摘要
阿尔茨海默病(AD)是一种不可逆转的神经退行性疾病,是老年人痴呆最常见的病因,约占所有痴呆比例的80%,临床表现为两个或多个认知领域(记忆力、语言、执行力和视觉空间功能、人格和行为)的进行性下降。当下尚无可以根治AD的药物。而传统中、藏药在防治AD上具有显著的优势。近年来,越来越多的国内外中、藏药干预AD发病机制的研究显示其主要通过抑制β-淀粉样蛋白聚集及Tau蛋白过度磷酸化、抑制氧化应激反应及清除自由基、改善胆碱能系统学说等方面,来保护神经元,可以有效地延缓和抑制AD的发生发展。本文将传统中、藏药及复方制剂干预AD的研究进展做一综述。
Alzheimer’s disease(AD),an irreversible neurodegenerative disease,is the most common cause of dementia in the elderly,accounting for about 80%of all dementias,with clinical manifestations in two or more cognitive domains(memory,language,executive and visuospatial function,personality and behavior)progressive decline.There are currently no drugs that can cure AD.Traditional Chi-nese and Tibetan medicines have significant advantages in the prevention and treatment of AD.In recent years,more and more domestic and foreign studies on the intervention of Chinese and Ti-betan medicine on the pathogenesis of AD have shown that it mainly inhibitsβ-amyloid protein ag-gregation and Tau protein hyperphosphorylation,inhibits oxidative stress response,scavenges free radicals,improves biliary Alkaline system theory and other aspects,to protect neurons,can effec-tively delay and inhibit the occurrence and development of AD.This article reviews the research progress of traditional Chinese and Tibetan medicines and compound preparations in AD interven-tion.
出处
《临床医学进展》
2022年第8期7326-7331,共6页
Advances in Clinical Medicine
