Nitrogen removal from domestic sewage is usually limited by insufficient carbon source and electron donor.An economical solid carbon source was developed by composition of polyvinyl alcohol,sodium alginate,and corncob...Nitrogen removal from domestic sewage is usually limited by insufficient carbon source and electron donor.An economical solid carbon source was developed by composition of polyvinyl alcohol,sodium alginate,and corncob,which was utilized as external carbon source in the anaerobic anoxic oxic(AAO)-biofilter for the treatment of low carbon-to-nitrogen ratio domestic sewage,and the nitrogen removal was remarkably improved from 63.2%to 96.5%.Furthermore,the effluent chemical oxygen demand maintained at 35 mg/L or even lower,and the total nitrogenwas reduced to less than 2mg/L.Metagenomic analysis demonstrated that the microbial communities responsible for potential denitrification and organic matter degradation in both AAO and the biofilter reactors were mainly composed of Proteobacteria and Bacteroides,respectively.The solid carbon source addition resulted in relatively high abundance of functional enzymes responsible for NO_(3)^(−)-N to NO_(2)^(−)-N con-version in both AAO and the biofilter reactors,thus enabled stable reaction.The carbon source addition during glycolysis primarily led to the increase of genes associated with the metabolic conversion of fructose 1.6P2 to glycerol-3P The reactor maintained high abun-dance of genes related to the tricarboxylic acid cycle,and then guaranteed efficient carbon metabolism.The results indicate that the composite carbon source is feasible for denitri-fication enhancement of AAO-biofilter,which contribute to the theoretical foundation for practical nitrogen removal application.展开更多
Bulk graphene nanofilms feature fast electronic and phonon transport in combination with strong light-matter interaction and thus have great potential for versatile applications,spanning from photonic,electronic,and o...Bulk graphene nanofilms feature fast electronic and phonon transport in combination with strong light-matter interaction and thus have great potential for versatile applications,spanning from photonic,electronic,and optoelectronic devices to charge-stripping and electromagnetic shielding,etc.However,large-area flexible close-stacked graphene nanofilms with a wide thickness range have yet to be reported.Here,we report a polyacrylonitrile-assisted’substrate replacement’strategy to fabricate large-area free-standing graphene oxide/polyacrylonitrile nanofilms(lateral size~20 cm).Linear polyacrylonitrile chains-derived nanochannels promote the escape of gases and enable macro-assembled graphene nanofilms(nMAGs)of 50-600 nm thickness following heat treatment at 3,000℃.The uniform nMAGs exhibit 802-1,540 cm^(2)V-1s-1carrier mobility,4.3-4.7 ps carrier lifetime,and>1,581 W m^(-1)K^(-1)thermal conductivity(n MAG-assembled 10μm-thick films,mMAGs).nMAGs are highly flexible and show no structure damage even after 1.0×10^(5)cycles of folding-unfolding.Furthermore,n MAGs broaden the detection region of graphene/silicon heterojunction from near-infrared to mid-infrared and demonstrate higher absolute electromagnetic interference(EMI)shielding effectiveness than state-of-the-art EMI materials of the same thickness.These results are expected to lead to the broad applications of such bulk nanofilms,especially as micro/nanoelectronic and optoelectronic platforms.展开更多
Graphene oxide(GO),an important chemical precursor of graphene,can stably disperse in aqueous surrounding and undergo aggregation as metal cations introduced.The usual instability of GO with ions is caused by the shie...Graphene oxide(GO),an important chemical precursor of graphene,can stably disperse in aqueous surrounding and undergo aggregation as metal cations introduced.The usual instability of GO with ions is caused by the shielding effect of ions and crosslinking between GO and ions.However,the dynamic stability of GO under ions exchange still remains unclear.Here,we investigated the dynamic dispersion stability of GO with metal ions and observed a redispersion behavior in concentrated Fe3+solution,other than permanent aggregation.The exchange with Fe3+ions drives the reversion of zeta(ζ)potential and enables the redispersion to individual GO-Fe3+complex sheets,following a dynamic electric double layer(EDL)mechanism.It is found that the specifically strong electrostatic shielding effect and coordination attraction between Fe3+and functional oxygen groups allows the selective redispersion of GO in concentrated Fe3+solution.The revealed dynamic dispersion stability complements our understanding on the dispersive stability of GO and can be utilized to fabricate graphene-metal hybrids for rich applications.展开更多
