摘要
2,4-二氨基-6-(取代苄基)-5-甲基吡啶(2,3d)并嘧啶类化合物是一类很有前途的抗癌新药。本文研究了24种7位氯代和氧代的该类化合物的碳谱,归属了母核及取代苄基上各碳的化学位移,并对两种取代对母核碳上的化学位移的影响规律进行了探讨,文中所有数据迄今未见文献报道。
2,4 -diamino-5 -methyl -6 -substituted -benzyl pyrido -(2,3d) pyrimidines are a kind of promising anticancer drugs. 13C NMR spectra of 24 kinds of 7-chloro and 7-oxo compounds have been studied in this paper. The chemical shifts of all carbons in the parent nuclei and subitituted benzyl have successfully been assigned. The influential factors on chemical shifts of all carbons in parent nuclei for two substituted groups have been approached in depth. To date, the data in this paper have not been published in the world.
出处
《波谱学杂志》
CAS
CSCD
1993年第2期177-184,共8页
Chinese Journal of Magnetic Resonance
基金
国家自然科学基金
关键词
NMR
甲基吡啶
嘧啶
抗癌药
13C NMR
2
4 -diamino-5 -methyl -6 -substituted-benzyl pyrido-( 2
3d ) pyrimidines .
