Objective:Metabolic syndrome is a complex medical condition that has become an alarming epidemic,but an effective therapy for this disease is still lacking.The use of the herbal formula Huangqisan(HQS)to treat diabete...Objective:Metabolic syndrome is a complex medical condition that has become an alarming epidemic,but an effective therapy for this disease is still lacking.The use of the herbal formula Huangqisan(HQS)to treat diabetes is documented in the Chinese medical literature as early as 1117 A.D.;however,its therapeutic effects and underlying mechanisms remain elusive.Methods:To investigate the beneficial effects of HQS on metabolic disorders,high-fat diet-induced obesity(DIO),leptin receptor dysfunction(db/db)and low-density lipoprotein receptor-knockout(LDLR^(-/-))mice were used.Obese mice were treated with either HQS or vehicle.Blood,liver tissue,white fat tissue and brown adipose tissue were harvested at the end of the treatment.Metabolic disease-related parameters were evaluated to test effects of HQS against diabetes,obesity and hyperlipidemia.Aortic arches from LDLR^(-/-)mice were analyzed to investigate the effects of HQS on atherosclerosis.RNA-sequence,quantitative real-time polymerase chain reaction and Western blot were performed to investigate the mechanisms of HQS against metabolic disorder.Results:HQS lowered body weight,fasting blood glucose and serum lipid levels and improved glucose tolerance and insulin sensitivity in DIO mice and db/db mice(P<0.05).HQS also blocked atherosclerotic plaque formation in LDLR^(^(-/-)) mice.HQS suppressed de novo lipid synthesis by reducing the expression of messenger RNA for sterol regulatory element-binding factor 1,stearyl coenzyme A desaturase 1 and fatty acid synthase,and enhancing adenosine 5’-monophosphate-activated protein kinase signaling in both in vivo and in vitro experiments,indicating potential mechanisms for HQS’s activity against diabetes.Conclusion:HQS is effective for reversing metabolic disorder and has the potential to be used as therapy for metabolic syndrome.展开更多
The isolated fracture-vug systems controlled by small-scale strike-slip faults within ultra-deep carbonate rocks of the Tarim Basin exhibit significant exploration potential.The study employs a novel training set inco...The isolated fracture-vug systems controlled by small-scale strike-slip faults within ultra-deep carbonate rocks of the Tarim Basin exhibit significant exploration potential.The study employs a novel training set incorporating innovative fault labels to train a U-Net-structured CNN model,enabling effective identification of small-scale strike-slip faults through seismic data interpretation.Based on the CNN faults,we analyze the distribution patterns of small-scale strike-slip faults.The small-scale strike-slip faults can be categorized into NNW-trending and NE-trending groups with strike lengths ranging 200–5000 m.The development intensity of small-scale strike-slip faults in the Lower Yingshan Member notably exceeds that in the Upper Member.The Lower and Upper Yingshan members are two distinct mechanical layers with contrasting brittleness characteristics,separated by a low-brittleness layer.The superior brittleness of the Lower Yingshan Member enhances the development intensity of small-scale strike-slip faults compared to the upper member,while the low-brittleness layer exerts restrictive effects on vertical fault propagation.Fracture-vug systems formed by interactions of two or more small-scale strike-slip faults demonstrate larger sizes than those controlled by individual faults.All fracture-vug system sizes show positive correlations with the vertical extents of associated small-scale strike-slip faults,particularly intersection and approaching fracture-vug systems exhibit accelerated size increases proportional to the vertical extents.展开更多
0 INTRODUCTION Gas injection refers to the natural gas charging into pre-existing oil reservoirs,which often leads to notable changes in gas-oil ratio(GOR),oil density,and phase states,depending on the pressure-temper...0 INTRODUCTION Gas injection refers to the natural gas charging into pre-existing oil reservoirs,which often leads to notable changes in gas-oil ratio(GOR),oil density,and phase states,depending on the pressure-temperature condition of the reservoirs(Meulbroek et al.,1998;Blanc and Connan,1994;Evans et al.,1971).展开更多
Background:Renal cell carcinoma(RCC)is a prevalent malignancy characterized by a rising incidence and significant mortality.Interleukins(ILs)are crucial in regulating immune cell trafficking and exhibit anti-tumor pro...Background:Renal cell carcinoma(RCC)is a prevalent malignancy characterized by a rising incidence and significant mortality.Interleukins(ILs)are crucial in regulating immune cell trafficking and exhibit anti-tumor properties.However,limited research has explored the expression levels and prognostic significance of interleukins in RCC.Methods:In this comprehensive study,we performed a detailed analysis of interleukins in RCC patients using multiple bioinformatics tools,including Oncomine,UALCAN,GEPIA,Kaplan-Meier plotter,cBioPortal,GeneMANIA,TRRUST,STRING,and Linked Omics.Results:Our analysis demonstrated a significant upregulation in the transcriptional levels of IL4,IL7,IL15,IL16,IL23A,IL26,and IL32 were significantly upregulated in RCC tissues,indicating their potential involvement in the pathogenesis of this malignancy.In contrast,IL1A,IL11,and IL27 were downregulated,indicating their potential function as tumor suppressors.Significant correlations were identified between the expression levels of IL11,IL23A,IL27,IL32,and the pathological stage of RCC patients.The expression levels of IL1A,IL4,IL11,IL15,IL16,IL23A,IL26,IL27,and IL32 were significantly correlated with improved prognosis.The differentially expressed interleukins primarily function in cytokine-cytokine receptor interactions and immune response-regulating signaling pathways.homeobox A10(HOXA10),v-myb myeloblastosis viral oncogene homolog(avian)(MYB),v-rel reticuloendotheliosis viral oncogene homolog A(avian)(RELA),and nuclear factor of kappa light polypeptide gene enhancer in B-cells 1(NFKB1)are key transcription factors for ILs,while LCK proto-oncogene(LCK),LYN proto-oncogene(LYN),spleen associated tyrosine kinase(SYK),Janus kinase 3(JAK3),and FER tyrosine kinase(FER)are IL targets.IL expression significantly correlated with the infiltration of six distinct immune cell types.IL1A potentially exerts an anti-tumor effect in RCC prognosis by inducing neutrophil extracellular traps(NETs).Additionally,NFKB1 may positively regulate IL1A,providing a rationale for further in vivo and clinical studies.Conclusion:In conclusion,our study demonstrates the potential role of IL 1A in the prognosis of RCC and establishes a theoretical foundation for subsequent in vivo and clinical investigations.展开更多
