Electromagnetic interference shielding and thermal management by wearable devices show great po-tential in emerging digital healthcare.Conventional metal films implementing the functions must sacri-fice either flexibi...Electromagnetic interference shielding and thermal management by wearable devices show great po-tential in emerging digital healthcare.Conventional metal films implementing the functions must sacri-fice either flexibility or permeability,which is far from optimal in practical applications.In this work,an ultra-thin(15μm),flexible,and porous Cu/PLLA fibrous membrane is developed by depositing cop-per particles on the polymer substrate.With novel acetone&heat treatment procedure,the mem-brane is considerably stronger while maintaining the porous fibre structure.Its fantastic breathabil-ity and super high electrical conductivity(9471.8130 S/cm)enable the composites to have fast electri-cal heating characteristics and excellent thermal conductivity for effective thermal management.Mean-while,the porous polymer substrate structure greatly enhances the diffusion of conductive substances and increases the electromagnetic interference shielding effectiveness of the membranes(7797.98 dB cm^(2)/g at the H band and 8072.73 dB cm^(2)/g at the Ku band respectively).The composites present high flexibility,breathability,and strength with the functions of thermal management and electromag-netic shielding,showing great potential for future portable electronic devices and wearable integrated garments.展开更多
The selective catalytic deoxygenation of oxy-organics in Fischer-Tropsch mixed oil for its high value utilization is challenging.Herein,a BaCO_(3)/γ-Al_(2)O_(3) catalyst was prepared calciningγ-Al_(2)O_(3) with BaCO...The selective catalytic deoxygenation of oxy-organics in Fischer-Tropsch mixed oil for its high value utilization is challenging.Herein,a BaCO_(3)/γ-Al_(2)O_(3) catalyst was prepared calciningγ-Al_(2)O_(3) with BaCO_(3),and the acid-alkalinity of the catalyst was regulated by introducing alkaline Ba basic sties.In a co ntinuous fixed-bed reactor with a feed mass space velocity of 1 h~(-1)and reaction temperature of 330℃,BaCO_(3)/γ-Al_(2)O_(3) catalyst can efficiently catalyzed the deoxygenation removal of 1-octanol in Fischer-Tropsch C10mixture oil.It also inhibited the isomerization of 1-decene in the C10 mixture.The catalytic deoxygenation kinetics of 1-octanol were also studied.The reaction was endothermic with an activation energy of 64 kJ·mol^(-1)and a reaction order of 2.In addition,theoretical studies revealed the adsorption and activation of 1-decene on the Lewis acidic site and the alkaline Ba basic sites,1-decene was more easily underwent isomerization into 2-decene at Lewis acid sites.This research provides a useful method to enable the industrial application of catalytic deoxygenation of alcohols in Fischer-Tropsch synthetic oil.展开更多
Background:Accumulating studies have shown the important role of circular RNAs(circRNAs)in the oncogenesis and metastasis of various cancers.We previously reported that circACTN4 could bind with FUBP1 to promote tumor...Background:Accumulating studies have shown the important role of circular RNAs(circRNAs)in the oncogenesis and metastasis of various cancers.We previously reported that circACTN4 could bind with FUBP1 to promote tumorigenesis and the development of breast cancer(BC)by increasing the expression of MYC.However,its exact molecular mechanism and biological function have not been fully elucidated.Methods:Here,Circular RNA microarray analysis was conducted in 3 pairs of BC and paracancerous tissues.The expression of circACTN4 in BC cells and tissues was detected via reverse transcription‒quantitative PCR(RT‒qPCR).Cell Counting Kit-8(CCK-8),5-ethynyl-2-deoxyuridine(EdU),transwell migration,and invasion assays were performed to further detect the biological functions of circACTN4 in BC cells.Xenograft models were used to investigate the in vivo role of circACTN4.Fluorescence in situ hybridization,Chromatin immunoprecipitation(ChIP)‒qPCR,coimmunoprecipitation,fluorometric,western blot,and rescue experiments were performed to explore the mechanism of circACTN4.Results:Our results revealed that circACTN4 was highly expressed in BC cells and tissues.The upregulated expression of circACTN4 was significantly related to the T stage and TNM stage and poor prognosis of patients with BC.circACTN4 was located primarily in the nucleus of BC cells.Upregulation of circACTN4 significantly increased the proliferation,invasion,and growth of BC cells,whereas the downregulation of circACTN4 exerted the opposite effects and induced G1/S cell cycle arrest.Mechanistically,we showed that circACTN4 could upregulate the expression of MYC and that MYC might interact with TIP60 histone acetyltransferase to increase the recruitment of TIP60 to MYC target genes and histone H4 acetylation(AcH4),thus promoting the progression of the breast cancer cell cycle and tumorigenesis.Conclusion:Taken together,our findings reveal for the first time a new mechanism by which circACTN4 could promote oncogenesis and the development of BC by increasing the AcH4 of MYC target genes via TIP60.Therefore,circACTN4 could be a novel target for BC diagnosis and remedy.展开更多
Accurately soft sensing of the mechanical properties of hot-rolled strips is essential to ensure product quality,optimize production,and reduce costs.However,it faces the difficulty caused by limited labeled samples,f...Accurately soft sensing of the mechanical properties of hot-rolled strips is essential to ensure product quality,optimize production,and reduce costs.However,it faces the difficulty caused by limited labeled samples,for which co-training based semi-supervised learning offers a potential solution.So in this paper,a novel soft sensing method for mechanical properties based on improved co-training(ICO)is proposed.Compared with the existing co-training framework,the proposed ICO introduces improvements from the aspects of multiple view partition,confidence estimation,and pseudo-label assignment.Specifically,(ⅰ)in the stage of multiple view partition,ICO integrates metallurgical mechanisms of hot rolling processes and statistical mutual information to achieve a balance between view sufficiency and independence,which improves model performance and interpretability;(ⅱ)in the stage of confidence estimation,ICO evaluates the confidence of unlabeled samples at the cluster level rather than at the level of a single sample,which facilitates the exploration of sample distribution and the selection of representative samples;(ⅲ)in the pseudo-label assignment stage,ICO adopts a safe pseudo-label algorithm(which is called SAFER by its author and originally used for each single sample)to assign pseudo-labels for cluster of samples with the highest confidence determined in the previous step stage,to take advantage of the merit of handling unlabeled samples at the cluster level mentioned above on one hand,and the merit of SAFER in enhancing the quality of pseudo-labels on the other hand.The proposed soft sensing method effectively predicts mechanical properties on the real hot rolling dataset,achieving approximately 5%improvement in R~2 compared to traditional supervised learning.展开更多
