Lung cancer is the most common but fatal malignant tumor worldwide.Patients with lung cancer experienced a relatively low 5-year overall survival rate,and issues such as metastasis and drug resistance remain prominent...Lung cancer is the most common but fatal malignant tumor worldwide.Patients with lung cancer experienced a relatively low 5-year overall survival rate,and issues such as metastasis and drug resistance remain prominent challenges in its clinical management.Neddylation,a novel type of post-translational modification,was overactivated in lung cancer and was closely associated with its occurrence,development,metastasis,and drug resistance.This review systematically summarizes the biological process of neddylation and deeply explores the latest research progress on how neddylation affects lung cancer cell proliferation,metastasis,and drug resistance mechanisms,with a focus on its regulation of key molecules such as Cullin-RING E3 ligases and the SCCRO family.Meanwhile,it concludes the current advances in potential therapeutic agents targeting neddylation-related targets,including small-molecule compounds(such as Pevonedistat)and natural extracts(such as arctigenin).Finally,the review prospectively evaluates the application potential and questions requiring further exploration of neddylation in lung cancer treatment.In conclusion,we aim to systematically summarize the biological process of neddylation,critically explore its roles in lung cancer proliferation,metastasis,and drug resistance,and evaluate the therapeutic potential of neddylation-targeting agents.展开更多
Fuel-coolant interaction(FCI)remains one of the most complex challenges in severe accident research,with the triggering process being a key aspect that may govern subsequent fine fragmentation and potential steam expl...Fuel-coolant interaction(FCI)remains one of the most complex challenges in severe accident research,with the triggering process being a key aspect that may govern subsequent fine fragmentation and potential steam explosions.In this study,the evolution characteristics of droplet-water interactions under external disturbance conditions were investigated using a self-designed FCI experimental setup.The experimental observations revealed that cavity formation reduced the drag force on the droplet,thereby increasing its peak velocity.However,the external disturbance pressure can disrupt the cavity,leading to a reduction in the droplet peak velocity.Furthermore,it was found that an increase in external disturbance pressure tended to increase the peak value of the droplet expansion rate,thereby promoting the fine-fragmentation process.This effect holds regardless of the initial droplet temperature,coolant temperature,or even when using droplet materials such as lead,which is generally considered unfavorable for steam explosions.Comparative analyses indicated that a higher external disturbance pressure may shorten the triggering time of the droplet surface and enhance the trigger intensity.These findings provide important phenomenological insights for further investigation of the triggering mechanisms in the initial stage of fuel-coolant interactions.展开更多
随着“双碳”战略推进,我国大力发展风电、光伏等新能源。处于电网末端的新能源场站因缺乏交流电源支撑,需依赖柔性直流输电技术(modular multilevel converter-high voltage direct current,MMC-HVDC)实现并网,但电力电子变流器的广泛...随着“双碳”战略推进,我国大力发展风电、光伏等新能源。处于电网末端的新能源场站因缺乏交流电源支撑,需依赖柔性直流输电技术(modular multilevel converter-high voltage direct current,MMC-HVDC)实现并网,但电力电子变流器的广泛应用引发了高频谐振的问题。首先,针对新能源场站经柔直并网中的高频谐振问题,建立了包含电磁式电压/电流互感器及其二次电缆在内的MMC孤岛系统主回路与控制环节的数学模型。其次,用π型电路等效电磁式电压/电流互感器二次电缆并对其进行特性分析。然后,对综合考虑电磁式电压/电流互感器二次电缆的MMC孤岛系统展开稳定性分析,明确了电磁式电压/电流互感器二次电缆的传变特性导致孤岛系统发生高频谐振的机理。最后,在PSCAD/EMTDC中进行仿真验证。结合现场试验,证明了所提电磁式电压/电流互感器二次电缆引起孤岛系统高频谐振机理的准确性。展开更多
基金supported by the National Natural Science Foundation of China(No.82574683)the National Natural Science Foundation of Science and Technology Department of Sichuan Province(Nos.2023NSFSC1928 and 2023NSFSC1992)+2 种基金Project of State Administration of Traditional Chinese Medicine of China(No.ZYYCXTD-D-202209)Project of Sichuan Provincial Administration of Traditional Chinese Medicine(No.2022C001)Fundamental Research Funds for the Central Universities(No.YJ201880).