Objective:Based on the theories of“defensive Qi entering Yin”and“Qi and blood in meridians”in traditional Chinese medicine(TCM),this study explores the synergistic intervention effect of the Brain Health Sleep-Aid...Objective:Based on the theories of“defensive Qi entering Yin”and“Qi and blood in meridians”in traditional Chinese medicine(TCM),this study explores the synergistic intervention effect of the Brain Health Sleep-Aid Pillow on brain diseases(such as insomnia,vertigo)and cervical spondylosis.The pillow achieves“marrow sea replenishment and unobstructed cerebral collaterals”by regulating cerebral blood perfusion and cervical mechanical balance through linear pulsed magnetic guidance of the Du Meridian and Bladder Meridian.Methods:A total of 120 patients with“neck impediment”and“insomnia”who met the Criteria for Diagnosis and Therapeutic Effect of TCM Syndromes were enrolled.They were randomly divided into an experimental group(60 cases,using Yuxuangong magnetic therapy pillow)and a control group(60 cases,using ordinary buckwheat pillow)by block randomization.The intervention lasted for 8 weeks.The efficacy was comprehensively evaluated using indicators including TCM syndrome scores,tongue and pulse analysis,cervical range of motion assessment,sleep quality(PSQI scale),and transcranial Doppler(TCD)[1].Results:The total TCM syndrome score in the experimental group decreased significantly more than that in the control group(-4.5±1.2 vs.-2.3±0.8,P<0.001);The cervical flexion range of motion increased by 15.3°±3.2°(P<0.01),and the total PSQI score decreased by 6.5 points(P<0.001);In the experimental group,the vertebral artery blood flow velocity increased by 12.3%(P<0.05),and the serum IL-6 level decreased by 0.08 pg/mL(P<0.05)[2].Conclusion:The Yuxuangong Brain Health Sleep-Aid Pillow provides a modern scientific interpretation of the TCM theory of“defensive Qi entering Yin”through a three-dimensional mechanism of“magnetic field regulating Qi and dredging collaterals,and physical mechanical reset”,which has significant clinical transformation value[3].展开更多
Poland syndrome(PS)is a rare congenital condition characterized by unilateral absence or underdevelopment of the pectoralis major muscle,frequently accompanied by breast and chest wall anomalies.We report the case of ...Poland syndrome(PS)is a rare congenital condition characterized by unilateral absence or underdevelopment of the pectoralis major muscle,frequently accompanied by breast and chest wall anomalies.We report the case of an 18-year-old Chinese female diagnosed with PS complicated by contralateral macromastia who presented with significant breast asymmetry.Magnetic resonance imaging revealed a left breast volume of 618.90 mL and a right breast volume of 1137.04 mL.The patient underwent a staged reconstruction that included a right breast reduction mammaplasty and three sessions of autologous fat grafting to the left breast.Postoperative imaging 3 months after the final procedure confirmed near symmetry,with volumes measuring 831.37 mL(left)and 841.07 mL(right).The clinical follow-up demonstrated stable results and no complications.This case underscores the importance of individualized surgical planning,precise volumetric assessment,and the role of fat grafting in achieving satisfactory aesthetic outcomes in patients with PS and complex breast deformities.展开更多
High-density planting increases maize yield but also canopy crowding and stalk lodging.Aiming this contradiction,a wavy canopy was created using interlaced chemical application(IC)of a plant growth retardant at the V1...High-density planting increases maize yield but also canopy crowding and stalk lodging.Aiming this contradiction,a wavy canopy was created using interlaced chemical application(IC)of a plant growth retardant at the V14 stage with three densities(60,000,75,000,and 90,000 plants ha-1,indicated by D1,D2,and D3,respectively)for two seasons.The results showed that the IC-treated wavy canopy featuring both natural height(IC-H)and dwarfed(IC-L)plants,improved light transmission by 8.54%,8.49%,and 16.49%on average than the corresponding controls(CK)at D1,D2,and D3,respectively.The alleviation of canopy crowding stimulated leaf photosynthesis,sugar availability,basal-internode strength,and decreased plant lodging ratios in both IC-H and IC-L,particularly under higher densities.Meanwhile,the IC populations produced significantly higher yield than CK,with an average increase of 3.38%,16.70%,and 15.28%at D1,D2,and D3,respectively.Collectively,this study proposed a new wavy canopy strategy using plant growth retardant to simultaneously increase yield performance and lodging resistance,thus offering a sustainable solution for further development of high-density maize production.展开更多
Industrial ebullated-bed is an important device for promoting the cleaning and upgrading of oil products. The lumped kinetic model is a powerful tool for predicting the product yield of the ebullated-bed residue hydro...Industrial ebullated-bed is an important device for promoting the cleaning and upgrading of oil products. The lumped kinetic model is a powerful tool for predicting the product yield of the ebullated-bed residue hydrogenation (EBRH) unit, However, during the long-term operation of the device, there are phenomena such as low frequency of material property analysis leading to limited operating data and diverse operating modes at the same time scale, which poses a huge challenge to building an accurate product yield prediction model. To address these challenges, a data augmentation-based eleven lumped reaction kinetics mechanism model was constructed. This model combines generative adversarial networks, outlier elimination, and L2 norm data filtering to expand the dataset and utilizes kernel principal component analysis-fuzzy C-means for operating condition partitioning. Based on the hydrogenation reaction mechanism, a single and sub operating condition eleven lumped reaction kinetics model of an ebullated-bed residue hydrogenation unit, comprising 55 reaction paths and 110 parameters, was constructed before and after data augmentation. Compared to the single model before data enhancement, the average absolute error of the sub-models under data enhancement division was reduced by 23%. Thus, these findings can help guide the operation and optimization of the production process.展开更多
