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Metastasis-associated protein 1 induces VEGF-C and facilitates lymphangiogenesis in colorectal cancer 被引量:25
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作者 bin du Zhen-Yu Yang +5 位作者 Xue-Yun Zhon Mao Fang Yong-Rong Yan Guo-Long Qi Yun-Long Pan Xu-Long Zhou 《World Journal of Gastroenterology》 SCIE CAS CSCD 2011年第9期1219-1226,共8页
AIM:To study the correlation between high metastasisassociated protein 1(MTA1)expression and lymphangiogenesis in colorectal cancer(CRC)and its role in production of vascular endothelial growth factor-C(VEGF-C). METHO... AIM:To study the correlation between high metastasisassociated protein 1(MTA1)expression and lymphangiogenesis in colorectal cancer(CRC)and its role in production of vascular endothelial growth factor-C(VEGF-C). METHODS:Impact of high MTA1 and VEGF-C expression levels on disease progression and lymphovasculardensity(LVD,D2-40-immunolabeled)in 81 cases of human CRC was evaluated by immunohistochemistry. VEGF-C mRNA and protein expressions in human LoVo and HCT116 cell lines were detected by real-time polymerase chain reaction and Western blotting,respectively,with a stable expression vector or siRNA. RESULTS:The elevated MTA1 and VEGF-C expression levels were correlated with lymph node metastasis and Dukes stages(P<0.05).Additionally,high MTA1 expression level was correlated with a large tumor size(P< 0.05).A significant correlation was found between MTA1 and VEGF-C protein expressions in tumor cells(r=0.371, P<0.05).Similar to the VEGF-C expression level,high MTA1 expression level was correlated with high LVD in CRC(P<0.05).Furthermore,over-expression of MTA1 significantly enhanced the VEGF-C mRNA and protein expression levels,whereas siRNAs-knocked down MTA1 decreased the VEGF-C expression level. CONCLUSION:MTA1,as a regulator of tumor-associated lymphangiogenesis,promotes lymphangiogenesis in CRC by mediating the VEGF-C expression. 展开更多
关键词 Metastasis-associated protein 1 Vascular endothelial growth factor-C LYMPHANGIOGENESIS Colorectal cancer
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Multi-objective model and optimization algorithm based on column generation for continuous casting production planning 被引量:2
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作者 Jian Yi Shu-jin Jia +1 位作者 bin du Qing Liu 《Journal of Iron and Steel Research International》 SCIE EI CAS CSCD 2019年第3期242-250,共9页
The optimization of continuous casting production planning(CCPP)in the steel industry was studied.The essence of CCPP is the productive capability balance of back-end facilities over the planning time period.The facil... The optimization of continuous casting production planning(CCPP)in the steel industry was studied.The essence of CCPP is the productive capability balance of back-end facilities over the planning time period.The facilities with the demands of productive capability are called the flows.On the basis of charge plans,the task of CCPP is to produce cast plans according to the rules of cast design in order to meet the flows.Firstly,a multi-objective model was established with considering the demands of flows,the capability requirements of liquid steel refini ng devices,and the rules of cast design.Secondly,the model was decomposed into a master problem(set partitioning problem model)and a series of subproblem(pricing problem model)by using Dantzig-Wolfe decomposition strategy.Finally,a column generation-based optimization algorithm(CGBOA)was presented.The experimental results on practical production data from Baosteel demonstrate that the proposed algorithm is effective and feasible.Moreover,a new decision support system based on CGBOA has been successfully established and applied to No.2 Steelmaking Plant at Baosteel. 展开更多
关键词 STEELMAKING Continuous CASTING Production planning CHARGE CAST COLUMN generation
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Hybrid optimization for charge planning problem in twin strands continuous casting production 被引量:1
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作者 Jian Yi Shu-jin Jia bin du 《Journal of Iron and Steel Research International》 SCIE EI CSCD 2021年第5期520-529,共10页
