摘要
本文提供了N_b-甲基四氢海曼和合成中间体,共十个化合物的~1H NMR谱。各谱线的归属依据它们的2D NMR的同核二维相关谱,COSY指定。根据NOE效应,指定了化合物的构型。借助分子模型,讨论了可能的构象。
Using Pictet-Spengler condensation, ammonification, methylation, dehydration and decyanation, Nb-methyl -tetrahydroharman and the synthetic intermediates 1S,S、1S,R、2S,S、 2S, R、3S,S、3S,R、4S,S、4S, R were obtained. Their 1H NMR spectra were assigned based on COSY spectroscopy and their configurations of 1-C were determined by NOE experiments. It was shown that for all of the S, S isomers there were NOE relationships between 1-H and 3-H and for all of the S, R isomers NOE relationships between 1-CH3 and 3-H. Based on the results of NOE and the help of Dreiding stereomodels their conformations were discussed.
出处
《波谱学杂志》
CAS
CSCD
1993年第2期149-156,共8页
Chinese Journal of Magnetic Resonance
基金
国家自然科学基金
国家教委优秀年轻教师基金
德国洪堡基金
关键词
四氢海曼
立体化学
NMR
二维
Nb-methyl -tetrahydroharman
Stereochemistry
2D NMR .