Natural fractures controlled by faults in ultradeep carbonate strata play substantial roles as both fluid migration channels and storage spaces.However,characterizing the heterogeneous distribution of underground frac...Natural fractures controlled by faults in ultradeep carbonate strata play substantial roles as both fluid migration channels and storage spaces.However,characterizing the heterogeneous distribution of underground fractures within the complex three-dimensional geometry of strike-slip fault zones remains challenging.This study investigates the characteristics of natural fractures controlled by strike-slip faults in the fractured Middle and Lower Ordovician reservoirs of the central and northern Tarim Basin,China.Seismics,cores,and image logs were integrated to quantitatively analyze the intensity and dip angle of natural fractures and findings were verified using published sandbox simulations.The carbonate reservoir contains three main types of natural fractures:tectonic fractures,abnormal high-pressure-related fractures,and stylolites.Strike-slip faults control the distribution and characteristics of tectonic fractures across various scales.Generally,both fracture intensity and porosity exhibit a decreasing trend as the distance from the main fault surface increases.Compared with those in non-stepover zones along a strike-slip fault,natural fractures and faults in stepover zones are more developed along the fault strike,with significantly greater development intensity in central stepover regions than that at its two ends.Furthermore,strike-slip faults influence the dip angles of both natural fractures and secondary faults.The proportion of medium-to-low-dip angle fractures and faults in the stepover zone is greater than that in the non-stepover zone.Additionally,the proportion of medium-to low-dip angle fractures and faults in the middle of the stepover is greater than that at both ends.Therefore,strike-slip fault structures control the dip angle of natural fracture and the heterogeneity of secondary fault and fracture intensity.The linking damage zone in the stepover contains a larger volume of fractured rocks,making it a promising petroleum exploration target.The development of stepovers and the orientation of present-day in-situ stress substantially influence the productivity of fractured reservoirs controlled by strike-slip faults.The analysis in this study reveals that reservoir productivity increases as the angle between the strike-slip fault segment and the maximum horizontal principal stress decreases.This study provides valuable insights for quantitatively evaluating fracture heterogeneity in fractured reservoirs and establishing optimized selection criteria for favorable targets in fault-related fractured reservoirs.展开更多
The 2D/3D heterojunction perovskites have garnered increasing attention due to their exceptional moisture and thermal stability.However,few works have paid attention to the influence of the subsequent change process o...The 2D/3D heterojunction perovskites have garnered increasing attention due to their exceptional moisture and thermal stability.However,few works have paid attention to the influence of the subsequent change process of 2D/3D heterojunction PSC on the stability of PSCs.Moreover,the evolution of the interface and carrier dynamic behavior of the 2D/3D perovskite films with long-term operation has not been systematically developed befo re.In this work,the effects of 2D/3 D heterojunction evolution on the interface of perovskite films and different carrier dynamics during 2D/3D evolution are systematically analyzed for the first time.The decomposition of 2D/3D heterojunction in the perovskite film will have a certain impact on the surface and carrier dynamics behavior of perovskite.During the evolution of 2D/3D heterojunction,PbI_(2)crystals will appear,which will improve the interfacial energy level matching between the electron transport layer and perovskite film.With a long evolution time,some holes will appear on the surface of perovskite film.The open circuit voltage(V_(OC))of PSCs increased from 1.14 to1.18 V and the PCE increased to 23.21%after 300 h storage in the nitrogen atmosphere,and maintained 89%initial performance for with 3000 h stability test in N_(2)box.This discovery has a significant role in promoting the development of inverted heterojunction PSCs and constructing the revolution mechanism of charge carrier dynamic.展开更多
Based on observed meteorological elements,photolysis rates(J-values)and pollutant concentrations,an automated J-values predicting system by machine learning(J-ML)has been developed to reproduce and predict the J-value...Based on observed meteorological elements,photolysis rates(J-values)and pollutant concentrations,an automated J-values predicting system by machine learning(J-ML)has been developed to reproduce and predict the J-values of O^(1)D,NO_(2),HONO,H_(2)O_(2),HCHO,and NO_(3),which are the crucial values for the prediction of the atmospheric oxidation capacity(AOC)and secondary pollutant concentrations such as ozone(O_(3)),secondary organic aerosols(SOA).The J-ML can self-select the optimal“Model+Hyperparameters”without human interference.The evaluated results showed that the J-ML had a good performance to reproduce the J-values wheremost of the correlation(R)coefficients exceed 0.93 and the accuracy(P)values are in the range of 0.68-0.83,comparing with the J-values from observations and from the tropospheric ultraviolet and visible(TUV)radiation model in Beijing,Chengdu,Guangzhou and Shanghai,China.The hourly prediction was also well performed with R from 0.78 to 0.81 for next 3-days and from 0.69 to 0.71 for next 7-days,respectively.Compared with O_(3)concentrations by using J-values from the TUV model,an emission-driven observation-based model(e-OBM)by using the J-values from the J-ML showed a 4%-12%increase in R and 4%-30%decrease in ME,indicating that the J-ML could be used as an excellent supplement to traditional numerical models.The feature importance analysis concluded that the key influential parameter was the surface solar downwards radiation for all J-values,and the other dominant factors for all J-values were 2-m mean temperature,O_(3),total cloud cover,boundary layer height,relative humidity and surface pressure.展开更多
