摘要
皮肤结核和麻风是以皮肤病变为主的传染病,烧伤、烫伤和机械破损是造成皮肤功能障碍的常见外科病,目前缺乏有效的皮肤修复制剂。本试验以细菌纤维素为材料,采用煮沸法荷载利福平,得到利福平纤维素膜。结果表明,利福平主要荷载于细菌纤维素的基质中,每cm2载药纤维素膜的质量为6 mg,载药量为5100 μg/cm2。动物试验显示,药片以自然融合的方式填补皮肤破损,发挥天然皮肤的作用。本试验为进一步研发广谱皮肤修复制剂奠定了基础。
Skin tuberculosis and leprosy are infectious diseases with skin lesions. Burns, hot scald and me-chanical damage are common surgical diseases that cause skin dysfunction. However, there are no effective skin-repairing preparations currently. In this study, rifampicin-cellulose film was pre-pared by boiling method based on bacterial cellulose. The results showed that rifampicin was mainly loaded in the matrix of bacterial cellulose. The weight of the drug-loaded cellulose mem-brane was 6 mg per cm2. The drug loading was 5100 μg/cm2. Animal tests have shown that the drug-loaded cellulose membrane fills the skin in a natural fusion and acts as a natural skin. Therefore, this study laid the foundation for the further development of a broad-spectrum skin-repairing preparation.
出处
《药物化学》
2018年第4期138-143,共6页
Hans Journal of Medicinal Chemistry
基金
国家自然科学基金(NSFC81460531)
国家自然科学基金(NSFC81760629)
贵州大学SRT(No.190)计划。
