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推进三级医院四级手术术前多学科讨论的实践探索
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作者 王宁燕 程冕 +2 位作者 闫蕾 岑晨 胡涛 《中国医疗管理科学》 2026年第1期105-109,共5页
目的基于《医疗机构手术分级管理办法》等国家政策要求,推动三级医院开展四级手术术前多学科讨论,提升讨论完成率,最大限度降低手术风险与并发症发生率,以保障手术质量与医疗安全。方法从四级手术术前多学科讨论的必要性出发,分析三级... 目的基于《医疗机构手术分级管理办法》等国家政策要求,推动三级医院开展四级手术术前多学科讨论,提升讨论完成率,最大限度降低手术风险与并发症发生率,以保障手术质量与医疗安全。方法从四级手术术前多学科讨论的必要性出发,分析三级医院开展此项工作的具体问题与实际困难,进而提出针对性措施并督导实施。结果以某院为例,通过深入调研,实施精准手术分级管理、全流程管理及监督机制等措施,定期召开多部门联席会议解决实际问题,为三级医院有效开展此项工作提供经验参考。结论三级医院开展四级手术术前多学科讨论面临多种挑战,可通过院、科两级在制度建设、教育培训和组织管理等方面提供支持,以有效推进这项工作深入进行。 展开更多
关键词 三级医院 四级手术 术前多学科讨论
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锁阳防治阿尔茨海默病药理学研究进展 被引量:1
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作者 李佳欣 范琦 +6 位作者 李义楠 岑辰 杨猛 东方 韩善仓 杨建 倪秀芹 《辽宁中医药大学学报》 2025年第2期99-104,共6页
锁阳作为我国传统中药,在临床中具有广泛的用途,化学、药理等多学科综合研究加深了人们对它的认识。锁阳及其提取物表现出一定的有益健康功能,吸引了更多的患者和药学研究者的关注,它具有广泛的体外和体内药理活性,包括抗疲劳、抗缺氧... 锁阳作为我国传统中药,在临床中具有广泛的用途,化学、药理等多学科综合研究加深了人们对它的认识。锁阳及其提取物表现出一定的有益健康功能,吸引了更多的患者和药学研究者的关注,它具有广泛的体外和体内药理活性,包括抗疲劳、抗缺氧、抗氧化、抗糖尿病、免疫调节、抗病毒等作用。目前也常用于阿尔茨海默病(Alzheimer's disease,AD)的临床治疗,在防治AD的研究中发现,锁阳可调控MAPK/ERK1/2等信号通路的表达,改善学习记忆能力;改善胰岛素信号通路,减少淀粉样蛋白β(Aβ)的积累;可降低海马组织损伤;促进神经元突触重塑;也可调节神经中胆碱能系统;延长脑组织细胞染色体末端端粒长度及血细胞端粒长度,起到抗衰老作用;也可通过对丝裂原活化蛋白激酶(MAPK)信号通路的调节发挥类雌激素作用等。锁阳通过多途径、多靶点共同作用,在神经退行性疾病AD防治中具有极大的潜在研究价值。该文总结了近年来锁阳防治AD的相关研究,以期为其开发和使用提供一定参考。 展开更多
关键词 锁阳 阿尔茨海默病 研究进展
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高效液相色谱法与离子色谱法测定化妆品原料乙酰基六肽-8中醋酸和三氟乙酸的比较研究 被引量:1
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作者 陈岑 戴小敏 +1 位作者 颜琳琦 程巧鸳 《日用化学工业(中英文)》 北大核心 2025年第8期1078-1084,共7页
考察高效液相色谱法和离子色谱法两种方法检测化妆品原料乙酰基六肽-8中醋酸和三氟乙酸结果的一致性。对高效液相色谱法和离子色谱法测定醋酸和三氟乙酸的方法进行改进和优化,对专属性、线性范围、检出限、定量下限、回收率、精密度、... 考察高效液相色谱法和离子色谱法两种方法检测化妆品原料乙酰基六肽-8中醋酸和三氟乙酸结果的一致性。对高效液相色谱法和离子色谱法测定醋酸和三氟乙酸的方法进行改进和优化,对专属性、线性范围、检出限、定量下限、回收率、精密度、重复性和稳定性等方法学指标作比对,并对15批次乙酰基六肽-8原料中醋酸和三氟乙酸的测定结果进行统计学分析。结果表明,两种方法均有良好的专属性,离子色谱法的线性范围较高效液相色谱法更宽,且检出限和定量下限比高效液相色谱法更低,但是高效液相色谱法的精密度更好。两种方法均能较好地对乙酰基六肽-8中醋酸和三氟乙酸进行定性和定量分析,经配对t检验处理,两种方法对酰基六肽-8中醋酸的测定结果无统计学差异(|t|=0.200,P>0.05)。两种方法各有优势,可根据实际情况选择适合的测定方法。 展开更多
关键词 醋酸 三氟乙酸 高效液相色谱法 离子色谱法 乙酰基六肽-8
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阶梯式湿法消解-原子荧光光谱法测定海洋生物体中砷的含量
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作者 岑陈 张临 +3 位作者 何书海 符式锦 李晓敏 吴小龙 《理化检验(化学分册)》 北大核心 2025年第12期1414-1419,共6页
为解决现行的海洋生物体中砷的前处理方法(国家标准GB 5009.11—2014和GB 17378.6—2007)中消解温度不明确或较低、不完全消解、测定结果准确度低的问题,提出了题示方法。取0.500~5.000 g生物体样品于100 mL三角锥瓶中,加入16 mL硝酸和4... 为解决现行的海洋生物体中砷的前处理方法(国家标准GB 5009.11—2014和GB 17378.6—2007)中消解温度不明确或较低、不完全消解、测定结果准确度低的问题,提出了题示方法。取0.500~5.000 g生物体样品于100 mL三角锥瓶中,加入16 mL硝酸和4 mL高氯酸的混合液,摇匀后置于电热板上,升温至120℃,消解0.5 h,再升温至200℃,消解至约1 mL,冷却后,加入3 mL硫酸,升温至300℃,消解1 h以上,至约0.5 mL。冷却后,用10%(体积分数)盐酸溶液20 mL于200℃加热溶解,直至剩余约10 mL,冷却后,将消解液转移至25 mL比色管中,用水定容。分取5.0 mL置于25 mL比色管中,加入2.5 mL盐酸、2.5 mL硫脲-抗坏血酸溶液(由10 g硫脲和10 g抗坏血酸溶于100 mL水中配制而成),室温放置15 min,用水定容,采用原子荧光光谱法测定其中砷的含量。结果表明:砷的质量浓度在20μg·L^(-1)以内与对应的荧光强度呈线性关系,检出限(3.143s)为0.006 mg·kg^(-1)。对海洋生物体标准物质平行分析6次,砷的测定平均值均在认定值的不确定度范围内,相对误差为-2.4%~14%。对海洋生物体实际样品进行加标回收试验,回收率为106%~108%;对两种类型的海洋生物体实际样品平行分析6次,测定值的相对标准偏差分别为3.0%,3.8%。将本方法与GB 5009.11—2014中第二法(微波消解-电感耦合等离子体质谱法)进行对比,F检验和t检验结果显示,两种方法无显著性差异。 展开更多
关键词 原子荧光光谱法 阶梯式湿法消解 海洋生物体
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Gastric cancer in children infected with Helicobacter pylori
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作者 Xia Gong cen chen Jun-Fei Shen 《World Journal of Gastrointestinal Oncology》 2025年第6期186-194,共9页