Charge planning is one of batching problems for steelmaking and continuous casting production,and its optimization will be conducive to subsequent cast planning.Charge planning problem in the twin strands continuous c... Charge planning is one of batching problems for steelmaking and continuous casting production,and its optimization will be conducive to subsequent cast planning.Charge planning problem in the twin strands continuous casting production was studied,where casting width of the odd strand might be different from that of the even strand.Considering the different widths in the twin strands,the resulting counterweights and the constraints of steelmaking and continuous casting,a multiobjective optimization model was established to minimize the number of charges,the number of scale pairs,the surplus and the upgrading costs of steel grades.Furthermore,a hybrid optimization algorithm combined with heuristic and mutation-based estimation of distribution algorithm was proposed to solve the model.Experiments were conducted on several groups of test data collected from practical production orders of Baosteel.The computational results demonstrate that the proposed algorithm can generate better solutions than the manual method.The proposed model and algorithm proved to be effective and practical. 展开更多
关键词 STEELMAKING Continuous casting Production planning CHARGE CAST Estimation of distribution algorithm
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Reduction of methylviologen-mediated oxidative stress tolerance in antisense transgenic tobacco seedlings through restricted expression of StAPX
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作者 Wei-hong SUN Yong WANG +4 位作者 Hua-gang HE Xue LI Wan SONG bin du Qing-wei MENG 《Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)》 SCIE CAS CSCD 2013年第7期578-585,共8页
Ascorbate peroxidases are directly involved in reactive oxygen species (ROS) scavenging by reducing hydrogen peroxide to water. The tomato thylakoid-bound ascorbate peroxidase gene (StAPX) was introduced into tobacco.... Ascorbate peroxidases are directly involved in reactive oxygen species (ROS) scavenging by reducing hydrogen peroxide to water. The tomato thylakoid-bound ascorbate peroxidase gene (StAPX) was introduced into tobacco. RNA gel blot analysis confirmed that StAPX in tomato leaves was induced by methylviologen-mediated oxidative stress. The sense transgenic seedlings exhibited higher tAPX activity than that of the wild type (WT) plants under oxidative stress conditions, while the antisense seedlings exhibited lower tAPX activity. Lower APX activities of antisense transgenic seedlings caused higher malondialdehyde contents and relative electrical conductivity. The sense transgenic seedlings with higher tAPX activity maintained higher chlorophyll content and showed the importance of tAPX in maintaining the optimal chloroplast development under methylviologen stress conditions, whereas the antisense lines maintained lower chlorophyll content than WT seedlings. Results indicated that the over-expression of StAPX enhanced tolerance to methylviologen-mediated oxidative stress in sense transgenic to- bacco early seedlings, whereas the suppression of StAPX in antisense transgenic seedlings showed high sensitivity to oxidative stress. 展开更多
关键词 METHYLVIOLOGEN Oxidative stress StAPX Stress tolerance Transgenic tobacco seedling
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Effect of You-Gui Yin on glucocorticoid-induced apoptosis of bone marrow mesenchymal stem cells
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作者 Hao Chen Peng Yuan +4 位作者 Hao Sun Fei-Fei Gao Yang Chen Xin Liu bin du 《Journal of Hainan Medical University》 2021年第24期11-16,共6页
Objective:To investigate the effect of You-Gui Yin on glucocorticoid-induced apoptosis of rat bone marrow mesenchymal stem cells and its possible mechanism.Methods:20 SD rats were divided into normal saline group and ... Objective:To investigate the effect of You-Gui Yin on glucocorticoid-induced apoptosis of rat bone marrow mesenchymal stem cells and its possible mechanism.Methods:20 SD rats were divided into normal saline group and You-Gui Yin group.Ten rats in each group were given normal saline and You-Gui Yin by gavage for 2 weeks,once daily.After the gavage,the rats were sacrificed by spinal removal,blood was taken from the abdominal aorta and centrifuged to obtain blank serum and medicated serum.The rat bone marrow mesenchymal stem cells were extracted and cultured and administered in groups:blank group(10%blank serum),Model group(10%blank serum+dexamethasone 5×10-5mol/ml),traditional Chinese medicine group(10%medicated serum+dexamethasone 5×10-5mol/ml),control group(10%medicated serum),CCK-8 method was used to detect cell proliferation changes in different groups,ELISA method was used to detect bone alkaline phosphatase levels in each group,Alizarin red staining was used to compare red-stained calcium mineralized nodules in each group,Western Blot Detect the expression of apoptosis-related proteins in BMSCs,and perform molecular docking of the quantitative components to evaluate the binding strength and activity of the target and the active compound.Results:The ratio of absorbance(A450)in each time period of the model