目的为临床安全使用司美格鲁肽提供参考。方法检索中国知网、万方、维普、PubMed、Web of Science数据库自建库起至2024年2月司美格鲁肽药品不良反应(ADR)个案报道,分析ADR特点,并按Naranjo评分系统进行关联性评价。结果共纳入17篇文献...目的为临床安全使用司美格鲁肽提供参考。方法检索中国知网、万方、维普、PubMed、Web of Science数据库自建库起至2024年2月司美格鲁肽药品不良反应(ADR)个案报道,分析ADR特点,并按Naranjo评分系统进行关联性评价。结果共纳入17篇文献,收集21例(国外19例,我国2例)ADR病例,其中男12例,女9例,年龄25~80岁,平均51岁;使用注射液20例,片剂1例;ADR多于用药后2个月内发生(9例,42.86%);主要累及消化系统(13例,61.90%),主要表现为反流和胃内容物的肺部误吸,其中1例患者同时出现泌尿系统ADR。经停药或对症处理后18例(85.71%)患者好转,3例预后欠佳。Naranjo评分为4~9分,平均6.48分。结论医务工作者应加强对司美格鲁肽ADR的认识,对老年患者、肝肾功能不全、既往存在相关ADR危险因素的患者加强用药监护和用药教育,并长期随访,以减轻严重ADR程度,降低ADR发生率。展开更多
Alzheimer's disease(AD)and Alzheimer's diseaserelated dementias(ADRD)represent a significant public health challenge,with projections indicating a substantial increase in affected individuals due to the aging ...Alzheimer's disease(AD)and Alzheimer's diseaserelated dementias(ADRD)represent a significant public health challenge,with projections indicating a substantial increase in affected individuals due to the aging global population.From the World Health Organization,AD/ADRD has affected more than 55 million individuals worldwide,with an additional 10 million cases diagnosed each year.展开更多
文摘目的为临床安全使用司美格鲁肽提供参考。方法检索中国知网、万方、维普、PubMed、Web of Science数据库自建库起至2024年2月司美格鲁肽药品不良反应(ADR)个案报道,分析ADR特点,并按Naranjo评分系统进行关联性评价。结果共纳入17篇文献,收集21例(国外19例,我国2例)ADR病例,其中男12例,女9例,年龄25~80岁,平均51岁;使用注射液20例,片剂1例;ADR多于用药后2个月内发生(9例,42.86%);主要累及消化系统(13例,61.90%),主要表现为反流和胃内容物的肺部误吸,其中1例患者同时出现泌尿系统ADR。经停药或对症处理后18例(85.71%)患者好转,3例预后欠佳。Naranjo评分为4~9分,平均6.48分。结论医务工作者应加强对司美格鲁肽ADR的认识,对老年患者、肝肾功能不全、既往存在相关ADR危险因素的患者加强用药监护和用药教育,并长期随访,以减轻严重ADR程度,降低ADR发生率。
文摘Alzheimer's disease(AD)and Alzheimer's diseaserelated dementias(ADRD)represent a significant public health challenge,with projections indicating a substantial increase in affected individuals due to the aging global population.From the World Health Organization,AD/ADRD has affected more than 55 million individuals worldwide,with an additional 10 million cases diagnosed each year.