1978—2015年中国产业结构转型的典型事实是:农业部门的就业份额和产值份额大幅度萎缩;工业部门的就业份额不断扩张而产值份额变化幅度不大;而服务业部门的就业和产值份额大幅度扩张,而且服务业部门就业份额的扩张快于工业部门。通过在K...1978—2015年中国产业结构转型的典型事实是:农业部门的就业份额和产值份额大幅度萎缩;工业部门的就业份额不断扩张而产值份额变化幅度不大;而服务业部门的就业和产值份额大幅度扩张,而且服务业部门就业份额的扩张快于工业部门。通过在Kongsamut et al.(2001)模型中引入家庭生产工业品和要素市场扭曲,本文试图为中国经济的产业结构转型提供一个理论解释。研究表明,由于存在农业生存消费品、家庭生产工业品和家庭生产服务品,因此消费者关于农产品的需求收入弹性小于1而关于工业品和服务品的需求收入弹性都大于1。因而,当技术进步同时推动三部门经济增长时,农业在国民经济中的产值和就业比重不断减少,而工业和服务业的产值和就业比重都不断增加。由于相对于各自的技术系数,家庭生产服务品比家庭生产工业品的数量更大,因此服务业部门比工业部门扩张得更快。而且,数值模拟的产业动态跟中国经济的实际数据非常接近。展开更多
For understanding acoustic emission （AE） activity and accumulation of micro-damage inside rock under pure tensile state, the AE signals has been monitored on the test of directly tension on two kinds of marble speci...For understanding acoustic emission （AE） activity and accumulation of micro-damage inside rock under pure tensile state, the AE signals has been monitored on the test of directly tension on two kinds of marble specimens. A tensile constitutive model was proposed with the damage factor calculated by AE energy rate. The tensile strength of marble was discrete obviously and was sensitive to the inside microdefects and grain composition. With increasing of loading, the tensile stress-strain curve obviously showed nonlinear with the tensile tangent modulus decreasing. In repeated loading cycle, the tensile elastic modulus was less than that in the previous loading cycle because of the generation of micro damage during the prior loading. It means the linear weakening occurring in the specimens. The AE activity was corresponding with occurrence of nonlinear deformation. In the initial loading stage which only elastic deformation happened on the specimens, there were few AE events occurred; while when the nonlinear deformation happened with increasing of loading, lots of AE events were generated. The quantity and energy of AE events were proportionally related to the variation of tensile tangent modulus. The Kaiser effect of AE activity could be clearly observed in tensile cycle loading. Based on the theory of damage mechanics, the damage factor was defined by AE energy rate and the tensile damage constitutive model was proposed which only needed two property constants. The theoretical stress-strain curve was well fitted with the curve plotted with tested datum and the two property constants were easily gotten by the laboratory testing.展开更多
For the first time, we developed porous Pt-Ni alloying nanoparticles with predominant(111) facets under intense magnetic fields. Electrochemical analysis revealed that the Pt-Ni alloying nanoparticles obtained at 2 Te...For the first time, we developed porous Pt-Ni alloying nanoparticles with predominant(111) facets under intense magnetic fields. Electrochemical analysis revealed that the Pt-Ni alloying nanoparticles obtained at 2 Tesla exhibited a superior catalytic activity and durability for oxygen reduction reaction. This work demonstrated that the imposition of intense magnetic field could be considered as a new approach for developing efficient alloying electrocatalysts with preferential facets.展开更多
Objective The aim of this study was to investigate the correlation between pretreatment fibrinogen levels and metastasis in non-small cell lung cancer(NSCLC).Methods The study included 503 NSCLC patients with a clear ...Objective The aim of this study was to investigate the correlation between pretreatment fibrinogen levels and metastasis in non-small cell lung cancer(NSCLC).Methods The study included 503 NSCLC patients with a clear pathological diagnosis and 168 patients diagnosed with benign lung diseases by histological examination.Pretreatment plasma fibrinogen values were quantified,and the relationship between plasma fibrinogen level and clinical variables comprising tumor size,metastasis,and clinical stage was examined using Kruskal-Wallis test,Wilcoxon rank sum test,and Chi-square test.Results The median plasma fibrinogen values were statistically higher in NSCLC patients with metastasis than patients with benign lung diseases and NSCLC patients without metastasis(Kruskal-Wallis test;P<0.001).Plasma fibrinogen values were also significantly higher in advanced clinical stages(Wilcoxon rank sum test;P<0.001).A significant relationship was observed between elevated fibrinogen(>2.974 g/L)and metastasis,clinical stage,and tumor size(Chi-square test;P<0.001).Conclusion This correlation suggests that elevated pretreatment plasma fibrinogen levels can predict metastasis and advanced tumor stage in NSCLC patients.展开更多
Tellurene, an emerging two-dimensional chain-like semiconductor, stands out for its high switch ratio, carrier mobility and excellent stability in air. Directly contacting the 2D semiconductor materials with metal ele...Tellurene, an emerging two-dimensional chain-like semiconductor, stands out for its high switch ratio, carrier mobility and excellent stability in air. Directly contacting the 2D semiconductor materials with metal electrodes is a feasible doping means to inject carriers. However, Schottky barrier often arises at the metal–semiconductors interface, impeding the transport of carriers. Herein, we investigate the interfacial properties of BL tellurene by contacting with various metals including graphene by using ab initio calculations and quantum transport simulations. Vertical Schottky barriers take place in Ag, Al, Au and Cu electrodes according to the maintenance of the noncontact tellurene layer band structure. Besides, a p-type vertical Schottky contact is formed due to the van der Waals interaction for graphene electrode. As for the lateral direction, p-type Schottky contacts take shape for bulk metal electrodes(hole Schottky barrier heights(SBHs) ranging from 0.19 to 0.35 eV). Strong Fermi level pinning takes place with a pinning factor of 0.02. Notably, a desirable p-type quasi-Ohmic contact is developed for graphene electrode with a hole SBH of 0.08 eV. Our work sheds light on the interfacial properties of BL tellurene based transistors and could guide the experimental selections on electrodes.展开更多
