摘要
目的 :研究p2 7蛋白在胃癌组织的表达情况及其与胃癌生物学行为、预后的关系。方法 :免疫组化SP法检测胃癌组织中p2 7蛋白的表达。结果 :胃癌组织中 2 7蛋白的表达阳性率为 36 8% ,无脉管侵犯病例p2 7表达高于有脉管侵犯病例 ,二者差异有显著性 (P <0 0 5 ) ;p2 7低表达、有脉管侵犯、肿瘤直径≥ 4cm这 3种因素与胃癌的不良预后有关。结论 :p2 7蛋白表达为判断胃癌组织恶性程度及预后的有价值指标之一。
Objective: To investigate the relationship between the expression of p27 and biologic behavior and prognosis in stomach carcinoma . Methods: Study the expression of p27 by immunohistochemical method of SP in stomach carcinoma in 70 cases . Results:The positive expression rates of p27 were 36.8% in stomach carcinoma , the expression of p27 is stronger in vascular metastasis-negative than in vascular metastasis-positive (P<0.05). The three factors of the loss expression of p27,the vascular metastasis-positive and the director of tumor ≥4cm was related to the poor prognosis in stomach carcinoma. Conclusion: Expression of p27 may serve as a parameter for evaluating prognosis in stomach carcinoma.
出处
《湖北省卫生职工医学院学报》
2004年第1期18-19,29,共3页
Journal of Hubei Medical Staff College
关键词
胃癌
P27
预后
免疫组化
stomach carcinoma
p27
prognosis
immunohistochemistry