We present two haze removal algorithms for single image based on haziness analysis.One algorithm regards haze as the veil layer,and the other takes haze as the transmission.The former uses the illumination component i...We present two haze removal algorithms for single image based on haziness analysis.One algorithm regards haze as the veil layer,and the other takes haze as the transmission.The former uses the illumination component image obtained by retinex algorithm and the depth information of the original image to remove the veil layer.The latter employs guided filter to obtain the refined haze transmission and separates it from the original image.The main advantages of the proposed methods are that no user interaction is needed and the computing speed is relatively fast.A comparative study and quantitative evaluation with some main existing algorithms demonstrate that similar even better quality results can be obtained by the proposed methods.On the top of haze removal,several applications of the haze transmission including image refocusing,haze simulation,relighting and 2-dimensional(2D)to 3-dimensional(3D) stereoscopic conversion are also implemented.展开更多
In this study,spent WO_(3)/V_(2)O_(5)-TiO_(2) catalysts used for selective catalytic reduction were treated by a hydrometallurgical process to comprehensively recover valuable metallic elements,such as W,V,and Ti.Al a...In this study,spent WO_(3)/V_(2)O_(5)-TiO_(2) catalysts used for selective catalytic reduction were treated by a hydrometallurgical process to comprehensively recover valuable metallic elements,such as W,V,and Ti.Al and Si impurities were preferentially removed by selective micro wave-assisted alkali leaching.W and V were leached by enhanced high-pressure leaching with efficiencies estimated at 95% and 81%.The leaching of W and V followed the nuclear shrinkage model controlled by the combination of product layer diffusion and interfacial chemical reaction.A synergistic extraction was applied to separate W and V using an extractant mixture of di-(2-ethylhexyl)phosphoric acid P204 and the primary amine N1923.The extraction efficiencies of V and W reached 86.5% and 6.3%,respectively,with a separation coefficient(V/W) of 95.30.The product was precipitated after extraction to yield ammonium paratung state(APT) and NH_(4)VO_(3).The TiO_(2)catalyst carrier residue meets commercial specifications for reuse.This comprehensive recovery process with the characteristics of high-pressure leaching and synergistic extraction realizes the resourceful utilization of the spent catalysts.展开更多
In this paper,the results of tests on a 0.76-TW linear transformer driver(LTD)module for Z-pinch research are presented for the first time.Ten LTD cavities,each generating a 1-MA/90-kV pulse on a matched load,were con...In this paper,the results of tests on a 0.76-TW linear transformer driver(LTD)module for Z-pinch research are presented for the first time.Ten LTD cavities,each generating a 1-MA/90-kV pulse on a matched load,were connected in series with a magnetically insulated voltage adder to drive the e-beam diode.Three inner stalks with different radii were tested,and the results indicate that the output parameters of the ten cavities are sensitive to the cathode radii.As an intermediate step,a high-current pulse with 832 kV/912 kA/130 ns was obtained on the e-beam diode.To date,this is the maximum power generated directly by a fast LTD with mega-ampere current output.展开更多
Information flow among auditory and language processing-related regions implicated in the pathophysiology of auditory verbal hallucinations（AVHs） in schizophrenia（SZ） remains unclear. In this study, we used stocha...Information flow among auditory and language processing-related regions implicated in the pathophysiology of auditory verbal hallucinations（AVHs） in schizophrenia（SZ） remains unclear. In this study, we used stochastic dynamic causal modeling（s DCM） to quantify connections among the left dorsolateral prefrontal cortex（inner speech monitoring）, auditory cortex（auditory processing）, hippocampus（memory retrieval）, thalamus（information filtering）, and Broca＇s area（language production） in 17 first-episode drug-na？