摘要
在离体大鼠主动脉条上,观察纤维蛋白(原)降解产物肽6A灌流对血管反应性及血管组织cGMP含量的影响。结果表明,肽6A呈剂量依赖地显著扩张离体血管,其作用在去内皮后消失;肽6A还能显著提高离体血管组织cGMP含量,NO合成抑制剂L-NNA可阻断这一作用。NO前体L-精氨酸可逆转L-NNA的效应。提示,肽6A可通过促进血管内皮释放内皮舒张因子而扩张血管。
For the purpose of investigating the action of endothelium-derived relaxing factor (EDRF) invasodilatation induced by peptide 6 A (P6A), the influence of P 6 A on the vasoreactivity and tissuecGMP content was observed on the isolated perfused rat aorta. It was found that P 6A significantlyrelaxed isolated aortic ring in a dose-dependent manner, and the vasodilation action of P 6A disappearedin the denuded vessel; and that P 6A markedly increased aorta cGMP content, which was blocked byNO synthesis inhibitor L-NNA. This blocking action of L-NNA could be reversed by a precursor ofNO, L-arginine. These results show that P 6A dilates vascular vessels by stimulating the release ofEDRF from endothelium.
出处
《北京医科大学学报》
CSCD
1993年第5期359-361,共3页
Journal of Peking University(Health Sciences)