Because of the recent growth in ground-level ozone and increased emission of volatile organic compounds(VOCs),VOC emission control has become a major concern in China.In response,emission caps to control VOC have been...Because of the recent growth in ground-level ozone and increased emission of volatile organic compounds(VOCs),VOC emission control has become a major concern in China.In response,emission caps to control VOC have been stipulated in recent policies,but few of them were constrained by the co-control target of PM_(2.5)and ozone,and discussed the factor that influence the emission cap formulation.Herein,we proposed a framework for quantification of VOC emission caps constrained by targets for PM_(2.5)and ozone via a new response surface modeling(RSM)technique,achieving 50%computational cost savings of the quantification.In the Pearl River Delta(PRD)region,the VOC emission caps constrained by air quality targets varied greatly with the NOxemission reduction level.If control measures in the surrounding areas of the PRD region were not considered,there could be two feasible strategies for VOC emission caps to meet air quality targets(160μg/m^(3)for the maximum 8-hr-average 90th-percentile(MDA8-90%)ozone and 25μg/m^(3)for the annual average of PM_(2.5)):a moderate VOC emission cap with<20%NOxemission reductions or a notable VOC emission cap with>60%NOxemission reductions.If the ozone concentration target were reduced to 155μg/m^(3),deep NOxemission reductions is the only feasible ozone control measure in PRD.Optimization of seasonal VOC emission caps based on the Monte Carlo simulation could allow us to gain higher ozone benefits or greater VOC emission reductions.If VOC emissions were further reduced in autumn,MDA8-90%ozone could be lowered by 0.3-1.5μg/m^(3),equaling the ozone benefits of 10%VOC emission reduction measures.The method for VOC emission cap quantification and optimization proposed in this study could provide scientific guidance for coordinated control of regional PM_(2.5)and O_(3)pollution in China.展开更多
The discovery of ferroelectricity in HfO_(2)-based materials with high dielectric constant has inspired tremendous research interest for next-generation electronic devices.Importantly,films structure and strain are ke...The discovery of ferroelectricity in HfO_(2)-based materials with high dielectric constant has inspired tremendous research interest for next-generation electronic devices.Importantly,films structure and strain are key factors in exploration of ferroelectricity in fluorite-type oxide HfO_(2) films.Here we investigate the structures and straininduced ferroelectric transition in different phases of few-layer HfO_(2) films(layer number𝑁=1–5).It is found that HfO_(2) films for all phases are more stable with increasing films thickness.Among them,the Pmn2_(1)(110)-oriented film is most stable,and the films of𝑁=4,5 occur with a𝑃21 ferroelectric transition under tensile strain,resulting in polarization about 11.8μC/cm^(2) along in-plane𝑎-axis.The ferroelectric transition is caused by the strain,which induces the displacement of Hf and O atoms on the surface to non-centrosymmetric positions away from the original paraelectric positions,accompanied by the change of surface Hf–O bond lengths.More importantly,three new stable HfO_(2)2D structures are discovered,together with analyses of computed electronic structures,mechanical,and dielectric properties.This work provides guidance for theoretical and experimental study of the new structures and strain-tuned ferroelectricity in freestanding HfO_(2) films.展开更多
Visual Attention Prediction(VAP)is widely applied in GIS research,such as navigation task identification and driver assistance systems.Previous studies commonly took color information to detect the visual saliency of ...Visual Attention Prediction(VAP)is widely applied in GIS research,such as navigation task identification and driver assistance systems.Previous studies commonly took color information to detect the visual saliency of natural scene images.However,these studies rarely considered adaptively feature integration to different geospatial scenes in specific tasks.To better predict visual attention while driving tasks,in this paper,we firstly propose an Adaptive Feature Integration Fully Convolutional Network(AdaFI-FCN)using Scene-Adaptive Weights(SAW)to integrate RGB-D,motion and semantic features.The quantitative comparison results on the DR(eye)VE dataset show that the proposed framework achieved the best accuracy and robustness performance compared with state-of-the-art models(AUC-Judd=0.971,CC=0.767,KL=1.046,SIM=0.579).In addition,the experimental results of the ablation study demonstrated the positive effect of the SAW method on the prediction robustness in response to scene changes.The proposed model has the potential to benefit adaptive VAP research in universal geospatial scenes,such as AR-aided navigation,indoor navigation,and street-view image reading.展开更多
Simulated compounds were prepared by loading K2SO4 onto V2O5/AC catalysts. Study the effect of K2SO4 on V1/AC catalysts in the presence of low concentration SO2. Transient response techniques, TPD was carried out. The...Simulated compounds were prepared by loading K2SO4 onto V2O5/AC catalysts. Study the effect of K2SO4 on V1/AC catalysts in the presence of low concentration SO2. Transient response techniques, TPD was carried out. The results indicated that the DeNO activity of V1/AC catalysts was decreased seriously in the early period of operation, but the deactivation was gradually diminished with SO2 adsorption and then, it was completely eliminated. For the sulphated catalysts (saturated catalysts by sulphate), their SCR activity were free from existence of gaseous SO2. the loss of activity about 10% caused by K2SO4 was found on them. The deactivation of K2SO4 deposited catalysts was due to the decrease of adsorbed and activated NH3, or some acid sites.展开更多