¨ve SZ patients with AVHs, 15 without AVHs, and 19 healthy controls using resting-state functional magnetic resonance imaging.Finally, we performed receiver operating characteristic（ROC） analysis and correlation analysis between image measures and symptoms. s DCM revealed an increasedsensitivity of auditory cortex to its thalamic afferents and a decrease in hippocampal sensitivity to auditory inputs in SZ patients with AVHs. The area under the ROC curve showed the diagnostic value of these two connections to distinguish SZ patients with AVHs from those without AVHs. Furthermore, we found a positive correlation between the strength of the connectivity from Broca＇s area to the auditory cortex and the severity of AVHs. These findings demonstrate, for the first time, augmented AVHspecific excitatory afferents from the thalamus to the auditory cortex in SZ patients, resulting in auditory perception without external auditory stimuli. Our results provide insights into the neural mechanisms underlying AVHs in SZ. This thalamic-auditory cortical-hippocampal dysconnectivity may also serve as a diagnostic biomarker of AVHs in SZ and a therapeutic target based on direct in vivo evidence.展开更多
The processing capability is vital for the wide applications of materials to forge structures as-demand.Graphene-based macroscopic materials have shown excellent mechanical and functional properties.However,different ...The processing capability is vital for the wide applications of materials to forge structures as-demand.Graphene-based macroscopic materials have shown excellent mechanical and functional properties.However,different from usual polymers and metals,graphene solids exhibit limited deformability and processibility for precise forming.Here,we present a precise thermoplastic forming of graphene materials by polymer intercalation from graphene oxide(GO)precursor.The intercalated polymer enables the thermoplasticity of GO solids by thermally activated motion of polymer chains.We detect a critical minimum containing of intercalated polymer that can expand the interlayer spacing exceeding 1.4 nm to activate thermoplasticity,which becomes the criteria for thermal plastic forming of GO solids.By thermoplastic forming,the flat GO-composite films are forged to Gaussian curved shapes and imprinted to have surface relief patterns with size precision down to 360 nm.The plastic-formed structures maintain the structural integration with outstanding electrical(3.07×10^(5) S m^(−1))and thermal conductivity(745.65 W m^(−1) K^(−1))after removal of polymers.The thermoplastic strategy greatly extends the forming capability of GO materials and other layered materials and promises versatile structural designs for more broad applications.展开更多
In this paper, a calculation model for the breakdown time delay and jitter of gas switches under hundred-nanosecond pulses is proposed and applied in a self-triggered pre-ionized switch. The effects of injection time ...In this paper, a calculation model for the breakdown time delay and jitter of gas switches under hundred-nanosecond pulses is proposed and applied in a self-triggered pre-ionized switch. The effects of injection time of pre-ionization, pulse rise time, and the pre-ionization jitter are discussed and verified through experiments. It indicates that the pre-ionization should be injected when the electric field is high enough in the gap, injection after 80% peak-time can ensure its effectiveness.Then the statistical time delay jitter will be determined by the pre-ionization jitter, which is an intrinsic restriction of the self-triggered switch. However, when the changing rate of the pulsed electric field exceeds a certain value, the breakdown time delay jitter can be partly offset in the formative stage because the formative time delay has an exponential relationship with the electric field. Therefore, lower time jitter can be obtained under pulses with a shorter pulse rise time. In general, the results of the calculation model agree with the experimental results, and the experimental parameters which lead to a low jitter can also be used as a reference.展开更多