文摘Lung cancer is the most common but fatal malignant tumor worldwide.Patients with lung cancer experienced a relatively low 5-year overall survival rate,and issues such as metastasis and drug resistance remain prominent challenges in its clinical management.Neddylation,a novel type of post-translational modification,was overactivated in lung cancer and was closely associated with its occurrence,development,metastasis,and drug resistance.This review systematically summarizes the biological process of neddylation and deeply explores the latest research progress on how neddylation affects lung cancer cell proliferation,metastasis,and drug resistance mechanisms,with a focus on its regulation of key molecules such as Cullin-RING E3 ligases and the SCCRO family.Meanwhile,it concludes the current advances in potential therapeutic agents targeting neddylation-related targets,including small-molecule compounds(such as Pevonedistat)and natural extracts(such as arctigenin).Finally,the review prospectively evaluates the application potential and questions requiring further exploration of neddylation in lung cancer treatment.In conclusion,we aim to systematically summarize the biological process of neddylation,critically explore its roles in lung cancer proliferation,metastasis,and drug resistance,and evaluate the therapeutic potential of neddylation-targeting agents.
基金supported by the operating fund of Key Laboratory of Nuclear Power Systems and Equipment(Shanghai Jiao Tong University),Ministry of Education,China,the Natural Science Foundation of Shanghai Municipality(25ZR1402177)the National Natural Science Foundation of China(12105167)。
文摘Fuel-coolant interaction(FCI)remains one of the most complex challenges in severe accident research,with the triggering process being a key aspect that may govern subsequent fine fragmentation and potential steam explosions.In this study,the evolution characteristics of droplet-water interactions under external disturbance conditions were investigated using a self-designed FCI experimental setup.The experimental observations revealed that cavity formation reduced the drag force on the droplet,thereby increasing its peak velocity.However,the external disturbance pressure can disrupt the cavity,leading to a reduction in the droplet peak velocity.Furthermore,it was found that an increase in external disturbance pressure tended to increase the peak value of the droplet expansion rate,thereby promoting the fine-fragmentation process.This effect holds regardless of the initial droplet temperature,coolant temperature,or even when using droplet materials such as lead,which is generally considered unfavorable for steam explosions.Comparative analyses indicated that a higher external disturbance pressure may shorten the triggering time of the droplet surface and enhance the trigger intensity.These findings provide important phenomenological insights for further investigation of the triggering mechanisms in the initial stage of fuel-coolant interactions.
文摘随着“双碳”战略推进,我国大力发展风电、光伏等新能源。处于电网末端的新能源场站因缺乏交流电源支撑,需依赖柔性直流输电技术(modular multilevel converter-high voltage direct current,MMC-HVDC)实现并网,但电力电子变流器的广泛应用引发了高频谐振的问题。首先,针对新能源场站经柔直并网中的高频谐振问题,建立了包含电磁式电压/电流互感器及其二次电缆在内的MMC孤岛系统主回路与控制环节的数学模型。其次,用π型电路等效电磁式电压/电流互感器二次电缆并对其进行特性分析。然后,对综合考虑电磁式电压/电流互感器二次电缆的MMC孤岛系统展开稳定性分析,明确了电磁式电压/电流互感器二次电缆的传变特性导致孤岛系统发生高频谐振的机理。最后,在PSCAD/EMTDC中进行仿真验证。结合现场试验,证明了所提电磁式电压/电流互感器二次电缆引起孤岛系统高频谐振机理的准确性。
