摘要
目的 :了解本地肠球菌属细菌的耐药性变化 ,为临床经验用药提供参考。方法 :对 1998～ 2 0 0 3年临床分离之肠球菌属细菌进行耐药趋势分析。结果 :90 6株肠球菌属细菌以粪肠球菌和屎肠球菌为主 ,占 87 86 % ,高浓度庆大霉素耐药 (HLGR)肠球菌分离率为 6 1 4 1% ,万古霉素耐药肠球菌 (VRE)分离率为 0 4 4 % ,对青霉素、氨苄西林、环丙沙星的耐药率呈逐年增加趋势 ;粪肠球菌对青霉素的耐药率为 14 0 7% ,而屎肠球菌对青霉素耐药率达 83 33% ,对相同抗生素的耐药率屎肠球菌明显高于粪肠球菌。结论 :肠球菌对临床常用抗生素以万古毒素最敏感 ,但青霉素类药物仍不失为治疗粪肠球菌的首选 ;对于屎肠球菌、HLGR、VRE等感染的治疗 ,应全面考虑肠球菌对不同抗生素的耐药水平 ,采取联合用药 ;而实验室对于肠球菌属的正确鉴定、分型、耐药监测以及临床治疗肠球菌感染中有效控制抗生素疗程 ,缩短平均住院日也是控制肠球菌耐药传播的有效手段之一。
Objective:To investigate the antibiotic resistant of enterococci in clinical issue,Method:To analyze susceptibility test results of enterococci from year 1998 to year 2003.Results:The main species were E.faecalis and E.faecium,whose percentage was 87.86%.HLGR enterococci and VRE were 61.41% and 0.44% respectively.The resistant pattern of entercocci to penicillin,ampcillin,and ciprofloxcin became more and more common;The resistant rate of E.faecalis to penicillin was only 14.07%,but resistant rate of E.faecium was as high as 83.33%.the same resistant rate was observed to other antibiotics.Conclusion:Vancomycin is still the most effective antibiotic to infection caused by enterococci,and penillin was most effective to E.faecalis.Since different species of enterococci had different antibiotic resistant characteristic it should be identified into species to entercocci in clinical microbiology laboratory.
出处
《华西医学》
CAS
2004年第2期227-228,共2页
West China Medical Journal
