The most common cytotoxic effects of chemotherapy drugs alone include bone marrow suppression,gastrointestinal symptoms,and liver and kidney function problems.With the continuous research on non-small cell lung cancer...The most common cytotoxic effects of chemotherapy drugs alone include bone marrow suppression,gastrointestinal symptoms,and liver and kidney function problems.With the continuous research on non-small cell lung cancer(NSCLC),various treatment modalities such as targeted therapy and immunotherapy have emerged in recent years,but there is no denying that chemotherapy remains one of the most basic treatment modalities.Shen Jia et al.,in exploring the efficacy of detoxification and yin clearing soup(Astragalus membranaceus(Fisch.)Bunge,Atractylodes macrocephala Koidz,et al.),found that the addition of the soup treatment significantly reduced the number of adverse reactions such as bone marrow suppression,nausea and vomiting,and abnormal liver and kidney function,and the incidence of adverse reactions was also significantly lower than that of the group with chemotherapy drugs alone[1].展开更多
Nuo culture is one of the most popular traditions in southeastern China. Forms of presentation of Nuo culture include Nuo dance, Nuo sacrifice and Nuo opera. During the early Ming Dynasty (1368-1644), imperial troops ...Nuo culture is one of the most popular traditions in southeastern China. Forms of presentation of Nuo culture include Nuo dance, Nuo sacrifice and Nuo opera. During the early Ming Dynasty (1368-1644), imperial troops from inland China continued to be dispatched to southwestern China for permanent habitation, with an aim to keep stability of the empire’s frontier areas. These soldiers dwelled together with local residents and thus villages展开更多
Colon cancer is currently a highly prevalent cancer with a high mortality rate worldwide.Modern medical technology provides a range of treatments for colon cancer through different means,and research on the modulating...Colon cancer is currently a highly prevalent cancer with a high mortality rate worldwide.Modern medical technology provides a range of treatments for colon cancer through different means,and research on the modulating adjuvant treatment of colon cancer with Chinese medicine is currently undergoing continuous theoretical and practical exploration to find highly effective herbal remedies to modulate,alleviate or treat the disease.The present study reviews different aspects of colon cancer in relation to different factors and the modulating adjuvant treatment of colon cancer with Chinese medicine.展开更多
Background Mitogen-inducible gene 6(Mig6),also known as RALT or gene 33,is a multiadaptive protein implicated in the regulation of RTK and stress signaling 1-3.In recent years,the negative control of RTK signaling has...Background Mitogen-inducible gene 6(Mig6),also known as RALT or gene 33,is a multiadaptive protein implicated in the regulation of RTK and stress signaling 1-3.In recent years,the negative control of RTK signaling has piqued the interest of researchers.with an increasing number of negative feedback regulators of tyrosine kinase(Receptor Protein Tyrosine Kinase,RTK).Although several commonly used inhibitors have been identified at this stage,this merely emphasizes the significance of signal attenuation and regulation for proper signal output.However,the mechanisms of their action are not well understood,especially those in vivo function and metabolic expression.展开更多
目的探讨固本降消汤联合达格列净经腺苷酸活化蛋白激酶(AMPK)信号通路、沉默信息调节因子调治2型糖尿病(T2DM)伴肥胖的效果及机制。方法选取2021年1—12月收治的T2DM伴肥胖120例,根据治疗方案不同将其分为观察组和对照组2组各60例。观...目的探讨固本降消汤联合达格列净经腺苷酸活化蛋白激酶(AMPK)信号通路、沉默信息调节因子调治2型糖尿病(T2DM)伴肥胖的效果及机制。方法选取2021年1—12月收治的T2DM伴肥胖120例,根据治疗方案不同将其分为观察组和对照组2组各60例。观察组采用固本降消汤联合达格列净治疗,对照组采用达格列净治疗,连续治疗3个月。比较2组治疗3个月后临床效果,治疗前及治疗1、3个月后血糖指标[空腹血糖(FPG)、糖化血红蛋白(HbA1c)、餐后2 h血糖(2 h PG)]、氧化应激指标[丙二醛(MDA)、超氧化物歧化酶(ROS)、谷胱甘肽过氧化物酶(GSH-Px)]、腺苷酸活化蛋白激酶α1/Toll样受体4(AMPKα1/TLR4)、转化生长因子-β1(TGF-β1)、核因子-κB(NF-κB)、能量平衡相关蛋白(Adropin)、鸢尾素(Irisin)、趋化素(Chemerin)及沉默信息调节因子1(SIRT1)、沉默信息调节因子3(SIRT3),以及治疗期间不良反应发生情况。结果治疗3个月后,总有效率观察组为96.67%高于对照组83.33%(P<0.05)。治疗1和3个月后,FPG、HbA1c、2 h PG、MDA、ROS、TGF-β1、NF-κB及Chemerin 2组均较治疗前降低,且观察组低于对照组;GSH-Px、AMPKα1/TLR4、Adropin、Irisin及SIRT1、SIRT32组均较治疗前升高,且观察组高于对照组(P<0.05,P<0.01)。治疗期间,不良反应总发生率观察组为13.33%,对照组为10.00%,2组比较差异无统计学意义(P>0.05)。结论固本降消汤联合达格列净调治T2DM伴肥胖可提高临床效果,改善血糖水平,减轻氧化应激损伤,并可经AMPK信号通路抑制肾损伤,调节SIRT1和SIRT3,延缓病情进展。展开更多
基金This work was supported by National Natural Science Foundation of China(81360684)Guangxi Key Research and Development Program Project(Guike AB18221095)+2 种基金Teaching Master Teacher Training Program Project of the Right River School of Ethnic Medicine-National Teaching Master Teacher Training Program Project(Right Hospital Word[2018]No.98)High-level Talent Scientific Research Project of the Right River School of Ethnic Medicine(01002018079).National and autonomous region level college student innovation and entrepreneurship training program project fund funding project(No.:202010599030)autonomous region level college student innovation and entrepreneurship training program project fund funding project(No.:20110599065)。
文摘The most common cytotoxic effects of chemotherapy drugs alone include bone marrow suppression,gastrointestinal symptoms,and liver and kidney function problems.With the continuous research on non-small cell lung cancer(NSCLC),various treatment modalities such as targeted therapy and immunotherapy have emerged in recent years,but there is no denying that chemotherapy remains one of the most basic treatment modalities.Shen Jia et al.,in exploring the efficacy of detoxification and yin clearing soup(Astragalus membranaceus(Fisch.)Bunge,Atractylodes macrocephala Koidz,et al.),found that the addition of the soup treatment significantly reduced the number of adverse reactions such as bone marrow suppression,nausea and vomiting,and abnormal liver and kidney function,and the incidence of adverse reactions was also significantly lower than that of the group with chemotherapy drugs alone[1].
