuracy of the algorithm in identifying rNET from all the images was 97.8%,the sensitivity was 72.6%,the specificity was 99.7%,the positive predictive value was 93.9%,and the negative predictive value was 98.1%.CONCLUSION Our model,which was based on YOLOv7,could effectively detect rNET lesions,which was better than that of most endoscopists.
基金Supported by Binzhou Social Science Planning Project(25-SKGH-063)Shandong Agricultural Innovation Team Project(SDAIT-10-06,SDAIT-23-10).
文摘This paper systematically analyzed the development status of sheep industry in Lubei region,and comprehensively expounded the scale and distribution of key industries,breed resources and genetic characteristics,feeding management status,disease prevention and control and veterinary services,and sheep product processing and sales.The research shows that the sheep industry in Lubei region has formed a certain scale,but there are some problems such as intensified resource and environmental constraints,unreasonable industrial structure,insufficient scientific and technological innovation capacity and market competitiveness to be improved.In view of these problems,this paper put forward some countermeasures and suggestions to promote the high-quality development of the industry,including establishing forage and feed system,promoting the adjustment and optimization of industrial structure,strengthening scientific and technological innovation and talent cultivation and introduction,and enhancing brand influence and market competitiveness,providing useful reference for the sustainable development of sheep industry in Lubei region.
基金Supported by the Key R&D Projects of Hainan Province,No.ZDYF2022SHFZ295.
文摘BACKGROUND Schizophrenia(SZ),a chronic and widespread brain disorder,presents with complex etiology and pathogenesis that remain inadequately understood.Despite the absence of a universally recognized endophenotype,peripheral blood mononuclear cells(PBMCs)serve as a robust model for investigating intracellular alterations linked to SZ.AIM To preliminarily investigate potential pathogenic mechanisms and identify novel biomarkers for SZ.METHODS PBMCs from SZ patients were subjected to integrative transcriptomic and proteomic analyses to uncover differentially expressed genes(DEGs)and differentially expressed proteins while mapping putative disease-associated signaling pathways.Key findings were validated using western blot(WB)and real-time fluorescence quantitative PCR(RT-qPCR).RNAi-lentivirus was employed to transfect rat hippocampal CA1 neurons in vitro,with subsequent verification of target gene expression via RT-qPCR.The levels of neuronal conduction proteins,including calmodulin-dependent protein kinase II(caMKII),CREB,and BDNF,were assessed through WB.Apoptosis was quantified by flow cytometry,while cell proliferation and viability were evaluated using the Cell Counting Kit-8 assay.RESULTS The integration of transcriptomic and proteomic analyses identified 6079 co-expressed genes,among which 25 DEGs were significantly altered between the SZ group and healthy controls.Notably,haptoglobin(HP),lactotransferrin(LTF),and SERPING1 exhibited marked upregulation.KEGG pathway enrichment analysis implicated neuroactive ligand-receptor interaction pathways in disease pathogenesis.Clinical sample validation demonstrated elevated protein and mRNA levels of HP,LTF,and SERPING1 in the SZ group compared to controls.WB analysis of all clinical samples further corroborated the significant upregulation of SERPING1.In hippocampal CA1 neurons transfected with lentivirus,reduced SERPING1 expression was accompanied by increased levels of CaMKII,CREB,and BDNF,enhanced cell viability,and reduced apoptosis.CONCLUSION SERPING1 may suppress neural cell proliferation in SZ patients via modulation of the CaMKII-CREB-BDNF signaling pathway.
基金funded by the National Natural Science Foundation of China(No.22379052)Taishan Scholars of Shandong Province,China(No.tsqnz20221143)。
文摘The effects of synthesis conditions,especially the heating rate,on the reaction kinetics of Ni-rich cathodes were systematically studied.The growth rate of Ni-rich oxide increases continuously as the heating rate increases.Ab initio molecular dynamics simulations demonstrate that a high heating rate induces anabatic oscillations,indicating a decrease in thermodynamic stability and a tendency for the crystal surface to undergo reconstruction.The presence of an intermediate phase at the grain boundary amplifies atomic migration-induced interface fusion and consequently augments crystal growth kinetics.However,the excessively high heating rate aggravates the Li+/Ni2+mixing in the Ni-rich cathode.The single-crystal Ni-rich cathode exhibits enhanced structural/thermal stability but a decreased specific capacity and rate performance compared with its polycrystalline counterpart.
基金Project supported by the China Postdoctoral Science Foundation (2023M731268)National Natural Science Foundation of China (51902029)Young Elite Scientists Sponsorship Program by CAST (2022QNRC001)。
文摘Lanthanum ferrite is a representative perovskite-structured rare earth-based bimetallic oxide,which has been widely studied in magnetic materials,sensors,catalysts and batteries.Herein,we designed and prepared polyoxometalate electron acceptor decorated LaFeO_(3)gas-sensitive composite materials with one-dimensional nanoribbons morphology by electrospinning.The effects of different mass fraction of Keggin type phosphotungstic acid(PW_(12)) on the gas-sensitive properties of LaFeO_(3)nanoribbons were investigated.The results show that the response value of LaFeO_(3)/PW_(12)sensor to acetone gas first increases and then decreases with the increase of PW_(12)content.The LaFeO_(3)/3%PW_(12)sensor exhibits a maximum response of 3.35-5 ppm acetone at 250℃,a 2.6 times increase in response value and a 90℃reduction in operating temperature compared to pure LaFeO_(3)nanoribbons.The LaFeO_(3)/3%PW_(12)sensor exhibits good linear relation in ppb-level concentrations and the lowest detection concentration is100 ppb.The sensors also show good repeatability in 6 tests and excellent long-term stability in 30 d.The improvement of the gas sensitive properties of the composite can be attributed to the synergistic effect between the two components.As an electron acceptor,PW_(12) promotes carrier migration between PW_(12)and LaFeO_(3),thereby improving the gas sensing performance of LaFeO_(3).This work promotes the practical application of polyoxometalate to promote rare earth-based gas sensitive materials in sensing field.