Coaxial-disk transitions can generate non-uniform magnetic fields and abrupt impedance variations in magnetically insulated transmission lines(MITLs),resulting in disturbed electron flow and non-negligible current los...Coaxial-disk transitions can generate non-uniform magnetic fields and abrupt impedance variations in magnetically insulated transmission lines(MITLs),resulting in disturbed electron flow and non-negligible current loss.In this paper,3 D particle-in-cell simulations are conducted with UNPIC-3 d to investigate the current loss mechanism and the influence of the input parameters of the coaxial-disk transition on current loss in an MITL system.The results reveal that the magnetic field non-uniformity causes major current loss in the MITL after the coaxialdisk transition,and the non-uniformity decreases with the distance away from the transition.The uniformity of the magnetic field is improved when increasing the number of feed lines of a linear transformer driver-based accelerator with coaxial-disk transitions.The number of input feed lines should be no less than four in the azimuthal distribution to obtain acceptable uniformity of the magnetic field.To make the ratio of the current loss to the total current of the accelerator less than 2%at peak anode current,the ratio of the current in each feed line to the total current should be no less than 8%.展开更多
Background:Chronic kidney disease(CKD)is a global health issue,with renal fibrosis being a common pathway in CKD development.Histone modification plays crucial roles in transcriptional regulation,but their pathologica...Background:Chronic kidney disease(CKD)is a global health issue,with renal fibrosis being a common pathway in CKD development.Histone modification plays crucial roles in transcriptional regulation,but their pathological functions and mechanisms in CKD are not well understood.Methods:We utilized chromatin immunoprecipitation with next-generation DNA sequencing(ChIP-seq)and RNA-seq to evaluate the states and functions of H3 lysine 27 acetylation(H3K27ac)and H3 lysine 4 trimethylation(H3K4me3)in kidney of CKD mice.We identified epigenetic factors regulating H3K27ac through motif analysis.Expression of activating transcription factor 3(ATF3)in CKD mouse models and patients’kidneys was validated via immunofluorescence staining or Western blot.We further generated the Atf3 deficient(Atf3^(-/-)) mice to explore its effect in kidney function and fibrosis.ChIP-seq of H3K27ac from Atf3-/-CKD mice was employed to validate ATF3’s regulatory effects.We explored how ATF3 maintains the state of H3K27ac by integrating the data sources from multiple databases.Results:The states of H3K27ac and H3K4me3 were changed during CKD,and positively correlated with differential gene expression.ATF3 was highly expressed in kidney of both patients and mice with CKD,and co-localized with H3K27ac in genome,epigenetically regulating H3K27ac state.Atf3 deficient in CKD mice significantly ameliorated kidney dysfunction and fibrotic phenotype,and reduced H3K27ac levels at the ATF3 binding sites.Mechanically,ATF3 may facilitate H3K27ac maintenance by corrodinating histone acetyltransferase(HATs)-associated regulatory machinery during CKD.Conclusion:ATF3 promotes kidney injury and fibrosis in CKD by maintaining the state of H3k27ac via coordinating HATs regulatory machinery.展开更多
Engineering nonmetallic atom-doped metal-organic framework(MOF)catalyst to promote C−C coupling and realize conversion of CO_(2) into C_(2 )multi-carbon hydrocarbon products is still challenging.Herein,with 2-methylim...Engineering nonmetallic atom-doped metal-organic framework(MOF)catalyst to promote C−C coupling and realize conversion of CO_(2) into C_(2 )multi-carbon hydrocarbon products is still challenging.Herein,with 2-methylimidazole as a dopant of N element,an N-doped NH_(2)-CuBDC catalyst was obtained via a facile and simple stirring procedure.Upon illumination,compared with catalytic CO_(2) reduction to C1 product of CO by original MOF,N-doped NH_(2)-CuBDC can motivate generation of C_(2)H_(4),which is difficult to achieve in photocatalytic system by MOF-based catalysts.The transfer rates of photo-generated charges have been expedited due to the high electron density around Cu catalytic sites after N-doping.More importantly,C–C coupling intermediate CO–CHO*was identified by in situ Fourier transform infrared spectroscopy during the catalytic CO_(2) reduction reaction process,which further indicates the presence of Cu–N sites in the NH_(2)-CuBDC can facilitate the formation of C2H_(4) effectively.This work uncovers a new paradigm to design photocatalysts for enhancing the reduction of CO_(2) to C_(2) products.展开更多
基金supported by the Special Funds for Chengde national innovation demonstration area construction of science and technology special project sustainable development agenda(No.202104F001)the National Basic Research Program of China(No.2019YFC0408602).