A so-called grid-overlay finite difference method(GoFD)was proposed recently for the numerical solution of homogeneous Dirichlet boundary value problems(BVPs)of the fractional Laplacian on arbitrary bounded domains.It...A so-called grid-overlay finite difference method(GoFD)was proposed recently for the numerical solution of homogeneous Dirichlet boundary value problems(BVPs)of the fractional Laplacian on arbitrary bounded domains.It was shown to have advantages of both finite difference(FD)and finite element methods,including their efficient implementation through the fast Fourier transform(FFT)and the ability to work for complex domains and with mesh adaptation.The purpose of this work is to study GoFD in a meshfree setting,a key to which is to construct the data transfer matrix from a given point cloud to a uniform grid.Two approaches are proposed,one based on the moving least squares fitting and the other based on the Delaunay triangulation and piecewise linear interpolation.Numerical results obtained for examples with convex and concave domains and various types of point clouds are presented.They show that both approaches lead to comparable results.Moreover,the resulting meshfree GoFD converges in a similar order as GoFD with unstructured meshes and finite element approximation as the number of points in the cloud increases.Furthermore,numerical results show that the method is robust to random perturbations in the location of the points.展开更多
Drug-receptor interaction analysis has been broadly adopted as a tool for the evaluation of the drug-like property.Nowadays,growing evidence has demonstrated that drug e fficacy and safety are highly related to reside...Drug-receptor interaction analysis has been broadly adopted as a tool for the evaluation of the drug-like property.Nowadays,growing evidence has demonstrated that drug e fficacy and safety are highly related to residence time,which equals the reciprocal of the dissociation rate constant(k_(d))of a drug to its target protein.Using endothelin receptor A(ET_(A)R)as a probe,we immobilized the receptor on the surface of macroporous silica gel through a covalent interaction between the epidermal growth factor tyrosine kinase(EGFR)at the C terminal of ET_(A)R and the covalent inhibitor ibrutinib modified on the gel in a one-step fashion.The a ffinity stationary phase was used to semi-quantitatively determine the residence time of natural products on ET_(A)R and evaluate their drug-like property.The k_(d)values of three specific ligands(bosentan,macitentan,and ambrisentan)to ET_(A)R were determined by nonlinear chromatography,peak profiling and peak_(d)ecay.Compared the data determined in free solution of the three methods,peak profiling is considered as the best-fit method for k_(d)determination.Thus,peak profiling was applied for predicting the residence time of three natural products(ferulic acid,berberine,and palmatine)on ET_(A)R.With the longest residence time of 61.11±3.47 s on ET_(A)R,palmatine was evaluated as the most potent compound,which could be developed as a long-acting lead for the receptor.We demonstrate that the high-performance a ffinity chromatography with immobilized ET_(A)R is an alternative for the semi-quantitative measurement of residence time for the drug-like property evaluation of natural products.展开更多
Wasted tofu rich in protein was subject to hydrothermal pretreatment(HTPT)under different conditions(at 120,140,160 and 180℃;for 0,30,60 and 90 min)followed by biochemical methane potential(BMP)tests,and 140℃and 0 m...Wasted tofu rich in protein was subject to hydrothermal pretreatment(HTPT)under different conditions(at 120,140,160 and 180℃;for 0,30,60 and 90 min)followed by biochemical methane potential(BMP)tests,and 140℃and 0 min were found to be respectively the best temperature and duration for HTPT of tofu in terms of its biogas production.Under the under the optimal conditions(140℃,0 min)the accumulative methane yield reached up to 510.9 mL⋅(gVS)-1,which was 26.98%higher than that without HTPT(402.3 mL⋅(gVS)-1).The start-up process of continuous anerobic digestion(AD)of the tofu before and after hydrothermal treated(HT)at the optimal HTPT conditions(140℃,0 min)was examined,to investigate and compare how their consequent AD responded to HTPT.It was found that,for start-up of continuous AD,the HT tofu delivered more balanced nutrients and thus led to more stable AD and quicker biogas production.Unavoidably,HTPT generated products refractory to biodegradation,to slightly decrease the total biogas production.During AD of HT tofu some weak ammonia-tolerant microbes,such as methylotrophic methanogens,survived and played indispensable roles.Analyses of living microbial community structure indicated that,some hydrolytic acidification bacteria intolerant to ammonia nitrogen(such as Proteobacteria)were always active and appeared at high proportion.The viable methylotrophic methanogens,e.g.RumEn M2,took obvious responsibilities in start-up of the AD for HT tofu.展开更多
Whether the alternated microbiota in the gut contribute to the risk of allograft rejection(AR)and pulmonary infection(Pl)in the setting of lung transplant recipients(LTRs)remains unexplored.A prospective multicenter c...Whether the alternated microbiota in the gut contribute to the risk of allograft rejection(AR)and pulmonary infection(Pl)in the setting of lung transplant recipients(LTRs)remains unexplored.A prospective multicenter cohort of LTRs was identified in the four lung transplant centers.Paired fecal and serum specimens were collected and divided into AR,Pl,and event-free(EF)groups according to the diagnosis at sampling.Fecal samples were determined by metagenomic sequencing.展开更多
Antarctic krill has been widely studied because of its abundant biomass,rich nutritional value,and great production potential.Notably,krill oil(KO)is rich in phospholipids(PLs),polyunsaturated fatty acids(PUFAs),and a...Antarctic krill has been widely studied because of its abundant biomass,rich nutritional value,and great production potential.Notably,krill oil(KO)is rich in phospholipids(PLs),polyunsaturated fatty acids(PUFAs),and astaxanthin.A method based on a green switchable hydrophilicity solvent N,7V-dimethyIcyclohexylamine(DMCHA),which can reversibly change from oil soluble to water soluble in the presence of CO2 was used to extract KO from frozen Antarctic krill as it consumes less energy than traditional methods.We showed that DMCHA destroyed the surface structure of Antarctic krill and accelerated the dissolution of KO.In addition,this method enabled the PL extraction to reach up to 80.2%of total PLs,among which PC accounted for the highest proportion,up to 90.91%in PL.In fact,the astaxanthin extraction reached up to 81.44%of total astaxanthin while the fatty acid(FA)extraction up to 84.35%.The KO extracted through DMCHA was rich in PUFA,up to 47.74%,and the content of EPA+DHA reached 42.16%of total FA content.Furthermore,the amount of residual solvent in the lipid phase was just 0.23%of the DMCHA used for the extraction and the recovery rate of solvent was up to 93.2%.Our results demonstrated the high efficiency of oil extraction and the environmental friendliness of this method.展开更多
基金We acknowledge the support of the Electron Microscopy Centre at The University of Manchester.