group was significantly reduced(P<0.05),and the ratio of absorbance(A450)between the traditional Chinese medicine group and the control group was significantly higher than that of the model group(P<0.05).There was no difference between the control group and the blank group(P>0.05);ELISA method showed that the ALP level of the model group was significantly lower than that of the blank group and the control group(P<0.05),the traditional Chinese medicine group significantly increased the ALP level(P<0.05),there was no significant difference between the control group and the blank group;Observation of the number of calcium mineralized nodules under alizarin red staining microscope suggests that the number of calcium mineralized nodules in the model group is significantly lower than that of each group,and there is no significant difference between the control group and the blank group.Both groups are higher than the model group and traditional Chinese medicine Group;Western Blot indicated that compared with the blank group,the expression levels of proapoptotic proteins Bax and Cleaved-casepase-3 in the model group were significantly increased(P<0.01),and the expression levels of anti-apoptotic protein Bcl-2 were decreased(P<0.01),on the contrary in the traditional Chinese medicine group,the expression of the control group did not change significantly compared with the blank group;the molecular docking results showed that You-Gui Yin mainly regulates the apoptosis of BMSCs through Epicatechin 5,7,3'-trimethyl ether,Delphinin,etc.promote bone formation.Conclusion:You-Gui Yin medicated serum can protect BMSCs from apoptosis induced by GCs and promote BMSCs proliferation and osteogenic differentiation by regulating Bax,Cleaved-caspase3,and Bcl-2. 展开更多
关键词 You-Gui Yin Bone marrow mesenchymal stem cells Apoptosis Target protein Molecular docking
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Mean 24-hour end-tidal carbon dioxide following diagnosis predicts mortality in patients with sepsis
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作者 Jingyi Wang Li Weng +1 位作者 Jun Xu bin du 《World Journal of Emergency Medicine》 2025年第4期383-386,共4页
Sepsis management has significantly improved over the past decades,with intensivists playing a pivotal role in its identification and treatment.[1,2]However,resource constraints in large tertiary hospitals in China li... Sepsis management has significantly improved over the past decades,with intensivists playing a pivotal role in its identification and treatment.[1,2]However,resource constraints in large tertiary hospitals in China limit patient admissions,leading to overcrowding in the emergency departments(EDs)with critically ill patients.[3]This highlights the urgent need for enhanced risk stratification and optimized sepsis management in emergency settings. 展开更多
关键词 enhanced risk stratification hour end tidal carbon dioxide emergency departments eds intensivists SEPSIS MORTALITY sepsis management resource constraints
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经结肠镜标本取材及CEA、CA125水平与结肠癌的关系研究 被引量:11
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作者 李东言 杜斌 +1 位作者 郑燕君 沈友辉 《中国现代医学杂志》 CAS 2019年第1期113-116,共4页
目的探讨结肠癌患者经结肠镜标本取材诊断及癌胚抗原(CEA)、癌抗原125(CA125)水平检测与病理检查结果的相关性。方法选取2015年7月—2017年7月天津市泰达医院88例疑似结肠癌患者,分析结肠镜标本取材诊断及CEA、CA125水平与病理结果的相... 目的探讨结肠癌患者经结肠镜标本取材诊断及癌胚抗原(CEA)、癌抗原125(CA125)水平检测与病理检查结果的相关性。方法选取2015年7月—2017年7月天津市泰达医院88例疑似结肠癌患者,分析结肠镜标本取材诊断及CEA、CA125水平与病理结果的相关性,检测结肠镜标本取材及CEA、CA125水平诊断结肠癌的准确性。结果术后病理检查结肠癌恶性部位比例分别是64.52%、63.64%、61.54%、80.00%和71.43%,合计恶性比例67.05%;结肠镜对结肠癌诊断的敏感性76.36%,特异性45.45%,漏诊率23.64%,准确性64.77%,阳性预测值70.00%,阴性预测值53.57%;CEA联合CA125对结肠癌诊断的敏感性88.14%,特异性79.31%,漏诊率11.86%,准确性85.23%,阳性预测值89.66%,阴性预测值76.67%;结肠癌患者CEA和CA125水平与良性病变患者比较,差异有统计学意义(P <0.05),结肠癌患者高于良性病变患者。结论 CEA和CA125在早期结肠癌患者的诊断中具有较高准确性,其临床表达水平的升高与癌症恶性程度呈正相关,因此,为了进一步提高对早期结肠癌患者检查的准确性,建议采用结肠镜联合CEA和CA125检测共同诊断结肠癌,实现早发现早治疗,值得临床借鉴。 展开更多
关键词 结肠肿瘤 结肠镜 病理学 临床 癌胚抗原 癌抗原125
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Agile Satellite Mission Planning via Task Clustering and Double-Layer Tabu Algorithm 被引量:11
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作者 Yanbin Zhao bin du Shuang Li 《Computer Modeling in Engineering & Sciences》 SCIE EI 2020年第1期235-257,共23页
