Objective:This study aims to utilize data from the National Health and Nutrition Examination Survey(NHANES),which was conducted in the United States from 2009 to 2014,to investigate the risk of chronic drug-induced li...Objective:This study aims to utilize data from the National Health and Nutrition Examination Survey(NHANES),which was conducted in the United States from 2009 to 2014,to investigate the risk of chronic drug-induced liver injury(DILI)in patients with psoriasis and to establish a risk prediction model via machine learning.Methods:A total of 6,303 participants were selected,all of whom answered questions regarding psoriasis and drug use.Chronic DILI was diagnosed on the basis of persistent abnormalities in the serum alanine aminotransferase(ALT),aspartate aminotransferase(AST),alkaline phosphatase(ALP),and total bilirubin(TBIL)levels.Multiple logistic regression and other methods have been employed in different models to explore the relationship between psoriasis and chronic DILI.Potential confounding factors(age,sex,ethnicity,household income,education,alcohol consumption,smoking,and body mass index(BMI))were controlled.Results:After controlling for potential confounding factors,the results revealed a significant positive correlation between psoriasis and chronic DILI,and an optimal predictive model was generated on the basis of diabetes status and BMI.Conclusion:Patients with psoriasis appear to be at increased risk of chronic DILI.More prospective studies are needed to confirm this clinical correlation.展开更多
Atmospheric pressure cold plasma, with advantages such as high particle activity, no thermal damage, high efficiency and direct and friendly contact with human tissues, is considered to have great potential in biomedi...Atmospheric pressure cold plasma, with advantages such as high particle activity, no thermal damage, high efficiency and direct and friendly contact with human tissues, is considered to have great potential in biomedical applications. Therefore, 'plasma medicine' as a new interdiscipline has been developed in the past two decades. This review first briefly describes the development of typical plasma sources suitable for biomedical applications, and those with different discharge forms are simply compared, evaluated and summarized. Subsequently, measurement of the crucial gaseous reactive particles(e.g. OH and O) and their spatio-temporal distributions are introduced. Meanwhile, the generation and variation rules and the related critical macroscopic parameters of the plasma-induced aqueous reactive species are summarized. Finally, related studies in the last ten years on the mechanisms of the plasma-driven microbial inactivation and plasma-induced apoptosis of cancer cells are introduced. Moreover, some scientific problems that need to be urgently solved in the field of plasma medicine are also discussed. This review will provide useful guidance for future related research.展开更多
In this research,an atmospheric-pressure air plasma is used to inactivate the multidrug-resistant Acinetobacter baumannii in liquid.The efficacy of the air plasma on bacterial deactivation and the cytobiological varia...In this research,an atmospheric-pressure air plasma is used to inactivate the multidrug-resistant Acinetobacter baumannii in liquid.The efficacy of the air plasma on bacterial deactivation and the cytobiological variations after the plasma treatment are investigated.According to colony forming units,nearly all the bacteria（6-log） are inactivated after 10 min of air plasma treatment.However,7% of the bacteria enter a viable but non-culturable state detected by the resazurin based assay during the same period of plasma exposure.Meanwhile,86% of the bacteria lose their membrane integrity in the light of SYTO 9/PI staining assay.The morphological changes in the cells are examined by scanning electron microscopy and bacteria with morphological changes are rare after plasma exposure in the liquid.The concentrations of the long-living RS,such as H2O2,NO3^- and O3,in liquid induced by plasma treatment are measured,and they increase with plasma treatment time.The changes of the intracellular ROS may be related to cell death,which may be attributed to oxidative stress and other damage effects induced by RS plasma generated in liquid.The rapid and effective bacteria inactivation may stem from the RS in the liquid generated by plasma and air plasmas may become a valuable therapy in the treatment of infected wounds.展开更多
基金supported by the Natural Science Foundation of Anhui Province(240808QH272).