BACKGROUND This retrospective study aimed to define associations between Helicobacter pylori(H.pylori)in childhood and risk factors for gastric cancer with special emphasis on the role of family history of cancer.AIM ... BACKGROUND This retrospective study aimed to define associations between Helicobacter pylori(H.pylori)in childhood and risk factors for gastric cancer with special emphasis on the role of family history of cancer.AIM To define associations between H.pylori in childhood and risk factors for gastric cancer with special emphasis on the role of family history of cancer.METHODS Details of 600 children who were subjected to upper gastrointestinal endoscopies at our institution are analyzed.Children were classified into positive and negative groups for H.pylori infection based on biopsy and rapid urease tests.The oc-currences of gastric carcinoma,chronic superficial gastritis,glandular atrophy,and intestinal metaplasia among the groups are compared.RESULTS In our study,among the overall population,330 children tested positive for H.pylori,which constituted 55%of the study population.The group denoting H.pylori positivity was found to have strikingly higher frequencies of chronic superficial gastritis(78.8%vs 5.9%),gastric atrophy(39.4%vs 7%),and intestinal metaplasia(0.9%vs 0%),as compared to the H.pylori-negative group.It is interesting to observe that there were a few but statistically significant cases of H.pylori-positive children having a family history of gastric cancer(1.2%),whereas no such cases were reported in children who were H.pylori-negative.CONCLUSION Our study finds that H.pylori infection in childhood is associated with an increased risk of precancerous gastric conditions and that family history might provide an additional risk.These insights recommend the necessity of early H.pylori detection and intervention and management strategies in childhood,especially in those families with histories of gastric cancer. 展开更多
关键词 Helicobacter pylori Gastric cancer Stomach neoplasms CHILDREN Risk factors
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Early field performance of three planted inland northwest conifer species:Effects of root growth potential,morphology,and environmental conditions
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作者 cen chen Jacob A.Reely Andrew S.Nelson 《Forest Ecosystems》 2025年第2期231-242,共12页
A common concern to planting for reforestation is seedling failure that is directly measurable by seedling early field performance of growth and survival.Root growth potential(RGP)is a commonly used metric of seedling... A common concern to planting for reforestation is seedling failure that is directly measurable by seedling early field performance of growth and survival.Root growth potential(RGP)is a commonly used metric of seedling quality and has been considered indicative of seedling field performance.The effect of RGP is thought to be dependent on planting site and underlining environmental conditions.Moisture stress often is considered the primary cause of seedling failure in addition to other environmental factors such as soil physicochemical properties in regions such as the Inland Northwest of the United States that is prone to growing season drought.In addition,it is interesting to test whether seedling early field performance is related to their morphological attributes and whether the morphological attributes are related to RGP.A comprehensive evaluation on early field performance of three planted conifer species of interior Douglas-fir(Pseudotsuga menziesii(Mirb.)Franco var.glauca(Beissn.)Franco),grand fir(Abies grandis(Douglas ex D.Don)Lindl.),and western larch(Larix occidentalis Nutt.)was conducted in this study.It was found that RGP did not show clear