Satellite observation schedule is investigated in this paper.A mission planning algorithm of task clustering is proposed to improve the observation efficiency of agile satellite.The newly developed method can make the... Satellite observation schedule is investigated in this paper.A mission planning algorithm of task clustering is proposed to improve the observation efficiency of agile satellite.The newly developed method can make the satellite observe more targets and therefore save observation resources.First,for the densely distributed target points,a preprocessing scheme based on task clustering is proposed.The target points are clustered according to the distance condition.Second,the local observation path is generated by Tabu algorithm in the inner layer of cluster regions.Third,considering the scatter and cluster sets,the global observation path is obtained by adopting Tabu algorithm in the outer layer.Simulation results show that the algorithm can effectively reduce the task planning time of large-scale point targets while ensuring the optimal solution quality. 展开更多
关键词 Mission planning agile satellite task clustering Tabu algorithm
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Blood gas analysis as a surrogate for microhemodynamic monitoring in sepsis 被引量:8
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作者 Jingyi Wang Li Weng +1 位作者 Jun Xu bin du 《World Journal of Emergency Medicine》 SCIE CAS CSCD 2023年第6期421-427,共7页
BACKGROUND:Emergency patients with sepsis or septic shock are at high risk of death.Despite increasing attention to microhemodynamics,the clinical use of advanced microcirculatory assessment is limited due to its shor... BACKGROUND:Emergency patients with sepsis or septic shock are at high risk of death.Despite increasing attention to microhemodynamics,the clinical use of advanced microcirculatory assessment is limited due to its shortcomings.Since blood gas analysis is a widely used technique reflecting global oxygen supply and consumption,it may serve as a surrogate for microcirculation monitoring in septic treatment.METHODS:We performed a search using PubMed,Web of Science,and Google scholar.The studies and reviews that were most relevant to septic microcirculatory dysfunctions and blood gas parameters were identified and included.RESULTS:Based on the pathophysiology of oxygen metabolism,the included articles provided a general overview of employing blood gas analysis and its derived set of indicators for microhemodynamic monitoring in septic care.Notwithstanding flaws,several parameters are linked to changes in the microcirculation.A comprehensive interpretation of blood gas parameters can be used in order to achieve hemodynamic optimization in septic patients.CONCLUSION:Blood gas analysis in combination with clinical performance is a reliable alternative for microcirculatory assessments.A deep understanding of oxygen metabolism in septic settings may help emergency physicians to better use blood gas analysis in the evaluation and treatment of sepsis and septic shock. 展开更多
关键词 SEPSIS MICROCIRCULATION Blood gas analysis Emergency service
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Association of fluid balance trajectories with clinical outcomes in patients with septic shock:A prospective multicenter cohort study 被引量:6
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作者 Mei-Ping Wang Li Jiang +5 位作者 Bo Zhu bin du Wen Li Yan He Xiu-Ming Xi China Critical Care Sepsis Trial(CCCST)workgroup 《Military Medical Research》 SCIE CSCD 2021年第3期395-404,共10页
Background:Septic shock has a high incidence and mortality rate in Intensive Care Units(ICUs).Earlier intravenous fluid resuscitation can significantly improve outcomes in septic patients but easily leads to fluid ove... Background:Septic shock has a high incidence and mortality rate in Intensive Care Units(ICUs).Earlier intravenous fluid resuscitation can significantly improve outcomes in septic patients but easily leads to fluid overload(FO),which is associated with poor clinical outcomes.A single point value of fluid cannot provide enough fluid information.The aim of this study was to investigate the impact of fluid balance(FB)latent trajectories on clinical outcomes in septic patients.Methods:Patients were diagnosed with septic shock during the first 48 h,and sequential fluid data for the first 3 days of ICU admission were included.A group-based trajectory model(GBTM)which is designed to identify groups of individuals following similar developmental trajectories was used to identify latent subgroups of individuals following a similar progression of FB.The primary outcomes were hospital mortality,organ dysfunction,major adverse kidney events(MAKE)and severe respiratory adverse events(SRAE).We used multivariable Cox or logistic regression analysis to assess the association between FB trajectories and clinical outcomes.Results:Nine hundred eighty-six patients met the inclusion criteria and were assigned to GBTM analysis,and three latent FB trajectories were detected.64(6.5%),841(85.3%),and 81(8.2%)patients were identified to have decreased,low,and high FB,respectively.Compared with low FB,high FB was associated with increased hospital mortality[hazard ratio(HR)=1.63,95%CI 1.22–2.17],organ dysfunction[odds ratio(OR)=2.18,95%CI 1.22–3.42],MAKE(OR=1.80,95%CI 1.04–2.63)and SRAE(OR=2.33,95%CI 1.46–3.71),and decreasing FB was significantly associated with decreased MAKE(OR=0.46,95%CI 0.29–0.79)after adjustment for potential covariates.Conclusion:Latent subgroups of septic patients followed a similar FB progression.These latent fluid trajectories were associated with clinical outcomes.The decreasing FB trajectory was associated with a decreased risk of hospital mortality and MAKE. 展开更多