Current breast reconstruction evaluations mostly focus on static cosmetic analysis as a measure of the clinical outcomes.Moreover,it is essential to consider the dynamic changes in the reconstructed breast alongside a...Current breast reconstruction evaluations mostly focus on static cosmetic analysis as a measure of the clinical outcomes.Moreover,it is essential to consider the dynamic changes in the reconstructed breast alongside assessments of aesthetic symmetry,functional restoration,complication rates,and long-term stability of the reconstruction.This study aimed to assess the mobility of the reconstructed breast following various breast reconstruction techniques,specifically by comparing deep inferior epigastric perforator(DIEP) flaps and pedicled transverse rectus abdominis musculocutaneous(TRAM) flaps.We conducted a longitudinal case study to investigate the changes in breast movement resulting from different surgical interventions.The comparison showed that DIEP flap reconstruction was more likely to achieve superior breast mobility outcomes than TRAM flap reconstruction.For a better breast aesthetic outcome,it is fundamental to improve the awareness of the dynamic evaluation of the reconstructed breast at the surgical strategy level.展开更多
The angiogenic response is essential for the repair of ischemic brain tissue.Integrin α6(Itga6)expression has been shown to increase under hypoxic conditions and is expressed exclusively in vascular structures;howeve...The angiogenic response is essential for the repair of ischemic brain tissue.Integrin α6(Itga6)expression has been shown to increase under hypoxic conditions and is expressed exclusively in vascular structures;however,its role in post-ischemic angiogenesis remains poorly understood.In this study,we demonstrate that mice with endothelial cell-specific knockout of Itga6 exhibit reduced neovascularization,reduced pericyte coverage on microvessels,and accelerated breakdown of microvascular integrity in the peri-infarct area.In vitro,endothelial cells with ITGA6 knockdown display reduced proliferation,migration,and tube-formation.Mechanistically,we demonstrated that ITGA6 regulates post-stroke angiogenesis through the PI3K/Akt-eNOS-VEGFA axis.Importantly,the specific overexpression of Itga6 in endothelial cells significantly enhanced neovascularization and enhanced the integrity of microvessels,leading to improved functional recovery.Our results suggest that endothelial cell Itga6 plays a crucial role in key steps of post-stroke angiogenesis,and may represent a promising therapeutic target for promoting recovery after stroke.展开更多
Background: China has a high prevalence of HP infection, and the rate of HP infection in highland populations is higher than the average rate of HP infection in natural populations. However, there is a lack of compara...Background: China has a high prevalence of HP infection, and the rate of HP infection in highland populations is higher than the average rate of HP infection in natural populations. However, there is a lack of comparative studies on the current status of HP infection in high- and low-altitude. Therefore, this study aims to investigate the current status and differences in HP infection between the health check-up populations in the highland region and the plain area. Methods: This is a multicenter cross-sectional study, using convenience sampling method, which included the health check-up population of Ruoergai County People’s Hospital and the health check-up population of Deyang City People’s Hospital from January 2023 to December 2023, to carry out the questionnaire survey of HP-related factors, and to detect HP infection by a 13C-urea breath test. Results: The number of positives was 144 out of 260 health checkups in the plateau region, with a detection rate of 55.4%, which was significantly higher than that of 29.8% in the plains (P H. pylori infection-positive population, the health checkups in the plateau group had a lower education level, a higher proportion of overweight and obesity, a higher proportion of frequent smokers, a higher frequency of frequent eating out, and a lower proportion of abnormalities of uric acid, total cholesterol, LDL cholesterol, alanine aminotransferase, aspartate aminotransferase, and direct bilirubin but a higher proportion of abnormalities of total bilirubin. There was no statistically significant difference between the two groups in terms of age, gender, history of alcohol consumption, family history, urea, creatinine, and blood glucose. Conclusion: Preliminary results indicate that the rate of HP infection in the plateau population is significantly higher than that in the plains, and HP-related health education should be strengthened in the plateau region.展开更多
基金supported by Shanghai Municipal Planning Commission of Science and Research Fund(Shanghai,China,No.20174Y0164)to SF。
