摘要
目的 探讨间α胰蛋白酶抑制物 (ITI)在脉络膜黑色素瘤中的表达及与病理学分型和恶性程度、浸润能力的关系。方法 选择石蜡包埋脉络膜黑色素瘤组织 2 8例 ,通过脱色素免疫组织化学方法和计算机图像分析技术进行ITI表达的检测。结果 ITI在瘤细胞胞浆中被检测到。梭形细胞型、混合细胞型、上皮细胞型ITI的阳性表达率依次降低。脉络膜黑色素瘤的恶性程度、浸润能力与ITI的表达呈负相关。平均吸光度值在各型脉络膜黑色素瘤中无明显不同。结论 脉络膜黑色素瘤表达ITI。其存在抑制了脉络膜黑色素瘤的恶化浸润和转移 ,且一定程度上可以反映其恶性程度及预后。
Objective To evaluate the expression of inter-alpha-trypsin inhibitor(ITI) in choroidal melanoma and its significance. Methods Depigment immunohistochemical technique and computer-imaging analysis were used to localize and observe the expression of ITI in 28 patients with choroidal melanoma. Results Intracytoplasmic staining with ITI antiserum was observed in tumor cells.The rate of ITI expression in the spindle cell,mixed cell and epithelial cell tumors was successively decreased.The average A values in different types of choroidal melanoma were not significantly different.There was a negative correlation between the level of ITI expression and malignancy,extrascleral extension. Conclusion Existance of ITI inhibits the transformation and infiltration of choroidal melanoma.it can reflect the extent of malignancy and prognosis of choroidal melanoma in part.
出处
《眼科研究》
CAS
CSCD
北大核心
2004年第3期293-295,共3页
Chinese Ophthalmic Research
