摘要
目的 探讨应用分子吸附循环系统结合肝移植治疗急性肝功能衰竭的效果。方法 8例急性肝功能衰竭患者 (7例原发病为乙型肝炎后肝硬化 ,1例为Wilson病 )在等待肝移植期间经分子吸附循环系统治疗 3～ 7次 ,所有患者均接受同种异体改良背驮式肝移植术。结果 患者等待供肝时间 8～ 30d ,平均 13d ,所有患者均顺利渡过围手术期 ,痊愈出院。应用分子吸附循环系统治疗后 ,患者的血清丙氨酸转氨酶、天冬氨酸转氨酶及总胆红素水平明显下降 (P <0 .0 1) ,但凝血功能的改善不明显。结论 分子吸附循环系统可暂时替代肝脏的部分功能 ,帮助急性肝功能衰竭患者顺利渡过肝移植等待期。
Objective To study the molecular adsorbent recycling system (MARS), which may bridge to liver transplantation, in treating acute liver failure patients.Methods Biochemical indexes and other clinical data of 8 acute liver failure patients, who were treated by MARS (altogether 34 times) and then experienced modified piggyback liver transplantation.Results When treated with MARS, the levels of transaminases and total bilirubin index were decreased dramatically, while coagulating function was not improved. All patients were survived and discharged. Conclusion MARS is an effective method in bridging acute liver failure patients to liver transplantation.
出处
《中华器官移植杂志》
CAS
CSCD
北大核心
2004年第3期138-139,共2页
Chinese Journal of Organ Transplantation