文摘Objective:Metabolic syndrome is a complex medical condition that has become an alarming epidemic,but an effective therapy for this disease is still lacking.The use of the herbal formula Huangqisan(HQS)to treat diabetes is documented in the Chinese medical literature as early as 1117 A.D.;however,its therapeutic effects and underlying mechanisms remain elusive.Methods:To investigate the beneficial effects of HQS on metabolic disorders,high-fat diet-induced obesity(DIO),leptin receptor dysfunction(db/db)and low-density lipoprotein receptor-knockout(LDLR^(-/-))mice were used.Obese mice were treated with either HQS or vehicle.Blood,liver tissue,white fat tissue and brown adipose tissue were harvested at the end of the treatment.Metabolic disease-related parameters were evaluated to test effects of HQS against diabetes,obesity and hyperlipidemia.Aortic arches from LDLR^(-/-)mice were analyzed to investigate the effects of HQS on atherosclerosis.RNA-sequence,quantitative real-time polymerase chain reaction and Western blot were performed to investigate the mechanisms of HQS against metabolic disorder.Results:HQS lowered body weight,fasting blood glucose and serum lipid levels and improved glucose tolerance and insulin sensitivity in DIO mice and db/db mice(P<0.05).HQS also blocked atherosclerotic plaque formation in LDLR^(^(-/-)) mice.HQS suppressed de novo lipid synthesis by reducing the expression of messenger RNA for sterol regulatory element-binding factor 1,stearyl coenzyme A desaturase 1 and fatty acid synthase,and enhancing adenosine 5’-monophosphate-activated protein kinase signaling in both in vivo and in vitro experiments,indicating potential mechanisms for HQS’s activity against diabetes.Conclusion:HQS is effective for reversing metabolic disorder and has the potential to be used as therapy for metabolic syndrome.
基金supported by the National Natural Science Foundation of China(No.U21B2062).
文摘The isolated fracture-vug systems controlled by small-scale strike-slip faults within ultra-deep carbonate rocks of the Tarim Basin exhibit significant exploration potential.The study employs a novel training set incorporating innovative fault labels to train a U-Net-structured CNN model,enabling effective identification of small-scale strike-slip faults through seismic data interpretation.Based on the CNN faults,we analyze the distribution patterns of small-scale strike-slip faults.The small-scale strike-slip faults can be categorized into NNW-trending and NE-trending groups with strike lengths ranging 200–5000 m.The development intensity of small-scale strike-slip faults in the Lower Yingshan Member notably exceeds that in the Upper Member.The Lower and Upper Yingshan members are two distinct mechanical layers with contrasting brittleness characteristics,separated by a low-brittleness layer.The superior brittleness of the Lower Yingshan Member enhances the development intensity of small-scale strike-slip faults compared to the upper member,while the low-brittleness layer exerts restrictive effects on vertical fault propagation.Fracture-vug systems formed by interactions of two or more small-scale strike-slip faults demonstrate larger sizes than those controlled by individual faults.All fracture-vug system sizes show positive correlations with the vertical extents of associated small-scale strike-slip faults,particularly intersection and approaching fracture-vug systems exhibit accelerated size increases proportional to the vertical extents.
基金supported by the National Natural Science Foundation of China(NSFC)(No.42272169)the efficient exploration and development technologies and integrated demonstration project for deep and ultra-deep carbonate oil and gas reservoirs in the Tarim Basin(No.2025ZD1402301)+1 种基金the Integrated Project of the Joint Fund for Enterprise Innovation and Development of the National Natural Science Foundation of China(No.U24B6001)the Bureau-Level Scientific Research Project of Northwest Oilfield Company(No.KJ202501).
文摘0 INTRODUCTION Gas injection refers to the natural gas charging into pre-existing oil reservoirs,which often leads to notable changes in gas-oil ratio(GOR),oil density,and phase states,depending on the pressure-temperature condition of the reservoirs(Meulbroek et al.,1998;Blanc and Connan,1994;Evans et al.,1971).
基金supported by Natural Science Foundation of Anhui Province(2008085MH273)Anhui Fund for Distinguished Young Scholars(2022AH020050)+3 种基金the Scientific Research Platform Improvement Project of Anhui Medical University(2022xkjT045)the Natural Science Foundation of Anhui Province(No.2108085MH278)Graduate Research and Practice Innovation Project of Anhui Medical University(YJS20230110)the Science and Technology Program of Ma’anshan City(No.YL-2022-8)。
文摘Background:Renal cell carcinoma(RCC)is a prevalent malignancy characterized by a rising incidence and significant mortality.Interleukins(ILs)are crucial in regulating immune cell trafficking and exhibit anti-tumor properties.However,limited research has explored the expression levels and prognostic significance of interleukins in RCC.Methods:In this comprehensive study,we performed a detailed analysis of interleukins in RCC patients using multiple bioinformatics tools,including Oncomine,UALCAN,GEPIA,Kaplan-Meier plotter,cBioPortal,GeneMANIA,TRRUST,STRING,and Linked Omics.Results:Our analysis demonstrated a significant upregulation in the transcriptional levels of IL4,IL7,IL15,IL16,IL23A,IL26,and IL32 were significantly upregulated in RCC tissues,indicating their potential involvement in the pathogenesis of this malignancy.In contrast,IL1A,IL11,and IL27 were downregulated,indicating their potential function as tumor suppressors.Significant correlations were identified between the expression levels of IL11,IL23A,IL27,IL32,and the pathological stage of RCC patients.The expression levels of IL1A,IL4,IL11,IL15,IL16,IL23A,IL26,IL27,and IL32 were significantly correlated with improved prognosis.The differentially expressed interleukins primarily function in cytokine-cytokine receptor interactions and immune response-regulating signaling pathways.homeobox A10(HOXA10),v-myb myeloblastosis viral oncogene homolog(avian)(MYB),v-rel reticuloendotheliosis viral oncogene homolog A(avian)(RELA),and nuclear factor of kappa light polypeptide gene enhancer in B-cells 1(NFKB1)are key transcription factors for ILs,while LCK proto-oncogene(LCK),LYN proto-oncogene(LYN),spleen associated tyrosine kinase(SYK),Janus kinase 3(JAK3),and FER tyrosine kinase(FER)are IL targets.IL expression significantly correlated with the infiltration of six distinct immune cell types.IL1A potentially exerts an anti-tumor effect in RCC prognosis by inducing neutrophil extracellular traps(NETs).Additionally,NFKB1 may positively regulate IL1A,providing a rationale for further in vivo and clinical studies.Conclusion:In conclusion,our study demonstrates the potential role of IL 1A in the prognosis of RCC and establishes a theoretical foundation for subsequent in vivo and clinical investigations.
