This study begins with the fabrication and simulation of high-performance back-illuminated AlGaN-based solar-blind ultraviolet(UV)photodetectors.Based on the photodetectors,a low-noise,high-gain UV detection system ci...This study begins with the fabrication and simulation of high-performance back-illuminated AlGaN-based solar-blind ultraviolet(UV)photodetectors.Based on the photodetectors,a low-noise,high-gain UV detection system circuit is designed and fabricated,enabling the detection,acquisition,and calibration of weak solar-blind UV signals.Experimental results demonstrate that under zero bias conditions,with a UV light power density of 3.45μW/cm^(2) at 260 nm,the sample achieves a peak responsivity(R)of 0.085 A·W^(−1),an external quantum efficiency(EQE)of 40.7%,and a detectivity(D^(*))of 7.46×10^(12) cm·Hz^(1/2)·W^(−1).The system exhibits a bandpass characteristic within the 240–280 nm wavelength range,coupled with a high signal-to-noise ratio(SNR)of 39.74 dB.展开更多
为探索胃癌中BICC1基因表达水平的临床预后意义及其在胃癌进展中的功能,通过分析肿瘤基因组图谱计划(the cancer genome atlas program,TCGA)中BICC1在胃癌及癌旁组织中转录水平表达的差异,回顾性研究了BICC1转录表达水平与临床病理特...为探索胃癌中BICC1基因表达水平的临床预后意义及其在胃癌进展中的功能,通过分析肿瘤基因组图谱计划(the cancer genome atlas program,TCGA)中BICC1在胃癌及癌旁组织中转录水平表达的差异,回顾性研究了BICC1转录表达水平与临床病理特征及预后之间的关系。利用单样本基因集富集分析(single sample gene set enrichment analysis,ss GSEA)研究BICC1高表达与肿瘤免疫细胞浸润的相关性,用基因集富集分析(gene set enrichment analysis,GSEA)研究胃癌中BICC1高表达相关的信号通路。TCGA泛癌的数据集分析结果表明,多种肿瘤组织中BICC1的mRNA相对表达量显著高于癌旁组织(P<0.01)。进行Wilcoxon秩和检验和logistic回归分析,认为胃癌BICC1转录水平的高表达与肿瘤原发灶大小、Lauren分型、肿瘤分化期、人种等特征均显著相关(P<0.05)。通过Kaplan-Meier生存分析和多因素Cox回归,认为胃癌BICC1的高表达与患者更差的总生存期(overall survival,OS)显著相关(P<0.05),是影响总生存期的独立风险因素之一。通过ssGSEA分析,认为BICC1的表达与自然杀伤细胞、巨噬细胞、未成熟树突状细胞(immature dendritic cells,iDCs)、效应型记忆T细胞(effector memory T cells,Tem)浸润水平具有显著相关性(P<0.001)。通过GSEA分析,认为BICC1的高表达与肿瘤细胞TGF-β1、MAPK、Wnt、JAK-STAT和mTOR等信号通路显著富集有关(FDR<0.25,P<0.05)。综上所述,BICC1转录水平高表达与影响胃癌进展的恶性表型密切相关,其可能是一个可预测胃癌预后的独立风险因素。展开更多
基金supported by the Director’s Fund for the‘Climbing Plan’of the National Space Science Centre of the Chinese Academy of Sciences(No.E2PD10011S)the National Engineering Research Centre for Mobile Private Networks Project(No.BJTU20221102).
文摘This study begins with the fabrication and simulation of high-performance back-illuminated AlGaN-based solar-blind ultraviolet(UV)photodetectors.Based on the photodetectors,a low-noise,high-gain UV detection system circuit is designed and fabricated,enabling the detection,acquisition,and calibration of weak solar-blind UV signals.Experimental results demonstrate that under zero bias conditions,with a UV light power density of 3.45μW/cm^(2) at 260 nm,the sample achieves a peak responsivity(R)of 0.085 A·W^(−1),an external quantum efficiency(EQE)of 40.7%,and a detectivity(D^(*))of 7.46×10^(12) cm·Hz^(1/2)·W^(−1).The system exhibits a bandpass characteristic within the 240–280 nm wavelength range,coupled with a high signal-to-noise ratio(SNR)of 39.74 dB.
文摘为探索胃癌中BICC1基因表达水平的临床预后意义及其在胃癌进展中的功能,通过分析肿瘤基因组图谱计划(the cancer genome atlas program,TCGA)中BICC1在胃癌及癌旁组织中转录水平表达的差异,回顾性研究了BICC1转录表达水平与临床病理特征及预后之间的关系。利用单样本基因集富集分析(single sample gene set enrichment analysis,ss GSEA)研究BICC1高表达与肿瘤免疫细胞浸润的相关性,用基因集富集分析(gene set enrichment analysis,GSEA)研究胃癌中BICC1高表达相关的信号通路。TCGA泛癌的数据集分析结果表明,多种肿瘤组织中BICC1的mRNA相对表达量显著高于癌旁组织(P<0.01)。进行Wilcoxon秩和检验和logistic回归分析,认为胃癌BICC1转录水平的高表达与肿瘤原发灶大小、Lauren分型、肿瘤分化期、人种等特征均显著相关(P<0.05)。通过Kaplan-Meier生存分析和多因素Cox回归,认为胃癌BICC1的高表达与患者更差的总生存期(overall survival,OS)显著相关(P<0.05),是影响总生存期的独立风险因素之一。通过ssGSEA分析,认为BICC1的表达与自然杀伤细胞、巨噬细胞、未成熟树突状细胞(immature dendritic cells,iDCs)、效应型记忆T细胞(effector memory T cells,Tem)浸润水平具有显著相关性(P<0.001)。通过GSEA分析,认为BICC1的高表达与肿瘤细胞TGF-β1、MAPK、Wnt、JAK-STAT和mTOR等信号通路显著富集有关(FDR<0.25,P<0.05)。综上所述,BICC1转录水平高表达与影响胃癌进展的恶性表型密切相关,其可能是一个可预测胃癌预后的独立风险因素。
