布兰斯菲尔德海峡为南极磷虾主要捕捞区域,为了进一步研究该海域南极磷虾资源分布及生物学特征,基于2018/19渔季中国南极磷虾商业捕捞数据,从时间和空间两个维度对南极磷虾CPUE(catch per unit fishing effort,CPUE)、体长及年龄组成进...布兰斯菲尔德海峡为南极磷虾主要捕捞区域,为了进一步研究该海域南极磷虾资源分布及生物学特征,基于2018/19渔季中国南极磷虾商业捕捞数据,从时间和空间两个维度对南极磷虾CPUE(catch per unit fishing effort,CPUE)、体长及年龄组成进行了分析。结果表明,布兰斯菲尔德海峡南极磷虾CPUE月间差异显著(P<0.001),4—7月平均CPUE整体呈下降趋势;CPUE沿海峡呈东北-西南向分布,高值区多分布在海峡东北海域(58°45′00"~59°45′00"W、62°52′30"~63°07′30"S)。空间冷热点分析结果表明,CPUE热点主要位于海峡东北海域,核心冷点和次冷点主要分布在海峡西南海域和东南海域。不同月间南极磷虾体长差异显著(P<0.001),平均体长变化范围为39.72~44.51 mm;平均体长低值区沿东北-西南走向平行分布于海峡西缘的南设得兰群岛近岸海域,高值区多分布在海峡中部及海峡东缘的南极半岛近岸海域。不同月间南极磷虾年龄组成差异较大,5月年龄组成以3~+龄为主,其余月份以2~+龄为主;年龄组成整体上由西北向东南增大,海峡西缘的南设得兰群岛近岸海域年龄组成略低于海峡中部及海峡东缘的南极半岛近岸海域。展开更多
目的观察参附注射液对心脏骤停心肺复苏术后患者脏器功能的保护作用。方法选取我院2017年3月-2018年6月收治的心脏骤停后心肺复苏成功患者83例,根据心脏骤停心肺复苏术后治疗方法的不同分为观察组43例和对照组40例。对照组给予常规救治...目的观察参附注射液对心脏骤停心肺复苏术后患者脏器功能的保护作用。方法选取我院2017年3月-2018年6月收治的心脏骤停后心肺复苏成功患者83例,根据心脏骤停心肺复苏术后治疗方法的不同分为观察组43例和对照组40例。对照组给予常规救治,观察组在常规救治基础上联合参附注射液治疗。比较两组心肺复苏成功即刻及治疗后24、48 h时血C反应蛋白(CRP)、肿瘤坏死因子α(TNF-α)、神经元特异性烯醇化酶、氧合指数、心肌型肌酸激酶同工酶(CK-MB)、肌钙蛋白T(cTnT)、天冬氨酸转氨酶(AST)、丙氨酸转氨酶(ALT)、血肌酐(Cr)、尿素(BUN)水平,以及1个月生存率。结果两组复苏成功后24、48 h CRP和TNF-α水平均较复苏成功即刻升高,且复苏成功后48 h上述指标升高更为明显(P<0.05或P<0.01);观察组复苏成功后24、48 h CRP和TNF-α水平均低于对照组同时间(P<0.05)。两组复苏成功后24、48 h神经元特异性烯醇化酶较复苏成功即刻降低,氧合指数较复苏成功即刻升高,且复苏成功后48 h神经元特异性烯醇化酶降低及氧合指数升高程度更为显著(P<0.05或P<0.01);观察组复苏成功后24、48 h神经元特异性烯醇化酶均低于对照组同时间,氧合指数均高于对照组同时间,差异均有统计学意义(P<0.05)。两组复苏成功后24、48 h CK-MB、cTnT、AST、ALT、Cr、BUN水平均降低,且复苏成功后48 h CK-MB、cTnT、AST、ALT、Cr、BUN降低程度更为显著(P<0.05或P<0.01);观察组复苏成功后24、48 h CK-MB、cTnT、AST、ALT、Cr、BUN水平均低于对照组同时间(P<0.05)。观察组1个月生存率为76.74%高于对照组1个月生存率52.50%,差异有统计学意义(P<0.05)。结论心脏骤停心肺复苏术后患者给予参附注射液治疗,可有效减轻相关脏器损伤程度,保护脑、肺、心肌、肝肾功能,并能改善患者预后。展开更多
In the present study, the efficacy and safety of oxycodone and morphine in the treatment of cancer pain were compared in a meta-analysis with the goal of providing a reference for drug selection in clinical practice. ...In the present study, the efficacy and safety of oxycodone and morphine in the treatment of cancer pain were compared in a meta-analysis with the goal of providing a reference for drug selection in clinical practice. Electronic literature databases were searched for articles published through February 2015, including PubMed, MEDLINE, the Cochrane library, and Embase; and the China National Knowledge Intemet, VIP Databases and Wanfang Databases for studies published in Chinese. Only randomized controlled trials were selected. The primary outcome measures were efficacy and the incidence of adverse drug reactions （ADRs）. Data were extracted from the studies by two independent reviewers. A total of 15 studies containing 1338 patients were included in the analysis. The studies were divided into two subgroups according to different scoring methods. The pain relief efficacies of oxycodone and morphine were rated by the numerical rating scale （NRS） （risk ratio [RR]： 1.04; 95% confidence interval [CI]： 0.97-1.11）. Others were rated by the visual analog scale （VAS） （RR： 1.03; 95% CI： 0.97-1.10）. Five studies showed that pain intensity scores did not significantly differ between oxycodone and morphine treatments （standard mean difference [SMD] = 0.16, 95% CI： -0.01-0.33, P = 0.06）. Regarding ADRs, the incidence of constipation was lower in the oxycodone group （RR： 0.70; 95% CI： 0.58-0.85）. No statistical difference was observed among other ADRs. The efficacies of oxycodone and morphine were similar in treating cancer pain. However, the incidence of constipation was lower in patients treated with oxycodone.展开更多
