摘要
目的 :探讨小儿特发性血小板减少性紫癜 (ITP)与多种病毒感染的关系。方法 :用ELISA技术对 10 2例诊断明确的ITP患儿进行人细小病毒 (HPVB19) ,柯萨基病毒 (CBV1- 6 ) ,人类巨细胞病毒 (HCMV)及EB病毒 (EBV)特异性IgM的检测。结果 :10 2例ITP中HPVB19-IgM阳性 4 1例 ( 4 0 .12 % ) ;CBV1- 6 -IgM阳性 2 8例 ( 2 7.4 5 % ) ;HCMV -IgM阳性 17例( 16 .6 6 % ) ;EBV -IgM阳性 7例 ( 6 .86 % ) ;四种病毒总阳性率 5 0 .98% ,除EBV外其他三种病毒感染阳性率均明显高于正常对照组 ,两组比较有显著性差异 (P <0 .0 5 )。结论 :( 1)病毒感染是小儿ITP的主要致病因素 ;( 2 )HPVB19感染是引起ITP最常见的病因 ;( 3)HCMV感染与婴儿ITP的发生、治疗效果及预后有着明确的关系 ;( 4 )CBV1- 6感染也是ITP的主要致病因素之一。
Objective:To study the relationship between idiopathic thrombocytopenic purpura (ITP) and various virus infections in children.Methods:The human parvovirusB 19(HPV-B 19),Epstein-Barr virus(EBV),Cytomegalovirus and Coxsackie virus (CBV 1-6) were detected using ELISA test in 102 patients with ITP.Results:The HPVB-19 IgM was positive in 41 patients(40.12%).CBV1-6 IgM was positive in 28 patients(27.45%).The CMV IgM was positive in 17 patients(16.66%).The EBV IgM was positive in 7 patients(6.86% ).The total rate of these four viruses was 50.98% of the patients with ITP observed in this study.Except EBV,the virus infections positive rate in this study were significantly higher than that of control group.( P <0.05).Conclusion:(1)These results suggest that the pathogenesis of ITP in childhood might be correlated with virus infections.(2)HPV-B19 infecteion is the most common virus in the patients with ITP.(3)The CMV infection is associated with the treatment effect and prognosis clinically in infant with ITP.(4)The CBV1-6 infection may be one of the virus caused ITP.
出处
《重庆医科大学学报》
CAS
CSCD
2004年第3期375-376,共2页
Journal of Chongqing Medical University
关键词
特发性血小板减少性紫癜
病毒感染
儿童
Idiopathic thrombocytopenic purpura (ITP)
Virus infection
Children
