目的运用文献计量学方法系统解析银杏内酯药理作用研究的演进轨迹、知识结构与前沿热点,为深化药理机制研究及临床转化提供循证依据。方法基于中国学术期刊全文数据库(CNKI)和Web of Science核心合集数据库,系统检索建库至2025年2月20...目的运用文献计量学方法系统解析银杏内酯药理作用研究的演进轨迹、知识结构与前沿热点,为深化药理机制研究及临床转化提供循证依据。方法基于中国学术期刊全文数据库(CNKI)和Web of Science核心合集数据库,系统检索建库至2025年2月20日收录的银杏内酯药理作用相关文献,纳入中英文文献1000篇(中文751篇、英文249篇),运用Cite Space 6.2.R4和VOSviewer软件进行多维度计量分析,构建作者、期刊、机构、国家合作图谱及关键词共现、聚类、演进图谱。结果研究呈现显著阶段性特征,年均发文量由2000年前的不足3篇增长至2025年的79篇。发文期刊聚焦药学领域,《中国中药杂志》《中国药理学通报》及Journal of Ethnopharmacology为核心载体,3刊累计发文量占比达21.3%。科研合作网络分析显示,以肖伟(江苏康缘药业)、王振中(南京中医药大学)及谢鹏(澳门大学)为核心的跨学科团队形成3大研究集群。关键词共现网络识别出“神经保护”“氧化应激”“血脑屏障”等核心节点,时区图检测发现“肥胖”“认知障碍”“衰老”“抗癌”等为新兴研究热点。结论近30年来银杏内酯研究呈现从基础药理向临床转化、从单一机制向多组学整合的研究范式转变。当前热点集中于神经保护及脑卒中的治疗与预后领域。未来重点攻关方向包括分子机制的精准解析和银杏内酯递药系统的创新设计。展开更多
Verticillium wilt,caused by the infamous pathogen Verticillium dahliae,presents a primary constraint on cotton cul-tivation worldwide.The complexity of disease resistance in cotton and the largely unexplored interacti...Verticillium wilt,caused by the infamous pathogen Verticillium dahliae,presents a primary constraint on cotton cul-tivation worldwide.The complexity of disease resistance in cotton and the largely unexplored interaction dynamics between the cotton plant host and V.dahliae pathogen pose a crucial predicament for effectively managing cotton Verticillium wilt.Nevertheless,the most cost-effective approach to controlling this disease involves breeding and cul-tivating resistant cotton varieties,demanding a meticulous analysis of the mechanisms underlying cotton’s resistance to Verticillium wilt and the identification of pivotal genes.These aspects constitute focal points in disease-resistance breeding programs.In this review,we comprehensively discuss genetic inheritance associated with Verticillium wilt resistance in cotton,the advancements in molecular markers for disease resistance,the functional investiga-tion of resistance genes in cotton,the analysis of pathogenicity genes in V.dahliae,as well as the intricate interplay between cotton and this fungus.Moreover,we delve into the future prospects of cutting-edge research on cotton Verticillium wilt,aiming to proffer valuable insights for the effective management of this devastating fungus.展开更多
文摘目的运用文献计量学方法系统解析银杏内酯药理作用研究的演进轨迹、知识结构与前沿热点,为深化药理机制研究及临床转化提供循证依据。方法基于中国学术期刊全文数据库(CNKI)和Web of Science核心合集数据库,系统检索建库至2025年2月20日收录的银杏内酯药理作用相关文献,纳入中英文文献1000篇(中文751篇、英文249篇),运用Cite Space 6.2.R4和VOSviewer软件进行多维度计量分析,构建作者、期刊、机构、国家合作图谱及关键词共现、聚类、演进图谱。结果研究呈现显著阶段性特征,年均发文量由2000年前的不足3篇增长至2025年的79篇。发文期刊聚焦药学领域,《中国中药杂志》《中国药理学通报》及Journal of Ethnopharmacology为核心载体,3刊累计发文量占比达21.3%。科研合作网络分析显示,以肖伟(江苏康缘药业)、王振中(南京中医药大学)及谢鹏(澳门大学)为核心的跨学科团队形成3大研究集群。关键词共现网络识别出“神经保护”“氧化应激”“血脑屏障”等核心节点,时区图检测发现“肥胖”“认知障碍”“衰老”“抗癌”等为新兴研究热点。结论近30年来银杏内酯研究呈现从基础药理向临床转化、从单一机制向多组学整合的研究范式转变。当前热点集中于神经保护及脑卒中的治疗与预后领域。未来重点攻关方向包括分子机制的精准解析和银杏内酯递药系统的创新设计。
基金supported by National Natural Science Foundation of China(32201752)Xinjiang Tianchi Talents Program (TCYC2023TP02)Key Project of the Natural Science Foundation of Xinjiang Production and Construction Corps (2024DA001)
文摘Verticillium wilt,caused by the infamous pathogen Verticillium dahliae,presents a primary constraint on cotton cul-tivation worldwide.The complexity of disease resistance in cotton and the largely unexplored interaction dynamics between the cotton plant host and V.dahliae pathogen pose a crucial predicament for effectively managing cotton Verticillium wilt.Nevertheless,the most cost-effective approach to controlling this disease involves breeding and cul-tivating resistant cotton varieties,demanding a meticulous analysis of the mechanisms underlying cotton’s resistance to Verticillium wilt and the identification of pivotal genes.These aspects constitute focal points in disease-resistance breeding programs.In this review,we comprehensively discuss genetic inheritance associated with Verticillium wilt resistance in cotton,the advancements in molecular markers for disease resistance,the functional investiga-tion of resistance genes in cotton,the analysis of pathogenicity genes in V.dahliae,as well as the intricate interplay between cotton and this fungus.Moreover,we delve into the future prospects of cutting-edge research on cotton Verticillium wilt,aiming to proffer valuable insights for the effective management of this devastating fungus.