correlation with early field performance across species.RGP also was not significantly correlated with seedling morphological measures such as below-and above-ground biomass and root-to-shoot ratio(R:S,by mass).Early field performance of growth and survival varied greatly across individuals of seedlings.The most influential predictors of early seedling growth and survival were their initial size(indicative of energy reserve)and soil temperature that likely interacted with soil moisture.Our findings suggest that seed stock selection for reforestation probably should favor species and genotypes with greatest heat tolerance that may be better adapted to future conditions in the region. 展开更多
关键词 Seedling quality Growth MORTALITY Moisture stress Heat tolerance
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一种多路视频的360度实时拼接技术 被引量:5
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作者 黄樟钦 母召 +1 位作者 岑陈 高寒 《西安电子科技大学学报》 EI CAS CSCD 北大核心 2020年第2期1-8,31,共9页
针对视频拼接实现过程中图像配准阶段耗时较大的问题,设计出一种基于二进制鲁棒尺度不变性特征算法与运动统计算法的组合式图像配准算法。在二进制鲁棒尺度不变性特征算法快速特征提取特性的基础上,利用网格化方法对重叠区域图像进行划... 针对视频拼接实现过程中图像配准阶段耗时较大的问题,设计出一种基于二进制鲁棒尺度不变性特征算法与运动统计算法的组合式图像配准算法。在二进制鲁棒尺度不变性特征算法快速特征提取特性的基础上,利用网格化方法对重叠区域图像进行划分,使特征点分布更加均匀,从而减少需要操作的特征点数量以提高速率;在匹配环节,利用运动统计算法剔除误匹配对,利用双向匹配策略提高匹配准确率。为使图像融合的更加自然流畅,设计出一种区域化的渐入渐出加权融合算法:为减少求解重叠区域存在的误差,构建融合区域并进行区域化划分,利用最佳缝合线法求得拼接缝,在不同区域使用渐入渐出加权算法实现图像融合,从而获取融合质量更高的全景图像。最后,设计出完整的全景视频拼接系统,通过实验验证了系统方案的可行性和实用性。实验证明,相对于传统的视频拼接技术,新算法在消除拼接时出现的重影和接缝问题的同时,保证了视频拼接的实时性。 展开更多
关键词 全景视频拼接 图像配准 图像融合
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39例肺肉瘤样癌临床病理特征及预后分析 被引量:3
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作者 陈岑 任占良 +4 位作者 董宇杰 王莹 高远 李红霞 张同梅 《中国肺癌杂志》 CAS CSCD 北大核心 2024年第7期514-522,共9页
背景与目的肺肉瘤样癌(pulmonary sarcomatoid carcinoma,PSC)是非小细胞肺癌(non-small cell lung cancer,NSCLC)的罕见类型,具有低发病率、高度恶性、强侵袭性、预后差的特点,当前无标准治疗方案。本研究拟通过收集PSC患者临床病理特... 背景与目的肺肉瘤样癌(pulmonary sarcomatoid carcinoma,PSC)是非小细胞肺癌(non-small cell lung cancer,NSCLC)的罕见类型,具有低发病率、高度恶性、强侵袭性、预后差的特点,当前无标准治疗方案。本研究拟通过收集PSC患者临床病理特征、当前诊治情况并分析预后因素,总结诊治经验,旨在提高临床对PSC的认识。方法回顾性收集2013年12月至2023年12月于北京胸科医院确诊、接受治疗且临床资料完整的39例PSC患者的人口学信息、临床病理特征、肿瘤原发灶-淋巴结-转移(tumor-node-metastasis,TNM)分期和诊疗方案资料,并完成临床预后随访。应用Kaplan-Meier法进行单因素生存分析。结果39例PSC患者年龄范围45-76岁,其中男性35例,女性4例,首诊临床表现缺乏特异性;20例患者接受手术治疗,19例患者行姑息性放化疗或对症支持治疗。患者1、5年生存率分别为61.90%、35.20%。单因素分析结果提示恶性肿瘤家族史、肿瘤部位、TNM分期、淋巴结转移、远处转移、是否手术、手术类型、治疗方案、细胞程序性死亡配体1(programmed cell death ligand 1,PD-L1)蛋白表达≥1%、间质上皮细胞转化因子(mesenchymal-epithelial transition factor,MET)通路异常与患者总生存期(overall survival,OS)有关(P<0.05);多因素分析结果显示,淋巴结转移是患者OS的独立影响因素(P=0.037)。结论PSC临床发病率低,多见于有吸烟史的老年男性。PD-L1蛋白表达≥1%及MET通路异常可提示患者不良预后,淋巴结转移是患者OS的独立危险因素。以手术为主的综合治疗是早期及局部晚期患者的主要治疗模式,靶向治疗和免疫治疗的临床应用价值有待进一步探索。 展开更多
关键词 肺肉瘤样癌 临床特征 病理特征 预后
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市售儿童化妆品中苯氧乙醇的测定及初步风险特征评估 被引量:3
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作者 王任 吴鸳鸯 +3 位作者 乔佳 颜琳琦 陈岑 张丽媛 《日用化学工业(中英文)》 CAS 北大核心 2024年第2期224-230,共7页
研究市售儿童化妆品中苯氧乙醇防腐剂的暴露参数,对其进行初步风险特征描述,旨在为完善我国化妆品安全风险评估体系提供参考。本实验依据《化妆品安全技术规范》(2015年版)(国家药品监督管理局2021年第17号通告)检验,测得市售50批儿童... 研究市售儿童化妆品中苯氧乙醇防腐剂的暴露参数,对其进行初步风险特征描述,旨在为完善我国化妆品安全风险评估体系提供参考。本实验依据《化妆品安全技术规范》(2015年版)(国家药品监督管理局2021年第17号通告)检验,测得市售50批儿童化妆品中苯氧乙醇含量,并通过ConsExpo Web暴露评估软件建立数学模型,获得适用中国儿童化妆品中苯氧乙醇的暴露参数。结果表明:实验所测的50批市售儿童化妆品中,苯氧乙醇的使用频率为50%。0~3岁儿童有吸吮行为,会增加苯氧乙醇的安全边际风险。市售儿童化妆品中苯氧乙醇的安全边际(MoS)均大于50。结论:儿童化妆品中苯氧乙醇的使用频率较高,市售儿童化妆品中苯氧乙醇的初步风险特征评估为安全。儿童化妆品暴露参数要充分参考到儿童不同年龄段的皮肤特点,儿童特有的行为模式和儿童特定的应用场景,以便更加科学合理地评估儿童化妆品安全。 展开更多
关键词 儿童化妆品 苯氧乙醇 暴露参数 ConsExpo Web暴露评估软件 初步风险特征评估
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石墨消解-原子荧光光谱法测定海洋生物体中的砷 被引量:2
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作者 张临 岑陈 +3 位作者 符式锦 李晓敏 吴小龙 黄玉洁 《中国无机分析化学》 CAS 北大核心 2023年第10期1047-1053,共7页