文摘Objective:Based on the theories of“defensive Qi entering Yin”and“Qi and blood in meridians”in traditional Chinese medicine(TCM),this study explores the synergistic intervention effect of the Brain Health Sleep-Aid Pillow on brain diseases(such as insomnia,vertigo)and cervical spondylosis.The pillow achieves“marrow sea replenishment and unobstructed cerebral collaterals”by regulating cerebral blood perfusion and cervical mechanical balance through linear pulsed magnetic guidance of the Du Meridian and Bladder Meridian.Methods:A total of 120 patients with“neck impediment”and“insomnia”who met the Criteria for Diagnosis and Therapeutic Effect of TCM Syndromes were enrolled.They were randomly divided into an experimental group(60 cases,using Yuxuangong magnetic therapy pillow)and a control group(60 cases,using ordinary buckwheat pillow)by block randomization.The intervention lasted for 8 weeks.The efficacy was comprehensively evaluated using indicators including TCM syndrome scores,tongue and pulse analysis,cervical range of motion assessment,sleep quality(PSQI scale),and transcranial Doppler(TCD)[1].Results:The total TCM syndrome score in the experimental group decreased significantly more than that in the control group(-4.5±1.2 vs.-2.3±0.8,P<0.001);The cervical flexion range of motion increased by 15.3°±3.2°(P<0.01),and the total PSQI score decreased by 6.5 points(P<0.001);In the experimental group,the vertebral artery blood flow velocity increased by 12.3%(P<0.05),and the serum IL-6 level decreased by 0.08 pg/mL(P<0.05)[2].Conclusion:The Yuxuangong Brain Health Sleep-Aid Pillow provides a modern scientific interpretation of the TCM theory of“defensive Qi entering Yin”through a three-dimensional mechanism of“magnetic field regulating Qi and dredging collaterals,and physical mechanical reset”,which has significant clinical transformation value[3].
文摘Poland syndrome(PS)is a rare congenital condition characterized by unilateral absence or underdevelopment of the pectoralis major muscle,frequently accompanied by breast and chest wall anomalies.We report the case of an 18-year-old Chinese female diagnosed with PS complicated by contralateral macromastia who presented with significant breast asymmetry.Magnetic resonance imaging revealed a left breast volume of 618.90 mL and a right breast volume of 1137.04 mL.The patient underwent a staged reconstruction that included a right breast reduction mammaplasty and three sessions of autologous fat grafting to the left breast.Postoperative imaging 3 months after the final procedure confirmed near symmetry,with volumes measuring 831.37 mL(left)and 841.07 mL(right).The clinical follow-up demonstrated stable results and no complications.This case underscores the importance of individualized surgical planning,precise volumetric assessment,and the role of fat grafting in achieving satisfactory aesthetic outcomes in patients with PS and complex breast deformities.
基金supported by the National Key Research and Development Program of China(2023YFD2303302,2022YFD2300803)the National Natural Science Foundation of China(32160445)the China Agriculture Research System of MOF and MARA(CARS-02-16).
文摘High-density planting increases maize yield but also canopy crowding and stalk lodging.Aiming this contradiction,a wavy canopy was created using interlaced chemical application(IC)of a plant growth retardant at the V14 stage with three densities(60,000,75,000,and 90,000 plants ha-1,indicated by D1,D2,and D3,respectively)for two seasons.The results showed that the IC-treated wavy canopy featuring both natural height(IC-H)and dwarfed(IC-L)plants,improved light transmission by 8.54%,8.49%,and 16.49%on average than the corresponding controls(CK)at D1,D2,and D3,respectively.The alleviation of canopy crowding stimulated leaf photosynthesis,sugar availability,basal-internode strength,and decreased plant lodging ratios in both IC-H and IC-L,particularly under higher densities.Meanwhile,the IC populations produced significantly higher yield than CK,with an average increase of 3.38%,16.70%,and 15.28%at D1,D2,and D3,respectively.Collectively,this study proposed a new wavy canopy strategy using plant growth retardant to simultaneously increase yield performance and lodging resistance,thus offering a sustainable solution for further development of high-density maize production.
