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代谢组学在后基因组时代的作用 被引量：25

METABONOMICS IN POST-GENOMIC ERA
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摘要 基于核磁共振技术的代谢组学研究 ,是近几年发展起来的一种新的“组学”技术 .它主要利用生物体液的核磁共振谱 ,提供了生物体内全部小分子代谢物的丰富信息 .代谢组学在功能基因组学、病理生理学、药理毒理学等方面都有着广泛的应用前景 . Metabonomics has now become an important component of systems biology, with promising applications in toxicology, functional genomics, disease diagnosis, environmental analysis and nutritional assessment. In this review, the recent developments in NMR-based metabonomics were discussed.
作者 颜贤忠 赵剑宇 彭双清 廖明阳
机构地区 国家生物医学分析中心 军事医学科学院毒物药物研究所
出处 《波谱学杂志》 CAS CSCD 北大核心 2004年第2期263-271,共9页 Chinese Journal of Magnetic Resonance
基金 国家高技术研究发展计划 (2 0 0 2AA2Z3 42D) 国家自然科学基金 (3 0 3 71 70 5 )资助项目
关键词 代谢组学 毒理学 功能基因组学 疾病诊断 核磁共振技术 NMR, metabonomics, functional genomics, toxicology disease diagnosis
分类号 Q591 [生物学—生物化学] R99 [医药卫生—毒理学]
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参考文献55

  • 1Nicholson L K, Lindon J C, Holmes E. 'Metabonomics': understanding the metabolic responses of living systems to pathophysiological stimuli via multivariate statistical analysis of biological NMR spectroscopic data[J]. Xenobiotica, 1999, 29(2): 1 181-1 189.
  • 2Nicholson J K, Connelly J, Lindon J C, et al. Metabonomics: a platform for studying drug toxicity and gene function[J]. Nat Rev Drug Disc, 2002, 1(2): 153-161.
  • 3Oliver, S. Guilt-by-association goes global[J]. Nature,2000, 403: 601-603.
  • 4Thomas,GH. Metabolomics breaks the silence[J]. Trends Microbiol. 2001, 9(4): 158.
  • 5Fiehn O. Metabolomics-the link between genotypes and phenotypes[J]. Plant Mol Biol. 2002, 48(1-2): 155-171.
  • 6Choi H K, Choi Y H, Verberne M, et al. Metabolic fingerprinting of wild type and transgenic tobacco plants by (1)H NMR and multivariate analysis technique[J]. Phytochemistry. 2004, 65(7): 857-864.
  • 7Ketchum R E, Rithner C D, Qiu D, et al. Taxus metabolomics: methyl jasmonate preferentially induces production of taxoids oxygenated at C-13 in Taxus x media cell cultures[J]. Phytochemistry. 2003, 62(6): 901-909.
  • 8Fiehn O. Metabolic networks of Cucurbita maxima phloem[J]. Phytochemistry. 2003, 62(6): 875-886.
  • 9Fiehn O, Kopka J, Dormann P, et al. Metabolite profiling for plant functional genomics[J]. Nat Biotechnol. 2000, 18(11): 1 157-1 161.
  • 10Bruder E D, Lee P C, Raff H. Metabolomic analysis of adrenal lipids during hypoxia in the neonatal rat: implications in steroidogenesis[J]. Am J Physiol-Endoc Metab. 2004, 286(5): E697-703.

二级参考文献13

  • 1Nicholson JK, Lindon JC, Holmes E. Metabonomics:understanding the metabolic responses of living systems to pathophysiological stimuli via multivariate statistical analysis of biological NMR data. Xenobiotica, 1999,29:1181-1189.
  • 2Lindon JC,Nicholson JK,Holmes E,et al. Metabonomics:metabolic processes studied by NMR spectroscopy of biofluids. Concepts Magn Reson ,2000,12:289-320.
  • 3Nicholson JK, Foxall P, Spranl M, et al.750 MHz 1H and 1H-13 C NMR spectroscopy of human blood plasma. Anal Chem, 1995,67:793-811.
  • 4Deredy EI. Pattem recognition approaches in biomedical and clinical magnetic resonance spectroscopy: A review. NMR Biomed, 1997,10: 99-124.
  • 5Beckwith-Hall BM, Thompson NA,Nicholson JK, et al. A metabonomics investigation of hepatotoxicity using diffusionedited 1H NMR spectroscopy of blood serum.Analyst, 2003,128,814-818.
  • 6Eriksson L, Johansson E, Kettaneh-wold N, et al. Introduction to multi-and megavariate data analysis using projection methods (PCA &PLS). Umea, Sweden, Umetrics. 1999,195-221.
  • 7Beckwith-Hall BM, Nicholson JK, Nicholls AW, et al. Nuclear magnetic resonance spectroscopic and principal components analysis investigations into biochemical effects of three model hepatotoxins. Chem Res Toxicol,1998,11:260-272.
  • 8Jaeschke H, Gores GJ, Cederbaum AI, et al. Mechanisms of Hepatotoxicity. Toxicol Sci, 2002, 65: 166-176.
  • 9Travlos GS, Morris RW, Elwell MR, et al. Frequency and relationships of clinical chemistry and liver and kidney histopathology findings in 13-week toxicity studies in rats.Toxicology, 1996,107:17-19.
  • 10Holmes E, Nicholson JK, Tranter G. Metabonomic classification of genetic variations in toxicological and metabolic responses using probabalistic neural networks, Chem Res Toxicol, 2001,14:182-191.

共引文献7

同被引文献455

引证文献25

二级引证文献249

波谱学杂志
2004年 第2期

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