为解决电热板消解海洋生物体时存在的消解温度低、前处理时间长、消解不完全、重复性差、正确度差等问题。通过考察不同消解仪器、消解温度、时间、消解管材质和消解液体系等消解条件,建立了以石墨高温消解海洋生物体,用原子荧光光谱法... 为解决电热板消解海洋生物体时存在的消解温度低、前处理时间长、消解不完全、重复性差、正确度差等问题。通过考察不同消解仪器、消解温度、时间、消解管材质和消解液体系等消解条件,建立了以石墨高温消解海洋生物体,用原子荧光光谱法测定海洋生物体中砷的方法,确定了海洋生物体砷前处理与测试的最佳条件,实验结果表明,有证标准物质加标回收率为98.9%~101%,各类型海洋生物体样品的加标回收率为93.4%~95.8%。方法操作简单、快速,适用于各类海洋生物体中砷的分析。 展开更多
关键词 海洋生物体 石墨高温消解 原子荧光光谱法
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Effects of fertilization on the growth dominance of Inland Northwest forests of the United States 被引量:1
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作者 cen chen Andrew SNelson +1 位作者 Terry Shaw Mark Kimsey 《Forest Ecosystems》 SCIE CSCD 2022年第3期407-416,共10页
Large trees have disproportionally large competitive advantage in access to light, which has been proposed to increase growth dominance of large trees (e.g., a larger proportion of volume growth than standing volume i... Large trees have disproportionally large competitive advantage in access to light, which has been proposed to increase growth dominance of large trees (e.g., a larger proportion of volume growth than standing volume is in large trees in a stand). Tree growth may also be limited by the availability of other resources besides light.Nutrient deficiency, especially of nitrogen, is considered common among temperate forests including mixedconifer forests of the Inland Northwest of the United States. Data from a long-term forest nutrition study across four Inland Northwest states were analyzed to evaluate nitrogen×potassium fertilization?s effects on growth dominance over an eight-year period following treatment. Our results show that growth dominance varied substantially across plots in each vegetation series and fertilization treatment, and its mean values generally were at minuscule magnitudes, negative, and not significantly different from 0. We propose that this lack of a clear pattern in growth dominance was the result of the mixed-species composition where shade-tolerant species remained in lower crown positions, yet their relative growth kept pace with large trees. Limited moisture availability at dry sites may have hampered the development of growth dominance. Growth dominance also was lowered by mortality observed among relatively large trees. The largely negative growth dominance across fertilization treatments indicated that small trees seem to have maintained higher relative growth rates than large trees, even if absolute growth was higher among large trees. In the case fertilization does improve stand growth, a significant part of this improved growth will be lost in density-dependent mortality over time if not captured through thinning/harvesting. 展开更多
关键词 Stand dynamics Forest management Nitrogen Potassium DOUGLAS-FIR Mixed conifer
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3D printed porous titanium filled with mineralized UV-responsive chitosan hydrogel promotes cell proliferation and osteogenesis in vitro 被引量:1
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作者 Jiazhao Yang Fan Liu +7 位作者 Changshun Zhou Hejie Li Gaolin Yang Shiyuan Fang In-Seop Lee Yi Liu Hao Bai cen chen 《Journal of Materials Science & Technology》 SCIE EI CAS CSCD 2023年第11期34-44,共11页