文摘Electromagnetic interference shielding and thermal management by wearable devices show great po-tential in emerging digital healthcare.Conventional metal films implementing the functions must sacri-fice either flexibility or permeability,which is far from optimal in practical applications.In this work,an ultra-thin(15μm),flexible,and porous Cu/PLLA fibrous membrane is developed by depositing cop-per particles on the polymer substrate.With novel acetone&heat treatment procedure,the mem-brane is considerably stronger while maintaining the porous fibre structure.Its fantastic breathabil-ity and super high electrical conductivity(9471.8130 S/cm)enable the composites to have fast electri-cal heating characteristics and excellent thermal conductivity for effective thermal management.Mean-while,the porous polymer substrate structure greatly enhances the diffusion of conductive substances and increases the electromagnetic interference shielding effectiveness of the membranes(7797.98 dB cm^(2)/g at the H band and 8072.73 dB cm^(2)/g at the Ku band respectively).The composites present high flexibility,breathability,and strength with the functions of thermal management and electromag-netic shielding,showing great potential for future portable electronic devices and wearable integrated garments.
基金supported by the Scientific and technological innovation project of Ningxia Coal Industry Co.,LTD,China Energy Investment(NXMY-24-36)。
文摘The selective catalytic deoxygenation of oxy-organics in Fischer-Tropsch mixed oil for its high value utilization is challenging.Herein,a BaCO_(3)/γ-Al_(2)O_(3) catalyst was prepared calciningγ-Al_(2)O_(3) with BaCO_(3),and the acid-alkalinity of the catalyst was regulated by introducing alkaline Ba basic sties.In a co ntinuous fixed-bed reactor with a feed mass space velocity of 1 h~(-1)and reaction temperature of 330℃,BaCO_(3)/γ-Al_(2)O_(3) catalyst can efficiently catalyzed the deoxygenation removal of 1-octanol in Fischer-Tropsch C10mixture oil.It also inhibited the isomerization of 1-decene in the C10 mixture.The catalytic deoxygenation kinetics of 1-octanol were also studied.The reaction was endothermic with an activation energy of 64 kJ·mol^(-1)and a reaction order of 2.In addition,theoretical studies revealed the adsorption and activation of 1-decene on the Lewis acidic site and the alkaline Ba basic sites,1-decene was more easily underwent isomerization into 2-decene at Lewis acid sites.This research provides a useful method to enable the industrial application of catalytic deoxygenation of alcohols in Fischer-Tropsch synthetic oil.
基金supported by National Natural Science Foundation of China(No.82173170,Junxia ChenNo.82103089,Lei Xing)Natural Science Foundation of Chongqing,China(No.CSTB2022BSXMJCX0057,Lei Xing).
文摘Background:Accumulating studies have shown the important role of circular RNAs(circRNAs)in the oncogenesis and metastasis of various cancers.We previously reported that circACTN4 could bind with FUBP1 to promote tumorigenesis and the development of breast cancer(BC)by increasing the expression of MYC.However,its exact molecular mechanism and biological function have not been fully elucidated.Methods:Here,Circular RNA microarray analysis was conducted in 3 pairs of BC and paracancerous tissues.The expression of circACTN4 in BC cells and tissues was detected via reverse transcription‒quantitative PCR(RT‒qPCR).Cell Counting Kit-8(CCK-8),5-ethynyl-2-deoxyuridine(EdU),transwell migration,and invasion assays were performed to further detect the biological functions of circACTN4 in BC cells.Xenograft models were used to investigate the in vivo role of circACTN4.Fluorescence in situ hybridization,Chromatin immunoprecipitation(ChIP)‒qPCR,coimmunoprecipitation,fluorometric,western blot,and rescue experiments were performed to explore the mechanism of circACTN4.Results:Our results revealed that circACTN4 was highly expressed in BC cells and tissues.The upregulated expression of circACTN4 was significantly related to the T stage and TNM stage and poor prognosis of patients with BC.circACTN4 was located primarily in the nucleus of BC cells.Upregulation of circACTN4 significantly increased the proliferation,invasion,and growth of BC cells,whereas the downregulation of circACTN4 exerted the opposite effects and induced G1/S cell cycle arrest.Mechanistically,we showed that circACTN4 could upregulate the expression of MYC and that MYC might interact with TIP60 histone acetyltransferase to increase the recruitment of TIP60 to MYC target genes and histone H4 acetylation(AcH4),thus promoting the progression of the breast cancer cell cycle and tumorigenesis.Conclusion:Taken together,our findings reveal for the first time a new mechanism by which circACTN4 could promote oncogenesis and the development of BC by increasing the AcH4 of MYC target genes via TIP60.Therefore,circACTN4 could be a novel target for BC diagnosis and remedy.
基金supported in part by National Key Research&Development Program of China(2021YFB3301200)in part by the National Natural Science Foundation of China(61933015)。
文摘Accurately soft sensing of the mechanical properties of hot-rolled strips is essential to ensure product quality,optimize production,and reduce costs.However,it faces the difficulty caused by limited labeled samples,for which co-training based semi-supervised learning offers a potential solution.So in this paper,a novel soft sensing method for mechanical properties based on improved co-training(ICO)is proposed.Compared with the existing co-training framework,the proposed ICO introduces improvements from the aspects of multiple view partition,confidence estimation,and pseudo-label assignment.Specifically,(ⅰ)in the stage of multiple view partition,ICO integrates metallurgical mechanisms of hot rolling processes and statistical mutual information to achieve a balance between view sufficiency and independence,which improves model performance and interpretability;(ⅱ)in the stage of confidence estimation,ICO evaluates the confidence of unlabeled samples at the cluster level rather than at the level of a single sample,which facilitates the exploration of sample distribution and the selection of representative samples;(ⅲ)in the pseudo-label assignment stage,ICO adopts a safe pseudo-label algorithm(which is called SAFER by its author and originally used for each single sample)to assign pseudo-labels for cluster of samples with the highest confidence determined in the previous step stage,to take advantage of the merit of handling unlabeled samples at the cluster level mentioned above on one hand,and the merit of SAFER in enhancing the quality of pseudo-labels on the other hand.The proposed soft sensing method effectively predicts mechanical properties on the real hot rolling dataset,achieving approximately 5%improvement in R~2 compared to traditional supervised learning.