文摘Nuo culture is one of the most popular traditions in southeastern China. Forms of presentation of Nuo culture include Nuo dance, Nuo sacrifice and Nuo opera. During the early Ming Dynasty (1368-1644), imperial troops from inland China continued to be dispatched to southwestern China for permanent habitation, with an aim to keep stability of the empire’s frontier areas. These soldiers dwelled together with local residents and thus villages
基金This work was supported by National Natural Science Foundation of China(No.81360684)Guangxi Key Research and Development Plan Project(Gui Ke AB18221095)+3 种基金Teaching Teacher Training Project from Youjiang Medical University for Nationalities-National Teaching TeacherTraining Project(You Hospital Zi[2018]No.98)High-level Talent Research Projects from Youjiang Medical University For Nationalities(No.01002018079)China National and Regional University Students Innovation and Entrepreneurship Training Scheme Funding(No.202010599022)China Regional University Students Innovation and Entrepreneurship Training Scheme Funding(No.202010599065).
文摘Colon cancer is currently a highly prevalent cancer with a high mortality rate worldwide.Modern medical technology provides a range of treatments for colon cancer through different means,and research on the modulating adjuvant treatment of colon cancer with Chinese medicine is currently undergoing continuous theoretical and practical exploration to find highly effective herbal remedies to modulate,alleviate or treat the disease.The present study reviews different aspects of colon cancer in relation to different factors and the modulating adjuvant treatment of colon cancer with Chinese medicine.
基金supported by National Natural Science Foundation of China(No.81360684)Guangxi Key Research and Development Plan Project(Gui Ke AB18221095)+3 种基金Teaching Teacher Training Project from Youjiang Medical University for Nationalities-National Teaching Teacher Training Project(You Hospital Zi[2018]No.98)High-level Talent Research Projects from Youjiang Medical University For Nationalities(No.01002018079)China National and Regional University Students Innovation and Entrepreneurship Training Scheme Funding(No.201910599012)China Regional University Students Innovation and Entrepreneurship Training Scheme Funding(No.202010599072).
文摘Background Mitogen-inducible gene 6(Mig6),also known as RALT or gene 33,is a multiadaptive protein implicated in the regulation of RTK and stress signaling 1-3.In recent years,the negative control of RTK signaling has piqued the interest of researchers.with an increasing number of negative feedback regulators of tyrosine kinase(Receptor Protein Tyrosine Kinase,RTK).Although several commonly used inhibitors have been identified at this stage,this merely emphasizes the significance of signal attenuation and regulation for proper signal output.However,the mechanisms of their action are not well understood,especially those in vivo function and metabolic expression.
文摘目的探讨固本降消汤联合达格列净经腺苷酸活化蛋白激酶(AMPK)信号通路、沉默信息调节因子调治2型糖尿病(T2DM)伴肥胖的效果及机制。方法选取2021年1—12月收治的T2DM伴肥胖120例,根据治疗方案不同将其分为观察组和对照组2组各60例。观察组采用固本降消汤联合达格列净治疗,对照组采用达格列净治疗,连续治疗3个月。比较2组治疗3个月后临床效果,治疗前及治疗1、3个月后血糖指标[空腹血糖(FPG)、糖化血红蛋白(HbA1c)、餐后2 h血糖(2 h PG)]、氧化应激指标[丙二醛(MDA)、超氧化物歧化酶(ROS)、谷胱甘肽过氧化物酶(GSH-Px)]、腺苷酸活化蛋白激酶α1/Toll样受体4(AMPKα1/TLR4)、转化生长因子-β1(TGF-β1)、核因子-κB(NF-κB)、能量平衡相关蛋白(Adropin)、鸢尾素(Irisin)、趋化素(Chemerin)及沉默信息调节因子1(SIRT1)、沉默信息调节因子3(SIRT3),以及治疗期间不良反应发生情况。结果治疗3个月后,总有效率观察组为96.67%高于对照组83.33%(P<0.05)。治疗1和3个月后,FPG、HbA1c、2 h PG、MDA、ROS、TGF-β1、NF-κB及Chemerin 2组均较治疗前降低,且观察组低于对照组;GSH-Px、AMPKα1/TLR4、Adropin、Irisin及SIRT1、SIRT32组均较治疗前升高,且观察组高于对照组(P<0.05,P<0.01)。治疗期间,不良反应总发生率观察组为13.33%,对照组为10.00%,2组比较差异无统计学意义(P>0.05)。结论固本降消汤联合达格列净调治T2DM伴肥胖可提高临床效果,改善血糖水平,减轻氧化应激损伤,并可经AMPK信号通路抑制肾损伤,调节SIRT1和SIRT3,延缓病情进展。