The modification of 3D printed porous titanium(Ti),especially for the internal pore structure,is critical and has received more attention to promoting its osteogenesis for clinical use.Ultra-violet(UV)responsive chito... The modification of 3D printed porous titanium(Ti),especially for the internal pore structure,is critical and has received more attention to promoting its osteogenesis for clinical use.Ultra-violet(UV)responsive chitosan(CSMA),as an injectable filling material,was firstly incorporated into porous Ti,and then CSMA was in-situ mineralized by carbon oxide(CO_(2))diffusion(CSMA/CaCO_(3)).Their physical-chemical and biological properties were investigated in vitro.CaCO_(3) crystals within CSMA hydrogels were successfully deposited into pores of porous Ti,which exhibited favorable biocompatibility.Ti implants filled with CSMA/CaCO_(3) promoted adhesion and proliferation of bone mesenchymal stem cells(BMSCs).Moreover,Ti implant filled CSMA/CaCO_(3) hydrogels could increase alkaline phosphatase(ALP)activities,up-regulate osteopontin(OPN)and osteocalcin(OCN)expression levels,and enhance extracellular mineralization.3D printed porous Ti filled with mineralized UV-responsive chitosan hydrogel could promote proliferation and osteogenesis of BMSCs,and have great potential for the modification of porous Ti implants in bone tissue engineering. 展开更多
关键词 Porous titanium Chitosan Ultraviolet(UV)-responsive MINERALIZATION OSTEOGENESIS
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高效液相色谱法测定化妆品中3种α-羟基酸及其酯 被引量:1
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作者 张丽媛 程巧鸳 +3 位作者 陈岑 李泽桦 黄柳倩 戚绿叶 《日用化学工业(中英文)》 北大核心 2024年第1期102-106,共5页
建立了高效液相色谱法(HPLC)同时测定化妆品中葡糖酸、葡糖酸内酯和乳糖酸的含量,并结合高效液相色谱-串联质谱联用法(HPLC-MS/MS)对结果进行确证。样品经水超声提取,并在氢氧化钠的作用下将葡糖酸、葡糖酸内酯、乳糖酸转化为葡糖酸盐... 建立了高效液相色谱法(HPLC)同时测定化妆品中葡糖酸、葡糖酸内酯和乳糖酸的含量,并结合高效液相色谱-串联质谱联用法(HPLC-MS/MS)对结果进行确证。样品经水超声提取,并在氢氧化钠的作用下将葡糖酸、葡糖酸内酯、乳糖酸转化为葡糖酸盐和乳糖酸盐,采用高效液相色谱法,以0.04 mol/L的磷酸氢二铵水溶液和乙腈为流动相进行洗脱,Comixsil HCS(4.6 mm×150 mm,3μm)色谱柱分离,二极管阵列检测器(214 nm)检测,外标法定量。采用高效液相色谱-串联质谱联用法,以0.1%甲酸水溶液和含0.1%甲酸乙腈为流动相进行梯度洗脱,Waters T3-C18(2.1 mm×100 mm,1.8μm)色谱柱分离,电喷雾电离,负离子多反应监测模式定性。结果显示,葡糖酸与乳糖酸在相应线性范围内线性关系良好,相关系数均大于0.999。葡糖酸与葡糖酸内酯的方法检出限为100μg/g,乳糖酸的方法检出限为500μg/g。3种化合物4种基质样品加标平均回收率为90.8%~110.1%,相对标准偏差为0.3%~4.4%。该方法操作简便、准确度好、灵敏度高,适用于化妆品中葡糖酸、葡糖酸内酯和乳糖酸的测定。 展开更多
关键词 化妆品 葡糖酸 葡糖酸内酯 乳糖酸 高效液相色谱法 高效液相色谱-质谱联用法
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Can a multistage approach improve individual tree mortality predictions across the complex mixed-species and managed forests of eastern North America?
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作者 cen chen John Kershaw Jr +1 位作者 Aaron Weiskittel Elizabeth McGarrigle 《Forest Ecosystems》 SCIE CSCD 2023年第1期21-30,共10页
Tree mortality plays a fundamental role in the dynamics of forest ecosystems,yet it is one of the most difficult phenomena to accurately predict.Various modeling strategies have been developed to improve individual tr... Tree mortality plays a fundamental role in the dynamics of forest ecosystems,yet it is one of the most difficult phenomena to accurately predict.Various modeling strategies have been developed to improve individual tree mortality predictions.One less explored strategy is the use of a multistage modeling approach.Potential improvements from this approach have remained largely unknown.In this study,we developed a novel multistage approach and compared its performance in individual tree mortality predictions with a more conventional approach using an identical individual tree mortality model formulation.Extensive permanent plot data(n=9442)covering the Acadian Region of North America and over multiple decades(1965–2014)were used in this study.Our results indicated that the model behavior with the multistage approach better depicted the observed mortality and showed a notable improvement over the conventional approach.The difference between the observed and predicted numbers of dead