摘要
Atmospheric pressure cold plasma, with advantages such as high particle activity, no thermal damage, high efficiency and direct and friendly contact with human tissues, is considered to have great potential in biomedical applications. Therefore, 'plasma medicine' as a new interdiscipline has been developed in the past two decades. This review first briefly describes the development of typical plasma sources suitable for biomedical applications, and those with different discharge forms are simply compared, evaluated and summarized. Subsequently, measurement of the crucial gaseous reactive particles(e.g. OH and O) and their spatio-temporal distributions are introduced. Meanwhile, the generation and variation rules and the related critical macroscopic parameters of the plasma-induced aqueous reactive species are summarized. Finally, related studies in the last ten years on the mechanisms of the plasma-driven microbial inactivation and plasma-induced apoptosis of cancer cells are introduced. Moreover, some scientific problems that need to be urgently solved in the field of plasma medicine are also discussed. This review will provide useful guidance for future related research.
作者
Zimu XU
Yan LAN
Jie MA
Jie SHEN
Wei HAN
Shuheng HU
Chaobing YE
Wenhao XI
Yudi ZHANG
Chunjun YANG
Xiao ZHAO
Cheng CHENG
许子牧;兰彦;马洁;沈洁;韩伟;胡淑恒;叶朝兵;奚文灏;张雨迪;杨春俊;赵晓;程诚(School of Resources and Environmental Engineering,Hefei University of Technology,Hefei 230009,People’s Republic of China;Institute of Plasma Physics,Hefei Institutes of Physical Science,Chinese Academy of Sciences,Hefei 230031,People's Republic of China;Center of Medical Physics and Technology,Hefei Institutes of Physical Science,Chinese Academy of Sciences,Hefei 230031,People's Republic of China;Anhui Province Key Laboratory of Medical Physics and Technology,Hefei Institutes of Physical Science.Chinese Academy of Sciences,Hefei 230031,People's Republic of China;Department of Dermatology,the Second Affiliated Hospital,Anhui Medical University,Hefei 230601.People's Republic of China;Department of Medical Genetics,College of Medicine,Henan University of Science and Technology,Luoyang 471023,People's Republic of China)
基金
financially supported by National Natural Science Foundation of China (Grant Nos. 51777206, 51807046 and 51877208)
the Natural Science Foundation of Anhui Province (Grant Nos. 1908085MA29 and 1808085MA13)。
