摘要
目的 了解广州市流动人群A群流行性脑脊髓膜炎 (简称流脑 )抗体水平及流脑多糖菌苗的接种情况。方法 采用横断面研究、整群抽样方法 ,于 2 0 0 0年 1 0～ 1 2月在广州市流动人口聚集地采集流动人群血清样本 ,应用酶联免疫吸附试验 ,进行A群流脑抗体检测 ,并进行问卷调查。结果 调查的 1 0 2 6名流动人群中 ,A群流脑抗体阳性 91 7人 ,阳性率为 89 2 8% ,GMT为 1∶1 7。流脑菌苗接种率为 1 7 6 4 % ,1 81人已接种流脑菌苗者抗体阳性率 (93 90 % )和GMT(1∶2 1 86 )明显高于 84 5人未接种者 (阳性率和GMT分别为 88 4 0 %和 1∶1 6 1 1 ) (P <0 0 5 )。抗体阳性率和GMT有随年龄增长而下降的趋势 ,<2 0岁组最高 (93 6 % ) ,4 0岁以上组最低 (71 4 % ) ,各年龄组间的差异有显著性 (P <0 0 5 )。结论 广州市流动人群对A群流脑具有较高的免疫力 ,但人群流脑菌苗接种率低 ,且高年龄组人群抗体水平较低。
Objective To define the antibody level against epidemic cerebrospinal meningitis A (ECM A) and the vaccination coverage among floating population in Guangzhou. Results Cross sectional study was employed and 1 026 subjects were recruited by cluster sampling in a development district of Guangzhou. Antibody against ECM A was tested by ELISA and vaccination coverage by structured questionnaire. Results Nine hundred and seventeen persons were antibody positive against ECM A (positive rate 89 28%, GMT 1∶17).Meningococcal polysaccharide vaccination coverage was 17 64%. Antibody positive rate and GMT in vaccinated group were significantly higher then that in unvaccinated group (antibody positive rate 93 90% vs 88 40%; GMT 1∶21 86 vs. 1∶16 11, Z=3 76, P <0 05). Antibody level had significant different in age groups (chisq=27 80, P <0 05). The antibody level and GMT was negatively correlated to age with the highest antibody level in less than 20 years group and the lowest in age 40 and over groups. Conclusion The immunity against ECM A was considerably high in floating population in Guangzhou but the antibody level and the vaccination coverage were low in older age group. It is necessary to implement vaccination program in floating population.
出处
《华南预防医学》
2004年第2期4-6,共3页
South China Journal of Preventive Medicine
基金
广东省医学科研基金立项课题 (项目编号A2 0 0 0 60 7)
关键词
流行性脑脊髓膜炎
流动人1:7
抗体
接种
Epidemic cerebrospinal meningitis
Floating population
Antibodies
Vaccination