关键词 Septic shock Fluid overload Group-based trajectory model Clinical outcomes
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Mechanism study on direct synthesis of glycerol carbonate from CO_(2)and glycerol over shaped CeO_(2)model catalysts 被引量:3
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作者 Jiarui Gao Jia-Wei Yang +5 位作者 Tenglin Ma Jia Wang Dan Xia bin du Yan Cui Chengwu Yang 《Chinese Chemical Letters》 SCIE CAS CSCD 2023年第12期348-353,共6页
Direct synthesis of glycerol carbonate(GC)from CO_(2)and glycerol(a byproduct of biodiesel production)is a route to obtain a high-value chemical from waste and low-cost byproducts but has not yet industrialized due to... Direct synthesis of glycerol carbonate(GC)from CO_(2)and glycerol(a byproduct of biodiesel production)is a route to obtain a high-value chemical from waste and low-cost byproducts but has not yet industrialized due to the lack of efficient catalysts.Ceria(CeO_(2))exhibits the highest catalytic activity and GC selectivity among the heterogeneous catalysts studied so far.However,the mechanism of this reaction over CeO_(2)catalysts has not been studied in detail.Herein,we synthesized CeO_(2)nanocrystals with different morphologies as model catalysts that can predominantly expose(111),(110),and(100)facets,and their surface acid-base properties were characterized using high-sensitivity temperature-programmed desorption of NH3 and CO_(2)with quadrupole mass spectrometry as detector(NH3-TPD-QMS and CO_(2)-TPD-QMS).We found that the catalytic performance(GC formation rate)is strictly linearly dependent on the density of basic sites,which is relevant to the adsorption and activation of CO_(2).In addition,to illustrate a more microscopic reaction mechanisms underlying the formation of GC from CO_(2)and glycerol on all three low-index surfaces(111),(110)and(100),we also performed comprehensive first principles calculations.A three-step Langmuir-Hinshelwood(LH)mechanism was identified in which the annulation reaction is the rate-limiting step.The CeO_(2)(11)surface exhibits the lowest overall activation energy,which agrees well with the catalytic performance that the CeO_(2)nano-octahedra,predominantly exposing(111)facets,have the highest GC formation rate.This work is the first to combine experiments on shaped CeO_(2)model catalysts with first-principles calculations to gain insight into the mechanism of direct synthesis of GC from CO_(2)and glycerol,and will aid in the development of catalysts with improved performance. 展开更多
关键词 CO_(2)conversion Glycerol carbonate CeO_(2) Acid-base properties Reaction mechanism
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Investigation of Hydrolysis in Poly(ethylene terephthalate) by FTIR-ATR 被引量:2
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作者 bin du 杨睿 Xu-ming Xie 《Chinese Journal of Polymer Science》 SCIE CAS CSCD 2014年第2期230-235,共6页
The hydrothermal aging of poly(ethylene terephthalate) (PET) was investigated at 70-95 ℃. A new method to investigate the hydrolysis degree of PET by Fourier transform infrared spectroscopy (FTIR) was proposed.... The hydrothermal aging of poly(ethylene terephthalate) (PET) was investigated at 70-95 ℃. A new method to investigate the hydrolysis degree of PET by Fourier transform infrared spectroscopy (FTIR) was proposed. The spectra during the hydrothermal aging were measured using attenuated total reflection accessory (ATR). Peak resolving of carbonyl regions was performed, and the ratio of two groups of bands representing carboxylic acids and esters respectively were calculated to show the hydrolysis degree of ester groups in PET. The acid/ester ratio shows exactly the same trend as the average chain scission number per unit mass at various temperatures and thus can be used as a parameter to characterize the hydrolysis and random chain scission of PET. This method related to the hydrolysis mechanism directly, is simple, fast and convenient compared to the traditional methods such as viscometry, end-group titration and size exclusion chromatography (SEC). It may also be useful in hydrolysis characterization of other polyesters. 展开更多
关键词 Poly(ethylene terephthalate) FTIR-ATR HYDROLYSIS Acid/ester ratio.