文摘Nitrogen removal from domestic sewage is usually limited by insufficient carbon source and electron donor.An economical solid carbon source was developed by composition of polyvinyl alcohol,sodium alginate,and corncob,which was utilized as external carbon source in the anaerobic anoxic oxic(AAO)-biofilter for the treatment of low carbon-to-nitrogen ratio domestic sewage,and the nitrogen removal was remarkably improved from 63.2%to 96.5%.Furthermore,the effluent chemical oxygen demand maintained at 35 mg/L or even lower,and the total nitrogenwas reduced to less than 2mg/L.Metagenomic analysis demonstrated that the microbial communities responsible for potential denitrification and organic matter degradation in both AAO and the biofilter reactors were mainly composed of Proteobacteria and Bacteroides,respectively.The solid carbon source addition resulted in relatively high abundance of functional enzymes responsible for NO_(3)^(−)-N to NO_(2)^(−)-N con-version in both AAO and the biofilter reactors,thus enabled stable reaction.The carbon source addition during glycolysis primarily led to the increase of genes associated with the metabolic conversion of fructose 1.6P2 to glycerol-3P The reactor maintained high abun-dance of genes related to the tricarboxylic acid cycle,and then guaranteed efficient carbon metabolism.The results indicate that the composite carbon source is feasible for denitri-fication enhancement of AAO-biofilter,which contribute to the theoretical foundation for practical nitrogen removal application.
基金supported by the National Natural Science Foundation of China(No.52090030)the China Postdoctoral Science Foundation(2022T150558,2020M681819)+1 种基金the Fundamental Research Funds for the Central Universities(No.2021FZZX001-17)the Postdoctoral Research Program of Zhejiang Province(ZJ2021145).
文摘Bulk graphene nanofilms feature fast electronic and phonon transport in combination with strong light-matter interaction and thus have great potential for versatile applications,spanning from photonic,electronic,and optoelectronic devices to charge-stripping and electromagnetic shielding,etc.However,large-area flexible close-stacked graphene nanofilms with a wide thickness range have yet to be reported.Here,we report a polyacrylonitrile-assisted’substrate replacement’strategy to fabricate large-area free-standing graphene oxide/polyacrylonitrile nanofilms(lateral size~20 cm).Linear polyacrylonitrile chains-derived nanochannels promote the escape of gases and enable macro-assembled graphene nanofilms(nMAGs)of 50-600 nm thickness following heat treatment at 3,000℃.The uniform nMAGs exhibit 802-1,540 cm^(2)V-1s-1carrier mobility,4.3-4.7 ps carrier lifetime,and>1,581 W m^(-1)K^(-1)thermal conductivity(n MAG-assembled 10μm-thick films,mMAGs).nMAGs are highly flexible and show no structure damage even after 1.0×10^(5)cycles of folding-unfolding.Furthermore,n MAGs broaden the detection region of graphene/silicon heterojunction from near-infrared to mid-infrared and demonstrate higher absolute electromagnetic interference(EMI)shielding effectiveness than state-of-the-art EMI materials of the same thickness.These results are expected to lead to the broad applications of such bulk nanofilms,especially as micro/nanoelectronic and optoelectronic platforms.
基金supported by the National Natural Science Foundation of China(Nos.51533008,51603183,51703194,51803177,21805242 and 5197030056)National Key R&D Program of China(No.2016YFA0200200)+4 种基金Fujian Provincial Science and Technology Major Projects(No.2018HZ0001-2)Hundred Talents Program of Zhejiang University(No.188020*194231701/113)Key Research and Development Plan of Zhejiang Province(No.2018C01049)the Fundamental Research Funds for the Central Universities(Nos.2017QNA4036,2017XZZX001-04)Foundation of National Key Laboratory on Electromagnetic Environment Effects(No.614220504030717)。
文摘Graphene oxide(GO),an important chemical precursor of graphene,can stably disperse in aqueous surrounding and undergo aggregation as metal cations introduced.The usual instability of GO with ions is caused by the shielding effect of ions and crosslinking between GO and ions.However,the dynamic stability of GO under ions exchange still remains unclear.Here,we investigated the dynamic dispersion stability of GO with metal ions and observed a redispersion behavior in concentrated Fe3+solution,other than permanent aggregation.The exchange with Fe3+ions drives the reversion of zeta(ζ)potential and enables the redispersion to individual GO-Fe3+complex sheets,following a dynamic electric double layer(EDL)mechanism.It is found that the specifically strong electrostatic shielding effect and coordination attraction between Fe3+and functional oxygen groups allows the selective redispersion of GO in concentrated Fe3+solution.The revealed dynamic dispersion stability complements our understanding on the dispersive stability of GO and can be utilized to fabricate graphene-metal hybrids for rich applications.