文摘1978—2015年中国产业结构转型的典型事实是:农业部门的就业份额和产值份额大幅度萎缩;工业部门的就业份额不断扩张而产值份额变化幅度不大;而服务业部门的就业和产值份额大幅度扩张,而且服务业部门就业份额的扩张快于工业部门。通过在Kongsamut et al.(2001)模型中引入家庭生产工业品和要素市场扭曲,本文试图为中国经济的产业结构转型提供一个理论解释。研究表明,由于存在农业生存消费品、家庭生产工业品和家庭生产服务品,因此消费者关于农产品的需求收入弹性小于1而关于工业品和服务品的需求收入弹性都大于1。因而,当技术进步同时推动三部门经济增长时,农业在国民经济中的产值和就业比重不断减少,而工业和服务业的产值和就业比重都不断增加。由于相对于各自的技术系数,家庭生产服务品比家庭生产工业品的数量更大,因此服务业部门比工业部门扩张得更快。而且,数值模拟的产业动态跟中国经济的实际数据非常接近。
文摘For understanding acoustic emission （AE） activity and accumulation of micro-damage inside rock under pure tensile state, the AE signals has been monitored on the test of directly tension on two kinds of marble specimens. A tensile constitutive model was proposed with the damage factor calculated by AE energy rate. The tensile strength of marble was discrete obviously and was sensitive to the inside microdefects and grain composition. With increasing of loading, the tensile stress-strain curve obviously showed nonlinear with the tensile tangent modulus decreasing. In repeated loading cycle, the tensile elastic modulus was less than that in the previous loading cycle because of the generation of micro damage during the prior loading. It means the linear weakening occurring in the specimens. The AE activity was corresponding with occurrence of nonlinear deformation. In the initial loading stage which only elastic deformation happened on the specimens, there were few AE events occurred; while when the nonlinear deformation happened with increasing of loading, lots of AE events were generated. The quantity and energy of AE events were proportionally related to the variation of tensile tangent modulus. The Kaiser effect of AE activity could be clearly observed in tensile cycle loading. Based on the theory of damage mechanics, the damage factor was defined by AE energy rate and the tensile damage constitutive model was proposed which only needed two property constants. The theoretical stress-strain curve was well fitted with the curve plotted with tested datum and the two property constants were easily gotten by the laboratory testing.
基金financial support from the National Natural Science Foundation of China (Grant No. 51401134)the Scientific Research Funding Project of Liaoning Education Department (Grant No. LG201924)+1 种基金the Australian Research Council (ARCDE180101030) during the course of this work。
文摘For the first time, we developed porous Pt-Ni alloying nanoparticles with predominant(111) facets under intense magnetic fields. Electrochemical analysis revealed that the Pt-Ni alloying nanoparticles obtained at 2 Tesla exhibited a superior catalytic activity and durability for oxygen reduction reaction. This work demonstrated that the imposition of intense magnetic field could be considered as a new approach for developing efficient alloying electrocatalysts with preferential facets.
文摘Objective The aim of this study was to investigate the correlation between pretreatment fibrinogen levels and metastasis in non-small cell lung cancer(NSCLC).Methods The study included 503 NSCLC patients with a clear pathological diagnosis and 168 patients diagnosed with benign lung diseases by histological examination.Pretreatment plasma fibrinogen values were quantified,and the relationship between plasma fibrinogen level and clinical variables comprising tumor size,metastasis,and clinical stage was examined using Kruskal-Wallis test,Wilcoxon rank sum test,and Chi-square test.Results The median plasma fibrinogen values were statistically higher in NSCLC patients with metastasis than patients with benign lung diseases and NSCLC patients without metastasis(Kruskal-Wallis test;P<0.001).Plasma fibrinogen values were also significantly higher in advanced clinical stages(Wilcoxon rank sum test;P<0.001).A significant relationship was observed between elevated fibrinogen(>2.974 g/L)and metastasis,clinical stage,and tumor size(Chi-square test;P<0.001).Conclusion This correlation suggests that elevated pretreatment plasma fibrinogen levels can predict metastasis and advanced tumor stage in NSCLC patients.
基金supported by the National Natural Science Foundation of China(Nos.11674005,11664026,11704406)the National Materials Genome Project of China(No2016YFB0700600)+4 种基金the Key Research and Development Program of Ningxia(No.2018BEE03023)the Natural Science Foundation of Ningxia(No.2018AAC03236)the Higher Schoo Scientific Research Project of Ningxia Department of Education(No.NGY2018-130)the Key Scientific Research Project of Ningxia Normal University(No.NXSFZDA1807)the Youth Talent Support Program of Ningxia,China(2016)
文摘Tellurene, an emerging two-dimensional chain-like semiconductor, stands out for its high switch ratio, carrier mobility and excellent stability in air. Directly contacting the 2D semiconductor materials with metal electrodes is a feasible doping means to inject carriers. However, Schottky barrier often arises at the metal–semiconductors interface, impeding the transport of carriers. Herein, we investigate the interfacial properties of BL tellurene by contacting with various metals including graphene by using ab initio calculations and quantum transport simulations. Vertical Schottky barriers take place in Ag, Al, Au and Cu electrodes according to the maintenance of the noncontact tellurene layer band structure. Besides, a p-type vertical Schottky contact is formed due to the van der Waals interaction for graphene electrode. As for the lateral direction, p-type Schottky contacts take shape for bulk metal electrodes(hole Schottky barrier heights(SBHs) ranging from 0.19 to 0.35 eV). Strong Fermi level pinning takes place with a pinning factor of 0.02. Notably, a desirable p-type quasi-Ohmic contact is developed for graphene electrode with a hole SBH of 0.08 eV. Our work sheds light on the interfacial properties of BL tellurene based transistors and could guide the experimental selections on electrodes.