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Predictive value of neutrophil-to-lymphocyte ratio in coronary chronic total occlusion patients 被引量:2
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作者 Qian LI Yue YU +6 位作者 Ya-Qiong ZHOU Yi ZHAO Jin WU Yuan-Jing WU bin du Pei-Jian WANG Tao ZHENG 《Journal of Geriatric Cardiology》 SCIE CAS CSCD 2024年第5期542-549,共8页
BACKGROUND The neutrophil to lymphocyte ratio(NLR)has been reported as a novel predictor for atherosclerosis and car-diovascular outcomes.This study aimed to determine the effects of NLR on long-term clinical outcomes... BACKGROUND The neutrophil to lymphocyte ratio(NLR)has been reported as a novel predictor for atherosclerosis and car-diovascular outcomes.This study aimed to determine the effects of NLR on long-term clinical outcomes of chronic total occlusion(CTO)patients.METHODS A total of 670 patients with CTO who met the inclusion criteria were included at the end of the follow-up period.Patients were divided into tertiles according to their baseline NLR levels at admission:low(n=223),intermediate(n=223),and high(n=224).The incidence of major adverse cardiac events(MACEs)during the follow-up period,including all-cause death,nonfatal myocardial infarction(MI),or ischemia-driven revascularization,were compared among the three groups.RESULTS Major adverse cardiac events were observed in 27 patients(12.1%)in the low tertile,40(17.9%)in the intermediate tertile,and 61(27.2%)in the high NLR tertile(P<0.001).Kaplan-Meier analysis demonstrated a significantly higher incidence of MACE,ischemia-driven coronary revascularization,non-fatal MI,and mortality in patients within the high tertile than those in the low and intermediate groups(all P<0.001).Multivariable COX regression analysis showed that the high tertile of baseline NLR level showed a strong association with the risk of MACE(hazard ratio[HR]=2.21;95%confidence interval[CI]:1.21-4.03;P=0.009),ischemia-driven coronary revascularization(HR=3.19;95%CI:1.56-6.52;P=0.001),MI(HR=2.61;95%CI:1.35-5.03;P=0.043)and mortality(HR=3.78;95%CI:1.65-8.77;P=0.001).CONCLUSION Our findings suggest that NLR is an inexpensive and readily available biomarker that can independently pre-dict cardiovascular risk in patients with CTO. 展开更多
关键词 PATIENTS CORONARY OCCLUSION
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Extract of ginkgo biloba EGb761 inhibits cell apoptosis following spinal cord injury 被引量:1
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作者 Jiejun Jiao Jiannong Jiang +3 位作者 bin du Yuan Mo Ming Zhou Hongquan Zhang 《Neural Regeneration Research》 SCIE CAS CSCD 2010年第22期1745-1749,共5页
The neuroprotective effects of ginkgo biloba extract have been shown in rats following spinal cord injury (SCI). However, the precise protective mechanisms remain unclear. In the present study, low-acid water-solubl... The neuroprotective effects of ginkgo biloba extract have been shown in rats following spinal cord injury (SCI). However, the precise protective mechanisms remain unclear. In the present study, low-acid water-soluble extract of ginkgo biloba EGb761 was used to treat rats with SCI. Xanthin oxidase, thiobarbituric acid, terminal deoxyribonucleotidyl transferase-mediated dUTP-digoxigenin nick end labeling assay, and immunohistochemistry were utilized to detect lipid peroxidation, neural cell apoptosis, and inducible nitric oxide synthase activity in rats with SCI. Results revealed significantly increased superoxide dismutase activity, decreased malondialdehyde content, apoptotic index, and inducible nitric oxide synthase expression in SCI rats following EGb761 treatment. Therefore, EGb761 suppressed lipid peroxidation following SCI, relieved neural cell apoptosis, inhibited inducible nitric oxide synthase expression, and ultimately exerted protective effects on SCI. 展开更多
关键词 ginkgo biloba spinal cord injury superoxide dismutase apoptosis nitric oxide synthase traditional Chinese medicine neural regeneration
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Self-assembled gel-assisted preparation of high-performance hydrophobic PDMS@MWCNTs/PEDOT:PSS composite aerogels for wearable piezoresistive sensors 被引量:1
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作者 Haibin Li Rubai Luo +4 位作者 Jingbo Hu Kenan Yang bin du Shisheng Zhou Xing Zhou 《Journal of Materials Science & Technology》 SCIE EI CAS CSCD 2024年第15期22-32,共11页
