We report the SrII optical lattice clock at the National Time Service Center(NTSC).In this system,a blackbody radiation shield with movable lattice mitigates blackbody radiation shifts through active temperature contr...We report the SrII optical lattice clock at the National Time Service Center(NTSC).In this system,a blackbody radiation shield with movable lattice mitigates blackbody radiation shifts through active temperature control.A shallow optical lattice with minimal tunneling minimizes AC Stark shifts.Phase-locked counter-propagating lattice beams and conductive vacuum viewports further reduce systematic uncertainties and a novel initial-state preparation method simplifies the system.Clock transition spectra achieve a linewidth of 2.5 Hz with a 400 ms clock pulse,and self-comparison stability reaches 5.1×10^(-16)at 1 s.These advancements give this clock the potential to be a critical platform for realizing outstanding systematic uncertainties in the future.展开更多
Coatings of marine equipment inevitably suffer from physical or chemical damage in service,together with biofouling from microbial attachment,leading to a shorter service life of them.Herein,a multi-functional corrosi...Coatings of marine equipment inevitably suffer from physical or chemical damage in service,together with biofouling from microbial attachment,leading to a shorter service life of them.Herein,a multi-functional corrosion-resistant coating with efficient photothermal self-healing and anti-biofouling per-formance was designed by using CuO/g-C_(3)N_(4)(CuO/CN)S-scheme heterojunction filler in combination with polydimethylsiloxane(PDMS)as the coating matrix for achieving the effective protection of Q235 steel.The results of the electrochemical impedance spectroscopy(EIS)experiments indicate that the CuO/CN/PDMS composite coatings possessed excellent corrosion resistance,in which the impedance ra-dius of optimal CuO/CN-1/PDMS composite coating could still remain 3.49×10^(9)Ωcm^(2)after 60 d of immersion in seawater under sunlight irradiation.Meanwhile,the as-prepared CuO/CN/PDMS compos-ite coating not only can be rapidly heated up under the Xenon lamp illumination to achieve complete self-repair of scratches within 45 min,but also exhibited excellent antimicrobial effects in the antifouling experiments.This study opens a new avenue for the development of g-C_(3)N_(4)-based multifunctional coat-ings and provides guidance for the development of the next generation of intelligent protective coatings.展开更多
This study presents an achievement of laser cooling of alkaline-earth atoms in the Chinese Space Station’s strontium(Sr)atomic space optical clock.The system’s core components,physical unit,optical unit,and electric...This study presents an achievement of laser cooling of alkaline-earth atoms in the Chinese Space Station’s strontium(Sr)atomic space optical clock.The system’s core components,physical unit,optical unit,and electrical unit,have a total volume of 306 L and a total mass of 163.8 kg.These compact and robust units can overcome mechanical vibrations and temperature fluctuations during space launch.The laser sources of the optical unit are composed of diode lasers,and the injection locking of slave lasers is automatically performed by a program.In the experiment,a blue magneto-optical trap of cold atoms was achieved,with the atom numbers estimated to be approximately(1.50±0.13)×10^(6) for 87Sr and(8.00±0.56)×10^(6) for 88Sr.This work establishes a foundation for atomic confinement and high-precision interrogation in space-based optical clocks and expands the frontiers of cold atom physics in microgravity.展开更多
Abnormal accumulation of collagen fibrils is a hallmark feature of oral submucous fibrosis(OSF).However,the precise characteristics and underlying mechanisms remain unclear,impeding the advancement of potential therap...Abnormal accumulation of collagen fibrils is a hallmark feature of oral submucous fibrosis(OSF).However,the precise characteristics and underlying mechanisms remain unclear,impeding the advancement of potential therapeutic approaches.Here,we observed that collagen Ⅰ,the main component of the extracellular matrix,first accumulated in the lamina propria and subsequently in the submucosa of OSF specimens as the disease progressed.Using RNA-seq and Immunofluorescence in OSF specimens,we screened the cartilage oligomeric matrix protein(COMP)responsible for the abnormal collagen accumulation.Genetic COMP deficiency reduced arecoline-stimulated collagen I deposition significantly in vivo.In comparison,both COMP and collagen Ⅰ were upregulated under arecoline stimulation in wild-type mice.Human oral buccal mucosal fibroblasts(hBMFs)also exhibited increased secretion of COMP and collagen I after stimulation in vitro.COMP knockdown in hBMFs downregulates arecoline-stimulated collagen Ⅰ secretion.We further demonstrated that hBMFs present heterogeneous responses to arecoline stimulation,of which COMP-positive fibroblasts secrete more collagen Ⅰ.Since COMP is a molecular bridge with Fibril-associated collagens with Interrupted Triple helices(FACIT)in the collagen network,we further screened and identified collagen XIV,a FACIT member,co-localizing with both COMP and collagen Ⅰ.Collagen XIV expression increased under arecoline stimulation in wild-type mice,whereas it was hardly expressed in the Comp^(-/-) mice,even with under stimulation.In summary,we found that COMP may mediates abnormal collagen Ⅰ deposition by functions with collagen XIV during the progression of OSF,suggesting its potential to be targeted in treating OSF.展开更多
基金supported by the Innovation Pro-gram for Quantum Science and Technology(Grant Nos.2021ZD0300900 and 2021ZD0300902)the Strate-gic Priority Research Program of the Chinese Academy of Sciences(Grant No.XDB35010202)the Operation and Maintenance of Major Scientific and Technological In-frastructure of the Chinese Academy of Sciences(Grant No.2024000014).