基金supported by the National Key Research and Development Program of China(No.2018YFC0213905)the National Natural Science Foundation of China(No.41805068)。
文摘Because of the recent growth in ground-level ozone and increased emission of volatile organic compounds(VOCs),VOC emission control has become a major concern in China.In response,emission caps to control VOC have been stipulated in recent policies,but few of them were constrained by the co-control target of PM_(2.5)and ozone,and discussed the factor that influence the emission cap formulation.Herein,we proposed a framework for quantification of VOC emission caps constrained by targets for PM_(2.5)and ozone via a new response surface modeling(RSM)technique,achieving 50%computational cost savings of the quantification.In the Pearl River Delta(PRD)region,the VOC emission caps constrained by air quality targets varied greatly with the NOxemission reduction level.If control measures in the surrounding areas of the PRD region were not considered,there could be two feasible strategies for VOC emission caps to meet air quality targets(160μg/m^(3)for the maximum 8-hr-average 90th-percentile(MDA8-90%)ozone and 25μg/m^(3)for the annual average of PM_(2.5)):a moderate VOC emission cap with<20%NOxemission reductions or a notable VOC emission cap with>60%NOxemission reductions.If the ozone concentration target were reduced to 155μg/m^(3),deep NOxemission reductions is the only feasible ozone control measure in PRD.Optimization of seasonal VOC emission caps based on the Monte Carlo simulation could allow us to gain higher ozone benefits or greater VOC emission reductions.If VOC emissions were further reduced in autumn,MDA8-90%ozone could be lowered by 0.3-1.5μg/m^(3),equaling the ozone benefits of 10%VOC emission reduction measures.The method for VOC emission cap quantification and optimization proposed in this study could provide scientific guidance for coordinated control of regional PM_(2.5)and O_(3)pollution in China.
基金supported by the National Key R&D Program of China(Grant No.2023YFB4402600)the National Natural Science Foundation of China(Grant Nos.12074241,11929401,52130204,12311530675,and 52271007)+5 种基金Key Research Project of Zhejiang Lab(Grant No.2021PE0AC02)Science and Technology Commission of Shanghai Municipality(Grant Nos.22XD1400900,20501130600,21JC1402700,and 21JC1402600)supports from the open projects of Key Laboratory of Green Fabrication and Surface Technology of Advanced Metal Materials(Anhui University of Technology),Ministry of Education(Grant No.GFST2022KF08)State Key Laboratory of Surface Physics(Fudan University)(Grant No.KF202210)State Key Laboratory of Infrared Physics,Shanghai Institute of Technical Physics,Chinese Academy of Sciences(Grant No.SITP-NLIST-YB-2022-08)the support of China Scholarship Council,and thanks Mr.Xiaowen Shi(from HZWTECH)for helpful discussions.
文摘The discovery of ferroelectricity in HfO_(2)-based materials with high dielectric constant has inspired tremendous research interest for next-generation electronic devices.Importantly,films structure and strain are key factors in exploration of ferroelectricity in fluorite-type oxide HfO_(2) films.Here we investigate the structures and straininduced ferroelectric transition in different phases of few-layer HfO_(2) films(layer number𝑁=1–5).It is found that HfO_(2) films for all phases are more stable with increasing films thickness.Among them,the Pmn2_(1)(110)-oriented film is most stable,and the films of𝑁=4,5 occur with a𝑃21 ferroelectric transition under tensile strain,resulting in polarization about 11.8μC/cm^(2) along in-plane𝑎-axis.The ferroelectric transition is caused by the strain,which induces the displacement of Hf and O atoms on the surface to non-centrosymmetric positions away from the original paraelectric positions,accompanied by the change of surface Hf–O bond lengths.More importantly,three new stable HfO_(2)2D structures are discovered,together with analyses of computed electronic structures,mechanical,and dielectric properties.This work provides guidance for theoretical and experimental study of the new structures and strain-tuned ferroelectricity in freestanding HfO_(2) films.
基金supported by the National Natural Science Foundation of China(NSFC)under Grant No.42230103the State Key Laboratory of Geographic Information Engineering and the Key Laboratory of Surveying and Mapping Science and Geospatial Information Technology of the Ministry of Natural Resources Jointly Funded Project under Grant No.2021-04-03.
文摘Visual Attention Prediction(VAP)is widely applied in GIS research,such as navigation task identification and driver assistance systems.Previous studies commonly took color information to detect the visual saliency of natural scene images.However,these studies rarely considered adaptively feature integration to different geospatial scenes in specific tasks.To better predict visual attention while driving tasks,in this paper,we firstly propose an Adaptive Feature Integration Fully Convolutional Network(AdaFI-FCN)using Scene-Adaptive Weights(SAW)to integrate RGB-D,motion and semantic features.The quantitative comparison results on the DR(eye)VE dataset show that the proposed framework achieved the best accuracy and robustness performance compared with state-of-the-art models(AUC-Judd=0.971,CC=0.767,KL=1.046,SIM=0.579).In addition,the experimental results of the ablation study demonstrated the positive effect of the SAW method on the prediction robustness in response to scene changes.The proposed model has the potential to benefit adaptive VAP research in universal geospatial scenes,such as AR-aided navigation,indoor navigation,and street-view image reading.
文摘Simulated compounds were prepared by loading K2SO4 onto V2O5/AC catalysts. Study the effect of K2SO4 on V1/AC catalysts in the presence of low concentration SO2. Transient response techniques, TPD was carried out. The results indicated that the DeNO activity of V1/AC catalysts was decreased seriously in the early period of operation, but the deactivation was gradually diminished with SO2 adsorption and then, it was completely eliminated. For the sulphated catalysts (saturated catalysts by sulphate), their SCR activity were free from existence of gaseous SO2. the loss of activity about 10% caused by K2SO4 was found on them. The deactivation of K2SO4 deposited catalysts was due to the decrease of adsorbed and activated NH3, or some acid sites.
基金supported in part by the University of Kansas General Research Fund FY23the Simons Foundation through Grant MP-TSM-00002397supported in part by the National Natural Science Foundation of China through Grant 12101509.
