Cerebral small vessel disease(CSVD),a chronic and progressive vascular disorder closely associated with stroke and dementia,is primarily identified and diagnosed in cranial magnetic resonance imaging(MRI).Given the li...Cerebral small vessel disease(CSVD),a chronic and progressive vascular disorder closely associated with stroke and dementia,is primarily identified and diagnosed in cranial magnetic resonance imaging(MRI).Given the limited evidence on the relationship between air pollution and CSVD,this study aimed to investigate the links between multiple air pollutants exposure and CSVD risk.Eligible subjects and their cranial MRI data were obtained from the Multi-modality Medical Imaging Study Based on Kailuan Study,totaling 1216 participants.Ordinal and binary logistic regression models were utilized to evaluate the associations between air pollution exposure and the neuroimaging markers of CSVD.For each interquartile range increase in air pollutant exposure during the examination year,the odds ratios and 95% confidence intervals of the increased white matter hyperintensity burden were 1.45(1.15,1.84)for PM_(2.5),1.72(1.27,2.34)for PM_(10),1.26(1.05,1.51)for SO_(2),1.52(1.16,2.00)for NO_(2),and 1.63(1.26,2.13)for CO.The results remained consistent even when the model was fitted using air pollution from different exposure windows.Furthermore,the estimated effect sizes for the total burden of CSVD were 1.20(1.01,1.43)for PM_(2.5),1.39(1.12,1.74)for PM_(10),1.26(1.03,1.53)for NO_(2),and 1.30(1.08,1.58)for CO.These findings suggest that a positive link between air pollutants exposure and neuroimaging markers of CSVD in the Chinese population,revealing the importance of controlling environmental pollutants to protect the population against cerebral small vessel damage.展开更多
What is already known about this topic?There has been a lack of attention to genitourinary diseases for an extended period,resulting in limited research on the mortality trends of genitourinary diseases in China.What ...What is already known about this topic?There has been a lack of attention to genitourinary diseases for an extended period,resulting in limited research on the mortality trends of genitourinary diseases in China.What is added by this report?This study examines the long-term trend of genitourinary diseases'mortality across Chinese individuals of all genders and in various urban and rural regions.Additionally,it investigates the impact of age-period-cohort effects on this trend.What are the implications for public health practice?It is imperative to address genitourinary diseases,particularly among vulnerable populations such as rural older men.Policymakers should prioritize these individuals by providing necessary policy interventions and healthcare support.展开更多
基金supported by the National Natural Science Foundation of China(grant 82304231)Natural Science Foundation of Hubei Province(grant 2022CFB621).
文摘Cerebral small vessel disease(CSVD),a chronic and progressive vascular disorder closely associated with stroke and dementia,is primarily identified and diagnosed in cranial magnetic resonance imaging(MRI).Given the limited evidence on the relationship between air pollution and CSVD,this study aimed to investigate the links between multiple air pollutants exposure and CSVD risk.Eligible subjects and their cranial MRI data were obtained from the Multi-modality Medical Imaging Study Based on Kailuan Study,totaling 1216 participants.Ordinal and binary logistic regression models were utilized to evaluate the associations between air pollution exposure and the neuroimaging markers of CSVD.For each interquartile range increase in air pollutant exposure during the examination year,the odds ratios and 95% confidence intervals of the increased white matter hyperintensity burden were 1.45(1.15,1.84)for PM_(2.5),1.72(1.27,2.34)for PM_(10),1.26(1.05,1.51)for SO_(2),1.52(1.16,2.00)for NO_(2),and 1.63(1.26,2.13)for CO.The results remained consistent even when the model was fitted using air pollution from different exposure windows.Furthermore,the estimated effect sizes for the total burden of CSVD were 1.20(1.01,1.43)for PM_(2.5),1.39(1.12,1.74)for PM_(10),1.26(1.03,1.53)for NO_(2),and 1.30(1.08,1.58)for CO.These findings suggest that a positive link between air pollutants exposure and neuroimaging markers of CSVD in the Chinese population,revealing the importance of controlling environmental pollutants to protect the population against cerebral small vessel damage.
基金the Population and Aging Health Science Program(WH10022023035)the National Key Research and Development Program(SQ2022YFC3600291).
文摘What is already known about this topic?There has been a lack of attention to genitourinary diseases for an extended period,resulting in limited research on the mortality trends of genitourinary diseases in China.What is added by this report?This study examines the long-term trend of genitourinary diseases'mortality across Chinese individuals of all genders and in various urban and rural regions.Additionally,it investigates the impact of age-period-cohort effects on this trend.What are the implications for public health practice?It is imperative to address genitourinary diseases,particularly among vulnerable populations such as rural older men.Policymakers should prioritize these individuals by providing necessary policy interventions and healthcare support.