文摘We report the SrII optical lattice clock at the National Time Service Center(NTSC).In this system,a blackbody radiation shield with movable lattice mitigates blackbody radiation shifts through active temperature control.A shallow optical lattice with minimal tunneling minimizes AC Stark shifts.Phase-locked counter-propagating lattice beams and conductive vacuum viewports further reduce systematic uncertainties and a novel initial-state preparation method simplifies the system.Clock transition spectra achieve a linewidth of 2.5 Hz with a 400 ms clock pulse,and self-comparison stability reaches 5.1×10^(-16)at 1 s.These advancements give this clock the potential to be a critical platform for realizing outstanding systematic uncertainties in the future.
基金supported by the National Natural Science Foundation of China(Nos.22006057 and 21906072)the China Postdoctoral Science Foundation(No.2023M743178)+2 种基金the Jiangsu Province Industry-University-Research Cooperation Project(No.BY20231482)the Open Fund of the Key Laboratory of Solar Cell electrode Materials in China Petroleum,Chemical Industry(No.2024A093)the Key Laboratory of Functional Inorganic Mate-rial Chemistry(Heilongjiang University),Ministry of Education and Postgraduate Research&Practice Innovation Program of Jiangsu Province(China)(No.SJCX24_2481).
文摘Coatings of marine equipment inevitably suffer from physical or chemical damage in service,together with biofouling from microbial attachment,leading to a shorter service life of them.Herein,a multi-functional corrosion-resistant coating with efficient photothermal self-healing and anti-biofouling per-formance was designed by using CuO/g-C_(3)N_(4)(CuO/CN)S-scheme heterojunction filler in combination with polydimethylsiloxane(PDMS)as the coating matrix for achieving the effective protection of Q235 steel.The results of the electrochemical impedance spectroscopy(EIS)experiments indicate that the CuO/CN/PDMS composite coatings possessed excellent corrosion resistance,in which the impedance ra-dius of optimal CuO/CN-1/PDMS composite coating could still remain 3.49×10^(9)Ωcm^(2)after 60 d of immersion in seawater under sunlight irradiation.Meanwhile,the as-prepared CuO/CN/PDMS compos-ite coating not only can be rapidly heated up under the Xenon lamp illumination to achieve complete self-repair of scratches within 45 min,but also exhibited excellent antimicrobial effects in the antifouling experiments.This study opens a new avenue for the development of g-C_(3)N_(4)-based multifunctional coat-ings and provides guidance for the development of the next generation of intelligent protective coatings.
基金supported by the Strategic Priority Research Program of the Chinese Academy of Sciences(Grant No.XDB35010202)the National Natural Science Foundation of China(Grants No.62275268)。
文摘This study presents an achievement of laser cooling of alkaline-earth atoms in the Chinese Space Station’s strontium(Sr)atomic space optical clock.The system’s core components,physical unit,optical unit,and electrical unit,have a total volume of 306 L and a total mass of 163.8 kg.These compact and robust units can overcome mechanical vibrations and temperature fluctuations during space launch.The laser sources of the optical unit are composed of diode lasers,and the injection locking of slave lasers is automatically performed by a program.In the experiment,a blue magneto-optical trap of cold atoms was achieved,with the atom numbers estimated to be approximately(1.50±0.13)×10^(6) for 87Sr and(8.00±0.56)×10^(6) for 88Sr.This work establishes a foundation for atomic confinement and high-precision interrogation in space-based optical clocks and expands the frontiers of cold atom physics in microgravity.
基金supported by the National Natural Science Foundation of China grant(81974150).
文摘Abnormal accumulation of collagen fibrils is a hallmark feature of oral submucous fibrosis(OSF).However,the precise characteristics and underlying mechanisms remain unclear,impeding the advancement of potential therapeutic approaches.Here,we observed that collagen Ⅰ,the main component of the extracellular matrix,first accumulated in the lamina propria and subsequently in the submucosa of OSF specimens as the disease progressed.Using RNA-seq and Immunofluorescence in OSF specimens,we screened the cartilage oligomeric matrix protein(COMP)responsible for the abnormal collagen accumulation.Genetic COMP deficiency reduced arecoline-stimulated collagen I deposition significantly in vivo.In comparison,both COMP and collagen Ⅰ were upregulated under arecoline stimulation in wild-type mice.Human oral buccal mucosal fibroblasts(hBMFs)also exhibited increased secretion of COMP and collagen I after stimulation in vitro.COMP knockdown in hBMFs downregulates arecoline-stimulated collagen Ⅰ secretion.We further demonstrated that hBMFs present heterogeneous responses to arecoline stimulation,of which COMP-positive fibroblasts secrete more collagen Ⅰ.Since COMP is a molecular bridge with Fibril-associated collagens with Interrupted Triple helices(FACIT)in the collagen network,we further screened and identified collagen XIV,a FACIT member,co-localizing with both COMP and collagen Ⅰ.Collagen XIV expression increased under arecoline stimulation in wild-type mice,whereas it was hardly expressed in the Comp^(-/-) mice,even with under stimulation.In summary,we found that COMP may mediates abnormal collagen Ⅰ deposition by functions with collagen XIV during the progression of OSF,suggesting its potential to be targeted in treating OSF.