基金supported by National Natural Science Foundation of China(Basic Science Center Program:61988101)National Natural Science Foundation of China(62394345,62373155,62173147)the Major Science and Technology Project of Xinjiang(No.2022A01006-4).
文摘Industrial ebullated-bed is an important device for promoting the cleaning and upgrading of oil products. The lumped kinetic model is a powerful tool for predicting the product yield of the ebullated-bed residue hydrogenation (EBRH) unit, However, during the long-term operation of the device, there are phenomena such as low frequency of material property analysis leading to limited operating data and diverse operating modes at the same time scale, which poses a huge challenge to building an accurate product yield prediction model. To address these challenges, a data augmentation-based eleven lumped reaction kinetics mechanism model was constructed. This model combines generative adversarial networks, outlier elimination, and L2 norm data filtering to expand the dataset and utilizes kernel principal component analysis-fuzzy C-means for operating condition partitioning. Based on the hydrogenation reaction mechanism, a single and sub operating condition eleven lumped reaction kinetics model of an ebullated-bed residue hydrogenation unit, comprising 55 reaction paths and 110 parameters, was constructed before and after data augmentation. Compared to the single model before data enhancement, the average absolute error of the sub-models under data enhancement division was reduced by 23%. Thus, these findings can help guide the operation and optimization of the production process.
基金supported by the National Natural Science Foundation of China(No.U21B2062)funding from the Chinese Scholarship Council(CSC)and the American Association of Petroleum Geologists Foundation Grantsin-Aid Program.
文摘Natural fractures controlled by faults in ultradeep carbonate strata play substantial roles as both fluid migration channels and storage spaces.However,characterizing the heterogeneous distribution of underground fractures within the complex three-dimensional geometry of strike-slip fault zones remains challenging.This study investigates the characteristics of natural fractures controlled by strike-slip faults in the fractured Middle and Lower Ordovician reservoirs of the central and northern Tarim Basin,China.Seismics,cores,and image logs were integrated to quantitatively analyze the intensity and dip angle of natural fractures and findings were verified using published sandbox simulations.The carbonate reservoir contains three main types of natural fractures:tectonic fractures,abnormal high-pressure-related fractures,and stylolites.Strike-slip faults control the distribution and characteristics of tectonic fractures across various scales.Generally,both fracture intensity and porosity exhibit a decreasing trend as the distance from the main fault surface increases.Compared with those in non-stepover zones along a strike-slip fault,natural fractures and faults in stepover zones are more developed along the fault strike,with significantly greater development intensity in central stepover regions than that at its two ends.Furthermore,strike-slip faults influence the dip angles of both natural fractures and secondary faults.The proportion of medium-to-low-dip angle fractures and faults in the stepover zone is greater than that in the non-stepover zone.Additionally,the proportion of medium-to low-dip angle fractures and faults in the middle of the stepover is greater than that at both ends.Therefore,strike-slip fault structures control the dip angle of natural fracture and the heterogeneity of secondary fault and fracture intensity.The linking damage zone in the stepover contains a larger volume of fractured rocks,making it a promising petroleum exploration target.The development of stepovers and the orientation of present-day in-situ stress substantially influence the productivity of fractured reservoirs controlled by strike-slip faults.The analysis in this study reveals that reservoir productivity increases as the angle between the strike-slip fault segment and the maximum horizontal principal stress decreases.This study provides valuable insights for quantitatively evaluating fracture heterogeneity in fractured reservoirs and establishing optimized selection criteria for favorable targets in fault-related fractured reservoirs.
基金financial support provided by the Sichuan Science and Technology Program(No.2022NSFSC0226)Sichuan Science and Technology Program(No.2023ZYD0163)+6 种基金the Production-Education Integration Demonstration Project of Sichuan Provincethe Photovoltaic Industry Production-Education Integration Comprehensive Demonstration Base of Sichuan Province(Sichuan Financial Education[2022]No.106)China Tianfu Yongxing Laboratory Science and Technology Key Project(2023KJGG15)National Key Research and Development Program of China(2022YFB3803300)Beijing Natural Science Foundation(IS23037)the Department for Energy Security and Net Zero(project ID:NEXTCCUS)the ACT program(Accelerating CCS Technologies,Horizon2020 project NO.691712)。
文摘The 2D/3D heterojunction perovskites have garnered increasing attention due to their exceptional moisture and thermal stability.However,few works have paid attention to the influence of the subsequent change process of 2D/3D heterojunction PSC on the stability of PSCs.Moreover,the evolution of the interface and carrier dynamic behavior of the 2D/3D perovskite films with long-term operation has not been systematically developed befo re.In this work,the effects of 2D/3 D heterojunction evolution on the interface of perovskite films and different carrier dynamics during 2D/3D evolution are systematically analyzed for the first time.The decomposition of 2D/3D heterojunction in the perovskite film will have a certain impact on the surface and carrier dynamics behavior of perovskite.During the evolution of 2D/3D heterojunction,PbI_(2)crystals will appear,which will improve the interfacial energy level matching between the electron transport layer and perovskite film.With a long evolution time,some holes will appear on the surface of perovskite film.The open circuit voltage(V_(OC))of PSCs increased from 1.14 to1.18 V and the PCE increased to 23.21%after 300 h storage in the nitrogen atmosphere,and maintained 89%initial performance for with 3000 h stability test in N_(2)box.This discovery has a significant role in promoting the development of inverted heterojunction PSCs and constructing the revolution mechanism of charge carrier dynamic.
