摘要
目的 :探讨绝经后高胆固醇血症妇女经戊炔雌三醇补充治疗后血中脂蛋白、瘦素 (leptin)及性激素水平的改变。方法 :选择 4 6例绝经后高胆固醇血症的妇女 ,给予戊炔雌三醇 2mg,1次 / 2周 ,甲羟孕酮 (安宫黄体酮 ) 2mg ,1次 /隔日治疗。于治疗后 3个月、6个月测定空腹血中胆固醇、瘦素及性激素的值 ,并在治疗后 12个月、18个月、2 4个月、30个月、36个月继续监测胆固醇水平。结果 :治疗后 3个月、6个月与治疗前相比 ,血中高密度脂蛋白 (HDL C)显著升高 ,低密度脂蛋白 (LDL C)显著下降 ,总胆固醇 (TC)有所降低 ,但差异无显著性 ;体重及体重指数略有降低 ,差异无显著性 ,Lep tin水平治疗后稍有降低但差异无显著性 ;促卵泡生成激素 (FSH)和黄体生成素 (LH)均有明显下降 (P <0 .0 1)。治疗后18～ 36个月HDL C、LDL C、TC均处于基本稳定的水平 ,而甘油三脂 (TG)在整个治疗过程中基本无变化。结论
Objective:To stuby the changes of blood lipoprotein,leptin,and sex hormone in post-menopausal women with hyper.lipohemia treated by oral Niletrioli.Methods:46 post-menopausal women with hyper-lipohemia were treated with oral 2mg Niletrioli once every other week and 2mg medroxyprogesterone acetate(MPA) once every other day.Serum cholesterol,leptin,and sex hormone were measured after 3 month and 6 month of treatment,and serum cholesterol was monitored lasting to 36 months after trestment.Results:Compared to pre-treatment,high-density lipoproteins-cholesterol(HDL-C)increased,low-density lipoprotein-cholesterol(LDL-C) and total cholesterol(TC) decreased after 3 and 6 months of treatment,but there was no significant difference;Serum leptin,body weight,and BMI weakly decreased and no remarkably difference;Serum FSH and LH decreased significantly(P<0.01).Serum HDL-C,LDL-C,and TC levels kept stable after 18-36 months of treatment,and serum TG almost had on changes during treatment and follow-up.Conclusions:Niletrioli is benefit for blood lipoprotein in postme nopausal women with hyper-lipohemia.
出处
《实用妇产科杂志》
CAS
CSCD
北大核心
2004年第3期149-150,共2页
Journal of Practical Obstetrics and Gynecology
