森林火点检测在林火应急救援中起着至关重要的作用.鉴于现有模型在样本质量、多尺度检测以及多视角图像泛化能力方面存在不足,以YOLOv7为基础,提出一种森林火点目标检测方法FFD-YOLO(forest fire detection based on YOLO).首先,构建多...森林火点检测在林火应急救援中起着至关重要的作用.鉴于现有模型在样本质量、多尺度检测以及多视角图像泛化能力方面存在不足,以YOLOv7为基础,提出一种森林火点目标检测方法FFD-YOLO(forest fire detection based on YOLO).首先,构建多视角可见光图像森林火灾高点检测数据集FFHPV(forest fire of high point view),旨在增强模型对多视角火点知识的学习能力;其次,引入全维动态卷积,构建空间金字塔池化层(OD-SPP),以此提升模型针对多视角数据的火点特征提取能力;最后,引入具有动态非单调聚焦机制的边界框定位损失函数Wise-IoU(wise intersection over union),降低低质量数据对模型精度的影响,提高小目标火点的检测能力.实验结果表明:所提出的FFD-YOLO方法相较于YOLOv7,精度提高3.9%,召回率提高3.7%,均值平均精度提高4.0%,F1分数提高0.038;同时,在与YOLOv5、YOLOv8、DDQ(dense distinct query)、DINO(detection transformer with improved denoising anchor boxes)、Faster R-CNN、Sparse R-CNN、Mask R-CNN、FCOS和YOLOX的对比实验中,FFD-YOLO具有最高的精度75.3%、召回率73.8%、均值平均精度77.6%和F1分数0.745,验证了该方法的可行性与有效性.展开更多
OBJECTIVE To investigate the therapeutic effects of Xianlian Jiedu Decoction(XLJDD)on colitis-associated colorectal cancer(CAC)and to explore its potential underlying mechanisms.METHODS An azoxymethane/dextran sulfate...OBJECTIVE To investigate the therapeutic effects of Xianlian Jiedu Decoction(XLJDD)on colitis-associated colorectal cancer(CAC)and to explore its potential underlying mechanisms.METHODS An azoxymethane/dextran sulfate sodium(AOM/DSS)-induced CAC mouse model was established.UPLC-Q-TOF/MS was employed to identify prototype compounds present in colonic tissue after XLJDD administration.Network pharmacology analysis,molecular docking,transcriptomic sequencing,and valida‑tion of key pathway-related genes were further conducted to systematically elucidate the intervention effects and potential mechanisms of XLJDD against CAC.RESULTS In the AOM/DSS-induced CAC mouse model,XLJDD treatment markedly improved tumor-associated pathological features,as evidenced by reduced tumor burden,restored colon length,and alleviated disease activity index(DAI).UPLC-Q-TOF/MS analysis identified 22 exogenous compounds derived from XLJDD in colonic tissue.In addition,XLJDD sig‑nificantly downregulated the expression of multiple inflammatory cytokines while upregulating tight junction-related genes in the co‑lon.Transcriptomic analysis revealed that XLJDD treatment enhanced overall PPAR signaling pathway activity while suppressing the Wnt signaling pathway.Consistently,the expression levels of PPAR pathway-related genes Pparα,Cpt1a,and Ehhadh were upregulated following XLJDD intervention(P<0.05,P<0.01),whereas the Wnt pathway-related genes Axin2 and Lef1 were significantly downregulated(P<0.05,P<0.01).CONCLUSION XLJDD may intervene in inflammation-associated colorectal carcinogenesis by activating the PPAR signaling pathway and suppressing the Wnt signaling pathway.展开更多
文摘森林火点检测在林火应急救援中起着至关重要的作用.鉴于现有模型在样本质量、多尺度检测以及多视角图像泛化能力方面存在不足,以YOLOv7为基础,提出一种森林火点目标检测方法FFD-YOLO(forest fire detection based on YOLO).首先,构建多视角可见光图像森林火灾高点检测数据集FFHPV(forest fire of high point view),旨在增强模型对多视角火点知识的学习能力;其次,引入全维动态卷积,构建空间金字塔池化层(OD-SPP),以此提升模型针对多视角数据的火点特征提取能力;最后,引入具有动态非单调聚焦机制的边界框定位损失函数Wise-IoU(wise intersection over union),降低低质量数据对模型精度的影响,提高小目标火点的检测能力.实验结果表明:所提出的FFD-YOLO方法相较于YOLOv7,精度提高3.9%,召回率提高3.7%,均值平均精度提高4.0%,F1分数提高0.038;同时,在与YOLOv5、YOLOv8、DDQ(dense distinct query)、DINO(detection transformer with improved denoising anchor boxes)、Faster R-CNN、Sparse R-CNN、Mask R-CNN、FCOS和YOLOX的对比实验中,FFD-YOLO具有最高的精度75.3%、召回率73.8%、均值平均精度77.6%和F1分数0.745,验证了该方法的可行性与有效性.
文摘OBJECTIVE To investigate the therapeutic effects of Xianlian Jiedu Decoction(XLJDD)on colitis-associated colorectal cancer(CAC)and to explore its potential underlying mechanisms.METHODS An azoxymethane/dextran sulfate sodium(AOM/DSS)-induced CAC mouse model was established.UPLC-Q-TOF/MS was employed to identify prototype compounds present in colonic tissue after XLJDD administration.Network pharmacology analysis,molecular docking,transcriptomic sequencing,and valida‑tion of key pathway-related genes were further conducted to systematically elucidate the intervention effects and potential mechanisms of XLJDD against CAC.RESULTS In the AOM/DSS-induced CAC mouse model,XLJDD treatment markedly improved tumor-associated pathological features,as evidenced by reduced tumor burden,restored colon length,and alleviated disease activity index(DAI).UPLC-Q-TOF/MS analysis identified 22 exogenous compounds derived from XLJDD in colonic tissue.In addition,XLJDD sig‑nificantly downregulated the expression of multiple inflammatory cytokines while upregulating tight junction-related genes in the co‑lon.Transcriptomic analysis revealed that XLJDD treatment enhanced overall PPAR signaling pathway activity while suppressing the Wnt signaling pathway.Consistently,the expression levels of PPAR pathway-related genes Pparα,Cpt1a,and Ehhadh were upregulated following XLJDD intervention(P<0.05,P<0.01),whereas the Wnt pathway-related genes Axin2 and Lef1 were significantly downregulated(P<0.05,P<0.01).CONCLUSION XLJDD may intervene in inflammation-associated colorectal carcinogenesis by activating the PPAR signaling pathway and suppressing the Wnt signaling pathway.