基金supported by the National Key Project of the Ministry of Science and Technology of China(No.2022YFC3701200)the National Natural Science Foundation of China(No.42090030).
文摘Based on observed meteorological elements,photolysis rates(J-values)and pollutant concentrations,an automated J-values predicting system by machine learning(J-ML)has been developed to reproduce and predict the J-values of O^(1)D,NO_(2),HONO,H_(2)O_(2),HCHO,and NO_(3),which are the crucial values for the prediction of the atmospheric oxidation capacity(AOC)and secondary pollutant concentrations such as ozone(O_(3)),secondary organic aerosols(SOA).The J-ML can self-select the optimal“Model+Hyperparameters”without human interference.The evaluated results showed that the J-ML had a good performance to reproduce the J-values wheremost of the correlation(R)coefficients exceed 0.93 and the accuracy(P)values are in the range of 0.68-0.83,comparing with the J-values from observations and from the tropospheric ultraviolet and visible(TUV)radiation model in Beijing,Chengdu,Guangzhou and Shanghai,China.The hourly prediction was also well performed with R from 0.78 to 0.81 for next 3-days and from 0.69 to 0.71 for next 7-days,respectively.Compared with O_(3)concentrations by using J-values from the TUV model,an emission-driven observation-based model(e-OBM)by using the J-values from the J-ML showed a 4%-12%increase in R and 4%-30%decrease in ME,indicating that the J-ML could be used as an excellent supplement to traditional numerical models.The feature importance analysis concluded that the key influential parameter was the surface solar downwards radiation for all J-values,and the other dominant factors for all J-values were 2-m mean temperature,O_(3),total cloud cover,boundary layer height,relative humidity and surface pressure.
文摘Current breast reconstruction evaluations mostly focus on static cosmetic analysis as a measure of the clinical outcomes.Moreover,it is essential to consider the dynamic changes in the reconstructed breast alongside assessments of aesthetic symmetry,functional restoration,complication rates,and long-term stability of the reconstruction.This study aimed to assess the mobility of the reconstructed breast following various breast reconstruction techniques,specifically by comparing deep inferior epigastric perforator(DIEP) flaps and pedicled transverse rectus abdominis musculocutaneous(TRAM) flaps.We conducted a longitudinal case study to investigate the changes in breast movement resulting from different surgical interventions.The comparison showed that DIEP flap reconstruction was more likely to achieve superior breast mobility outcomes than TRAM flap reconstruction.For a better breast aesthetic outcome,it is fundamental to improve the awareness of the dynamic evaluation of the reconstructed breast at the surgical strategy level.
基金supported by grants from the Scientific Research Foundation for Young Doctors of the Second Affiliated Hospital,Army Medical University(2022YQB041)the Chongqing Natural Science Foundation(CSTB2024NSCQ-MSX0924 and CSTB2024NSCQ-MSX0909).
文摘The angiogenic response is essential for the repair of ischemic brain tissue.Integrin α6(Itga6)expression has been shown to increase under hypoxic conditions and is expressed exclusively in vascular structures;however,its role in post-ischemic angiogenesis remains poorly understood.In this study,we demonstrate that mice with endothelial cell-specific knockout of Itga6 exhibit reduced neovascularization,reduced pericyte coverage on microvessels,and accelerated breakdown of microvascular integrity in the peri-infarct area.In vitro,endothelial cells with ITGA6 knockdown display reduced proliferation,migration,and tube-formation.Mechanistically,we demonstrated that ITGA6 regulates post-stroke angiogenesis through the PI3K/Akt-eNOS-VEGFA axis.Importantly,the specific overexpression of Itga6 in endothelial cells significantly enhanced neovascularization and enhanced the integrity of microvessels,leading to improved functional recovery.Our results suggest that endothelial cell Itga6 plays a crucial role in key steps of post-stroke angiogenesis,and may represent a promising therapeutic target for promoting recovery after stroke.
文摘Background: China has a high prevalence of HP infection, and the rate of HP infection in highland populations is higher than the average rate of HP infection in natural populations. However, there is a lack of comparative studies on the current status of HP infection in high- and low-altitude. Therefore, this study aims to investigate the current status and differences in HP infection between the health check-up populations in the highland region and the plain area. Methods: This is a multicenter cross-sectional study, using convenience sampling method, which included the health check-up population of Ruoergai County People’s Hospital and the health check-up population of Deyang City People’s Hospital from January 2023 to December 2023, to carry out the questionnaire survey of HP-related factors, and to detect HP infection by a 13C-urea breath test. Results: The number of positives was 144 out of 260 health checkups in the plateau region, with a detection rate of 55.4%, which was significantly higher than that of 29.8% in the plains (P H. pylori infection-positive population, the health checkups in the plateau group had a lower education level, a higher proportion of overweight and obesity, a higher proportion of frequent smokers, a higher frequency of frequent eating out, and a lower proportion of abnormalities of uric acid, total cholesterol, LDL cholesterol, alanine aminotransferase, aspartate aminotransferase, and direct bilirubin but a higher proportion of abnormalities of total bilirubin. There was no statistically significant difference between the two groups in terms of age, gender, history of alcohol consumption, family history, urea, creatinine, and blood glucose. Conclusion: Preliminary results indicate that the rate of HP infection in the plateau population is significantly higher than that in the plains, and HP-related health education should be strengthened in the plateau region.
