To overcome the strength-plasticity trade-offin the structural titanium alloys,a novel metastableβti-tanium alloy Ti-5Mo-4Cr-1V-1Zr(Ti-5411)with high strength and high plasticity was designed by the d-electrons theor...To overcome the strength-plasticity trade-offin the structural titanium alloys,a novel metastableβti-tanium alloy Ti-5Mo-4Cr-1V-1Zr(Ti-5411)with high strength and high plasticity was designed by the d-electrons theory,average electron-to-atom ratio(e/α^(-))and atomic radius difference(Δr^(-))theory.Com-bined in-situ scanning electron microscope(SEM)and electron backscatter diffraction(EBSD),the defor-mation mechanisms of the novel Ti-5411 metastableβtitanium alloy were systematically investigated.The results show that the Ti-5411 alloy exhibits excellent yield strength(∼689 MPa),tensile strength(∼930 MPa)and total elongation(∼39%).The in-situ tension indicates that slip activities,crystal rota-tion,stress induced martensite(SIM)α''transformation and{332}<113>deformation twin are the major deformation mechanisms of Ti-5411 alloy.Besides,with the increase of strain degree(0-0.5 mm displace-ment),deformation twins increase,widen and interlace.At 0.35 mm tensile displacement,the orientation of theβgrains rotates∼6.65°to accommodate the increased macrostrain.Additionally,martensiteα''also assists the nucleation of twins.Some{332}<113>twins grow and merge by consuming martensiteα''during deformation,and the residual martensiteα''remains in the merged twins.展开更多
BACKGROUND: The increasing morbidity of liver cancer has led to a growing demand for transplantation. Split liver transplantation(SLT) is a promising way to ameliorate organ shortages. However, the safety and efficacy...BACKGROUND: The increasing morbidity of liver cancer has led to a growing demand for transplantation. Split liver transplantation(SLT) is a promising way to ameliorate organ shortages. However, the safety and efficacy of SLT are still controversial. The aim of this study was to assess the clinical outcome of SLT in liver cancer patients at our center. METHODS: A total of 74 patients who received liver transplantation at a tertiary hospital from March 2019 to July 2023 were retrospectively studied, of whom 37 recipients underwent SLT and 37 recipients underwent whole-graft liver transplantation(WGLT). Clinical data were analyzed and compared between patients who underwent SLT and WGLT.RESULTS: SLT and WGLT were successfully performed, with no intraoperative transplantrelated mortality. Postoperatively, no significant differences in total bilirubin(TB, P=0.266), alanine transaminase(ALT, P=0.403) and aspartate transaminase(AST, P=0.160) levels within 30 d were detected between the two groups. The transplant-related mortality rates were 8.1% in the SLT group and 5.4% in the WGLT group within 30 d of surgery(P=1.000), and 10.8% and 8.1%, respectively, at 90 d after surgery(P=1.000). There were no significant differences in overall survival(OS) and progress-free survival(PFS) between the SLT and WGLT groups(P=0.910, P=0.190). CONCLUSION: Our results show that SLT does not imply additional risks in treating liver cancer compared with WGLT.展开更多
The effects of drawing strain during intermediate annealing on the microstructure and properties of Cu-20 wt%Fe alloy wires while maintaining constant total deformation were investigated.Intermediate annealing effecti...The effects of drawing strain during intermediate annealing on the microstructure and properties of Cu-20 wt%Fe alloy wires while maintaining constant total deformation were investigated.Intermediate annealing effectively removes work hardening in both the Cu matrix and Fe fibers,restoring their plastic deformation capacity and preserving fiber continuity during subsequent redrawing.The process also refines the Fe phase,leading to a more uniform size distribution and straighter,better-aligned Cu/Fe phase interfaces,thereby enhancing the comprehensive properties of the alloy.The magnitude of drawing strain during intermediate annealing plays a critical role in balancing the mechanical strength and electrical conductivity of redrawn wires.A lower initial drawing strain requires greater redrawing strain,leading to excessive hardening of the Fe fibers,which negatively impacts the electrical conductivity and tensile plasticity.Conversely,a higher initial drawing strain can result in insufficient work hardening during the redrawing deformation process,yielding minimal strength improvements.Among the tested alloys,H/3.5 wires show a slight reduction in strength and hardness compared to W and H/4.5 wires but exhibit a significant increase in tensile elongation and electrical conductivity.The tensile strength was 755 MPa,and the electrical conductivity was 47%international-annealed copper standard(IACS).The optimal performance is attributed to the formation of a high-density,ultrafine Fe fiber structure-aligned parallel to the drawing direction,which is achieved through a suitable combination of the drawing process and intermediate annealing.展开更多
