摘要
目的 研究尼莫地平在不同时期用药对高血压脑出血患者血肿、水肿体积和神经功能的影响。方法 治疗组30例,对照组30例。两组患者均采用传统脑出血的治疗方法(脱水、止血、抗炎及酌情用血管紧张素转换酶抑制剂(ACEI),治疗组在此基础上加用尼莫地平。观察尼莫地平于患者发病后3 d用药,对血肿、水肿体积的影响及神经功能的动态变化。 结果 治疗组患者较对照组患者,血肿和水肿体积明显减小、神经功能明显改善(P<0.05)。治疗组患者在应用尼莫地平10d后血肿体积由(25±10)ml变为(16±10)ml,水肿体积由(15±4)ml变为(25±8)ml;而对照组患者血肿体积由(25±11)ml变为(23±10)ml,水肿体积由(16±9)ml变为(35±22)ml,(P<0.05)。神经功能评分:第3天时,治疗组患者从24±10降至18±11,对照组患者从25±10降至25±6,两组比较P<0.05。 结论 早期使用尼莫地平对缩小血肿体积、减轻血肿周围水肿带、促进神经功能恢复和提高临床疗效有积极的作用。
Objective To study the effects of the nimodipme that used in different stages on the volume of hematoma and perilesional edema and neurological function in patients with cerebral hemorrhage. Methods 60 patients with ICH were randomly divided into 2 groups, therapeutic group and control group, 30 patients in each group. In the therapeutic group patients, Nimodipine were given within 3 days after the ictus, while no nimodipine was given in the control group. All patients were given conventional treatments (dehydration, antifibrmolytic agents, anti-inflammation drugs and angioterisin-converting enzyme inhibitors! ACE1) ?The volume of hematoma and perilesional edema measured by CT scan and Chinese Stroke Scale (CSS) obtained by physician were assessed respectively. Results The CSS of the patients of the therapeutie group was improved significantly compared with that of the control group, and the volume of hematoma and perilesional edema decreased significantly( P < 0. 05); After 10 days of treatment the hematoma volume of the therapeutic group changed from (25 ± 10) ml to( 16 ± 10) ml, and the volume of edema changed from (15 ± 4) ml to (25 ± 8) ml. In the control group the hematoma volume changed from (25 ± 11) ml to (23 ± 10) ml, and the edema volume changed from (16±9) ml to (35 ± 22) ml. The differences between the two groups were all significant ( P<0. 05). In the therapeutic: group, CSS changed from 24 ± 10 to 18 ± 11, from the 1 st day to the 10th day; while in the control group, CSS changed from 25 ± 10 to 25 ± 6 from the 1st day to the 10th day; differences between the two groups were significant (P <0. 05). Conclusion Nimodipine can improve the resolution of the hematoma, and reduces perilesional edema. It also enhance the recovery of the neurological function in patients with intracerebral hemorrhage in the early stage.
出处
《中国脑血管病杂志》
CAS
2004年第6期255-257,共3页
Chinese Journal of Cerebrovascular Diseases