基金supported by National Natural Science Foundation of China(Nos.91220301,61175064 and 61273314)Postdoctoral Science Foundation of Central South University(No.126648)New Teacher Fund for School of Information Science and Engineering,Central South University(No.2012170301)
文摘We present two haze removal algorithms for single image based on haziness analysis.One algorithm regards haze as the veil layer,and the other takes haze as the transmission.The former uses the illumination component image obtained by retinex algorithm and the depth information of the original image to remove the veil layer.The latter employs guided filter to obtain the refined haze transmission and separates it from the original image.The main advantages of the proposed methods are that no user interaction is needed and the computing speed is relatively fast.A comparative study and quantitative evaluation with some main existing algorithms demonstrate that similar even better quality results can be obtained by the proposed methods.On the top of haze removal,several applications of the haze transmission including image refocusing,haze simulation,relighting and 2-dimensional(2D)to 3-dimensional(3D) stereoscopic conversion are also implemented.
基金financially supported by Beijing Natural Science Foundation (No. 2222049)the National Natural Science Foundation of China (Nos. 52025042 and 51621003)National Key R&D Program of China (No. 2018YFC1901700)。
文摘In this study,spent WO_(3)/V_(2)O_(5)-TiO_(2) catalysts used for selective catalytic reduction were treated by a hydrometallurgical process to comprehensively recover valuable metallic elements,such as W,V,and Ti.Al and Si impurities were preferentially removed by selective micro wave-assisted alkali leaching.W and V were leached by enhanced high-pressure leaching with efficiencies estimated at 95% and 81%.The leaching of W and V followed the nuclear shrinkage model controlled by the combination of product layer diffusion and interfacial chemical reaction.A synergistic extraction was applied to separate W and V using an extractant mixture of di-(2-ethylhexyl)phosphoric acid P204 and the primary amine N1923.The extraction efficiencies of V and W reached 86.5% and 6.3%,respectively,with a separation coefficient(V/W) of 95.30.The product was precipitated after extraction to yield ammonium paratung state(APT) and NH_(4)VO_(3).The TiO_(2)catalyst carrier residue meets commercial specifications for reuse.This comprehensive recovery process with the characteristics of high-pressure leaching and synergistic extraction realizes the resourceful utilization of the spent catalysts.
基金the financial support from the National Natural Science Foundation of China(Grant No.51907181).
文摘In this paper,the results of tests on a 0.76-TW linear transformer driver(LTD)module for Z-pinch research are presented for the first time.Ten LTD cavities,each generating a 1-MA/90-kV pulse on a matched load,were connected in series with a magnetically insulated voltage adder to drive the e-beam diode.Three inner stalks with different radii were tested,and the results indicate that the output parameters of the ten cavities are sensitive to the cathode radii.As an intermediate step,a high-current pulse with 832 kV/912 kA/130 ns was obtained on the e-beam diode.To date,this is the maximum power generated directly by a fast LTD with mega-ampere current output.
