以三苯胺衍生物为原料,通过引入不同苯胺衍生物,构建了4种席夫碱荧光探针(FY1—FY4)用于Zn^(2+)的检测,其结构均用1 H NMR进行了表征.实验结果表明,探针FY1—FY4对Zn^(2+)都显示出特异性响应及良好的抗干扰能力.当Zn^(2+)浓度在一定范...以三苯胺衍生物为原料,通过引入不同苯胺衍生物,构建了4种席夫碱荧光探针(FY1—FY4)用于Zn^(2+)的检测,其结构均用1 H NMR进行了表征.实验结果表明,探针FY1—FY4对Zn^(2+)都显示出特异性响应及良好的抗干扰能力.当Zn^(2+)浓度在一定范围内时,探针FY1—FY4的荧光强度与Zn^(2+)浓度均呈良好的线性关系.其中,探针FY2的检测阈值最低,为1.15μmol/L.Job's Plot实验表明,探针FY1—FY4与Zn^(2+)配位的化学计量比约为2∶1.展开更多
OBJECTIVE: To investigate the safety and efficacy of Huatan Jieyu granules in treatment of Parkinson’s disease(PD) patients with sleep disorder identified as symptom pattern of phlegma-heat-stirring wind in terms of ...OBJECTIVE: To investigate the safety and efficacy of Huatan Jieyu granules in treatment of Parkinson’s disease(PD) patients with sleep disorder identified as symptom pattern of phlegma-heat-stirring wind in terms of the theory of Traditional Chinese Medicine.METHODS: In total, 107 Parkinson’s disease patients with sleep disorders identified as symptom pattern of phlegma-heat-stirring wind were selected and randomly divided into the experimental group(55 cases) and the control group(52 cases).Both groups were given basic treatment with prednisone. The experimental group of patients was treated with Huatan Jieyu granules and the control group of patents was treated with only the basic treatment. Treatment lasted for 4 weeks. Sleep polygraph were recorded before the study as well as 3 months and 6 months after treatment.RESULTS: After treated with Huatan Jieyu granules,the total sleep time, and the percentage of non rapid eye movement 2(NREM 2), non rapid eye movement 3(NREM 3) and rapid eye movement(REM)sleep period increased significantly, while the percentage of NREM1 sleep period decreased significantly compared with before treatment(P < 0.05).CONCLUSION: The treatment of PD patients with sleep disorder by Huatan Jieyu granules can improve their sleep structure and their sleep quality.展开更多
文摘以三苯胺衍生物为原料,通过引入不同苯胺衍生物,构建了4种席夫碱荧光探针(FY1—FY4)用于Zn^(2+)的检测,其结构均用1 H NMR进行了表征.实验结果表明,探针FY1—FY4对Zn^(2+)都显示出特异性响应及良好的抗干扰能力.当Zn^(2+)浓度在一定范围内时,探针FY1—FY4的荧光强度与Zn^(2+)浓度均呈良好的线性关系.其中,探针FY2的检测阈值最低,为1.15μmol/L.Job's Plot实验表明,探针FY1—FY4与Zn^(2+)配位的化学计量比约为2∶1.
基金Supported by Clinical Study on Treatment of Parkinson’s Disease with Sleep Disorder in Symptom Pattern of Phlegma-heat-stirring Wind Due to by Huatan Jieyu granules (No.2017-D-YY-70)。
文摘OBJECTIVE: To investigate the safety and efficacy of Huatan Jieyu granules in treatment of Parkinson’s disease(PD) patients with sleep disorder identified as symptom pattern of phlegma-heat-stirring wind in terms of the theory of Traditional Chinese Medicine.METHODS: In total, 107 Parkinson’s disease patients with sleep disorders identified as symptom pattern of phlegma-heat-stirring wind were selected and randomly divided into the experimental group(55 cases) and the control group(52 cases).Both groups were given basic treatment with prednisone. The experimental group of patients was treated with Huatan Jieyu granules and the control group of patents was treated with only the basic treatment. Treatment lasted for 4 weeks. Sleep polygraph were recorded before the study as well as 3 months and 6 months after treatment.RESULTS: After treated with Huatan Jieyu granules,the total sleep time, and the percentage of non rapid eye movement 2(NREM 2), non rapid eye movement 3(NREM 3) and rapid eye movement(REM)sleep period increased significantly, while the percentage of NREM1 sleep period decreased significantly compared with before treatment(P < 0.05).CONCLUSION: The treatment of PD patients with sleep disorder by Huatan Jieyu granules can improve their sleep structure and their sleep quality.