基金supported by the National Natural Science Foundation of China(Grant No 52401209,52192603,52275308)Fundamental Research Funds for the Central Universities(2023JG007)。
文摘This study systematically investigates the unusual tensile mechanical behavior of Mg-RE solid solution(SS)alloys,exhibiting anomalous tensile strengths(ATS)and an enhanced strain-hardening rate at high temperature.Both the peak ultimate tensile strength(UTS)and tensile yield strength(TYS)values occur at 150-200℃,which are 12-50%higher compared to those at room temperature(RT).Meanwhile,the strain-hardening rate increases with the temperature rising from RT to 200℃ during the plastic deformation process.The results reveal that the formation of stacking faults(SFs)and the locking of dislocations,particularly immobile (c) partial dislocations,enhance resistance to plastic deformation,leading to higher strengths at high temperature.Furthermore,the interactivity between SFs and (c+a) dislocations intensify with rising of temperature.The presence of RE atoms in the SS plays a critical role in this unique mechanical behavior,as they preferentially occupy non-basal planes rather than basal planes,thereby reducing the stacking fault(SF)formation energy.This study provides new insights into the high-temperature strengthening mechanisms of Mg-RE based alloys,offering potential guidance for the design of advanced lightweight materials with superior mechanical properties.
基金supported by the National Natural Science Foundation of China(Nos.22379052,22479062 and 52102252)Taishan Scholars of Shandong Province(No.tsqnz20221143)Independent Cultivation Program of Innovation Team of Ji’nan City(No.202333042).
文摘The unique oxygen stacking sequence of O2-type structures restricts the irreversible transition metal movement into Li vacancies for the delithiated Li-rich layered oxides(LLOs)and maintains outstanding voltage stability.However,the ion-exchange synthesis promotes the Mn-ion valence reduction and aggravates the Jahn-Teller(J-T)distortion alongside disproportionation.Since the main oxidation state of the Mn ions is+4 in the traditional O3-type LLOs,synergistic effects of the O2-type and O3-type structures are expected in the O2/O3 diphasic Li-rich material.Herein,O2/O3 biphasic intergrowth LLOs were rationally designed,and the synergic optimization of the biphasic structure was planned to retard the J-T effect.The O2/O3 intergrowth nature was confirmed,and the percentages of the O2 and O3 phases were 56%and 44%,respectively.Density functional theory calculations demonstrated that the Mn^(2+)(EC)sheath had a remarkably lower energy barrier than the Li^(+)(EC)sheath.This finding suggests that Mn^(2+)ions that are dissolved into the electrolyte accelerate the electrolyte oxidization,so the deposition of the cathode electrolyte interface for pristine O2-LLOs causes a high electrochemical impedance.The designed O2/O3 biphasic LLOs boost the capacity stability and suppress the voltage drop upon repeated Li^(+)de-intercalation.The phase regulation strategy offers great potential for developing low-cost LLOs with enhanced structural stability for advanced Li-ion batteries.
基金supported by the National Natural Science Foundation of China(No.22068031)Yunnan Precious Metals Laboratory Science and Technology Project(No.YPML-2022050237)+4 种基金Major Science and Technology Project of Yunnan Precious Metal Laboratory(No.YPML-2023050202)the Science and Technology Project of Xinjiang Bingtuan supported by Central Government(No.2022BC001)Tianshan Talents Training Program of Xinjiang Science and Technology Innovation Team(No.2022TSYCTD0021)the Start-Up Foundation for Young Scientists of Shihezi University(No.RCZK202419)the Project of Achievement Transformation and Technology Extension of Shihezi University(No.CGZH202302)。
文摘Introducing ligand into the surface of gold(Au)-based catalyst has been recognized as an efficient strategy to enhance the performance of catalyst in acetylene hydrochlorination reaction.However,due to the multifactorial deactivation,the usage of single type of ligand has limitations on the performance improvement.In this work,two types of ligands including a molecular 2-methylimidazole and an ionic cetrimonium are selected to protect Au^(n+)species.After kinetics analysis,advanced characterization,and density functional theory simulation,we demonstrate the optimal interaction model between two ligands and Au species:Two 2-methylimidazole molecules are coordinated with high-valent Au species while cetrimonium is interacted via electrostatic interaction.Except the synergistic effect in the decrease of Au species reduction and agglomeration,the existence of molecular ligand greatly increases the adsorption of hydrogen chloride while the ionic ligand significantly inhibits the deposition of coke.Due to the positive effect of dual-ligands,we achieved 97.1%of acetylene conversion and 0.29 h^(−1) of deactivation rate under high gas hourly space velocity of acetylene.This work establishes a foundation to explore the property-activity relationships in Au-based catalyst via ligand engineering.