trees using the multistage approach was much smaller when compared with the conventional approach.In addition,tree survival probabilities predicted by the multistage approach generally were not significantly different from the observations,whereas the conventional approach consistently underestimated mortality across species and overestimated tree survival probabilities over the large range of DBH in the data.The new multistage approach also predictions of zero mortality in individual plots,a result not possible in conventional models.Finally,the new approach was more tolerant of modeling errors because it based estimates on ranked tree mortality rather than error-prone predicted values.Overall,this new multistage approach deserves to be considered and tested in future studies. 展开更多
关键词 Tree mortality modeling Mortality disaggregation Mixed effect model Annualization Mixed forests
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A new thermo-elasto-plasticity constitutive theory for polycrystalline metals
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作者 cen chen Qiheng Tang Tzuchiang Wang 《Acta Mechanica Sinica》 SCIE EI CAS CSCD 2015年第3期338-348,共11页
In this study, the behavior of polycrystalline metals at different temperatures is investigated by a new thermo-elasto-plasticity constitutive theory. Based on solid mechanical and interatomic potential, the constitut... In this study, the behavior of polycrystalline metals at different temperatures is investigated by a new thermo-elasto-plasticity constitutive theory. Based on solid mechanical and interatomic potential, the constitutive equa- tion is established using a new decomposition of the deformation gradient. For polycrystalline copper and magnesium, the stress-strain curves from 77 to 764 K (copper), and 77 to 870 K (magnesium) under quasi-static uniaxial loading are calculated, and then the calculated results are compared with the experiment results. Also, it is determined that the present model has the capacity to describe the decrease of the elastic modulus and yield stress with the increasing temperature, as well as the change of hardening behaviors of the polycrystalline metals. The calculation process is simple and explicit, which makes it easy to implement into the applications. 展开更多
关键词 Thermo-elasto-plasticity constitutive theory Yield stress Hardening behaviors Finite temperature
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高效液相色谱法同时测定淋洗类化妆品中7种异噻唑啉酮类防腐剂及质谱确证
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作者 陈岑 崔邶周 +2 位作者 张丽媛 颜琳琦 程巧鸳 《日用化学工业(中英文)》 CAS 北大核心 2024年第10期1268-1275,共8页
建立了同时检测淋洗类化妆品中7种异噻唑啉酮类防腐剂的高效液相色谱分析方法及液相色谱-串联质谱确证方法。膏霜乳和液体两种不同基质类型的化妆品样品分别经甲醇超声提取,提取液以离心处理后,取上清液经微孔滤膜过滤后测定。经CAPCELL... 建立了同时检测淋洗类化妆品中7种异噻唑啉酮类防腐剂的高效液相色谱分析方法及液相色谱-串联质谱确证方法。膏霜乳和液体两种不同基质类型的化妆品样品分别经甲醇超声提取,提取液以离心处理后,取上清液经微孔滤膜过滤后测定。经CAPCELL PAK C_(18)MGIII(4.6 mm×250 mm,5μm)色谱柱分离,以甲醇和0.1%磷酸水溶液为流动相梯度洗脱,流速1.0 ml/min,柱温40℃。检测波长为275,282,和319 nm。以高效液相色谱法的结果进行定性筛查,并采用标准曲线法定量,以液相色谱-串联质谱法的结果进行确证。结果表明,7种异噻唑啉酮类防腐剂在0.1~50 mg/L质量浓度范围内线性关系良好,相关系数均≥0.9999。在低、中、高3种加标浓度水平下,平均加标回收率分别为97.5%~109.9%(膏霜乳)和95.6%~103.6%(液体);相对标准偏差(RSD)小于3.0%,检出限为0.05~0.11 mg/kg。该方法具有简单、快速、准确性好的特点,适用于淋洗类化妆品中7种异噻唑啉酮类防腐剂的含量测定及质谱确证。 展开更多
关键词 淋洗类化妆品 高效液相色谱法 质谱确证 异噻唑啉酮类防腐剂
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Association rules analysis of Fufang Kushen injection in combination with traditional Chinese medicine or modern medications in treating Cervical cancer: real-world retrospective study
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作者 Fu-Mei Liu Yan-Ming Xie +3 位作者 Yin Zhang cen chen Chang Zhang Yan Zhuang 《Medical Data Mining》 2018年第1期2-9,共8页