The deformation of Cu–20 wt.%Fe alloy wires leads to a significant improvement in mechanical properties and a decrease in electrical conductivity.Simultaneous improvements in strength and conductivity were achieved b...The deformation of Cu–20 wt.%Fe alloy wires leads to a significant improvement in mechanical properties and a decrease in electrical conductivity.Simultaneous improvements in strength and conductivity were achieved by intermediate annealing of drawn Cu–20 wt.%Fe wires.As the annealing temperature increased,the strength of Cu–20 wt.%Fe alloy wire decreased monotonically,but the electrical conductivity first increased and then decreased,reaching its peak value after annealing at 500℃.The decrease in strength is related to dislocation recovery and static recrystallization of Cu and Fe phases,and the increase in electrical conductivity mainly results from the aging precipitation of solid solution Fe.After annealing at 500℃,there was no obvious recrystallization of Cu phase,and many of the nano-Fe particles precipitated from Cu matrix.An annealing temperature of 600℃ induced the recrystallization of Cu matrix and an increase in Fe solid solubility,resulting in a decrease in strength and electrical conductivity.Subsequently,the wires annealed at 500℃ were drawn to 2 mm.Compared with those of the continuously drawn Cu–20 wt.%Fe alloy wires,the deformation ability,strength,and electrical conductivity of Cu–20 wt.%Fe alloy wires subjected to intermediate annealing treatment are significantly greater.This is mainly related to the sufficient precipitation of Fe in Cu matrix and the strengthening of refined Fe fibers parallel to the drawing direction.展开更多
基金supported by the National Natural Science Foundation of China(Nos.52104372,52374332)the Postdoctoral Research Foundation of China(Nos.2019M651129,2019TQ0053)the Fundamental Research Funds for the Central Universities(No.N2324003-02).
文摘To overcome the strength-plasticity trade-offin the structural titanium alloys,a novel metastableβti-tanium alloy Ti-5Mo-4Cr-1V-1Zr(Ti-5411)with high strength and high plasticity was designed by the d-electrons theory,average electron-to-atom ratio(e/α^(-))and atomic radius difference(Δr^(-))theory.Com-bined in-situ scanning electron microscope(SEM)and electron backscatter diffraction(EBSD),the defor-mation mechanisms of the novel Ti-5411 metastableβtitanium alloy were systematically investigated.The results show that the Ti-5411 alloy exhibits excellent yield strength(∼689 MPa),tensile strength(∼930 MPa)and total elongation(∼39%).The in-situ tension indicates that slip activities,crystal rota-tion,stress induced martensite(SIM)α''transformation and{332}<113>deformation twin are the major deformation mechanisms of Ti-5411 alloy.Besides,with the increase of strain degree(0-0.5 mm displace-ment),deformation twins increase,widen and interlace.At 0.35 mm tensile displacement,the orientation of theβgrains rotates∼6.65°to accommodate the increased macrostrain.Additionally,martensiteα''also assists the nucleation of twins.Some{332}<113>twins grow and merge by consuming martensiteα''during deformation,and the residual martensiteα''remains in the merged twins.
基金Key Project of Traditional Chinese Medicine Science and Technology Plan of Zhejiang Province (GZY-ZJ-KJ-24077)National Natural Science Foundation of China (No. U23A202181, 8207101520, 82272860)+2 种基金Central Guidance on Local Science and Technology Development Fund of Zhejiang Province (2023ZY1017)Fundamental Research Funds for the Central Universities (No. 226-2023-00038)Special Financial Support for Zhejiang Traditional Chinese Medicine Innovation Teams。
文摘BACKGROUND: The increasing morbidity of liver cancer has led to a growing demand for transplantation. Split liver transplantation(SLT) is a promising way to ameliorate organ shortages. However, the safety and efficacy of SLT are still controversial. The aim of this study was to assess the clinical outcome of SLT in liver cancer patients at our center. METHODS: A total of 74 patients who received liver transplantation at a tertiary hospital from March 2019 to July 2023 were retrospectively studied, of whom 37 recipients underwent SLT and 37 recipients underwent whole-graft liver transplantation(WGLT). Clinical data were analyzed and compared between patients who underwent SLT and WGLT.RESULTS: SLT and WGLT were successfully performed, with no intraoperative transplantrelated mortality. Postoperatively, no significant differences in total bilirubin(TB, P=0.266), alanine transaminase(ALT, P=0.403) and aspartate transaminase(AST, P=0.160) levels within 30 d were detected between the two groups. The transplant-related mortality rates were 8.1% in the SLT group and 5.4% in the WGLT group within 30 d of surgery(P=1.000), and 10.8% and 8.1%, respectively, at 90 d after surgery(P=1.000). There were no significant differences in overall survival(OS) and progress-free survival(PFS) between the SLT and WGLT groups(P=0.910, P=0.190). CONCLUSION: Our results show that SLT does not imply additional risks in treating liver cancer compared with WGLT.