文摘Objective:This study aims to utilize data from the National Health and Nutrition Examination Survey(NHANES),which was conducted in the United States from 2009 to 2014,to investigate the risk of chronic drug-induced liver injury(DILI)in patients with psoriasis and to establish a risk prediction model via machine learning.Methods:A total of 6,303 participants were selected,all of whom answered questions regarding psoriasis and drug use.Chronic DILI was diagnosed on the basis of persistent abnormalities in the serum alanine aminotransferase(ALT),aspartate aminotransferase(AST),alkaline phosphatase(ALP),and total bilirubin(TBIL)levels.Multiple logistic regression and other methods have been employed in different models to explore the relationship between psoriasis and chronic DILI.Potential confounding factors(age,sex,ethnicity,household income,education,alcohol consumption,smoking,and body mass index(BMI))were controlled.Results:After controlling for potential confounding factors,the results revealed a significant positive correlation between psoriasis and chronic DILI,and an optimal predictive model was generated on the basis of diabetes status and BMI.Conclusion:Patients with psoriasis appear to be at increased risk of chronic DILI.More prospective studies are needed to confirm this clinical correlation.
基金financially supported by National Natural Science Foundation of China (Grant Nos. 51777206, 51807046 and 51877208)the Natural Science Foundation of Anhui Province (Grant Nos. 1908085MA29 and 1808085MA13)。
文摘Atmospheric pressure cold plasma, with advantages such as high particle activity, no thermal damage, high efficiency and direct and friendly contact with human tissues, is considered to have great potential in biomedical applications. Therefore, 'plasma medicine' as a new interdiscipline has been developed in the past two decades. This review first briefly describes the development of typical plasma sources suitable for biomedical applications, and those with different discharge forms are simply compared, evaluated and summarized. Subsequently, measurement of the crucial gaseous reactive particles(e.g. OH and O) and their spatio-temporal distributions are introduced. Meanwhile, the generation and variation rules and the related critical macroscopic parameters of the plasma-induced aqueous reactive species are summarized. Finally, related studies in the last ten years on the mechanisms of the plasma-driven microbial inactivation and plasma-induced apoptosis of cancer cells are introduced. Moreover, some scientific problems that need to be urgently solved in the field of plasma medicine are also discussed. This review will provide useful guidance for future related research.
基金supported by the Spark Program of the second Affiliated Hospital of Anhui Medical University (Grant No.2015hhjh04)National Natural Science Foundation of China under Grant No.51777206+6 种基金Natural Science Foundation of Anhui Province (Grant No.1708085MA13 and No.1708085MB47)Science Foundation of Institute of Plasma Physics,Chinese Academy of Sciences under Grant (No.DSJJ-14-YY02)City University of Hong Kong Applied Research Grant (ARG) (No.9667144)Hong Kong Research Grants Council (RGC) General Research Funds (GRF) (No.City U 11301215)Doctoral Fund of Ministry of Education of China (No.2017M612058)Specialized Research Fund for the Doctoral Program of Hefei University of Technology (No.JZ2016HGBZ0768)Foundation of Anhui Province Key Laboratory of Medical Physics and Technology (Grant No.LMPT2017Y7BP0U1581)
文摘In this research,an atmospheric-pressure air plasma is used to inactivate the multidrug-resistant Acinetobacter baumannii in liquid.The efficacy of the air plasma on bacterial deactivation and the cytobiological variations after the plasma treatment are investigated.According to colony forming units,nearly all the bacteria（6-log） are inactivated after 10 min of air plasma treatment.However,7% of the bacteria enter a viable but non-culturable state detected by the resazurin based assay during the same period of plasma exposure.Meanwhile,86% of the bacteria lose their membrane integrity in the light of SYTO 9/PI staining assay.The morphological changes in the cells are examined by scanning electron microscopy and bacteria with morphological changes are rare after plasma exposure in the liquid.The concentrations of the long-living RS,such as H2O2,NO3^- and O3,in liquid induced by plasma treatment are measured,and they increase with plasma treatment time.The changes of the intracellular ROS may be related to cell death,which may be attributed to oxidative stress and other damage effects induced by RS plasma generated in liquid.The rapid and effective bacteria inactivation may stem from the RS in the liquid generated by plasma and air plasmas may become a valuable therapy in the treatment of infected wounds.