Objective: The present study aimed to analyze the association rules of Fufang Kushen injection in combination with other traditional Chinese medicine ( TCM) or modern medications in treating cervical cancer (CC) based... Objective: The present study aimed to analyze the association rules of Fufang Kushen injection in combination with other traditional Chinese medicine ( TCM) or modern medications in treating cervical cancer (CC) based on the electrical medical records extracted from real-world hospital information system. Methods: The clinicians’ prescriptions regarding to the combination of with TCM or modern medications were from hospital information system electronic medical data integration warehouse established by the Institute of Basic Medical Research of Chinese Medicine, China Academy of Chinese Medical Sciences, which integrated the hospital information system data of 22 hospitals. The association rules of the drug characteristics were analyzed through Apriori algorithm. Results: A total of 839 patients with CC were included. We found that is often combined with prescriptions which could clear heat, remove toxicity, supplement Qi. also combined with chemotherapeutic drugs, immunomodulatory drugs, 5-HT receptor blockers, and glucocorticoids. The combination presents a specific law. Conclusion: Fufang Kushen injection combined with hepatoprotective drugs, immunomodulators and glucocorticoids is often used to treat cervical cancer. 展开更多
关键词 Fufang Kushen injection COMBINATIONS CERVICAL cancer Real world Association rules
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Reutilization and upcycling of spent graphite for sustainable lithium-ion batteries:Progress and perspectives
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作者 Xueqian Li chenglong Deng +9 位作者 Mengyao Liu Jiawei Xiong Xiaodong Zhang Qiaoyi Yan Jiao Lin cen chen Feng Wu Yi Zhao Renjie chen Li Li 《eScience》 2025年第4期34-48,共15页
In the development of sustainable lithium-ion batteries,achieving the efficient and cost-effective recycling of all components,particularly spent graphite(SG)anodes,has become a critical requirement.While considerable... In the development of sustainable lithium-ion batteries,achieving the efficient and cost-effective recycling of all components,particularly spent graphite(SG)anodes,has become a critical requirement.While considerable ef-forts have been devoted to recovering and reusing SG materials under conventional conditions,limited attention has been given to recycling under extreme conditions.This review systematically elucidates the main failure mechanisms of graphite anodes,including lithium plating and dendrite formation,solid electrolyte interface film failure,structural degradation,and current collector corrosion,with a particular focus on low-temperature and fast-charging conditions.As a contribution toward optimizing resource utilization,this review comprehensively summarizes the industrial perspective on strategies for recycling SG anodes,which aim to produce high-purity regenerated graphite(RG)powders.We also analyze current methods for modifying RG,such as structural reconstruction and surface reconditioning,to bring added value to modified RG materials.A detailed examination of the technical challenges in SG recycling and RG upgrading is presented,offering guidance for the future development of graphite upcycling technologies.This review also provides valuable insights into achieving high efficiency,intelligence,and sustainability in graphite utilization. 展开更多