基金supported by the National Key Basic Research and Development Program(973)(2011CB707805)the National Natural Science Foundation of China(81571651,81301199,and 81230035)the Fund for the Dissertation Submitted to Fourth Military Medical University for the Academic Degree of Doctor,China(2014D07)
文摘Information flow among auditory and language processing-related regions implicated in the pathophysiology of auditory verbal hallucinations（AVHs） in schizophrenia（SZ） remains unclear. In this study, we used stochastic dynamic causal modeling（s DCM） to quantify connections among the left dorsolateral prefrontal cortex（inner speech monitoring）, auditory cortex（auditory processing）, hippocampus（memory retrieval）, thalamus（information filtering）, and Broca＇s area（language production） in 17 first-episode drug-na？¨ve SZ patients with AVHs, 15 without AVHs, and 19 healthy controls using resting-state functional magnetic resonance imaging.Finally, we performed receiver operating characteristic（ROC） analysis and correlation analysis between image measures and symptoms. s DCM revealed an increasedsensitivity of auditory cortex to its thalamic afferents and a decrease in hippocampal sensitivity to auditory inputs in SZ patients with AVHs. The area under the ROC curve showed the diagnostic value of these two connections to distinguish SZ patients with AVHs from those without AVHs. Furthermore, we found a positive correlation between the strength of the connectivity from Broca＇s area to the auditory cortex and the severity of AVHs. These findings demonstrate, for the first time, augmented AVHspecific excitatory afferents from the thalamus to the auditory cortex in SZ patients, resulting in auditory perception without external auditory stimuli. Our results provide insights into the neural mechanisms underlying AVHs in SZ. This thalamic-auditory cortical-hippocampal dysconnectivity may also serve as a diagnostic biomarker of AVHs in SZ and a therapeutic target based on direct in vivo evidence.
基金the support of the National Natural Science Foundation of China(Nos.51803177,51973191,51533008,and 51636002)National Key R&D Program of China(No.2016YFA0200200)+5 种基金the China Postdoctoral Science Foundation(No.2021M690134)Hundred Talents Program of Zhejiang University(188020*194231701/113)Key Research and Development Plan of Zhejiang Province(2018C01049)the National Postdoctoral Program for Innovative Talents(No.BX201700209)the Fundamental Research Funds for the Central Universities(2021FZZX001-17),the Natural Science Foundation of Jiangsu Province(BK20210353)the Fundamental Research Funds for the Central Universities(No.30920041106).
文摘The processing capability is vital for the wide applications of materials to forge structures as-demand.Graphene-based macroscopic materials have shown excellent mechanical and functional properties.However,different from usual polymers and metals,graphene solids exhibit limited deformability and processibility for precise forming.Here,we present a precise thermoplastic forming of graphene materials by polymer intercalation from graphene oxide(GO)precursor.The intercalated polymer enables the thermoplasticity of GO solids by thermally activated motion of polymer chains.We detect a critical minimum containing of intercalated polymer that can expand the interlayer spacing exceeding 1.4 nm to activate thermoplasticity,which becomes the criteria for thermal plastic forming of GO solids.By thermoplastic forming,the flat GO-composite films are forged to Gaussian curved shapes and imprinted to have surface relief patterns with size precision down to 360 nm.The plastic-formed structures maintain the structural integration with outstanding electrical(3.07×10^(5) S m^(−1))and thermal conductivity(745.65 W m^(−1) K^(−1))after removal of polymers.The thermoplastic strategy greatly extends the forming capability of GO materials and other layered materials and promises versatile structural designs for more broad applications.
文摘In this paper, a calculation model for the breakdown time delay and jitter of gas switches under hundred-nanosecond pulses is proposed and applied in a self-triggered pre-ionized switch. The effects of injection time of pre-ionization, pulse rise time, and the pre-ionization jitter are discussed and verified through experiments. It indicates that the pre-ionization should be injected when the electric field is high enough in the gap, injection after 80% peak-time can ensure its effectiveness.Then the statistical time delay jitter will be determined by the pre-ionization jitter, which is an intrinsic restriction of the self-triggered switch. However, when the changing rate of the pulsed electric field exceeds a certain value, the breakdown time delay jitter can be partly offset in the formative stage because the formative time delay has an exponential relationship with the electric field. Therefore, lower time jitter can be obtained under pulses with a shorter pulse rise time. In general, the results of the calculation model agree with the experimental results, and the experimental parameters which lead to a low jitter can also be used as a reference.