基金support provided by the National Natural Science Foundation of China(Nos.52405364,and 52171110)the Jiangsu Funding Program for Excellent Postdoctoral Talent.W.Huo acknowledges the support from the European Union Horizon 2020 Research and Innovation Program(No.857470)+1 种基金from the European Regional Development Fund via the Foundation for Polish Science International Research Agenda PLUS Program(No.MAB PLUS/2018/8)The publication was partly created within the framework of the project of the Minister of Science and Higher Education"Support for the activities of Centers of Excellence established in Poland under Horizon 2020"(No.MEiN/2023/DIR/3795).
文摘The effects of drawing strain during intermediate annealing on the microstructure and properties of Cu-20 wt%Fe alloy wires while maintaining constant total deformation were investigated.Intermediate annealing effectively removes work hardening in both the Cu matrix and Fe fibers,restoring their plastic deformation capacity and preserving fiber continuity during subsequent redrawing.The process also refines the Fe phase,leading to a more uniform size distribution and straighter,better-aligned Cu/Fe phase interfaces,thereby enhancing the comprehensive properties of the alloy.The magnitude of drawing strain during intermediate annealing plays a critical role in balancing the mechanical strength and electrical conductivity of redrawn wires.A lower initial drawing strain requires greater redrawing strain,leading to excessive hardening of the Fe fibers,which negatively impacts the electrical conductivity and tensile plasticity.Conversely,a higher initial drawing strain can result in insufficient work hardening during the redrawing deformation process,yielding minimal strength improvements.Among the tested alloys,H/3.5 wires show a slight reduction in strength and hardness compared to W and H/4.5 wires but exhibit a significant increase in tensile elongation and electrical conductivity.The tensile strength was 755 MPa,and the electrical conductivity was 47%international-annealed copper standard(IACS).The optimal performance is attributed to the formation of a high-density,ultrafine Fe fiber structure-aligned parallel to the drawing direction,which is achieved through a suitable combination of the drawing process and intermediate annealing.
基金support provided by National Natural Science Foundation of China(Nos.52405364 and 52171110)Jiangsu Funding Program for Excellent Postdoctoral Talent+3 种基金JITRI Advanced Materials R&D Co.Ltdsupport by European Union Horizon 2020 Research and Innovation Program(857470)European Regional Development Fund via the Foundation for Polish Science International Research Agenda PLUS program(MAB PLUS/2018/8)The publication was created within the framework of the project of the Minister of Science and Higher Education,Support for the Activities of Centres of Excellence established in Poland under Horizon 2020,under contract No.MEiN/2023/DIR/3795.
文摘The deformation of Cu–20 wt.%Fe alloy wires leads to a significant improvement in mechanical properties and a decrease in electrical conductivity.Simultaneous improvements in strength and conductivity were achieved by intermediate annealing of drawn Cu–20 wt.%Fe wires.As the annealing temperature increased,the strength of Cu–20 wt.%Fe alloy wire decreased monotonically,but the electrical conductivity first increased and then decreased,reaching its peak value after annealing at 500℃.The decrease in strength is related to dislocation recovery and static recrystallization of Cu and Fe phases,and the increase in electrical conductivity mainly results from the aging precipitation of solid solution Fe.After annealing at 500℃,there was no obvious recrystallization of Cu phase,and many of the nano-Fe particles precipitated from Cu matrix.An annealing temperature of 600℃ induced the recrystallization of Cu matrix and an increase in Fe solid solubility,resulting in a decrease in strength and electrical conductivity.Subsequently,the wires annealed at 500℃ were drawn to 2 mm.Compared with those of the continuously drawn Cu–20 wt.%Fe alloy wires,the deformation ability,strength,and electrical conductivity of Cu–20 wt.%Fe alloy wires subjected to intermediate annealing treatment are significantly greater.This is mainly related to the sufficient precipitation of Fe in Cu matrix and the strengthening of refined Fe fibers parallel to the drawing direction.
基金financially supported by the National Natural Science Foundation of China(No.52104372)the Fundamental Research Funds for the Central Universities,China(No.N2107001)the Postdoctoral Research Foundation of China(Nos.2019M651129,2019TQ0053)。