文摘布兰斯菲尔德海峡为南极磷虾主要捕捞区域,为了进一步研究该海域南极磷虾资源分布及生物学特征,基于2018/19渔季中国南极磷虾商业捕捞数据,从时间和空间两个维度对南极磷虾CPUE(catch per unit fishing effort,CPUE)、体长及年龄组成进行了分析。结果表明,布兰斯菲尔德海峡南极磷虾CPUE月间差异显著(P<0.001),4—7月平均CPUE整体呈下降趋势;CPUE沿海峡呈东北-西南向分布,高值区多分布在海峡东北海域(58°45′00"~59°45′00"W、62°52′30"~63°07′30"S)。空间冷热点分析结果表明,CPUE热点主要位于海峡东北海域,核心冷点和次冷点主要分布在海峡西南海域和东南海域。不同月间南极磷虾体长差异显著(P<0.001),平均体长变化范围为39.72~44.51 mm;平均体长低值区沿东北-西南走向平行分布于海峡西缘的南设得兰群岛近岸海域,高值区多分布在海峡中部及海峡东缘的南极半岛近岸海域。不同月间南极磷虾年龄组成差异较大,5月年龄组成以3~+龄为主,其余月份以2~+龄为主;年龄组成整体上由西北向东南增大,海峡西缘的南设得兰群岛近岸海域年龄组成略低于海峡中部及海峡东缘的南极半岛近岸海域。
文摘目的观察参附注射液对心脏骤停心肺复苏术后患者脏器功能的保护作用。方法选取我院2017年3月-2018年6月收治的心脏骤停后心肺复苏成功患者83例,根据心脏骤停心肺复苏术后治疗方法的不同分为观察组43例和对照组40例。对照组给予常规救治,观察组在常规救治基础上联合参附注射液治疗。比较两组心肺复苏成功即刻及治疗后24、48 h时血C反应蛋白(CRP)、肿瘤坏死因子α(TNF-α)、神经元特异性烯醇化酶、氧合指数、心肌型肌酸激酶同工酶(CK-MB)、肌钙蛋白T(cTnT)、天冬氨酸转氨酶(AST)、丙氨酸转氨酶(ALT)、血肌酐(Cr)、尿素(BUN)水平,以及1个月生存率。结果两组复苏成功后24、48 h CRP和TNF-α水平均较复苏成功即刻升高,且复苏成功后48 h上述指标升高更为明显(P<0.05或P<0.01);观察组复苏成功后24、48 h CRP和TNF-α水平均低于对照组同时间(P<0.05)。两组复苏成功后24、48 h神经元特异性烯醇化酶较复苏成功即刻降低,氧合指数较复苏成功即刻升高,且复苏成功后48 h神经元特异性烯醇化酶降低及氧合指数升高程度更为显著(P<0.05或P<0.01);观察组复苏成功后24、48 h神经元特异性烯醇化酶均低于对照组同时间,氧合指数均高于对照组同时间,差异均有统计学意义(P<0.05)。两组复苏成功后24、48 h CK-MB、cTnT、AST、ALT、Cr、BUN水平均降低,且复苏成功后48 h CK-MB、cTnT、AST、ALT、Cr、BUN降低程度更为显著(P<0.05或P<0.01);观察组复苏成功后24、48 h CK-MB、cTnT、AST、ALT、Cr、BUN水平均低于对照组同时间(P<0.05)。观察组1个月生存率为76.74%高于对照组1个月生存率52.50%,差异有统计学意义(P<0.05)。结论心脏骤停心肺复苏术后患者给予参附注射液治疗,可有效减轻相关脏器损伤程度,保护脑、肺、心肌、肝肾功能,并能改善患者预后。
基金Evaluation of Safe and Rational Medication and Study and Application of Interventional Technology(Grant No.2013BAI06B04)
文摘In the present study, the efficacy and safety of oxycodone and morphine in the treatment of cancer pain were compared in a meta-analysis with the goal of providing a reference for drug selection in clinical practice. Electronic literature databases were searched for articles published through February 2015, including PubMed, MEDLINE, the Cochrane library, and Embase; and the China National Knowledge Intemet, VIP Databases and Wanfang Databases for studies published in Chinese. Only randomized controlled trials were selected. The primary outcome measures were efficacy and the incidence of adverse drug reactions （ADRs）. Data were extracted from the studies by two independent reviewers. A total of 15 studies containing 1338 patients were included in the analysis. The studies were divided into two subgroups according to different scoring methods. The pain relief efficacies of oxycodone and morphine were rated by the numerical rating scale （NRS） （risk ratio [RR]： 1.04; 95% confidence interval [CI]： 0.97-1.11）. Others were rated by the visual analog scale （VAS） （RR： 1.03; 95% CI： 0.97-1.10）. Five studies showed that pain intensity scores did not significantly differ between oxycodone and morphine treatments （standard mean difference [SMD] = 0.16, 95% CI： -0.01-0.33, P = 0.06）. Regarding ADRs, the incidence of constipation was lower in the oxycodone group （RR： 0.70; 95% CI： 0.58-0.85）. No statistical difference was observed among other ADRs. The efficacies of oxycodone and morphine were similar in treating cancer pain. However, the incidence of constipation was lower in patients treated with oxycodone.