基金supported by National Natural Science Foundation of China(Nos.U1530133 and 52007152)the Special Foundation of State Key Laboratory of Intense Pulsed Radiation Simulation and Effect(No.SKLIPR2005)the Youth Innovation Team of Shaanxi Universities。
文摘Coaxial-disk transitions can generate non-uniform magnetic fields and abrupt impedance variations in magnetically insulated transmission lines(MITLs),resulting in disturbed electron flow and non-negligible current loss.In this paper,3 D particle-in-cell simulations are conducted with UNPIC-3 d to investigate the current loss mechanism and the influence of the input parameters of the coaxial-disk transition on current loss in an MITL system.The results reveal that the magnetic field non-uniformity causes major current loss in the MITL after the coaxialdisk transition,and the non-uniformity decreases with the distance away from the transition.The uniformity of the magnetic field is improved when increasing the number of feed lines of a linear transformer driver-based accelerator with coaxial-disk transitions.The number of input feed lines should be no less than four in the azimuthal distribution to obtain acceptable uniformity of the magnetic field.To make the ratio of the current loss to the total current of the accelerator less than 2%at peak anode current,the ratio of the current in each feed line to the total current should be no less than 8%.
基金supported by grants from the 1.3.5 project for disciplines of excellence from West China Hospital of Sichuan University(No.ZYGD23015)National Natural Science Foundation of China(No.32100927)+1 种基金Sichuan Science and Technology Program(No.2023NSFSC1598)Chengdu Municipal Science and Technology Bureau Program(No.2022-YF05-01538-SN).
文摘Background:Chronic kidney disease(CKD)is a global health issue,with renal fibrosis being a common pathway in CKD development.Histone modification plays crucial roles in transcriptional regulation,but their pathological functions and mechanisms in CKD are not well understood.Methods:We utilized chromatin immunoprecipitation with next-generation DNA sequencing(ChIP-seq)and RNA-seq to evaluate the states and functions of H3 lysine 27 acetylation(H3K27ac)and H3 lysine 4 trimethylation(H3K4me3)in kidney of CKD mice.We identified epigenetic factors regulating H3K27ac through motif analysis.Expression of activating transcription factor 3(ATF3)in CKD mouse models and patients’kidneys was validated via immunofluorescence staining or Western blot.We further generated the Atf3 deficient(Atf3^(-/-)) mice to explore its effect in kidney function and fibrosis.ChIP-seq of H3K27ac from Atf3-/-CKD mice was employed to validate ATF3’s regulatory effects.We explored how ATF3 maintains the state of H3K27ac by integrating the data sources from multiple databases.Results:The states of H3K27ac and H3K4me3 were changed during CKD,and positively correlated with differential gene expression.ATF3 was highly expressed in kidney of both patients and mice with CKD,and co-localized with H3K27ac in genome,epigenetically regulating H3K27ac state.Atf3 deficient in CKD mice significantly ameliorated kidney dysfunction and fibrotic phenotype,and reduced H3K27ac levels at the ATF3 binding sites.Mechanically,ATF3 may facilitate H3K27ac maintenance by corrodinating histone acetyltransferase(HATs)-associated regulatory machinery during CKD.Conclusion:ATF3 promotes kidney injury and fibrosis in CKD by maintaining the state of H3k27ac via coordinating HATs regulatory machinery.
基金supported by the National Natural Science Foundation of China (22101246, 22231006, and 22171131)supported by a Project Funded by the Priority Academic Program Development of Jiangsu Higher Education Institutions
文摘Engineering nonmetallic atom-doped metal-organic framework(MOF)catalyst to promote C−C coupling and realize conversion of CO_(2) into C_(2 )multi-carbon hydrocarbon products is still challenging.Herein,with 2-methylimidazole as a dopant of N element,an N-doped NH_(2)-CuBDC catalyst was obtained via a facile and simple stirring procedure.Upon illumination,compared with catalytic CO_(2) reduction to C1 product of CO by original MOF,N-doped NH_(2)-CuBDC can motivate generation of C_(2)H_(4),which is difficult to achieve in photocatalytic system by MOF-based catalysts.The transfer rates of photo-generated charges have been expedited due to the high electron density around Cu catalytic sites after N-doping.More importantly,C–C coupling intermediate CO–CHO*was identified by in situ Fourier transform infrared spectroscopy during the catalytic CO_(2) reduction reaction process,which further indicates the presence of Cu–N sites in the NH_(2)-CuBDC can facilitate the formation of C2H_(4) effectively.This work uncovers a new paradigm to design photocatalysts for enhancing the reduction of CO_(2) to C_(2) products.