文摘A so-called grid-overlay finite difference method(GoFD)was proposed recently for the numerical solution of homogeneous Dirichlet boundary value problems(BVPs)of the fractional Laplacian on arbitrary bounded domains.It was shown to have advantages of both finite difference(FD)and finite element methods,including their efficient implementation through the fast Fourier transform(FFT)and the ability to work for complex domains and with mesh adaptation.The purpose of this work is to study GoFD in a meshfree setting,a key to which is to construct the data transfer matrix from a given point cloud to a uniform grid.Two approaches are proposed,one based on the moving least squares fitting and the other based on the Delaunay triangulation and piecewise linear interpolation.Numerical results obtained for examples with convex and concave domains and various types of point clouds are presented.They show that both approaches lead to comparable results.Moreover,the resulting meshfree GoFD converges in a similar order as GoFD with unstructured meshes and finite element approximation as the number of points in the cloud increases.Furthermore,numerical results show that the method is robust to random perturbations in the location of the points.
基金the National Natural Science Foundation of China(22074118,21775119,21974107)the Key Research and Development Program of Shaanxi Province(2020ZDLSF0507,2018KWZ-05)Science and Technology Major Project of Tibet Autonomous Region(XZ202101ZD0019G)for the support of this work
文摘Drug-receptor interaction analysis has been broadly adopted as a tool for the evaluation of the drug-like property.Nowadays,growing evidence has demonstrated that drug e fficacy and safety are highly related to residence time,which equals the reciprocal of the dissociation rate constant(k_(d))of a drug to its target protein.Using endothelin receptor A(ET_(A)R)as a probe,we immobilized the receptor on the surface of macroporous silica gel through a covalent interaction between the epidermal growth factor tyrosine kinase(EGFR)at the C terminal of ET_(A)R and the covalent inhibitor ibrutinib modified on the gel in a one-step fashion.The a ffinity stationary phase was used to semi-quantitatively determine the residence time of natural products on ET_(A)R and evaluate their drug-like property.The k_(d)values of three specific ligands(bosentan,macitentan,and ambrisentan)to ET_(A)R were determined by nonlinear chromatography,peak profiling and peak_(d)ecay.Compared the data determined in free solution of the three methods,peak profiling is considered as the best-fit method for k_(d)determination.Thus,peak profiling was applied for predicting the residence time of three natural products(ferulic acid,berberine,and palmatine)on ET_(A)R.With the longest residence time of 61.11±3.47 s on ET_(A)R,palmatine was evaluated as the most potent compound,which could be developed as a long-acting lead for the receptor.We demonstrate that the high-performance a ffinity chromatography with immobilized ET_(A)R is an alternative for the semi-quantitative measurement of residence time for the drug-like property evaluation of natural products.
基金supported by the National Natural Science Foundation of China(grant No.21976181).
文摘Wasted tofu rich in protein was subject to hydrothermal pretreatment(HTPT)under different conditions(at 120,140,160 and 180℃;for 0,30,60 and 90 min)followed by biochemical methane potential(BMP)tests,and 140℃and 0 min were found to be respectively the best temperature and duration for HTPT of tofu in terms of its biogas production.Under the under the optimal conditions(140℃,0 min)the accumulative methane yield reached up to 510.9 mL⋅(gVS)-1,which was 26.98%higher than that without HTPT(402.3 mL⋅(gVS)-1).The start-up process of continuous anerobic digestion(AD)of the tofu before and after hydrothermal treated(HT)at the optimal HTPT conditions(140℃,0 min)was examined,to investigate and compare how their consequent AD responded to HTPT.It was found that,for start-up of continuous AD,the HT tofu delivered more balanced nutrients and thus led to more stable AD and quicker biogas production.Unavoidably,HTPT generated products refractory to biodegradation,to slightly decrease the total biogas production.During AD of HT tofu some weak ammonia-tolerant microbes,such as methylotrophic methanogens,survived and played indispensable roles.Analyses of living microbial community structure indicated that,some hydrolytic acidification bacteria intolerant to ammonia nitrogen(such as Proteobacteria)were always active and appeared at high proportion.The viable methylotrophic methanogens,e.g.RumEn M2,took obvious responsibilities in start-up of the AD for HT tofu.
基金This work was supported by the National Key Research and Development Program of China(2022YFC2504800)National Natural Science Foundation of China(Nos.82072257 and 82202543)+2 种基金Scientific and Technological Innovation action Plan of Science and Technology Commission of Shanghai Municipality(Nos.20DZ2253700,20DZ2272000,21410750500,and 22Y21900500)Shanghai Municipal Health Commission(shslczdzk01001)Guangxi Department of Science and Technology Foundation(No.2020GXNSFGA238001).
文摘Whether the alternated microbiota in the gut contribute to the risk of allograft rejection(AR)and pulmonary infection(Pl)in the setting of lung transplant recipients(LTRs)remains unexplored.A prospective multicenter cohort of LTRs was identified in the four lung transplant centers.Paired fecal and serum specimens were collected and divided into AR,Pl,and event-free(EF)groups according to the diagnosis at sampling.Fecal samples were determined by metagenomic sequencing.
基金the National Natural Science Foundation of China(U606403):Marine Drugs and Biological Products was appreciated.
文摘Antarctic krill has been widely studied because of its abundant biomass,rich nutritional value,and great production potential.Notably,krill oil(KO)is rich in phospholipids(PLs),polyunsaturated fatty acids(PUFAs),and astaxanthin.A method based on a green switchable hydrophilicity solvent N,7V-dimethyIcyclohexylamine(DMCHA),which can reversibly change from oil soluble to water soluble in the presence of CO2 was used to extract KO from frozen Antarctic krill as it consumes less energy than traditional methods.We showed that DMCHA destroyed the surface structure of Antarctic krill and accelerated the dissolution of KO.In addition,this method enabled the PL extraction to reach up to 80.2%of total PLs,among which PC accounted for the highest proportion,up to 90.91%in PL.In fact,the astaxanthin extraction reached up to 81.44%of total astaxanthin while the fatty acid(FA)extraction up to 84.35%.The KO extracted through DMCHA was rich in PUFA,up to 47.74%,and the content of EPA+DHA reached 42.16%of total FA content.Furthermore,the amount of residual solvent in the lipid phase was just 0.23%of the DMCHA used for the extraction and the recovery rate of solvent was up to 93.2%.Our results demonstrated the high efficiency of oil extraction and the environmental friendliness of this method.