The conductive polymer poly(3,4-thylenedioxythiophene):poly(styrenesulfonate)(PEDOT:PSS)exhibits po-tential in the development of flexible devices due to its unique conjugated structure and water-solubility characteri... The conductive polymer poly(3,4-thylenedioxythiophene):poly(styrenesulfonate)(PEDOT:PSS)exhibits po-tential in the development of flexible devices due to its unique conjugated structure and water-solubility characteristics.To address the incompressibility of the original PEDOT:PSS aerogel without compromis-ing its high conductivity,a stable interpenetrating polymer network(IPN)was self-assembled by guiding the molecular motion within PEDOT:PSS and introducing multi-walled carbon nanotubes(MWCNTs).By combining critical surface removal,directional freeze-drying,and polydimethylsiloxane(PDMS)reinforce-ment processes,a hydrophobic PDMS@MWCNTs/PP aerogel with a highly oriented porous structure and high strength was prepared.Under the synergistic effect of MWCNTs/PEDOT:PSS electroactive scaffold,the composite aerogel exhibited a high sensitivity of up to 16.603 kPa^(-1) at 0-2 kPa,a fast response time of 74 ms,and excellent repeatability.Moreover,the sensor possessed hydrophobicity with a good water contact angle of 137°The sensor could serve as a wearable electronic monitoring device to achieve ac-curate and sensitive detection of human motion including large-scale human activities and tiny muscle movements.Therefore,our findings provide a new direction to fabricate high-performance piezoresistive sensors based on three-dimensional(3D)conductive polymer active scaffolds,demonstrating their great potential for flexible electronics,human-computer interaction,and a wide range of applications under special working conditions. 展开更多
关键词 Pressure sensor PEDOT:PSS/MWCNTs hydrogel Composite aerogel Hierarchical porous structure Human motion detection
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Programming Shape-Morphing Behavior of Zwitterionic Polymer/Liquid Crystal Composite with Humidity-responsive Self-healing Performance 被引量:1
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作者 Shao-Jun Chen Hui-Feng Cheng +3 位作者 bin du Jiao-Shi Liu Wen-Bo Shen Hai-Tao Zhuo 《Chinese Journal of Polymer Science》 SCIE EI CAS CSCD 2023年第2期212-221,共10页
In this study,a zwitterionic polymer/liquid crystals composite film with programming shape-morphing behavior and humidityresponsive self-healing performance was prepared by blending a zwitterionic polymer and liquid c... In this study,a zwitterionic polymer/liquid crystals composite film with programming shape-morphing behavior and humidityresponsive self-healing performance was prepared by blending a zwitterionic polymer and liquid crystalline azobenzene compound in solution,followed by film-forming in a mold without tedious or multistep synthetic route.The as-obtained zwitterionic polymer/liquid crystal composite film exhibited programming shape-morphing behavior under different stimuli.In this process,the temporary shape of the composite film was memorized after the removal of the stimuli.Such characteristics would fit the requirements of intelligence and energy-saving for stimuliresponsive shape-changing materials.Moreover,the composite film showed humidity-responsive self-healing performances under wet conditions at room temperature.In summary,the simple design and preparation route of the zwitterionic polymer/liquid crystal composite film with programming shape-morphing behavior and mild condition-responsive self-healing performance look promising for the fabrication and practical application of novel photo-driven devices and soft robotics. 展开更多
关键词 Zwitterionic polymer Polymer/liquid crystals composite Programming shape-morphing behavior Humidity-responsive self-healing performance Stimuli-responsive shape-changing
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中外教育大数据研究热点与发展趋势——基于中国知网和科学网2010-2020年数据库的分析 被引量:1
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作者 郑志宏 杜斌 +1 位作者 张硕 方海光 《中国教育信息化》 2022年第3期33-40,共8页
教育大数据在教育信息化中的作用愈发凸显,挖掘教育数据潜在价值已经成为当前教育技术研究领域的重要课题。文章以中国知网(CNKI)和科学网(Web of Science)数据库的期刊论文为研究对象,以Hist Cite软件分析和内容分析法为主要研究方法,... 教育大数据在教育信息化中的作用愈发凸显,挖掘教育数据潜在价值已经成为当前教育技术研究领域的重要课题。文章以中国知网(CNKI)和科学网(Web of Science)数据库的期刊论文为研究对象,以Hist Cite软件分析和内容分析法为主要研究方法,对比国内外教育大数据的研究热点与发展趋势。分析发现,“数据挖掘”“学习分析”等技术依然是教育大数据的技术研究热点,“思想政治教育”“人工智能”“智慧教育”等领域是目前国内教育大数据的热门研究方向,我国大数据标准正在走向国际并产生影响。 展开更多
关键词 教育大数据 研究热点 发展趋势 中国知网 WOS
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Solution processed nano-ZnMgO interfacial layer for highly efficient inverted perovskite solar cells
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作者 Ze Wang Yingdong Xia +6 位作者 Lingfeng Chao Yufeng Pan Meijin Li Renzhi Li bin du Yonghua Chen Wei Huang 《Journal of Energy Chemistry》 SCIE EI CAS CSCD 2019年第1期107-110,共4页
