摘要
Alginate microspheres were formed by coagulation of sodium alginate in CaCl 2 solutions,followed by lyophilization which could create the porous structure.Bovine serum albumin (BSA) was incorporated into the microspheres by mixing BSA with sodium alginate prior to coagulation.The release behavior of BSA from the Ca-alginate microspheres was studied.Further,the alginate microspheres loaded with BSA were embedded in PLGA films by mixing the alginate microspheres with PLGA solutions in order to study the sustained release of BSA from the PLGA film,which is widely used as cell scaffold materials in tissue engineering.The release behavior of BSA from the PLGA film embedded alginate microspheres indicated potential application for keeping the bioactivity of the growth factor.
Alginate microspheres were formed by coagulation of sodium alginate in CaCl2 solutions, followed by lyophilization which could create the porous structure. Bovine serum albumin ( BSA ) was incorporated into the microspheres by mixing BSA with sodium alginate prior to coagulation. The release behavior of BSA from the Ca-alginate microspheres was studied. Further, the alginate microspheres loaded with BSA were embedded in PLGA films by mixing the alginate microspheres with PLGA solutions, in order to study the sustained release of BSA from the PLGA film, which is widely used as cell scaffold materials in tissue engineering. The release behavior of BSA from the PLGA film embedded alginate microspheres indicated potential application for keeping the bioactivity of the growth factor.
出处
《高分子学报》
SCIE
CAS
CSCD
北大核心
2004年第3期454-457,共4页
Acta Polymerica Sinica
基金
国家重点基础研究资助项目 (项目号 973G1990 5 43 0 6)