关键词 Spent lithium-ion batteries Graphite anode Degradation mechanism RECYCLING REGENERATION
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Biomimetic aligned bacterial cellulose dressing containing polydeoxyribonucleotide for promoting wound healing
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作者 Xiaoqian Zhu Fan Liu +4 位作者 Tuwei Jin Hongkun chen Sung-Min Chung cen chen In-Seop Lee 《Bioactive Materials》 2025年第12期916-931,共16页
Chronic or non-healing wounds present a significant challenge in daily life,leading to increased interest in the design of wound dressings with enhanced healing capabilities.In this study,a bacterial cellulose(BC)memb... Chronic or non-healing wounds present a significant challenge in daily life,leading to increased interest in the design of wound dressings with enhanced healing capabilities.In this study,a bacterial cellulose(BC)membrane with an aligned structure was developed to guide cell migration and collagen orientation,serving as the primary component of the wound dressing.Polydeoxyribonucleotide(PDRN),a nucleic acid agent known for its excellent tissue-regenerative effect,were loaded into the aligned BC membrane.The obtained composite material(PDRN@BC aligned membrane)demonstrated aligned structure,high hydrophilicity,favorable air permeability,good mechanical properties,and sustained release of PDRN.The as-prepared membrane promoted cell spreading,proliferation and migration of L929 fibroblast in vitro,as well as angiogenesis in ovo.Application of the PDRN@BC aligned membrane in vivo significantly improved and speeded up wound healing by accelerating cell proliferation and migration,reducing inflammation,and facilitating angiogenesis.This innovative composite dressing,combining topographic and bioactive cues,holds promise to facilitate the regeneration of damaged skin tissue. 展开更多
关键词 Fiber alignment Bacterial cellulose Polydeoxyribonucleotide Wound healing
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Advances in the surface modification techniques of bone-related implants for last 10 years 被引量:14
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作者 Zhi-Ye Qiu cen chen +1 位作者 Xiu-Mei Wang In-Seop Lee 《Regenerative Biomaterials》 SCIE 2014年第1期67-79,共13页
At the time of implanting bone-related implants into human body,a variety of biological responses to the material surface occur with respect to surface chemistry and physical state.The commonly used biomaterials(e.g.t... At the time of implanting bone-related implants into human body,a variety of biological responses to the material surface occur with respect to surface chemistry and physical state.The commonly used biomaterials(e.g.titanium and its alloy,Co–Cr alloy,stainless steel,polyetheretherketone,ultra-high molecular weight polyethylene and various calcium phosphates)have many drawbacks such as lack of biocompatibility and improper mechanical properties.As surface modification is very promising technology to overcome such problems,a variety of surface modification techniques have been being investigated.This review paper covers recent advances in surface modification techniques of bone-related materials including physicochemical coating,radiation grafting,plasma surface engineering,ion beam processing and surface patterning techniques.The contents are organized with different types of techniques to applicable materials,and typical examples are also described. 展开更多
关键词 surface modification physicochemical coating radiation grafting plasma surface engineering ion beam processing surface patterning bone-related materials
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