Interfacial layer has a significant impact on the achievement of highly efficient organic–inorganic hybrid perovskite solar cells(PSCs). Here, we introduced a nano-ZnMgO(magnesium doped ZnO, abbreviated as ZnMgO) as ... Interfacial layer has a significant impact on the achievement of highly efficient organic–inorganic hybrid perovskite solar cells(PSCs). Here, we introduced a nano-ZnMgO(magnesium doped ZnO, abbreviated as ZnMgO) as interfacial layer between [6, 6]-Phenyl C_(61) butyric acid methyl ester(PC_(61) BM) layer and Al electrode to replace LiF or ZnO interlayer and enhance device performance. The device efficiency has been improved from 11.43% to 15.61% and the hysteresis was decreased dramatically. Such huge enhancement of power convert efficiency(PCE) can be attributed to the low dark current density, enhancement of electron-selective contact, and low energy barrier at the PC_(61) BM/Al interface. We suggest that this simple nano-scale interlayer can provide an efficient charge transport and extraction for highly efficient PSCs. 展开更多
关键词 Nano-ZnMgO INTERFACIAL layer High efficiency PEROVSKITE solar cells
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Recurrent perimesencephalic nonaneurysmal subarachnoid hemorrhage within a short period of time: A case report
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作者 Juan Li Xiang Fang +1 位作者 Fu-Chao Yu bin du 《World Journal of Clinical Cases》 SCIE 2021年第14期3356-3364,共9页
BACKGROUND Spontaneous subarachnoid hemorrhage(SAH)is primarily caused by a ruptured intracranial aneurysm.Perimesencephalic nonaneurysmal SAH(PNSAH)accounts for approximately 5%of all spontaneous SAH.PNSAH displays f... BACKGROUND Spontaneous subarachnoid hemorrhage(SAH)is primarily caused by a ruptured intracranial aneurysm.Perimesencephalic nonaneurysmal SAH(PNSAH)accounts for approximately 5%of all spontaneous SAH.PNSAH displays favorable prognosis.The risk of hemorrhage recurrence is low.We report a case of PNSAH recurrence,occurring within a short time after the initial episode in a patient not receiving antithrombotic or antiplatelet drugs.CASE SUMMARY A 66-year-old male,without any history of recent trauma or antithrombotic/antiplatelet medication,suffered two similar episodes of sudden onset of severe headache,nausea,and vomiting.A plain head computed tomography(CT)scan showed subarachnoid blood confined to the anterior part of the brainstem.Platelet count and coagulation function were normal.PNSAH was diagnosed by repeated head CT,magnetic resonance imaging,and cerebral angiography,none of which revealed the source of SAH.The patient was discharged without focal neurological deficits.At 6-mo follow-up,the patient had experienced no sudden onset of severe headache and presented favorable clinical outcome.Studies have reported a few patients with recurrent PNSAH,originating frequently from venous hemorrhage and conventionally associated with venous abnormalities.PNSAH recurs within a short time following the initial onset of symptoms,although the possibility of re-hemorrhage is extremely rare.CONCLUSION PNSAH recurrence should arouse vigilance;however,the definite source of idiopathic SAH in this case report deserves further attention. 展开更多
关键词 Negative angiography Perimesencephalic nonaneurysmal subarachnoid hemorrhage RECURRENCE Computed tomography Prognosis Case report
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Research on Printing Quality Evaluation of Decorative Paper Based on AHPEWM Model
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作者 Huailin Li Chan Zhang +2 位作者 Shisheng Zhou bin du Xue Li 《Journal of Renewable Materials》 SCIE EI 2022年第12期3425-3438,共14页
Printing quality evaluation is an important means to check whether prints are qualfied.However,the urrent printing quality evaluation system for gravure decorative paper is not perfect.In order to solve this problem,a... Printing quality evaluation is an important means to check whether prints are qualfied.However,the urrent printing quality evaluation system for gravure decorative paper is not perfect.In order to solve this problem,a method for evaluating quality of decorative paper based on analytical hierarchy process(AHP)and the entropy weight method(EWM)model is proposed in this paper.So as to verify the proposed model,decorative paper of different grades was selected as the experimental objects.Firstly,the data about five indices eflecting printing quality were measured.Secondly,the evaluation model was used to assign weights to the indices,and scores in each index were calculated according to scoring tables.Finally,the evalua tion scores were statistically analyzed.The results of data analysis showed that the 95% confidence intervals and coefficients of variation were small.The average error of the evaluation system was 0.2061.It indicates that the model can stably distinguish decorative paper of diferent grades,accuracy of which is high.The research in this paper can provide reference to the quality improvement of decorative paper and the printing quality evaluation of other paper. 展开更多
关键词 Quality evaluation analytic hierarchy process the entropy weight method decorative paper
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